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 1. Home
 2. >
 3. Diabetes
 4. >

 5. Remnant Cholesterol More Strongly Associated With Diabetes, Insulin
    Resistance Than Traditional Lipids


REMNANT CHOLESTEROL MORE STRONGLY ASSOCIATED WITH DIABETES, INSULIN RESISTANCE
THAN TRADITIONAL LIPIDS

By Cailin Conner - Last Updated: September 18, 2024


Despite a growing interest, large-scale studies comparing remnant cholesterol
(RC) with other lipid parameters in relation to diabetes and prediabetes remain
limited. Therefore, a team of investigators sought “to discover the relationship
between RC and prediabetes, diabetes, and insulin resistance (IR) and to
investigate RC, high-density lipoprotein cholesterol (HDL-C), non–HDL-C,
triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), total
cholesterol (TC), TC/HDL-C, LDL-C/HDL-C, and TG/HDL-C, which are the lipid
parameters that are most positively related to diabetes, prediabetes, and IR.”

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The multicenter, large sample survey, published in the Journal of Diabetes,
consisted of 36,684 participants. While controlling for potential confounders,
investigators employed multiple logistic regression analysis to examine the
association between different lipid parameters and the likelihood of diabetes,
prediabetes, and IR.

The results of the study showed that RC had the most substantial positive
association with diabetes, prediabetes, and IR among the lipid parameters
assessed. Specifically, the odds ratios (ORs) for diabetes, prediabetes, and IR
with respect to RC were 1.417 (95% CI, 1.345-1.492), 1.555 (95% CI,
1.438-1.628), and 1.488 (95% CI, 1.404-1.577), respectively.

Furthermore, the association between RC and these metabolic conditions remained
significant even when conventional lipid levels were within typical ranges. For
example, when triglycerides (TG) were below 2.3 mmol/L, the ORs for diabetes,
prediabetes, and IR were 1.256 (95% CI, 1.135-1.390), 1.503 (95% CI,
1.342-1.684), and 1.278 (95% CI, 1.140-1.433), respectively. Similarly, with
LDL-C levels below 2.6 mmol/L, the ORs were 1.306 (95% CI, 1.203-1.418) for
diabetes, 1.597 (95% CI, 1.418-1.798) for prediabetes, and 1.552 (95% CI,
1.416-1.701) for IR. When HDL-C was ≥1 mmol/L, the ORs were 1.456 (95% CI,
1.366-1.550) for diabetes, 1.553 (95% CI, 1.421-1.697) for prediabetes, and
1.490 (95% CI, 1.389-1.598) for IR.

“RC is more positively related to diabetes, prediabetes, and IR than
conventional lipids and lipid ratios in the general population,” the
investigators wrote. “RC could be calculated easily using the formula and is of
clinical relevance, and we recommend that health care professionals consider RC
as one of the major objectives of lipid management.”

Source: Journal of Diabetes

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