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“HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA IS A HEREDITARY LIPID DISORDER THAT
LEADS TO EXTREMELY PREMATURE CARDIOVASCULAR EVENTS AND MORTALITY SO IT IS
CRITICAL TO MAKE THE DIAGNOSIS AS EARLY AS POSSIBLE”


CHRISTIE M. BALLANTYNE, MD PROFESSOR OF MEDICINE CHIEF, SECTIONS OF CARDIOLOGY
AND CARDIOVASCULAR RESEARCH DIRECTOR, CENTER FOR CARDIOMETABOLIC DISEASE
PREVENTION BAYLOR COLLEGE OF MEDICINE HOUSTON, TEXAS

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THE NATURAL HISTORY OF HOFH IS PROGRESSIVE

PATIENTS WITH HOFH MAY EXPERIENCE MYOCARDIAL INFARCTION BEFORE THE AGE OF 10
YEARS, PARTICULARLY IF THEY HAVE THE SEVERE LDL RECEPTOR (LDLR)-DEFICIENT
GENOTYPE

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EARLY AND ACCURATE DIAGNOSIS IS CRITICAL

GIVEN THE PROGRESSIVE NATURE OF THE DISEASE, EARLY AND ACCURATE DIAGNOSIS IS KEY
TO ENSURING PROMPT DISEASE MANAGEMENT

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CONSENSUS STATEMENTS RECOMMEND LOWERING LDL-C TO REDUCE THE RISK OF
CARDIOVASCULAR MORBIDITY AND MORTALITY

THE EXTENT OF THE REDUCTION OF CHOLESTEROL LEVELS IS A MAJOR DETERMINANT OF
SURVIVAL IN PATIENTS WITH HOFH

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The information contained herein is provided for general educational purposes.
This site is intended for U.S. Healthcare Professionals.





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