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Science, Technology and Innovation – Time – Data – World @ Rodrigo Nunes Cal
Search
* I did very interesting, innovative, important and detailed graphics about
variations of all mice weights of different ages during all experimental time
of ´´my´´ dissertation. They´re available in this blog and they´re relevant
to the scientific community!! The diffusion of relevant knowledge and
information is always essential for the world progress. Scientific
discoveries need to emerge urgently!! @ Images, Texts, Links, Videos and
Websites
* In less than 2 years I was invited by Internet through direct messages to
participate in 77 very important scientific events in 32 cities in different
countries because I have participated of very important researches in Brazil
(my dissertation and my monograph). Data about it, like images, websites and
links are available in this Blog. Unfortunately there´re fatal diseases
without efficient drugs and total prevention methods
* It has a very big amount of relevant links, websites, texts, images and
YouTube Videos about human health and animal models for human diseases, such
as cardiovascular diseases, for example. It has a huge amount of very
important world data. This blog content is very good with a very high quality
and importance to the world! So, this blog sharing is relevant to the
society. #@& #HumanLongevity #DNA #Cell #Communication
* Many people worldwide have visited it and liked this blog, such as renowned
researchers, professors and/or scientists! The human expectancy of life needs
to increase so much faster by more efficient scientific research and
projects! Discovering how the initial stages of certain diseases work is of
huge importance for Science! Promoting Science like Scientific News is a very
important act to humanity in many aspects, for sure!
* About me and this blog #@ This blog goal is contribute significantly to the
world progress now and always! # @ Data about this blog statistics # I´ve
received positive feedbacks about this blog by LinkedIn, Twitter and
Facebook! Many of them are in this blog! & Animal and Human Research –
Different Efficiencies – Detailed Graphics – Ages/Age –
Person/People/Genetics – Drugs/Vaccines/Therapeutic Substances/Medical
Devices
Menu
* About me and this blog #@ This blog goal is contribute significantly to the
world progress now and always! # @ Data about this blog statistics # I´ve
received positive feedbacks about this blog by LinkedIn, Twitter and
Facebook! Many of them are in this blog! & Animal and Human Research –
Different Efficiencies – Detailed Graphics – Ages/Age –
Person/People/Genetics – Drugs/Vaccines/Therapeutic Substances/Medical
Devices
* It has a very big amount of relevant links, websites, texts, images and
YouTube Videos about human health and animal models for human diseases, such
as cardiovascular diseases, for example. It has a huge amount of very
important world data. This blog content is very good with a very high quality
and importance to the world! So, this blog sharing is relevant to the
society. #@& #HumanLongevity #DNA #Cell #Communication
* In less than 2 years I was invited by Internet through direct messages to
participate in 77 very important scientific events in 32 cities in different
countries because I have participated of very important researches in Brazil
(my dissertation and my monograph). Data about it, like images, websites and
links are available in this Blog. Unfortunately there´re fatal diseases
without efficient drugs and total prevention methods
* Many people worldwide have visited it and liked this blog, such as renowned
researchers, professors and/or scientists! The human expectancy of life needs
to increase so much faster by more efficient scientific research and
projects! Discovering how the initial stages of certain diseases work is of
huge importance for Science! Promoting Science like Scientific News is a very
important act to humanity in many aspects, for sure!
* I did very interesting, innovative, important and detailed graphics about
variations of all mice weights of different ages during all experimental time
of ´´my´´ dissertation. They´re available in this blog and they´re relevant
to the scientific community!! The diffusion of relevant knowledge and
information is always essential for the world progress. Scientific
discoveries need to emerge urgently!! @ Images, Texts, Links, Videos and
Websites
Search for:
– TWITTER MESSAGE FOR ME FROM @IEEEORG ABOUT THIS BLOG: ´´THANKS FOR YOUR HARD
WORK!´´ @ NATURE 567, 283 (2019) DOI: 10.1038/D41586-019-00874-8 – EDITORIAL 20
MARCH 2019 – ´´IT’S TIME TO TALK ABOUT DITCHING STATISTICAL SIGNIFICANCE LOOKING
BEYOND A MUCH USED AND ABUSED MEASURE WOULD MAKE SCIENCE HARDER, BUT BETTER. IF
RESEARCHERS DO DISCARD STATISTICAL SIGNIFICANCE, WHAT SHOULD THEY DO INSTEAD?
THEY CAN START BY EDUCATING THEMSELVES ABOUT STATISTICAL MISCONCEPTIONS. MOST
IMPORTANT WILL BE THE COURAGE TO CONSIDER UNCERTAINTY FROM MULTIPLE ANGLES IN
EVERY STUDY. LOGIC, BACKGROUND KNOWLEDGE AND EXPERIMENTAL DESIGN SHOULD BE
CONSIDERED ALONGSIDE P VALUES AND SIMILAR METRICS TO REACH A CONCLUSION AND
DECIDE ON ITS CERTAINTY. RESEARCHERS SHOULD SEEK TO ANALYSE DATA IN MULTIPLE
WAYS TO SEE WHETHER DIFFERENT ANALYSES CONVERGE ON THE SAME ANSWER.´´ @ FOME É O
FATOR QUE LEVA A CÉLULA TUMORAL A MIGRAR PELO CORPO, DIZ PESQUISADOR – HUNGER IS
THE FACTOR THAT CAUSES THE TUMOR CELL TO MIGRATE THROUGH THE BODY, SAYS
RESEARCHER #@ GENOME SEQUENCING: KEY TO SOLVING INDIA’S RARE DISEASES PROBLEM &
CRISPR TREATMENT INSERTED DIRECTLY INTO THE BODY FOR FIRST TIME – EXPERIMENT
TESTS A GENE-EDITING THERAPY FOR A HEREDITARY BLINDNESS DISORDER @ CORONAVIRUS
DISEASE 2019 (COVID-19): NEWS AND INFORMATION – MASSACHUSETTS GENERAL HOSPITAL &
´´NÃO HOUVE DIFERENÇA ESTATÍSTICA SIGNIFICATIVA. E AGORA?´´ @ ´´WHAT DOES
STATISTICALLY SIGNIFICANT MEAN?´´ BY JEFF SAURO, PHD | OCTOBER 21, 2014 @@ OTHER
VERY IMPORTANT INFORMATION OF THE WORLD LIKE WEBSITES, LINKS AND IMAGES @& THE
GRAPHICS I DID ABOUT ´´MY´´ DISSERTATION AND ´´MY´´ MONOGRAPH THAT CAN BE
EXCELLENT REFERENCES FOR MANY TYPES OF FUTURE RESEARCH AND PROJECTS, OF COURSE.
OS GRÁFICOS QUE FIZ SOBRE ´´MINHA´´ DISSERTAÇÃO E ´´MINHA´´ MONOGRAFIA PODEM SER
ÓTIMA REFERÊNCIA PARA FUTURAS PESQUISAS E PROJETOS DE VÁRIOS TIPOS, COM CERTEZA.
@ HTTPS://INANO.AU.DK/ABOUT/RESEARCH-GROUPS/GOTHELF-LAB
HTTPS://INANO.AU.DK/OPEN-POSITIONS/OPEN-PHD-POSITIONS # WWW.GOOGLE.COM
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7Mar 20207 Oct 2023
--------------------------------------------------------------------------------
48 Comments
10/07/2023 -> NO ONE informed me that what I did was illegal (Email list in
2015) when I sent an other e-mail to so much people of the Scientific Community
Worldwide and to American and Brazilian Govern that I have sent the email list,
informing that I didn’t ask permission to put each e-mail address on the e-mail
list.
The graphics I did about ´´my´´ dissertation and ´´my´´ monograph that can be
excellent references for many types of future research and projects, of course.
Os gráficos que fiz sobre ´´minha´´ dissertação e ´´minha´´ monografia podem ser
ótima referência para futuras pesquisas e projetos de vários tipos, com certeza.
Do the downloads!! Share!! The diffusion of very important information and
knowledge is essential for the world progress always!! Thanks!!
* – > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures
and Graphics – ´´My´´ Dissertation @ #Innovation #energy #life #health
#Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People
#Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis
#Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs
#VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests
#Laboratories #Investments #Details #HumanLongevity #DNA #Cell #Memory
#Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices
#GeneticEngineering #Internet #History #Science #World
Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi:
10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.
THE INFLUENCE OF PHYSICAL ACTIVITY IN THE PROGRESSION OF EXPERIMENTAL LUNG
CANCER IN MICE
Renato Batista Paceli 1, Rodrigo Nunes Cal, Carlos Henrique Ferreira dos
Santos, José Antonio Cordeiro, Cassiano Merussi Neiva, Kazuo Kawano
Nagamine, Patrícia Maluf Cury
* PMID: 22683274
* DOI: 10.1016/j.prp.2012.04.006
Impact_Fator-wise_Top100Science_Journals
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia –
´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física
Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia –
´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física
Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio
Preto
CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do
câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty
of Medicine of Sao Jose do Rio Preto
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https://pubmed.ncbi.nlm.nih.gov/22683274/
ABSTRACT
Lung cancer is one of the most incident neoplasms in the world, representing the
main cause of mortality for cancer. Many epidemiologic studies have suggested
that physical activity may reduce the risk of lung cancer, other works evaluate
the effectiveness of the use of the physical activity in the suppression,
remission and reduction of the recurrence of tumors. The aim of this study was
to evaluate the effects of aerobic and anaerobic physical activity in the
development and the progression of lung cancer. Lung tumors were induced with a
dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three
groups: group 1_24 mice treated with urethane and without physical activity;
group 2_25 mice with urethane and subjected to aerobic swimming free exercise;
group 3_18 mice with urethane, subjected to anaerobic swimming exercise with
gradual loading 5-20% of body weight. All the animals were sacrificed after 20
weeks, and lung lesions were analyzed. The median number of lesions (nodules and
hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When
comparing only the presence or absence of lesion, there was a decrease in the
number of lesions in group 3 as compared with group 1 (p=0.03) but not in
relation to group 2. There were no metastases or other changes in other organs.
The anaerobic physical activity, but not aerobic, diminishes the incidence of
experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.
https://www.ieee.org/
https://www.ieee.org/about/index.html
> Não houve diferença estatística significativa. E agora?
https://measuringu.com/statistically-significant/
https://www.nature.com/articles/d41586-019-00874-8
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https://www.nature.com/articles/d41586-020-00655-8?fbclid=IwAR3zOQtYzhQD2nNdLGOrdSKAqSmpE3JfYxP0VeV8bNy2OpucCW5igfkIIls
FOME É O FATOR QUE LEVA A CÉLULA TUMORAL A MIGRAR PELO CORPO, DIZ PESQUISADOR |
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Em palestra no 8º Workshop on Melanoma Models, o britânico Colin Goding falou
sobre como a escassez de nutrientes pode fazer a célula tumoral parar de se
proliferar e adquirir fenótipo invasivo (imagem: Sriram Subramaniam, National
Cancer Institute (NCI), 2012/Wikimedia Commons)
FOME É O FATOR QUE LEVA A CÉLULA TUMORAL A MIGRAR PELO CORPO, DIZ PESQUISADOR
18 DE AGOSTO DE 2017
*
*
*
Karina Toledo | Agência FAPESP – O pesquisador britânico Colin Goding está
convencido de que o mesmo fator que motivou o primeiro ser vivo unicelular a se
movimentar pela Terra – há mais de 3 bilhões de anos – também é a razão pela
qual algumas células tumorais se separam do tumor primário para colonizar outras
partes do corpo: a busca por comida.
Em seu laboratório, situado no Instituto Ludwig de Pesquisa do Câncer, vinculado
à Universidade de Oxford, no Reino Unido, ele demonstrou em experimentos com
culturas de melanoma humano que a falta de nutrientes desativa o maquinário de
proliferação celular e faz com que as células tumorais adquiram um fenótipo
invasivo.
“Nossa estimativa é que a mesma lógica funcione para a maioria dos tipos de
câncer e, talvez, possamos encontrar meios de manipular esse mecanismo de
sobrevivência celular para obter benefícios terapêuticos”, disse Goding em
entrevista à Agência FAPESP.
De passagem por São Paulo, onde proferiu no dia 10 de agosto a palestra de
abertura do 8º Workshop on Melanoma Models, Goding contou que seu grupo tem
usado o melanoma como um modelo para entender a progressão do câncer como um
todo.
“É um ótimo modelo porque conseguimos visualizar todos os estágios da doença.
Podemos perceber quando as células produtoras de pigmento começam a invadir
outros tecidos e formar metástases. Já em outros tipos de tumor, como pulmão ou
pâncreas, quando o paciente apresenta sintomas e procura um médico a doença já
se espalhou”, comentou.
Outro fator que tornou o melanoma um modelo interessante para o estudo do
câncer, segundo Goding, foi a identificação, há mais de uma década, de um gene
chamado BRAF, que se encontra alterado em metade dos casos da doença – emitindo
estímulos para a proliferação descontrolada das células.
“Em poucos anos surgiram drogas capazes de inibir especificamente essa forma
ativa do gene BRAF com efeitos dramáticos. Pacientes com múltiplas metástases
respondiam muito bem. Porém, após alguns meses, as células se tornavam
resistentes. Nossa pergunta então foi: por que essa resistência surge e o que
podemos fazer a respeito?”
Transformação do fenótipo
De acordo com Goding, estudo recentes têm mostrado que a resistência do melanoma
ao tratamento está relacionada com a existência, dentro de um mesmo tumor, de
subpopulações de células com fenótipos diferentes. Ou seja, embora possuam o
mesmo background genético, se comportam de forma distinta.
“Algumas podem estar mais diferenciadas e se comportar como o tecido de origem
[células produtoras de melanina], outras podem estar se proliferando rapidamente
e fazendo o tumor crescer, outras podem estar com o ciclo mais lento e fenótipo
invasivo e outras se tornam dormentes e permitem que, mesmo após uma terapia
bem-sucedida, a doença reapareça muitos anos depois”, explicou Goding.
Um dos objetivos do grupo britânico, portanto, tem sido compreender os fatores
que levam ao surgimento desses diferentes fenótipos. Segundo Goding, aspectos do
microambiente tumoral, como a disponibilidade de nutrientes, oxigênio e a
interação com sinais emitidos pelo sistema imune, são fundamentais para a
transformação.
A hipótese levantada pelo britânico é que, diante de uma situação de escassez de
nutrientes, ativa-se em parte das células tumorais um mecanismo de sobrevivência
que as faz migrar para procurar comida em outro local.
“Além disso, acreditamos que determinados sinais emitidos por células do sistema
imune – como as citocinas TNF-α [Fator de necrose tumoral alfa] e TGF-β [Fator
de transformação do crescimento beta] – podem induzir um estado de
pseudodesnutrição. Nesse caso, mesmo havendo abundância de nutrientes, esses
sinais imunes associados à inflamação acionam o mesmo mecanismo induzido pela
fome e fazem a célula migrar”, explicou o cientista.
Experimentos feitos por Goding com leveduras e também com células de melanoma
confirmaram que existe um mecanismo de sobrevivência celular conservado ao longo
da evolução. Quando passa fome, a célula reduz sua demanda por nutrientes para
se adequar à oferta. Isso significa desativar os processos biológicos
necessários para a síntese de proteínas e para a formação de novas células.
Porém, quando a célula tumoral consegue migrar para um novo ambiente, onde há
abundância de nutrientes e ausência dos sinais imunes que induzem a
pseudodesnutrição, ela volta a se proliferar para formar uma nova colônia.
“Se conseguirmos enganar as células para fazer com que acreditem que os sinais
de estresse já foram embora, o maquinário de fazer novas células volta a ficar
ativo e elas vão morrer porque a demanda por nutrientes vai exceder a oferta”,
avaliou.
A manipulação do estado fenotípico da célula tumoral, segundo Goding, poderia,
em teoria, evitar tanto a formação de metástase como a ocorrência de futuras
recaídas da doença.
“O processo de formação de metástase é muito ineficiente. Deve haver centenas de
milhares de células tumorais circulando e algumas poucas conseguem estabelecer
uma nova colônia com sucesso. Parte dessas células morre e parte se torna
dormente para sobreviver ao estresse associado com a fuga do tumor primário. Se
encontrarmos um mecanismo para eliminar a dormência, poderemos reduzir ainda
mais o porcentual de células que consegue escapar do tumor primário, sobreviver
e formar metástase. Isso é algo que buscamos em meu laboratório, em colaboração
com grupos do mundo todo, inclusive o de Silvya Stuchi, no Brasil”, contou.
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GENOME SEQUENCING: KEY TO SOLVING INDIA’S RARE DISEASES PROBLEM
The country recently having concluded a six-month pilot project of genome
sequencing of Indians, the solution to the problem of rare diseases may just be
around the corner.ETHealthWorld | March 03, 2020, 18:42 IST
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By Ashish Dubey
According to the Indian Council of Medical Research (ICMR), a rare disease is
something that affects 1 in 2,500 individuals. As much as 80% of these including
genetic disorders, rare cancers, infectious tropical diseases and degenerative
diseases are serious, chronic, debilitating and life threatening. They require
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intervention, they can lead to some form of severe handicap. Rare diseases also
impact children disproportionately and are responsible for 35% of deaths before
the age of 1 year. All this can have a huge impact on families both emotionally
and financially given the high cost of treatment. Another aspect to consider is
the lack of reliable genetic data in the country. However, a breakthrough
achieved six months ago is going to significantly alter the landscape of rare
diseases diagnosis in India. With the country recently having concluded a
six-month pilot project of genome sequencing of Indians, the solution to the
problem of rare diseases may just be around the corner.
A genome is defined as a person’s complete set of DNA, including genes with more
than 3 billion DNA base pairs. Genome sequencing can make it possible to
discover the functions of genes and identify mutations responsible for
conditions like cancer. The process is set to help parents undergo carrier
screening and identify diseases that can be inherited. The three million bases
making up the DNA sequence of our genomes help in understanding evolution,
similarities and differences between two individuals.
Data generated through genome sequencing can help assess a person’s genetic
tendencies to health conditions, diagnose inheritable cancers, and enable the
development of tests to prevent adverse drug reactions. Some examples include
prenatal genetic testing for expectant couples for detecting genetic disorders,
predictive genetic testing that can diagnose inheritable cancers, etc. In short,
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Genome sequencing can become a prognostic and diagnostic tool by helping
understand specific things about the Indian gene pool. This can further bring
down treatment costs significantly for many. It will also enhance the likelihood
of offering precision medicine rather than giving medication based on other
parameters. For instance, in previous genomic studies that were conducted in
India, there were genes uncovered that were exclusive to the Indian population
and presented the unique risk in developing diabetes. When such risks are known,
they can help the healthcare system and government policy makers to make more
informed decisions around disease prevention and treatment.
In conclusion
Genome sequencing can help determine the role of individual genes and how they
cause diseases. There are diagnostic tests available today that make use of the
latest technology and reporting to give reliable data. The use of precision
medicine and the data-pool gathered through such an approach will go a long way
in solving the issue of rare diseases in our country.
It is important to note that genomic data is sensitive and therefore, efforts
are also needed in the direction of minimizing the likelihood of data breaches.
This will help maintain public trust in institutions which gather and store
human genome data for analytical purposes. India is currently on the brink of a
major breakthrough – one that comes as a ray of hope for families at the risk of
rare and undiagnosed medical conditions. This is because with definitive
diagnosis, not only will our understanding of diseases grow but this will
further fuel the hope for a better future.
(The author is the COO & CO-Founder, Redcliffe Life Sciences.)
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NEWS
05 MARCH 2020
CRISPR TREATMENT INSERTED DIRECTLY INTO THE BODY FOR FIRST TIME
Experiment tests a gene-editing therapy for a hereditary blindness disorder.
HEIDI LEDFORD
*
*
*
The human retina: a CRISPR therapy has been inserted directly into a person for
the first time — in the eye.Prof. P. Motta/Dept. of Anatomy/University La
Sapienza of Rome/SPL
A person with a genetic condition that causes blindness has become the first to
receive a CRISPR–Cas9 gene therapy administered directly into their body.
The treatment is part of a landmark clinical trial to test the ability of
CRISPR–Cas9 gene-editing techniques to remove mutations that cause a rare
condition called Leber’s congenital amaurosis 10 (LCA10). No treatment is
currently available for the disease, which is a leading cause of blindness in
childhood.
SUPER-PRECISE CRISPR TOOL ENHANCED BY ENZYME ENGINEERING
For the latest trial, the components of the gene-editing system – encoded in the
genome of a virus — are injected directly into the eye, near photoreceptor
cells. By contrast, previous CRISPR–Cas9 clinical trials have used the technique
to edit the genomes of cells that have been removed from the body. The material
is then infused back into the patient.
“It’s an exciting time,” says Mark Pennesi, a specialist in inherited retinal
diseases at Oregon Health & Science University in Portland. Pennesi is
collaborating with the pharmaceutical companies Editas Medicine of Cambridge,
Massachusetts, and Allergan of Dublin to conduct the trial, which has been named
BRILLIANCE.
MUTATION ERADICATION
This is not the first time gene editing has been tried in the body: an older
gene-editing system, called zinc-finger nucleases, has already been administered
directly into people participating in clinical trials. Sangamo Therapeutics of
Brisbane, California, has tested a zinc-finger-based treatment for a metabolic
condition called Hunter’s syndrome. The technique inserts a healthy copy of the
affected gene into a specific location in the genome of liver cells. Although it
seems to be safe, early results suggest it might do little to ease the symptoms
of Hunter’s syndrome.
QUEST TO USE CRISPR AGAINST DISEASE GAINS GROUND
But the BRILLIANCE trial is the first to deploy the popular CRISPR–Cas9
technique — which has been hailed for its versatility and ease of design —
directly in the body. In BRILLIANCE, gene editing is used to delete a mutation
in the gene CEP290 that is responsible for LCA10.
The condition is a particularly attractive target for a gene-editing approach.
Conventional gene therapies use a virus to insert a healthy copy of the mutated
gene into affected cells. But CEP290 is too large to slip the entire gene into a
viral genome, says Artur Cideciyan, who studies retinal diseases at the
University of Pennsylvania in Philadelphia.
And although mutations in CEP290 disable light-sensing cells called
photoreceptors in the retina, the cells are still present and alive in people
with LCA10. “The hope is that you can reactivate those cells,” says Pennesi.
“This is one of the few diseases where we think you could actually get an
improvement in vision.”
Early results from another therapy suggest that this might be the case.
Cideciyan has teamed up with ProQR of Leiden, the Netherlands, to treat people
with LCA10 using an experimental treatment called sepofarsen. Early results
suggest that sepofarsen, which uses a technique called antisense therapy to
correct an LCA10-causing mutation in RNA made from the CEP290 gene, can improve
vision in people with LCA10.
For now, the use of CRISPR–Cas9 in the body is a significant jump from treating
cells in a dish, says Fyodor Urnov, who studies genome editing at the University
of California, Berkeley. “It is akin to space flight versus a regular plane
trip,” he says. “The technical challenges, and inherent safety concerns, are
much greater.”
doi: 10.1038/d41586-020-00655-8
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NEWSMAR | 13 | 2020
CORONAVIRUS DISEASE 2019 (COVID-19): NEWS AND INFORMATION
*
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The Centers for Disease Control and Prevention (CDC) is closely monitoring
developments around an outbreak of respiratory illness caused by a novel (new)
coronavirus first identified in Wuhan, Hubei Province, China. With new cases
reported across several different countries, including the United States, Mass
General has activated its Hospital Incident Command System (HICS) to monitor the
situation. Please find the latest news and information here.
--------------------------------------------------------------------------------
IN THIS ARTICLE:
* Frequently asked questions
* NEW: FAQs for cancer patients
* NEW: FAQs for pregnant patients
* Helpful preventative measures
* NEW: Updated visitor policy
* Virtual Visits
* Additional resources
* NEW: Calm in the time of Coronavirus
* NEW: Employer responsibility in the age of Coronavirus
* NEW: How to talk to your kids about Coronavirus
* NEW: Tips for keeping hands hydrated and healthy
--------------------------------------------------------------------------------
CORONAVIRUS: FREQUENTLY ASKED QUESTIONS
* FAQs for cancer patients >
* FAQs for pregnant patients >
Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread
from person to person. According to the Centers for Disease Control and
Prevention (CDC), the virus that causes COVID-19 is a novel coronavirus called
SARS-CoV2 that was first identified during an investigation into an outbreak in
Wuhan, China. It has now been detected in 60 locations internationally,
including the United States.
What should I do if I have COVID-19 symptoms?
Although your symptoms are most likely due to influenza or other respiratory
viruses that occur commonly here in winter, you should call your health care
provider if you have questions or concerns. If there is a reason to think you
may have been exposed to the new coronavirus, your health care provider will
work with your state’s public health department and the CDC to determine if you
need to be tested for COVID-19. They will provide instructions to you on where
testing can be arranged, if needed.
Is there a treatment for COVID-19?
There also is no specific antiviral treatment for COVID-19. People with COVID-19
commonly treat their symptoms at home with rest, fluids, and other common cold
or flu treatments, although some may require medical care to treat more severe
symptoms.
Is there a vaccine?
Scientists around the globe – including researchers at the Ragon Institute of
MGH, MIT and Harvard – are working on developing a vaccine to combat COVID-19,
however, currently there is no vaccine to protect against the virus.
I once took Tamiflu when I had the seasonal flu. Can I take a similar drug to
protect me from COVID-19?
No. There currently is no vaccine or specific antiviral treatment for COVID-19.
Is COVID-19 seasonal like the flu? Will warm weather stop the outbreak?
At this time, it is not known whether the spread of COVID-19 will decrease when
weather becomes warmer. There is much more to learn about the transmissibility,
severity and other features associated with COVID-19 and investigations are
ongoing.
I’m not feeling well. I recently traveled out of the United States and think I
may have been exposed to COVID-19. Should I stay home, or head to the Emergency
Department?
Before deciding to come to the hospital, please call your primary health care
provider and tell them about your symptoms – and if you’ve traveled to any of
the areas listed in the CDC travel warnings. They will give you instructions on
how to get care without exposing other people to your illness. While sick, avoid
contact with people, don’t leave your home and delay any travel to reduce the
possibility of spreading illness to others. If you come to any area of the
hospital and are concerned that you may have COVID-19, please wear a mask and go
directly to the reception desk to speak to a staff member. Do not wait in the
waiting room.
Should I wear a face mask to prevent COVID-19?
The CDC does not recommend that people who are feeling well wear a facemask to
protect themselves from respiratory illnesses, including COVID-19. You should
only wear a mask if a health care professional recommends it or if you are a
health care professional caring for patients who are on certain precautions. As
always, if you have a fever or cough when at any of the MGH campuses, please
pick up a mask at any information desk to help prevent the spread of germs of
all kinds.
Is the MGH prepared to care for patients with coronavirus?
The MGH is fully prepared to care for patients with coronavirus. Hospital
doctors, nurses, infection control specialists, emergency preparedness
specialists and administrators have been closely monitoring the coronavirus
outbreak. They have developed a hospital wide plan that will be put in place if
patients with coronavirus come to the hospital or a health center.
I’m worried about getting coronavirus. Should I cancel my upcoming appointment
at MGH?
The hospital is dedicated to providing world-class clinical care and treatment
to all of its patients. Staff are trained in infection prevention practices to
prevent the spread of any infectious disease. Should the hospital admit a
patient with COVID-19 in the future, the patient/s will be treated in a special
area of the hospital designated for this type of care. As always, if you have
specific questions about your appointment, please contact your health care
provider.
How can I protect myself and my family?
There are simple everyday preventive actions to help prevent the spread of
respiratory viruses. These include:
* Avoid close contact with people who are sick.
* Avoid touching your eyes, nose and mouth with unwashed hands.
* Wash your hands often with soap and water for at least 20 seconds. Use an
alcohol-based hand sanitizer that contains at least 60% alcohol if soap and
water are not available.
* Stay home if you are sick.
I have a vacation planned, should I cancel it?
The best, most up-to-date resource for information about travel alerts is
located on the CDC website. You can find a list of destinations the CDC
recommends travelers avoid for all nonessential travel due to the widespread
transmission of COVID-19. It also posts recommendations for older adults and
those with chronic medical conditions to postpone travel plans to certain areas.
Should I avoid crowded areas and public transportation?
At this time, the CDC has created precautionary guidelines for people who have
traveled to a country with widespread or sustained community transmission in an
attempt to slow the spread of COVID-19 – which includes staying at home and
avoiding contact with others. Currently here in Boston and in the New England
region, there are no restrictions. As always, if you feel sick and if you have a
fever or cough, it is recommended you stay home and rest. Contact your health
care provider if needed.
Can the virus that causes COVID-19 be spread through food, including
refrigerated or frozen food?
Currently there is no evidence to support transmission of COVID-19 associated
with food. Before preparing or eating food it is important to always wash your
hands with soap and water for 20 seconds for general food safety.
Should I have extra food and supplies at home?
For emergencies of any kind, it is always good to keep supplies on hand,
including food, water and medicine. Visit www.ready.gov/ for preparedness
checklists and plans. This is a good time for you to create, review and discuss
your family’s emergency plan.
COVID-19 INFOGRAPHIC
Download a PDF of information on symptoms, transmission, and prevention >
--------------------------------------------------------------------------------
CORONAVIRUS QUESTIONS AND ANSWERS FROM THE CDC
What is 2019 novel coronavirus?
The 2019 novel coronavirus (COVID-19) is a new virus that causes respiratory
illness in people and can spread from person-to-person. This virus was first
identified at the end of 2019 during an investigation into an outbreak of
respiratory illness and pneumonia in Wuhan, China.
Updates of the count of cases of infection with COVID-19 in the United States is
available on the CDC’s webpage
at https://www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html.
How do people catch coronavirus?
The virus is spread through respiratory droplets when an infected person coughs
or sneezes. It can also be spread when someone touches a contaminated surface,
such as a door handle.
Visit the CDC for more information >
--------------------------------------------------------------------------------
HELPFUL PREVENTATIVE MEASURES
Wash your hands often with soap and water for at least 20 seconds, especially
after going to the bathroom; before eating; and after blowing your nose,
coughing, or sneezing.
* If soap and water are not available, use an alcohol-based hand sanitizer with
at least 60% alcohol. Always wash hands with soap and water if they are
visibly dirty.
* Avoid touching your eyes, nose, and mouth with unwashed hands.
* Avoid close contact with people who are sick.
* Stay home when you are sick.
* Cover your cough or sneeze with a tissue, then throw the tissue in the trash.
* Clean and disinfect frequently touched objects and surfaces using a regular
household cleaning spray or wipe.
Follow these five steps to wash your hands the right way
Washing your hands is easy, and it’s one of the most effective ways to prevent
the spread of germs. Clean hands can stop germs from spreading from one person
to another and throughout an entire community—from your home and workplace to
childcare facilities and hospitals.
Follow these five steps every time.
1. Wet your hands with clean, running water (warm or cold), and apply soap.
2. Lather your hands by rubbing them together with the soap. Lather the backs
of your hands, between your fingers, and under your nails.
3. Scrub your hands for at least 20 seconds. You can count to 20 to be sure you
have scrubbed for the right amount of time.
4. Rinse your hands well under clean, running water.
5. Dry your hands using a clean towel or air dry them.
Download a PDF on the best practices for hand-washing >
--------------------------------------------------------------------------------
UPDATED VISITOR POLICY
Consistent with our commitment to help prevent further community spread, we are
implementing visitor restrictions across our system for the protection of our
patients, visitors and workforce. To continue providing the safest care
environment, temporary updates to our visitor policies have been made:
* There is a limit of one visitor per patient at the hospital at a time.
* Visitors may be screened for flu-like symptoms, such as fever, cough or sore
throat. Any visitor with obvious signs of illness will be asked to kindly
leave.
* No visitors under the age of 18 will be allowed during this time, since young
people are potential infectors without necessarily being ill themselves.
* Care teams will make exceptions in specific circumstances such as:
* End-of-life care
* Two parents or guardians for each pediatric patient
* Two visitors for each labor and delivery patient
* Each patient in the NICU is allowed up to two visitors at the bedside,
limited to parents or support persons
* Disruptive behavior patients
* We are discontinuing all public use of our conference and community space
effective immediately until future notice. This includes cancelling all
events open to the public and/or community groups at any of our facilities.
We recognize the valuable role that family members and visitors play in the
healing process and appreciate that these restrictions may cause challenges for
our patients and their families. Thank you for your understanding and adherence
to these policies as part of our continued efforts to keep our patients,
visitors and workforce protected and healthy during this time.
See the updated policy for our Obstetrical Labor & Delivery department >Download
a PDF with more visitor information >
--------------------------------------------------------------------------------
VIRTUAL VISITS
Our Virtual Care team, led by Lee Schwamm, MD, vice president of Virtual Care
for Partners Digital Health, has been working to develop new virtual and
telehealth options to increase patient access and help protect our workforce
during this time. We hope to have a suite of resources available to help with
the response in the coming days and weeks.
* Patients who have a smartphone (any type), tablet or laptop will be able to
join these visits by clicking on a simple link sent to them in advance, or at
the time of the visit.
* Information and resources will be available for patients on Patient Gateway.
A member of your care team will be able to respond to whether you will be
able to take part in a virtual visit.
--------------------------------------------------------------------------------
ADDITIONAL RESOURCES:
Calm in the time of Coronavirus
Drs. Darshan Mehta and Christina Luberta of the Benson-Henry Institute for Mind
Body Medicine at Mass General give tips on staying calm during the Coronavirus
outbreak.
Employer responsibility in the age of coronavirus
A perspective from Paul Biddinger, MD, Mass General Endowed Chair in Emergency
Preparedness and Director of the Mass General Center for Disaster Medicine; and
Eric Rosengren, PhD, President and CEO of the Federal Reserve Bank of Boston.
How to talk to your kids about coronavirus
The growing spread of COVID-19 has created a lot of anxiety and uncertainty for
many people, including children and teens. As parents and caregivers, it can be
difficult to talk with your kids about this global pandemic and address their
concerns. In this video, Gene Beresin, MD, executive director of the Mass
General Clay Center for Young Healthy Minds, offers helpful tips about how to
engage with children of all ages to support and maintain emotional stability
during this evolving situation. Watch on Youtube >
Tips for keeping hands hydrated and healthy
Handwashing often with soap and water for at least 20 seconds is a key step to
helping to prevent illness. But for many of us, it can also present a new
problem: dry or even cracked skin. Dr. Mathew Avram is the director of Mass
General’s Dermatology Laser and Cosmetic Center and offers up a couple of key
tips on keeping hands healthy – and hydrated – in the weeks ahead. Watch on
YouTube >
A look inside coronavirus preparations at a major U.S. hospital –Washington Post
coverage of emergency preparedness efforts at the MGH, features MGH physicians
Paul Biddinger and Erica Shenoy, MGH infection control staff Amir Mohareb and
Meredith Fahy, associate chief nurse Theresa Gallivan, director of Materials
Management Ed Raeke, and hospital incident commander Ann Prestipino
MORE MEDIA COVERAGE:
* Ten pressing questions about coronavirus, answered by experts – Boston Globe
quotes Mass General physician Paul Biddinger
* Everything to know about coronavirus testing – Popular Science quotes Mass
General Physician Paul Biddinger
* Some American Cities May Need to Wait Weeks for a Virus ‘Test That
Works’ – Bloomberg/Quint quotes Mass General physician David Hooper
* At senior living homes, a heightened readiness as coronavirus looms – Boston
Globe quotes Mass General physician David Hooper
* Our flawed health system isn’t up to the challenge of the
coronavirus – CNN opinion written by MGH physician Vanessa Kerry
* Top hospital braces for coronavirus pandemic – NBC News television report
covers emergency preparedness procedures featuring MGH physician Paul
Biddinger, MGH director of Materials Management Ed Raeke, chief pharmacy
officer Chris Fortier
* How the Greater Boston biomedical community is tackling the
coronavirus – Boston Globe article co-authored by MGH investigator Bruce
Walker
* They were already in China’s prisons. Now the coronavirus is there, too – Los
Angeles Times
quotes MGH physician Michael Callahan
* Partners hospitals advise physicians to regulate use of face masks as they
prepare for more coronavirus cases – Boston Globe mentions MGH
* Hand sanitizer, pain medication harder to find amid coronavirus
outbreak – WCVB Ch. 5
television report features MGH chief pharmacy officer Chris Fortier
* How to keep up a strong immune system and fight off the coronavirus – Boston
25 television report features MGH physician Caroline Sokol
* How To Self-Quarantine For Possible Coronavirus If Need Be, And Thank You In
Advance – WBUR/CommonHealth quotes MGH physician Rochelle Walensky
* What actually happens during a coronavirus test? – CNN quotes MGH physician
David Hooper
* Dr. Vanessa Kerry: ‘We had weeks to prepare ourselves’ for
coronavirus – MSNBC television program features MGH physician
* Ten pressing questions about coronavirus, answered by experts – Boston
Globe article features MGH physician Paul Biddinger
* Should you buy a mask? Health expert tells you how to plan for coronavirus in
the U.S. – CNN television report features MGH physician Erica Shenoy
* Mass. General Doctor Gives Update On Coronavirus – WGBH/All Things Considered
segment features MGH physician David Hooper
* How to keep up a strong immune system and fight off the coronavirus – Boston
25 television report features MGH physician Caroline Soko
FROM THE CDC:
* What you need to know about coronavirus disease 2019 (COVID-19) (pdf)
* Fight Germs. Wash Your Hands! (video) English Spanish
* Handwashing at Home, at Play, and Out and About (pdf poster)
* What to do if you are sick with coronavirus disease 2019 (COVID-19)
(pdf) English Spanish Simplified Chinese
--------------------------------------------------------------------------------
Additional information from the CDC on COVID-19
FEATURED PROVIDERS
* Paul Biddinger, MD
* Chief, Division of Emergency Preparedness
* Director, MGH Center for Disaster Medicine
* David Hooper, MD
* Chief, Infection Control Unit
* Associate Chief, Division of Infectious Diseases
* Erica Shenoy, MD, PhD
* Associate Physician
MORE INFORMATION
* COVID-19 Updates from the CDC
* Apollo, the Mass General Internet (for employees)
* Partners Pulse Updates (for employees)
TYPE
* News
TOPICS
* COVID-19 (Coronavirus)
A LOOK INSIDE CORONAVIRUS PREPARATIONS AT A MAJOR U.S. HOSPITAL
Read an article from the Washington Post on emergency preparedness efforts at
Mass General.
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EDITORIAL
20 MARCH 2019
IT’S TIME TO TALK ABOUT DITCHING STATISTICAL SIGNIFICANCE
Looking beyond a much used and abused measure would make science harder, but
better.
*
*
*
PDF version
Some statisticians are calling for P values to be abandoned as an arbitrary
threshold of significance.Credit: Erik Dreyer/Getty
Fans of The Hitchhiker’s Guide to the Galaxy know that the answer to life, the
Universe and everything is 42. The joke, of course, is that truth cannot be
revealed by a single number.
And yet this is the job often assigned to P values: a measure of how surprising
a result is, given assumptions about an experiment, including that no effect
exists. Whether a P value falls above or below an arbitrary threshold
demarcating ‘statistical significance’ (such as 0.05) decides whether hypotheses
are accepted, papers are published and products are brought to market. But
using P values as the sole arbiter of what to accept as truth can also mean that
some analyses are biased, some false positives are overhyped and some genuine
effects are overlooked.
SCIENTISTS RISE UP AGAINST STATISTICAL SIGNIFICANCE
Change is in the air. In a Comment in this week’s issue, three
statisticians call for scientists to abandon statistical significance. The
authors do not call for P values themselves to be ditched as a statistical tool
— rather, they want an end to their use as an arbitrary threshold of
significance. More than 800 researchers have added their names as signatories. A
series of related articles is being published by the American Statistical
Association this week (R. L. Wasserstein et al. Am.
Stat. https://doi.org/10.1080/00031305.2019.1583913; 2019). “The tool has become
the tyrant,” laments one article.
Statistical significance is so deeply integrated into scientific practice and
evaluation that extricating it would be painful. Critics will counter that
arbitrary gatekeepers are better than unclear ones, and that the more useful
argument is over which results should count for (or against) evidence of effect.
There are reasonable viewpoints on all sides; Nature is not seeking to change
how it considers statistical analysis in evaluation of papers at this time, but
we encourage readers to share their views (see go.nature.com/correspondence).
If researchers do discard statistical significance, what should they do instead?
They can start by educating themselves about statistical misconceptions. Most
important will be the courage to consider uncertainty from multiple angles in
every study. Logic, background knowledge and experimental design should be
considered alongside P values and similar metrics to reach a conclusion and
decide on its certainty.
When working out which methods to use, researchers should also focus as much as
possible on actual problems. People who will duel to the death over abstract
theories on the best way to use statistics often agree on results when they are
presented with concrete scenarios.
Researchers should seek to analyse data in multiple ways to see whether
different analyses converge on the same answer. Projects that have crowdsourced
analyses of a data set to diverse teams suggest that this approach can work to
validate findings and offer new insights.
In short, be sceptical, pick a good question, and try to answer it in many ways.
It takes many numbers to get close to the truth.
Nature 567, 283 (2019)
doi: 10.1038/d41586-019-00874-8
Latest on:
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SPOTLIGHT 24 JUN 20
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SPOTLIGHT 24 JUN 20
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WHAT DOES STATISTICALLY SIGNIFICANT MEAN?
BY JEFF SAURO, PHD | OCTOBER 21, 2014
Statistically significant.
It’s a phrase that’s packed with both meaning, and syllables. It’s hard to say
and harder to understand.
Yet it’s one of the most common phrases heard when dealing with quantitative
methods.
While the phrase statistically significant represents the result of a rational
exercise with numbers, it has a way of evoking as much emotion. Bewilderment,
resentment, confusion and even arrogance (for those in the know).
I’ve unpacked the most important concepts to help you the next time you hear the
phrase.
NOT DUE TO CHANCE
In principle, a statistically significant result (usually a difference) is a
result that’s not attributed to chance.
More technically, it means that if the Null Hypothesis is true (which means
there really is no difference), there’s a low probability of getting a result
that large or larger.
Statisticians get really picky about the definition of statistical significance,
and use confusing jargon to build a complicated definition. While it’s important
to be clear on what statistical significance means technically, it’s just as
important to be clear on what it means practically.
Consider these two important factors.
1. Sampling Error. There’s always a chance that the differences we observe when
measuring a sample of users is just the result of random noise; chance
fluctuations; happenstance.
2. Probability; never certainty. Statistics is about probability; you cannot
buy 100% certainty. Statistics is about managing risk. Can we live with a
10-percent likelihood that our decision is wrong? A 5-percent likelihood? 33
percent? The answer depends on context: what does it cost to increase the
probability of making the right choice, and what is the consequence (or
potential consequence) of making the wrong choice? Most publications suggest
a cutoff of 5%—it’s okay to be fooled by randomness 1 time out of 20. That’s
a reasonably high standard, and it may match your circumstances. It could
just as easily be overkill, or it could expose you to far more risk than you
can afford.
WHAT IT MEANS IN PRACTICE
Let’s look at a common scenario of A/B testing with, say, 435 users. During a
week, they are randomly served either website landing page A or website landing
page B.
* 18 out of 220 users (8%) clicked through on landing page A.
* 6 out of 215 (3%) clicked through on landing page B.
Do we have evidence that future users will click on landing page A more often
than on landing page B? Can we reliably attribute the 5-percentage-point
difference in click-through rates to the effectiveness of one landing page over
the other, or is this random noise?
HOW DO WE GET STATISTICAL SIGNIFICANCE?
The test we use to detect statistical difference depends on our metric type and
on whether we’re comparing the same users (within subjects) or different users
(between subjects) on the designs. To compare two conversion rates in an A/B
test, as we’re doing here, we use a test of two proportions on different users
(between subjects). These can be computed using the online
calculator or downloadable Excel calculator.
Below is a screenshot of the results using the A/B test calculator
To determine whether the observed difference is statistically significant, we
look at two outputs of our statistical test:
1. P-value: The primary output of statistical tests is the p-value (probability
value). It indicates the probability of observing the difference if no
difference exists. The p-value from our example, 0.014, indicates that we’d
expect to see a meaningless (random) difference of 5% or more only about 14
times in 1000. If we are comfortable with that level of chance (something we
must consider before running the test) then we declare the observed
difference to be statistically significant. In most cases, this would be
declared a statistically significant result.
2. CI around Difference: A confidence interval around a difference that does
not cross zero also indicates statistical significance. The graph below
shows the 95% confidence interval around the difference between the
proportions outputted from the stats package. The observed difference was 5%
(8% minus 3%) but we can expect that difference itself to fluctuate. The CI
around the difference tells us that it will most likely fluctuate between
about 1% and 10% in favor of Landing Page A. But because the difference is
greater than 0%, we can conclude that the difference is statistically
significant (not due to chance). If the interval crossed zero—if it went,
for example, from -2% to 7%—we could not be 95% confident that the
difference is nonzero, or even, in fact, that it favors Landing Page A.
Figure 1: The blue bar shows 5% difference. The black line shows the
boundaries of the 95% confidence interval around the difference. Because the
lower boundary is above 0%, we can also be 95% confident the difference is
AT LEAST 0–another indication of statistical significance.The boundaries of
this confidence interval around the difference also provide a way to see
what the upper and lower bounds of the improvement could be if we were to go
with landing page A. Many organizations want to change designs, for example,
only if the conversion-rate increase exceeds some minimum threshold—say 5%.
In this example, we can be only 95% confident that the minimum increase is
1%, not 5%.
WHAT IT DOESN’T MEAN
Statistical significance does not mean practical significance.
The word “significance” in everyday usage connotes consequence and
noteworthiness.
Just because you get a low p-value and conclude a difference is statistically
significant, doesn’t mean the difference will automatically be important. It’s
an unfortunate consequence of the words Sir Ronald Fisher used when describing
the method of statistical testing.
To declare practical significance, we need to determine whether the size of the
difference is meaningful. In our conversion example, one landing page is
generating more than twice as many conversions as the other. This is a
relatively large difference for A/B testing, so in most cases, this statistical
difference has practical significance as well. The lower boundary of the
confidence interval around the difference also leads us to expect at LEAST a 1%
improvement. Whether that’s enough to have a practical (or a meaningful) impact
on sales or website experience depends on the context.
SAMPLE SIZE
As we might expect, the likelihood of obtaining statistically significant
results increases as our sample size increases. For example, in analyzing the
conversion rates of a high-traffic ecommerce website, two-thirds of users saw
the current ad that was being tested and the other third saw the new ad.
* 13 out of 3,135,760 (0.0004%) clicked through on the current ad
* 10 out of 1,041,515 (0.0010%) clicked through on the new ad
The difference in conversion rates is statistically significant (p = 0.039) but,
at 0.0006%, tiny, and likely of no practical significance. However, since the
new ad now exists, and since a modest increase is better than none, we might as
well use it (oh and just in case you thought a lot of people clicked on ads, let
this remind you of how they don’t!)
Conversely, small sample sizes (say fewer than 50 users) make it harder to find
statistical significance; but when we do find statistical significance with
small sample sizes, the differences are large and more likely to drive action.
Some standardized methods express differences, called effect sizes, which help
us interpret the size of the difference. Here, too, the context determines
whether the difference warrants action.
CONCLUSION AND SUMMARY
Here’s a recap of statistical significance:
* Statistically significant means a result is unlikely due to chance
* The p-value is the probability of obtaining the difference we saw from a
sample (or a larger one) if there really isn’t a difference for all users.
* A conventional (and arbitrary) threshold for declaring statistical
significance is a p-value of less than 0.05.
* Statistical significance doesn’t mean practical significance. Only by
considering context can we determine whether a difference is practically
significant; that is, whether it requires action.
* The confidence interval around the difference also indicates statistical
significance if the interval does not cross zero. It also provides likely
boundaries for any improvement to aide in determining if a difference really
is noteworthy.
* With large sample sizes, you’re virtually certain to see statistically
significant results, in such situations it’s important to interpret the size
of the difference.
* Small sample sizes often do not yield statistical significance; when they do,
the differences themselves tend also to be practically significant; that is,
meaningful enough to warrant action.
Now say statistically significant three times fast.
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NÃO HOUVE DIFERENÇA ESTATÍSTICA SIGNIFICATIVA. E AGORA?
A frase “não houve diferença estatística significativa” soa quase como uma
sentença de morte para muitos alunos de graduação, pós-graduação e até mesmo
para alguns pesquisadores.
Como assim “não houve diferença estatística significativa”? Eu fiz tudo
certinho: calculei o tamanho da amostra de forma correta, tive cuidado na
implantação do experimento, tive cuidado na coleta de dados, escolhi os teste
estatísticos adequados e agora todo o meu trabalho não servirá para nada? Os
resultados que encontrei não têm valor?
Calma, não é bem assim! Se você tiver paciência (e fôlego) para ler este texto
até o fim, perceberá o quanto é equivocada essa ditadura do “p-significativo”
que rege a pesquisa científica atualmente.
1. POR QUE MESMO VOCÊ PRECISA UTILIZAR A ANÁLISE ESTATÍSTICA EM SUA PESQUISA
CIENTÍFICA?
Antes de embarcarmos na discussão sobre “diferença estatística significativa”, é
preciso relembrar primeiro por que precisamos utilizar a análise estatística em
uma pesquisa científica.
Milhares de trabalhos científicos são publicados anualmente em centenas de
periódicos, e a esmagadora maioria, tanto em estudos destinados à ciência
básica, quanto naqueles de pesquisa aplicada, utiliza a estatística para
referendar suas conclusões.
Em qualquer pesquisa científica, o procedimento geral é o de formular hipóteses
e verificá-las, diretamente, ou por meio de suas consequências (Vianna, 2001). E
o que nos obriga a utilizar a análise estatística para testar hipóteses
formuladas é a presença, em todas as observações ou dados, de efeitos de fatores
não controlados, que podem causar variação em nossos dados tanto quanto o efeito
dos tratamentos que são objeto de estudo (Pinto e Schwaab, 2011).
Em um mundinho científico perfeito, o cientista conseguiria controlar todos os
fatores que não estão sendo estudados e a única variação de dados na pesquisa
seria referente ao efeito ou ao fenômeno estudado.
Mas, na prática, um cientista da área médica não consegue controlar totalmente
os fatores genéticos, os hábitos alimentares, a rotina de trabalho e a rotina de
exercícios de todos os indivíduos do teste. Da mesma forma, um cientista da área
de Agronomia não consegue controlar fatores como clima, solo, ataque de pragas,
incidência de doenças, competição com plantas daninhas.
Portanto, quem recorre à estatística como ferramenta de tomada de decisão se
depara, antes mesmo de calcular qualquer medida ou teste estatístico, ou ainda
no processo de ensino aprendizagem da disciplina de investigação, com o conceito
de erro (Martins e Domingues, 2014).
Desta forma, os testes de hipóteses ou testes de significância nos permitem
decidir se rejeitamos ou não uma determinada hipótese estatística, com o menor
risco possível de se cometer um erro (Moore e Fligner, 2014).
2. O VALOR DE P E A DIFERENÇA ESTATÍSTICA SIGNIFICATIVA
Quando encontramos diferença estatística significativa entre grupos ou entre
tratamentos, inferimos que essas diferenças não devem ser atribuídas ao acaso
(ou ao erro, ou aos fatores não controlados), mas sim aos efeitos maiores de
alguns dos grupos ou dos tratamentos (Rumsey, 2009).
Assim, ao realizar um experimento, o cientista formula uma hipótese nula (H0),
também chamada de hipótese da nulidade, em que não existe diferença entre os
efeitos estudados, que será posta à prova. Os dados observados e a análise
estatística serão utilizados para tomar a decisão de rejeitar (assumindo que
seja falsa) ou não rejeitar (assumindo que seja verdadeira) essa hipótese
nula (Schwaab, 2007).
Admitindo-se inicialmente que a hipótese da nulidade seja verdadeira, se
verificarmos que os resultados obtidos em uma amostra diferem acentuadamente dos
resultados esperados para essa hipótese podemos concluir, com base na teoria das
probabilidades, que as diferenças são significativas e, portanto, rejeitamos a
hipótese de nulidade em favor de uma outra, denominada hipótese alternativa (H1)
ou (Ha) (Vieira, 2011).
Este processo é semelhante à presunção de inocência do direito penal. Até prova
em contrário, o réu é inocente; face às provas, o juiz ou jurados decidem:
culpado ou não culpado. Em analogia com os testes de hipóteses, a hipótese nula
é verdadeira até que uma evidência suficientemente forte indique que essa
afirmação é incorreta, com uma baixa probabilidade de erro.
Essa probabilidade de erro é o valor de p. Para Sir Ronald Aylmer Fisher, quanto
menor fosse o valor de p, maior seria a probabilidade de que a hipótese nula,
aquela em que não existe diferença entre os grupos ou entre os tratamento, fosse
falsa.
A ironia é que quando Fisher apresentou o valor de p na década de 1920, ele não
quis dizer que o valor de p seria um teste definitivo. O valor de p era visto
por Fischer apenas como uma maneira informal para julgar se determinada
evidência era digna de um segundo olhar. Ou seja, o valor de p não foi concebido
para ser utilizado da maneira como é utilizado hoje!
Quando se conclui que uma diferença não é estatisticamente significativa, isso
não indica propriamente que as médias sejam iguais, ou que não exista um efeito
substantivo. Indica apenas que não houve evidência suficientemente forte para
provar que a hipótese nula era falsa (Rumsey, 2009).
3. DIFERENÇA SIGNIFICATIVA OU DIFERENÇA ESTATÍSTICA SIGNIFICATIVA
Entre as consequências desta busca insana pelo p < 0,05 está a tendência em
desviar a atenção do tamanho real de um efeito. Algumas diferenças podem ser
significativas segundo a estatística, mas irrelevantes na prática. E vice-versa.
Em 2013, por exemplo, um estudo com mais de 19 mil pessoas concluiu que os
casais dos Estados Unidos que tiveram seu primeiro encontro online eram menos
propensos ao divórcio (p < 0,002) e mais propensos a ter uma alta satisfação
conjugal (p < 0,001) do que aqueles que tiveram seu primeiro encontro
pessoalmente.
Isso poderia soar impressionante, se os efeitos observados não fossem
minúsculos: os encontros online mudaram a taxa de divórcio de 7,67 para 5,96%,
enquanto a satisfação conjugal se moveu de 5,48 para 5,64, em uma escala de zero
a sete.
Em alguns artigos científicos (principalmente de língua inglesa), por economia
de espaço ou por outro motivo qualquer, os autores omitem o termo “estatística”
e escrevem apenas que “não houve diferença entre os grupos” ou “não houve
diferença significativa entre os grupos”. Em estudos com medicamentos, por
exemplo, é possível que diferentes tratamentos não possuam diferença estatística
significativa entre si, mas a morte de um paciente em um dos tratamentos seria
altamente significativa do ponto de vista clínico, por motivos óbvios (Moore e
Fligner, 2014).
4. A DITADURA DA DIFERENÇA ESTATÍSTICA SIGNIFICATIVA
Considerando que os valores de significância tenham erroneamente se revestido de
tamanha autoridade científica, temos presenciado um viés que privilegia apenas a
publicação de artigos que encontrem diferença estatística significativa, como se
os estudos que não encontrassem tais diferenças não tivessem aplicabilidade ou
pudessem despertar interesse!
Se com nossa pesquisa não conseguimos descobrir qual é a explicação para um
determinado fenômeno, ao menos descobrimos qual explicação NÃO é. Isso é
importante, pois resultados negativos também são resultados, tão válidos quanto
os positivos, e sua publicação evita a duplicação de esforços, ou seja,
cientistas da mesma área não irão tentar os mesmos experimentos (Vianna, 2001).
Além disso, a publicação deste tipo de artigo abre espaço para a discussão sobre
os motivos pelos quais os experimentos não tiveram os resultados esperados. O
resultado é o mesmo: economia de tempo e de recursos.
Uma prova de que essa percepção é importante é o surgimento de revistas como
o Journal of Negative Results in Biomedicine, o Journal of Negative Results –
Ecology and Evolutionary Biology, o Journal of Pharmaceutical Negative Results,
o Journal of Interesting Negative Results, entre outros, que publicam apenas
pesquisas de refutação de hipóteses.
Outro periódico, o Journal of Errology, publicou durante anos apenas os
resultados de pesquisas que NÃO deram certo, como protocolos que não funcionaram
como deveriam ou então erros que invalidaram a pesquisa. Esse periódico possuía
um sistema de revisão aberto, feito por meio de discussões online.
Entretanto, em alguns casos, não encontrar diferença estatística significativa é
tão relevante quanto encontrá-la. Este pesquisador, por exemplo, estudou adubos
verdes (leguminosas) e adubos industrializados (ureia) em lavouras de milho e
observou que quando o milho era cultivado após a ervilhaca-peluda (uma
leguminosa utilizada como adubo verde) não havia diferença estatística
significativa entre as doses de ureia utilizadas no cultivo de milho.
Olha só que bacana: todo o nitrogênio de que a planta de milho necessita foi
suprido pelo adubo verde (ervilhaca-peluda), de modo que qualquer dose de ureia
aplicada não afetava a produtividade das plantas de milho. Uma baita economia
para o agricultor, se levarmos em conta o custo dos fertilizantes
industrializados.
Portanto, ao se deparar com o “não houve diferença estatística significativa”,
ao invés de ficar #chateado e ir “xingar muito no Twitter”, procure entender:
1. Que o valor de p e a tal diferença estatística significativa não são essa
Coca-Cola toda.
O valor de p não é um teste definitivo. Leve em consideração a magnitude do
efeito, os intervalos de confiança, o tamanho da amostra, e o poder do teste
estatístico utilizado.
2. Quais foram os motivos/causas que levaram a não encontrar diferença
estatística significativa.
Foi um problema com o número de amostras? Foi um problema com o método de coleta
de dados? Houve influência de fatores não controlados conhecidos? A análise
estatística é a adequada? Ou, caso não encontre um dos problemas anteriores,
como posso explicar esse resultado? O que ocasionou esse resultado?
3. Se esse resultado possui aplicação prática.
Partindo do pressuposto que o efeito esperado realmente não aconteceu, o que
isso significa? Quais são as implicações práticas deste resultado?
4. Se esse resultado indica em qual direção seguir.
Já que esse efeito/fenômeno não pode ser observado dessa forma, de qual forma
seria possível? Como fazer para conseguir resolver esse problema?
Afinal, se você faz Ciência e não está cometendo erros, então provavelmente você
não está fazendo isso certo!
By Pós-Graduando|31-10-2015|debates|60 Comentários
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SOBRE O AUTOR: PÓS-GRADUANDO
Criador e editor de conteúdo do blog, é portador de uma imaginação hiperativa e
de uma necessidade patológica de estar sempre bem-humorado. Acredita que a
Pós-Graduação, como tudo na vida, pode ser interessante, divertida e
descomplicada.
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60 COMMENTS
1. Paulo César 31.10.15 em 12:02 – Responder
Excelente texto!
Além de ser muito didático, traz à tona uma discussão muito importante: o
uso equivocado das análises estatísticas.
O meio acadêmico é repleto de “achismos” e de pesquisadores que entendem
muito da sua área de domínio, mas pouco de estatística.
A gente ainda encontra por aí pesquisadores que fazem determinadas análises
estatísticas porque “todo mundo faz assim” (como se porque todo mundo faz
errado, não há problema em fazer também); porque “eu acho que fica melhor
desse jeito” (como se a opinião pessoal fosse mais importante que os
requisitos e pressupostos dos testes); ou porque “eu sempre fiz assim”
(prefiro nem comentar essa).
Esse texto é quase um serviço de utilidade pública (acadêmica).
2. Gabriela 31.10.15 em 12:06 – Responder
Eu sinto uma vergonha alheia quando leio em um artigo que “apesar dos
resultados não apresentarem diferença estatística significativa, o
tratamento I foi 5% superior ao tratamento II”.
Ora, se não houve diferença estatística significativa, então não houve, e
ponto final. Esses 5% de diferença aí provavelmente são efeitos do acaso
amostral ou do erro experimental.
Ao invés de tentar entender as limitações do valor de p ou de tentar
explicar o fenômeno observado e a ausência de diferença estatística
significativa, o cidadão tenta fazer “na marra” uma diferença entre os
tratamentos.
Se não vai aceitar os resultados da análise estatística, então nem os
apresente.
* Rodrigo Gomes 31.10.15 em 12:18 – Responder
Isso quando o cara não começa a tirar e/ou manipular os dados para que
fique significativo.
Nesse caso a gente não fica nem sabendo…
* Gabrielly 08.11.15 em 13:28 – Responder
Isso de colocar a diferença em porcentagem, em certos momentos torna-se
muito prático. Muitas empresas por exemplo, não colocam suas expectativas
em diferenças estatísticas. Quando se trata de produtividade, 1% de
diferença que seja é um BAITA resultado, que pode significar em perda ou
ganho em dinheiro para um produtor por exemplo. Acho que falta
praticidade em muitos trabalhos por aí…
* Gabriela 09.11.15 em 06:53 – Responder
Gabrielly, leia com atenção o tópico “1. Por que mesmo você precisa
utilizar a análise estatística em sua pesquisa científica?”
Quando não existe diferença significativa, esse 1% que você diz que é
um “baita resultado” pode ter ocorrido devido ao acaso ou ao erro
experimental, e NÃO devido aos efeitos que você estava estudando. Se
você repetir o experimento, provavelmente não irá obter novamente esse
1% de diferença.
Nesse caso, discutir essa diferença em função dos seus tratamentos é
correr um grande risco de discutir algo que, na prática, simplesmente
não existe.
E ao recomendar algo com base em um efeito que não existe, você corre
um grande risco de fazer com que o produtor que você citou perca
dinheiro.
Vale a pena correr esse risco?
Agora, se houve diferença significativa, você pode discutir esse 1%
como sendo um “baita resultado”, com uma probabilidade de erro muito
menor.
* Paulo Roberto 09.11.15 em 07:50 – Responder
Gabrielly, como você falou em “produtor” e em “produtividade“, acredito
que você também trabalhe na área de Ciências Agrárias.
Nessa área existe uma grande quantidade de produtos e tecnologias que
no campo não correspondem aos resultados divulgados pelas empresas.
E isso ocorre justamente porque algumas empresas deste ramo realizam
“experimentos” sem repetições, sem casualização, sem cuidado com o
método científico e não “colocam suas expectativas em diferenças
estatísticas“, porque o objetivo é apenas gerar dados para o marketing.
Entretanto, na minha opinião, as empresas da área agrícola deveriam ser
justamente as que mais “colocam suas expectativas em diferenças
estatísticas“, pois o controle sobre as condições do experimento é
muito precário, podendo ocorrer variações genéticas, edáficas,
climáticas, de manejo, fitossanitárias, etc.
Não por acaso uma boa parte dos testes estatísticos que utilizamos hoje
foram criados justamente para experimentos em Ciências Agrárias.
Afinal, quanto maior o risco de erro, mais importante se torna a
análise estatística para a tomada de decisões.
E enquanto o pessoal de Ciências Agrárias continuar a “não colocar suas
expectativas em diferenças estatísticas” e a considerar “1% de difença
como um baita resultado” quando não existe diferença estatística
significativa, os produtores vão continuar sofrendo com esses produtos
e tecnologias que são maravilhosos no panfleto da empresa, mas que
patinam no campo.
Concordo com a Gabriela, creio que você precise estudar com muito
empenho os conceitos descritos no item “Por que mesmo você precisa
utilizar a análise estatística em sua pesquisa?“
* Júlio César 09.11.15 em 08:06 – Responder
Gabrielly, leia com atenção o tópico “1. Por que mesmo você precisa
utilizar a análise estatística em sua pesquisa científica?” [3]
3. Claudia Cruz 31.10.15 em 12:10 – Responder
Bola pra frente! Dependendo da hipótese levantada e da teoria que sustenta,
pode ser um resultado!
4. Wesley GB 31.10.15 em 12:13 – Responder
Adiciona ou remove variáveis até ficar significativo ?
5. Pedro Aurélio Lima 31.10.15 em 12:18 – Responder
Aumenta o tamanho da amostra que uma hora vai ser “significativo”. Se não
puder fazer isso, use pseudorréplicas. Simples.
* Matheus Castro 31.10.15 em 16:23 – Responder
Que jeito interessante de fazer ciência
* Giovani Kolling 31.10.15 em 17:32 – Responder
Hahahaha
Cada um heim
6. Laurinha Bomdespacho 31.10.15 em 12:22 – Responder
é bem assim!
7. Edvaldo Antunes 31.10.15 em 12:23 – Responder
Agora eh deixar o seu currículo na Subway
* Romário Rodrigues 31.10.15 em 13:20 – Responder
Tem vagas em todo Brasil.
8. Rayan Santos 31.10.15 em 12:25 – Responder
Leram meu pensamento! Haha!
9. Luiz Eduardo Lazzarini 31.10.15 em 12:28 – Responder
Isso tb é resultado…
10. Jaqueline Hannoff Pilon 31.10.15 em 12:32 – Responder
No meu caso avaliei duas técnicas e deu isso. Ai na conclusão parti pro
lado do custo de cada técnica e uma se tornou mais viável por questões
financeiras…
* Antonio 01.11.15 em 09:38 – Responder
Cuidado Jaqueline, existe um desenho específico para estudos de não
inferioridade( se aceita que a nova técnica seja um pouco pior que a
tradicional) simplesmente por oferecer uma vantagem prática ou financeira
em comparada com a técnica tradicional. Uma outra questão é que seu
estudo pode estar sofrendo do erro do tipo II ( não ter poder estatístico
para detectar uma diferença que realmente existe).
11. Rodrigo Lacerda 31.10.15 em 12:35 – Responder
Sente e chora ou aumenta o N rs
12. Alex Farias 31.10.15 em 12:45 – Responder
Resultado negativo é tão importante quanto o positivo.
Leiam
* Millke Jasmine Morales 31.10.15 em 15:12 – Responder
Enfim uma boa resposta..
* Nara Muniz 31.10.15 em 15:32 – Responder
Ufa.
* Natália Paiva 31.10.15 em 17:12 – Responder
Concordo, mas n são “atrativos” p publicação (segundo as revistas e
pareceristas).
13. Claudia Cruz 31.10.15 em 12:49 – Responder
Ou: torture os dados até que eles confessem o resultado desejado!
* Anelena Carvalho 31.10.15 em 12:59 – Responder
Boa kkkk
14. Guido Humada 31.10.15 em 12:57 – Responder
refaz o experimento …
15. Michele Schnell 31.10.15 em 13:08 – Responder
É só escrever no final que ainda são necessários mais estudos! xD
16. Pedro Campelo 31.10.15 em 14:32 – Responder
Que texto top! E não sabia sobre estas revistas que publicam resultados
negativos.
17. Roberta Cysneiros 31.10.15 em 14:37 – Responder
Não há razão para desespero! Modéstia à parte, entendo razoavelmente bem da
famigerada bioestatística , e faço uso rotineiro de testes paramétricos e
não paramétricos. Fato eh que uma diferença ” estatisticamente
significante” pode não ser ” clinicamente importante”; visto que aquela
variável investigafa naquele seu projeto/ estudo não eh a única que
interfere no resultado final. A importância em termos biológicos não deve
ser julgada somente pela estatística. Ter profundo conhecimento da variável
investigada e da dimensão na qual ela está envolvida, irá contribuir
imensamente na interpretação dos dados.
18. Ramon Guedes 31.10.15 em 14:51 – Responder
É mais que um mero resultado…
19. Henrique Nunes 31.10.15 em 15:01 – Responder
-Orientadora: analise corretamente as variáveis!
-Eu: Mass doutora? Ahh entendi ..
-orientadora: Olha a deadline
20. Henrique Gomes 31.10.15 em 15:26 – Responder
O mais bacana é que o texto não tem aquela arrogância recorrente de que “só
um estatístico ou um especialista na área de análise de dados” sabe fazer
estatística de forma adequada.
Além disso, explica a estatística de forma simples e didática para leigos.
Tenho a impressão de que muitas vezes os estatísticos querem fazer reserva
de mercado e desqualificam qualquer um que tente escrever sobre estatística
de forma descomplicada e não tenha formação especificamente em estatística.
21. Fernanda Morena 31.10.15 em 16:15 – Responder
Isso tb é um resultado! E vale a pena ser divulgada!!!!
22. João Flávio 31.10.15 em 17:24 – Responder
Tem que tomar cuidado quando a amostra é muito grande, pois o teorema
informa que quando n tende a infinito a estatística tende ao parâmetro
populacional, logo com uma amostra grande o intervalo de erro será pequeno
(“quase pontual”), e talvez 5,51 seja diferente 5,56. Provavelmente foi o
caso do estudo citado 19 mil pessoas.
23. Lidiomar Soares 31.10.15 em 18:23 – Responder
Não deixa de ser um resultado.
24. Sicilia Avelar Gonçalves 31.10.15 em 19:03 – Responder
Faz análise descritiva! Kkkkk
25. Erisson Viana 31.10.15 em 20:26 – Responder
Comunica que os resultados não são significativos a p-valor tal e tal, o
que demanda novos estudos assim e assim.
26. Gisela Guadalupe 31.10.15 em 22:00 – Responder
De fato, o resultado ” negativo” tem seu valor na ciência…. Sem dúvidas
sobre isso….
27. Josue Augusto 31.10.15 em 22:33 – Responder
“Resultado negativo também é resultado é tão importante quanto o positivo!”
Pergunto: já conseguiu publicar? Não duvido da importância, concordo que é
importante… maaaas…
28. Maria Fernanda Salomão 31.10.15 em 23:54 – Responder
Resultado negativo ? Muda a abordagem, aumenta o N ou tortura a estatística
! ??
Pq somos obrigados a sempre dar resultados positivos?
29. Naty Ferreira 01.11.15 em 00:28 – Responder
Agora fudeu. Rsrs
30. Alex Franco 01.11.15 em 00:35 – Responder
Senta e chora….mentira, sempre tem um jeito.
31. Alessandra Soares 01.11.15 em 09:27 – Responder
Na minha área, essa frase ajuda muito. Porque aí posso defender as
vanatagens e desvantagens de cada método isoladamente e cria-se a liberdade
de escolherem a técnica como lhe convier.
32. Amanda Lima 01.11.15 em 10:50 – Responder
Dificil viu! o melhor são os comentários kk
33. Ricardo Felipini 01.11.15 em 16:48 – Responder
Às vezes é necessário reconhecer que a hipótese levantada não é verdadeira.
34. Thiago Cardoso de Oliveira 01.11.15 em 18:48 – Responder
Ótimo texto!! Parabéns!! Esclareceu muito meus pensamentos!! Abraços.
35. pesquisa 02.11.15 em 08:17 – Responder
Tudo isso no texto de dar importância aos resultados negativos é
interessante e tem um potencial de explicar mais teorias até mesmo do que
os resultados com estatística significativa. O problema na nossa ciência é
que SEMPRE TEMOS QUE DAR RESULTADOS significativos, senão os artigos não
são aceitos nas revistas. Se a postura dos editores e revisores não mudar
daqui pra frente de nada vai adiantar os nossos esforços. Além disso, TODA
PESQUISA TEM ERRO, SEJA DE ESFORÇO AMOSTRAL, TAMANHO DO N e por aí vai.
36. José Luiz 04.11.15 em 17:01 – Responder
Gostei, pesquisador que acompanha sua pesquisa tem condições de interpretar
os resultados e a estatistica é para ajuadar a interpretação.
37. Luís Oscar 05.11.15 em 09:41 – Responder
Excelente texto! Mas olha a quantidade de bobagens escritas: “tortura os
dados”, “aumenta N”, “use pseudo réplicas”, dentre outras asneiras… Por
isso a ciência não é levada a sério no Brasil. Se nem os pesquisadores
levam, quem dirá os políticos, responsáveis pela liberação dos
investimentos…
38. Exu Tranca-Bolsa 10.11.15 em 10:13 – Responder
Faz oferenda ou perde bolsa…
39. Junielson 26.04.17 em 02:35 – Responder
Todo mundo é forçado a apresentar diferença significativa e quando não tem
diferença o sujeito se desespera, pq a revista não vai publicar o artigo.
40. Márcia Teixeira 16.11.17 em 11:59 – Responder
Muito obrigada pela excelente explicação!! Uma luz enorme !!
41. Mauro Alves 15.03.18 em 08:59 – Responder
Texto muito bom!
42. Adriana Guercio 24.07.18 em 18:52 – Responder
Texto perfeito!!! Abordou um dos temas que mais nos assombra no mundo
científico atual! Obrigada!
43. Francisco Camolesi Ide 13.06.19 em 13:22 – Responder
Parabéns ! Excelente texto, me ajudou muito a entender um pouco mais de
estatística
44. Paula 06.05.20 em 17:04 – Responder
Nunca pensei em ler algo sobre estatística sorrindo. Sempre faço o
contrário, choro muito, de desespero mesmo.
Parabéns, texto maravilhoso! E muito obrigada por esclarecer esse
questionamento sobre diferença estatística significativa.
45. Jefferson 08.06.20 em 15:24 – Responder
Ser significativo é um resultado. Não ser significativo também é um
resultado. É assim que se faz ciência. Experimentando. Parabéns pelo texto.
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PUBLISHED BY CIENCIA100
- My intentions have always been, are and will always be to help people from
different countries in some way because this Blog content is excellent and
always has a high level of importance for the world progress! As you know,
everyone has their own way of thinking and always acting. For a better world in
all ways always! Minhas intenções sempre foram, são e sempre serão de ajudar de
alguma maneira as pessoas de diferentes países porque o conteúdo deste Blog está
excelente com um alto nível de importância para o progresso mundial sempre! Como
você sabe, cada um tem sua própria maneira de pensar e agir sempre. Por um mundo
melhor sempre de todas as formas!
https://science1984.wordpress.com/2023/11/21/my-intentions-have-always-been-are-and-will-always-be-to-help-people-from-different-countries-in-some-way-because-this-blog-content-is-excellent-and-always-has-a-high-level-of-importance-for-the-wo/
- I started to do this blog in 2018. It was a very hard work but very valuable
and rewarding because many people of different countries have visited it and
liked it, such as renowned professors, scientists and/or researchers worldwide.
This blog has already reached the 1 million views mark! (11/17/2023 -- Today -
Hoje) #probability #vision #time #reading #times #data #number #views #ThisBlog
#technology #HumanLongevity #innovation #DNA #Cell #RNA #science #WorldHistory
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#clicks #VeryEfficientTechnologies #VeryInnovativeBlog #VeryDifferentBlog
#RelevantContent #pioneer #internet #VeryHardWork #recognition – 9 equations
that changed the world – By Adam Mann last updated July 28, 2022 ->
https://science1984.wordpress.com/2023/04/04/protecao-mundial-sempre-a-favor-do-bem-worldwide-protection-always-in-favor-of-good-https-science1984-wordpress-com-2023-04-04-physicalimmortalityaccordingtoraykurzweil-veryhighcoincidence-prob/
– ´´O objetivo da argumentação, ou da discussão, não deve ser a vitória, mas o
progresso.´´ @ ´´The aim of argument, or discussion, should not be victory, but
progress.´´ Joseph Joubert @ Joseph JoubertHistory Timeline of The Jackson
Laboratory -
https://science1984.wordpress.com/2023/11/04/o-objetivo-da-argumentacao-ou-da-discussao-nao-deve-ser-a-vitoria-mas-o-progresso-joseph-joubert-the-aim-of-argument-or-discussion-should-not-be-victory-b/
– 10/15/2023 – I don´t earn any money from this Blog and my Website
www.rodrigocal.com
https://science1984.wordpress.com/2023/08/31/www-rodrigocal-com/ – 11/17/2023 –
Today – Many changes in the human lives over time – This Blog Posts – Reading –
Time – Data @ Internet – Society – Internet Society – Internet Pioneers – Very
Hard Work – Recognition – Probability – Change – Facts – Firt Idea – Other Ideas
– Communication – Person – People – Internet History – Probabilities – World
History – World – History – Inventions Human Longevity – Genetics – Physiology –
Graphics – DNA/RNA/Cell – Human Memory – Human Health – Human Life – Physical
Immortality – Other types of Research and Projects – Human Age/Ages – Goal/Goals
– Scientific Community – Professors – Scientists – Researchers – Students –
Govern – Authorities – This Blog – World Progress Always – Relevant Content,
Information and Knowledge
https://science1984.wordpress.com/2023/11/17/11-17-2023-today-hoje-many-changes-in-the-human-lives-over-time-this-blog-posts-reading-time-data-internet-society-internet-society-i-eu-internet-pion/
– No one informed me by email, for example, that they used or are using as
references the graphics I made of my dissertation (these graphics are not
included in the related scientific article) in scientific research on humans
and/or in experimental animals. The graphics in my monograph also serve as
excellent references for scientific projects and research. The human life
expectancy needs to increase significantly in a short time through more
efficient scientific projects and research in different areas of study. I will
include in this post the name of the person and the place of work of the person
who used and/or is using such very relevant graphics mentioned, so that there is
ease in Cooperation and Partnerships between the different Departments of
Research and Teaching Centers around the World, Companies and Industries because
there will be an understanding of these facts mentioned when accessing and
reading this post to know the names of the people and their respective places of
work. The World Scientific Community needs to increasingly improve the execution
of much more efficient scientific projects and research to increasingly
significantly improve the quality of human life and enormously increase human
life expectancy. It is obvious that several challenges are present, however,
understanding these challenges and scientific and/or political discussions is
always of great importance for the progress of world society. For a better world
in every way! Ninguém me informou por e-mail, por exemplo, que utilizou ou está
utilizando como referência os gráficos que fiz para minha dissertação (estes
gráficos não estão no artigo científico da minha dissertação) em pesquisas
científicas em humanos e/ou em animais de experimentação. Os gráficos da minha
monografia também servem como excelentes referências para projetos e pesquisas
científicas. A expectativa de vida humana precisa aumentar significativamente em
pouco tempo por meio de projetos científicos e pesquisas mais eficientes em
diferentes áreas de estudo. Incluirei neste post o nome da pessoa e o local de
trabalho de quem utilizou e/ou está utilizando os gráficos tão relevantes
mencionados, para que haja uma facilidade na Cooperação e Parcerias entre os
diferentes Departamentos dos Centros de Pesquisa e Ensino do Mundo, Empresas e
Indústrias porque haverá uma compreensão desses fatos citados ao acessar e ler
este post para saber os nomes das pessoas e seus respectivos locais de trabalho.
A Comunidade Científica Mundial precisa melhorar cada vez mais a execução de
projetos e pesquisas científicas muito mais eficientes para melhorar cada vez
mais significativamente a qualidade da vida humana e aumentar muito a
expectativa de vida humana. É óbvio que vários desafios estão presentes, porém,
a compreensão desses desafios e das discussões científicas e/ou políticas é
sempre de grande importância para o progresso da sociedade mundial. Por um mundo
melhor em todos os sentidos! @
https://science1984.wordpress.com/2019/12/22/thats-why-we-need-citation-and-reference-some-facebook-comments-about-this-blog/–
THAT´S WHY WE NEED CITATION AND REFERENCE -> ´´WITHOUT DATA WE´RE JUST ANOTHER
PERSON WITH AN OPINION´´ — WILLIAM EDWARDS DEMING – Engineer, Professor, Author,
Lecturer @ STRUCTURE OF A SCIENTIFIC ARTICLE @ Some Facebook Comments about this
Blog and Images @ ´´A citation is a reference to a published or unpublished
source.[2]´´ @ ´´An opinion is a judgment, viewpoint, or statement that is not
conclusive. A given opinion may deal with subjective matters in which there is
no conclusive finding, or it may deal with facts which are sought to be disputed
by the logical fallacy that one is entitled to their opinions. Distinguishing
fact from opinion is that facts are verifiable, i.e. can be agreed to by the
consensus of experts. An example is: “United States of America was involved in
the Vietnam War,” versus “United States of America was right to get involved in
the Vietnam War”. An opinion may be supported by facts and principles, in which
case it becomes an argument.´´ https://en.wikipedia.org/wiki/Opinion @ ´´Harvard
was established in 1636 by vote of the Great and General Court of the
Massachusetts Bay Colony.´´ https://en.wikipedia.org/wiki/Harvard_University @
OTHER VERY IMPORTANT INFORMATION @ www.wordpress.com www.wikipedia.org
www.nih.gov www.ucla.edu www.stanford.edu www.darpa.mil www.whitehouse.gov
www.usa.gov www.nature.com www.nejm.com www.google.com www.gmail.com
www.yahoo.com www.youtube.com www.linkedin.com www.facebook.com www.twitter.com
www.instagram.com www.cnn.com www.bbc.com www.reuters.com www.bloomberg.com
www.nasdaq.com www.wellsfargo.com www.harvard.edu www.mit.edu www.nasa.gov
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www.microsoft.com www.spacex.com www.tesla.com www.alibaba.com www.amazon.com
www.abc.com www.ft.com www.exame.com www.forbes.com www.time.com www.cdc.gov
www.genome.gov www.fda.gov www.pfizer.com www.cornell.edu www.nyu.edu
www.washingtonpost.com www.stripe.com www.worldbank.org www.proton.me
www.fbi.gov www.cia.gov @ * Name of People -> Place of Work – Time/Data –
Internet/Time/Subject/Internet Pioneers/Work/Life (Probability of this Fact –
Probabilidade deste Fato)
https://science1984.wordpress.com/2023/11/22/no-one-informed-me-by-email-for-example-that-they-used-or-are-using-as-references-the-graphics-i-made-of-my-dissertation-these-graphics-are-not-included-in-the-related-scientific-article-in-scie/
– So Many Positive Feedbacks about this Blog by Facebook, LinkedIn and Twitter –
This Blog Links ->
https://science1984.wordpress.com/2023/10/15/so-many-positive-feedbacks-about-this-blog-by-facebook-linkedin-and-twitter/
´´Thank you so much for sharing´´
https://www.linkedin.com/in/hosna-salmani-a016a5125/ ´´I would also like to
compliment you on your excellent writing skills. Do you do speaking
engagements?´´ https://www.linkedin.com/in/bill-remak-111a85a/ ´´I have a
colleague I would like to refer you to.´´
https://www.linkedin.com/in/bill-remak-111a85a/ ´´Very impressive work you have
done. You appear to be well on your way in a rewarding career. What inspired you
to take this path?´´ https://www.linkedin.com/in/bill-remak-111a85a/ ´´This is
amazing work you are doing. Let me look into my network and see who might be
best to refer you to. Very impressive what I see you have done so far. My son
does financial writing and maybe he might have more connections.´´
https://www.linkedin.com/in/bill-remak-111a85a/ ´´Thank you. I am interested to
learn if you have a good grasp on health economics from the consumer side and
also from the side of health system payers or health plans globally. Is this
part of your expertise?´´ https://www.linkedin.com/in/bill-remak-111a85a/ ´´I am
a Preceptor for masters in public health student.´´
https://www.linkedin.com/in/bill-remak-111a85a/ ´´Interesting´´
https://www.linkedin.com/in/bill-remak-111a85a/ ´´I am also involved in
https://healthspanaction.org/ ´´ https://www.linkedin.com/in/bill-remak-111a85a/
´´Let me know if you are interested in joining. It is a global effort.´´
https://www.linkedin.com/in/bill-remak-111a85a/ ´´Thanks.´´
https://www.linkedin.com/in/bill-remak-111a85a/
https://www.facebook.com/Bioquantumacademy ´´Thank you for sharing. Wonderful
work done. I will definitely visit your blog often.´´
https://www.facebook.com/Bioquantumacademy - For a better world always in all
ways! - Por um mundo melhor sempre de todas as formas - 10/14/2023 - I am
available to receive partnership proposals with this Blog. Estou disponível para
receber propostas de parceria com este Blog. #ThisBlogPost #ThisBlogIntentions
#Names #Times #IndeterminedTime #Probabilities #Countries #HighVisibility
#VeryHardWork #WorldHistory #Information #Knowledge #DNA #Cell #Person #Ages
#People #Age #ScientificDiscoveries #Research #Projects #HumanLongevity @ My
Email Accounts: rodrigoncal1984@gmail.com rodrigonunescal@yahoo.com
rodrigoncal1984@yahoo.com rodrigonunescal1984@proton.me & Maybe I can earn money
with this blog by a partnership like I do a post about the possible partner
because of the high visibility of my blog around the world. Many people from
different countries have visited it, including excellent professors, scientists
and/or researchers worldwide. Maybe a partner have interest in paying money to
me monthly for it. I am not sure about this subject. It is the first time I do
it. I do not have any experience about it. The most important fact is that this
blog content is excellent with a very high level of importance to the world
progress always! As you know, the human expectancy of life needs to increase so
much faster more and more by very efficient research and projects
always! #probability #reader #leitor #people #pessoas #possibilidade #economy
#memory #memória #economia #dinheiro #money #países #countries #cidades #city
#Internet A very important fact is that many people from diferent countries
visit it daily. Other ´´thing´´ is that excellent professors, scientists and/or
researchers from the world have visited it. Its goal is contribute significantly
to the world progress always, like increasing the human expectancy of life
faster, more and more. * There are very important posts in my blog and the
number of the posts is very high. My intention was always do my best in this
blog to the world. http://www.darpa.mil http://www.ucla.edu - Supreme Court of
the United States -> http://www.stanford.edu https://www.supremecourt.gov/ –
10/07/2023 – Probability->Money->Each email address in the email lists I did if
the person agree->Money to me (I did it)->Recognition of the very hard work to
do it, my idea about it and the level of importance of the email lists to the
world progress always in several aspects -> Supreme Court of the United States –
https://www.supremecourt.gov/ @ 10/07/2023 —> Very Important Phrases from Bill
Gates, Jeff Bezos, Elon Musk and Steve Jobs – YouTube Videos @ –> Frases Muito
Importantes/Reading/Leitura/Click/This Post/Este Post
-Probability/Possibilidade(s) – Change of Opinions/Mudança de Opiniões – Vida(s)
Humana(s) /Human Life / Human Lives – True Facts/Fatos Verdadeiros/Internet –
Pessoa(s)/Person/People – Tempo(s) de Vida/Time of Life/Idade(s) /Age/Ages –
Respect/Respeito @ ´´Se você quer chegar onde a maioria não chega, faça o que a
maioria não faz.´´ Bill Gates / ´´A chave do sucesso nos negócios é perceber
aonde o mundo se dirige e chegar ali primeiro.´´ Bill Gates / ´´O poder não vem
do conhecimento, e sim do conhecimento compartilhado.´´ Bill Gates Bill Gates /
´´As pessoas sempre têm medo das mudanças. Tinham medo da eletricidade quando
foi inventada.´´ Bill Gates / ´´Sem livros, sem leitura, os nossos filhos serão
incapazes de escrever – inclusive sua própria história.´´ Bill Gates / “Você
precisa estar disposto a ser incompreendido se você for inovar.” Jeff Bezos /
“Se você não quiser ser criticado, nunca faça nada.” Jeff Bezos / “Detalhes
importam, vale a pena esperar e fazê-los direito”. Steve Jobs / “A melhor
maneira de escapar de uma caixa é inventando seu próprio caminho para fora”.
Jeff Bezos / “Você quer passar o resto de sua vida vendendo água com açúcar, ou
você quer uma chance de mudar o mundo?” Steve Jobs / “As pessoas que estão mais
frequentemente corretas são aquelas que mais frequentemente mudam de opinião.”
Jeff Bezos / “Não deixe a opinião dos outros abafar sua voz interior”. Steve
Jobs / “Se você dobrar a quantidade de experimentos que faz por dia, estará
dobrando sua inventividade.” Jeff Bezos / “O que é perigoso é não evoluir”. Jeff
Bezos / “Trabalhe duro. Divirta-se. Faça história.” Jeff Bezos / “Os fazedores
são os maiores pensadores. As pessoas que criam e mudam a indústria são
pensadores e fazedores em uma só pessoa”. Steve Jobs / “Eu quero colocar uma
marca no universo”. Steve Jobs / “A única maneira de fazer algo excelente é amar
o que você faz. Se você ainda não a encontrou, continue procurando. Não se
acomode”. Steve Jobs / “Você pode encarar um erro como uma besteira a ser
esquecida, ou como um resultado que aponta uma nova direção”. Steve Jobs /
“Reclamar não é uma estratégia. Temos que lidar com o mundo tal como ele é, e
não tal como gostaríamos que ele fosse.” Jeff Bezos / “Acho que esse é o melhor
conselho de todos: pense constantemente sobre como você pode fazer as coisas
melhor e questione a si mesmo.” — Elon Musk
https://science1984.wordpress.com/2023/10/21/very-important-phrases-from-bill-gates-jeff-bezos-elon-musk-and-steve-jobs-youtube-videos-frases-muito-importantes-reading-leitura-click-this-post-este-post-probability-pos/
https://science1984.wordpress.com/2023/10/14/i-am-available-to-receive-partnership-proposals-with-this-blog-estou-disponivel-para-receber-propostas-de-parceria-com-este-blog-thisblogpost-name-indeterminedtime-time-probabilities-countries/
– 10/07/2023 – The graphics I did about ´´my´´ dissertation and ´´my´´ monograph
that can be excellent references for many types of future research and projects,
of course. Os gráficos que fiz sobre ´´minha´´ dissertação e ´´minha´´
monografia podem ser ótimas referências para futuras pesquisas e projetos de
vários tipos, com certeza. https://science1984.wordpress.com/2022/12/13/65792/ –
Internet – Gene – 100 gene – 100 – gene(s) – No Gene – No(s) Gene(s) - No
Internet – 100 – Sem Internet – Vida(s) Humana(s) – Human Life – Grau(s) de
Influência(s) – Level of Influence – No Communication – Sem Comunicação –
Internet History – Test – Teste(s) – Internet Pioneer – UCLA/Stanford – Internet
Pioneers – Pioneiro(s) da Internet – País(es) – USA – Time/Tempo – Country –
World – Countries – City – Cities – Person (Pessoa) – Other Person (Outra
Pessoa) – Distance – Distância(s) – World – History – World History – Internet
Society – Society – Times – Time(s) – Tempo(s) – Human Lives – Human Memory –
Memória(s) Humana(s) – Futuro – Future – Now – Agora – Passado – Past – Presente
– Present – Idade(s) – Age – Ages – Human Longevity – Longevidade Humana
https://science1984.wordpress.com/2018/12/20/15362/ -> "Service to mankind,
broadly or individually, is the greatest fulfillment in life" The Foundation's
Founder, Nobel Laureate, Dr. George H. Hitchings - I´ve graduated in Biomedicina
at Federal University of Triangulo Mineiro in Chagas disease in laboratory
(Uberaba – 2003-2007) and I have a Master´s degree at Faculty of Medicine of Sao
Jose do Rio Preto (2008-2012) in lung cancer research in mice. Nowadays I work
as inspector of students since 2012 in Sao Jose do Rio Preto, Brazil.
(09/17/2023) https://science1984.wordpress.com/2023/03/18/77283/ -> Share this
Blog and this Blog Posts to your contacts and inform them to do the same and so
on, if possible!! @ I – EU – Internet – Internet Society – World History –
Internet History – Probability – World Progress – Age – Ages – Human Longevity
https://science1984.wordpress.com/2023/04/04/protecao-mundial-sempre-a-favor-do-bem-worldwide-protection-always-in-favor-of-good-https-science1984-wordpress-com-2023-04-04-physicalimmortalityaccordingtoraykurzweil-veryhighcoincidence-prob/
– 9 equations that changed the world – By Adam Mann last updated July 28, 2022
For a better world always in all ways! Por um mundo sempre melhor de todas as
formas! @ #probabilities #person #people #lives #age #ages #life #countries
#cities #city #country #internet
https://science1984.wordpress.com/2023/01/08/goals-of-this-blog-emails-reading-leitura-probability-usa-authorities-team-times-tempos-memory-law-leis-energy-he/
Objectives of this Blog -@? E-mails – Reading – Leitura – Probability – USA –
Authorities – Team – Times – Tempo(s) – Memory – Law – Lei(s) – Energy – Health
– Life – Vida(s) – Feelings – Time(s) @ Positive Feedbacks about this Blog &
Sharing interesting and important information is a very important act because it
helps in the diffusion of them in the world. Of course, it has to be true and
not fake news. #probabilities #probabilidades #Internet
https://science1984.wordpress.com/2021/09/04/do-the-downloads-share-the-diffusion-of-very-important-information-and-knowledge-is-essential-for-the-world-progress-always-thanks/
-> The diffusion of relevant information and knowledge in this Blog is essential
for the world progress always in many aspects, of course! @ EU – Countries – I –
Internet Pioneer – Team – Internet Society – Society – Time – Times –
Probabilities – True Facts – Person – People @ #reader #ThisBlog #Science
#Technologies #Innovations #economy #cities #images #data #links #websites
#SocialNetworks #videos #texts #photos #prices #money #clicks #vision
#communication #HumanLongevity @
https://science1984.wordpress.com/2023/01/08/se-alguem-quiser-usar-as-listas-de-e-mails-que-fiz-em-2022-a-pessoa-tera-que-enviar-e-mail-para-os-seguintes-enderecos-de-e-mails-chancellorucla-edu-presidentwhitehouse-gov-vice_presidentw/
www.whitehouse.gov www.ucla.edu www.darpa.mil www.stanford.edu www.usa.gov
https://science1984.wordpress.com/2023/04/06/scientific-community-physicalimmortalityproject-veryhighmoneyinvolved-extensiveemaillistsidid-graphics-data-veryhighutilitiesinthisproject-investigations-logicalfacts-law-justice-fbi-cia/
Ray Kurzweil’s predictions are 86% accurate &@ Probability (0 or not
0)->Person/People->Money->Me->My Idea->I->Work (Recognition)->Use of the Email
Lists and/or the Graphics I did (´´my´´Dissertation and/or ´´my´´ Monograph) ->
Human Physical Immortality Projects and Research of the World and/or Other
Scientific Projects and Research Worldwide Subject (Assunto) @ Vida/Life – É
muito importante combater pessoas maldosas e muito maldosas até nos pensamentos.
#Memory #Memória – Past/Present/Future # Passado/Presente/Futuro
https://science1984.wordpress.com/2022/11/12/subject-assunto-vida-life/
https://science1984.wordpress.com/2023/04/04/physicalimmortalityaccordingtoraykurzweil-veryhighcoincidence-probability-time-extensiveemaillistsidid-gmail-emails-archive-database-google-yahoo-system-pioneer-thisblogposts-recognitio/
@ www.google.com www.gmail.com www.time.com www.yahoo.com www.youtube.com
https://web.whatsapp.com/ www.twitter.com www.facebook.com www.linkedin.com
www.nasdaq.com www.nih.gov www.timeshighereducation.com www.fda.gov www.cdc.gov
www.wellsfargo.com www.worldbank.org www.fbi.gov www.cia.gov www.pfizer.com
www.harvard.edu www.mit.edu www.ucla.edu www.usa.gov www.whitehouse.gov
www.nasa.gov www.stanford.edu www.apple.com www.microsoft.com www.spacex.com
www.tesla.com www.facebook.com/scientificblog www.ft.com www.nyt.com www.wsj.com
www.reuters.com www.washingtonpost.com www.cnn.com www.bbc.com www.abc.com
www.forbes.com www.wikipedia.org www.stripe.com www.wordpress.com
www.nobelprize.org www.columbia.edu www.yale.edu www.duke.edu www.cornell.edu
www.nyu.edu www.famerp.br www.uftm.edu.br www.ufscar.br www.uel.br www.pucsp.br
www.ita.br www.embraer.com www.nobelprize.org www.nejm.com
www.nature.comhttps://web.whatsapp.com/@ www.google.com www.gmail.com
www.time.com www.yahoo.com www.youtube.com www.twitter.com www.facebook.com
www.linkedin.com www.nasdaq.com www.nih.gov www.fda.gov www.cdc.gov
www.wellsfargo.com www.worldbank.org www.pfizer.com www.harvard.edu www.mit.edu
www.ucla.edu www.usa.gov www.whitehouse.gov www.nasa.gov www.stanford.edu
www.apple.com www.microsoft.com www.spacex.com www.tesla.com
www.facebook.com/scientificblog www.ft.com www.nyt.com www.wsj.com
www.reuters.com www.washingtonpost.com www.cnn.com www.bbc.com www.abc.com
www.forbes.com www.wikipedia.org www.stripe.com www.wordpress.com
www.nobelprize.org www.columbia.edu www.yale.edu www.duke.edu www.cornell.edu
www.nyu.edu www.famerp.br www.uftm.edu.br www.ufscar.br www.uel.br www.pucsp.br
www.ita.br www.embraer.com www.nobelprize.org www.nejm.com www.nature.com –
Unfortunately there are in the world fatal diseases, rare diseases and unknown
diseases
https://science1984.wordpress.com/2022/09/14/unfortunately-there-are-fatal-diseases-and-or-unknown-diseases/
World´s Protection in All Ways Now and Always!! @ Proteção Mundial de Todas As
Formas Agora e Sempre!!
https://science1984.wordpress.com/2022/09/02/worlds-protection-in-all-ways-and-aspects-always-protecao-do-mundo-em-todos-os-sentidos-e-aspectos-sempre/
https://science1984.wordpress.com/2022/08/14/61244/ Sempre serei do bem. I´ll
always be a good person. @ World History – História Mundial – 100 Genes – No
Gene/Sem gene – Numbers/DNA -Read/Listen/Speak/Type/Write – Country
https://science1984.wordpress.com/2022/09/16/human-dna-human-brain-human-cell-extraordinary-skills-work-the-mentalist-number-1-of-the-world-mind-reading-reading-of-minds-other-person-people-thinking-thoughts-visit-an/
Subject @ Vida/Life – It is very important to fight evil and very evil people,
even in your thoughts. #Memory #Memory – Past/Present/Future #
Passado/Presente/Futuro
https://science1984.wordpress.com/2022/09/17/protection-of-children-adolescents-women-and-elderly-people-now-and-always-protecao-de-criancas-adolescentes-mulheres-e-de-pessoas-idosas-agora-e-sempre/
– 09/17/22 – Protection of children, women, adolescents and elderly people now
and always!! Proteção de crianças, mulheres, adolescentes e de idosos agora e
sempre!! @ Sharing interesting and important information is a very important act
because it helps in the diffusion of them in the world. Of course, it has to be
true and not fake news.
https://science1984.wordpress.com/2022/09/17/unfortunately-there-are-in-brazil-and-other-countries-many-very-bad-people-the-world-always-needs-to-improve-quickly-in-the-best-way-for-people-to-live-better-and-longer-infelizmente-existem-no-br/
09/17/2022 – Unfortunately there are in Brazil and other countries many very bad
people. The world always needs to improve quickly in the best way for people to
live better and longer. @ Infelizmente existem no Brasil e em outros países
muita gente muito ruim. O mundo sempre precisa melhorar rapidamente da melhor
forma para que as pessoas vivam melhor e por mais tempo. @ Sharing interesting
and important information is a very important act because it helps in the
diffusion of them in the world. Of course, it has to be true and not fake news.
https://science1984.wordpress.com/2022/10/22/my-intentions-were-and-always-will-be-to-help-people-in-some-way-for-a-better-world-minhas-intencoes-foram-e-sempre-serao-de-ajudar-de-alguma-forma-as-pessoas-por-um-mundo-melhor-probability-r/
- My intentions were and always will be to help people in some way for a better
world. Minhas intenções foram e sempre serão de ajudar de alguma forma as
pessoas por um mundo melhor.
https://science1984.wordpress.com/2022/07/02/60219/ – Physical Immortality ?
There´re people linked to Scientific Community who believe in it in the future.
This is a very important subject in this post, of course.
https://science1984.wordpress.com/2021/11/27/world-scientific-community-detection-unknown-diseases-fatal-diseases-other-diseases-age-times-time-ages-person-birth-death-same-age-analysis-graphics-projects-scientifi/
– World Scientific Community – Detection – Unknown Diseases – Fatal Diseases –
Other Diseases – Age – Times – Time – Ages – Person – Birth – Age of Death –
Same Age – Same Ages – Facts – Time – Analysis – Different and Detailed Graphics
– Physical Immortality (?) – Different Tests – Projects – Scientific Researches
– Mice Researches – Human Researches – Animal Testing – DNA – Cell – RNA – New
Drugs – New Vaccines – New Therapeutical Substances – Personalized Medicine –
Details – People – Genetics – Physiology – Biochemistry – Molecular Biology –
Biological Factors – Human Body – New Prevention Methods – New Diagnosis Mehods
– New Prognosis Methods – New Treatments Mehods – New Medical Devices –
Different Graphics – New Tests – New Susbstances – New Analysis – Future –
Control Groups – Study Groups – Graphics Comparisons – p Values – Probabilities
– Statistics – Biostatistics – Very High Efficiencies – Money – Price –
Pharmacology – Parasitology – Cardiology – Neurology – Subjects – New Researches
– Very Innovative Graphics – Science Data – New References – Scientific Journals
– Dissertations – Monographs – Articles – Impact Factor – Science – Different
Technologies – Investments – Politics – Laboratories – Industries – Top
Universities – Top Research Centers – Researchers – Scientists – Professors –
Doctors – City – Cities – Internet – Internet Society – Internet History –
History – World History – Investigation – YouTube Videos (Internet Pionners) –
Lives – Thinking – Contribuitions – World – Energy – Intentions – Objectives –
Goal – Blog – Work – Improvement – Health – Mind – Human Life – Information –
Knowledge – New Projects – New Objectives – Team – Different Departments –
Innovations – Different Communication – Respect – Television – Radio – Journals
– Magazines – Write – Type – Listen – Speak – Read
https://science1984.wordpress.com/2021/01/10/40820/ – ´´Understanding the great
difficulties of a given subject can be a very long process, however, of great
value for the progress of Science in all aspects´´ Rodrigo Nunes Cal –
01/10/2021 @ ´´Compreender as grandes dificuldades de um determinado assunto
pode ser um processo muito demorado, porém, de grande valia para o progresso da
Ciência em todos os aspectos´´ Rodrigo Nunes Cal – 10/01/2021 @ Future pandemic
preparedness, powered by genomics – Next-generation sequencing is helping to
steer the global response to SARS-CoV-2, and will help the world to prepare for
future pandemics – Produced by Nature Research Custom Media Illumina – © 2021
Springer Nature Limited @ Mysterious ‘kick’ just after the Big Bang may have
created dark – By Paul Sutter – Astrophysicist @ Images about this blog stats
and other important images & Internet – Images – Texts – Data – Reading –
Thinking – Time – Person – People – Statistics – World – Countries – Cities –
Thinking – Thoughts – Intentions – Influences – Times – Memories – MEMORY –
Pesquisa – Research – Researches – References -Graphics – Dissertation –
Monograph – Innovations – Human Longevity – Internet Society – Society –
Internet History – History – Internet ´´The world people need to have very
efficient scientific research and projects resulting in very innovative drugs,
vaccines, therapeutical substances, medical devices and other technologies
according to the age, the genetics and medical records of the person. So, the
treatment, diagnosis and prognosis will be very efficient and better, of
course´´. Rodrigo Nunes Cal ´´É muito importante, com certeza absoluta, prevenir
e detectar crimes de abuso sexual contra crianças e adolescentes e demais crimes
no mundo digital e no mundo sem o uso da Internet´´. Rodrigo Nunes Cal ´´It´s
very important, with absolute certainty, to prevent and detect crimes of sexual
abuse against children and adolescents and other crimes in the digital world and
in the world without the use of the Internet´´. Rodrigo Nunes Cal ´´Sex
education is very important for sure´´. Rodrigo Nunes Cal ´´A educação sexual é
muito importante, com certeza absoluta´´. Rodrigo Nunes Cal ´´It is very
important to try to improve the society we live in in some way, at least on some
issue. Sometimes there is no success in this attempt, but the important thing is
to leave a very good example for other people to follow the same path in trying
to solve various types of problems present in today’s world, in which these
problems negatively influence people’s lives. somewhat reducing the life span of
people in different countries around the world´´. Rodrigo Nunes Cal ´´É muito
importante tentar melhorar a sociedade em que vivemos de alguma forma em algum
assunto, pelo menos. Às vezes não há êxito nesta tentativa, mas o importante é
deixar um exemplo muito bom para as outras pessoas seguirem no mesmo caminho na
tentativa de resolução de problemas de vários tipos presentes no mundo de hoje,
nos quais estes problemas influenciam negativamente na vida das pessoas
diminuindo de certa forma o tempo de vida das pessoas nos diferentes países do
mundo´´. Rodrigo Nunes Cal – ´´What happens in the digital world does not always
happen in human life without the internet, obviously ´´. Rodrigo Nunes Cal The
graphics I did about variations of all mice weights during all experimental time
are not in the article of my dissertation nor in my dissertation. The details of
exercise and rest times of the animals aren´t in the article: The influence of
physical activity in the progression of experimental lung cancer in mice –
Pathol Res Pract. 2012 Jul 15;208(7):377-81. Renato Batista Paceli 1, Rodrigo
Nunes Cal, Carlos Henrique Ferreira dos Santos, José Antonio Cordeiro, Cassiano
Merussi Neiva, Kazuo Kawano Nagamine, Patrícia Maluf Cury –
https://pubmed.ncbi.nlm.nih.gov/22683274/ These graphics I did of ´´my´´
dissertation that are related to all animal ages in each group including control
groups can be an excellent reference for future researches in animal testing and
in human researches in the area of genetic engineering for example. These data
are in my blog as well as the many direct invitations that I´ve received to
participate in relevant scientific events of the world in a very little time.
The age of the humans, animals and the genetics, physiology, biochemistry
related to them influence directly in determined ways in human expectancy of
life. ´´More than 800 researchers have added their names as signatories. A
series of related articles is being published by the American Statistical
Association this week (R. L. Wasserstein et al. Am. Stat.
https://doi.org/10.1080/00031305.2019.1583913; 2019). “The tool has become the
tyrant,” laments one article. https://www.nature.com/articles/d41586-019-00874-8
https://www.nature.com/articles/d41586-019-00857-9 American Statistical
Association – https://www.amstat.org/ ´´We propose to change the default P-value
threshold for statistical significance from 0.05 to 0.005 for claims of new
discoveries.´´ https://www.nature.com/articles/s41562-017-0189-z Published: 01
September 2017 Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature
Human Behaviour volume 2, pages6–10 (2018) – What levels of influence does the
Internet have on people’s lives in its various aspects? The fact is that many
situations that occurred and occur daily in the Internet environment would never
occur in these people’s lives, due to several interconnected factors, since this
virtual world is very complex and dynamic and is very linked to imagination and
assumptions, for example. Depending on the circumstance and other factors, a lot
of information that one person typed for another, he would not speak or read
what he typed. Obviously the Internet has its very good and important side in
people’s lives in many aspects. However, it has its negative and dark side in
several interconnected issues, coming to be dangerous in the lives of many
people, unfortunately. The Internet has two sides of the coin, one positive and
one negative. Furthermore, as many of you already know, there is a huge amount
of money directly and/or indirectly related to the Internet, which is strongly
linked to the economy of a certain place. As you already know, the Internet
originated from the great ideas and thoughts of people and since then, a lot has
changed and has been changing constantly, causing each time another significant
increase in the number of Internet users in various parts of the world. There
are several types of influences in different intensities that the Internet can
cause in people’s lives, depending, for example, on the types of website content
that people access and their frequency of access, as well as there are different
means of communication, such as the writing, speaking, writing something, and
others. Certainly, there are sites that are much better than others in various
subjects, causing a different type of behavior and view of the Internet user on
this site. As many say, there is a virtual world very different from the real
world. Obviously, the different technologies developed by people have impacts of
different degrees on people’s lives, bringing different types of consequences,
for example, very constructive and very negative and dangerous. Another very
obvious thing is that not always what happened and/or happens in the present in
the virtual environment happened and/or will happen in a personal contact
between 2 people in certain circumstances, for example. Therefore, it is
necessary to be very careful when browsing the Internet, as there are a lot of
sites of different types, some much better than others on the same topic,
causing different degrees of influence on people’s minds and actions at
different time intervals, depending a lot on the usage time of a certain
website, for example. Much Health and Peace for You Always!! #probability
#reader #time #pioneer #USA #pioneers #ideas #people #person #thoughts #thinking
#memory #tempo #probabilities #website #videos #links #websites #video #photo
#images #photos #names #name #DifferentInfluences #HumanMind #Feelings
#intentions #goal #objectives #tests #work #Internet #HumanInterdependence #test
#life #speak #sincerity #virtual #real #HumanMinds #actions #life #health
#probabilities #virtuality #reality #countries #economy #world @ YouTubeVideo –
@ Who invented the Internet? And Why? Quem inventou a internet? E por que?
https://www.youtube.com/watch?v=21eFwbb48sE www.youtube.com &
https://www.youtube.com/watch?v=KF6sLCeBj0s Como a internet funciona? – Glad You
Asked T1 – How does the Internet work?
https://science1984.wordpress.com/2021/12/25/what-levels-of-influence-does-the-internet-have-on-peoples-lives-in-its-various-aspects-the-fact-is-that-many-situations-that-occurred-and-occur-daily-in-the-internet-environment-would-never-occur/
* www.fbi.gov www.cia.gov www.whitehouse.gov www.usa.gov www.facebook.com
www.linkedin.com www.gmail.com www.yahoo.com www.proton.me Observação muito
importante: Não fui eu quem disponibilizou a lista de e-mail que criei em 2015
para qualquer pessoa acessar na Internet em um link que já especifiquei para
autoridades governamentais e policiais dos EUA pelo LinkedIn e Facebook (já
mencionei esse assunto na minha conta de e-mail). No meu blog há detalhes sobre
esta lista de e-mail que se refere a pesquisadores, cientistas e/ou cientistas
do mundo que trabalharam (trabalham) nas 20 melhores Instituições de Ensino e
Pesquisa do Mundo em 2015. Recebi muitos feedbacks positivos de excelentes
profissionais da área de pesquisa e ensino que estão no post do meu blog, onde
há explicações sobre os fatos envolvidos neste projeto, que foi enviado em
formato PDF para cada um deles. A Comunidade Científica Mundial precisa
obviamente de muito mais recursos de vários tipos para melhorar ainda mais os
projetos científicos e a investigação, a fim de aumentar ainda mais a esperança
de vida humana. Very important note: I was not the one who made the email list I
created in 2015 available for anyone to access on the Internet in a link I have
already specified to US government and law enforcement authorities via LinkedIn
and Facebook (I have already mentioned this subject in my email account).
email). On my blog there are details about this email list that refers to
researchers, scientists and/or scientists in the world who worked (work) in the
20 best Teaching and Research Institutions in the World in 2015. I received a
lot of positive feedback from excellent professionals from the area of research
and teaching that are in my blog post, where there are explanations about the
facts involved in this project, which was sent in PDF format to each of them.
The World Scientific Community obviously needs many more resources of various
types to further improve scientific projects and research in order to further
increase human life expectancy. – The Era of Modernity – Text typed by me on
09/18/2021. @ Very important links to download eBooks for free – Links muito
importantes para baixar e-Books gratuitamente @ Relevant information related to
book reading and its interconnected aspects in the school environment – Rodrigo
Nunes Cal – Part 1 and 2 (Documents) – Informações relevantes relacionadas à
leitura de livros e seus aspectos interligados no ambiente escolar – Rodrigo
Nunes Cal – Parte 1 e 2 (Documentos – Very important links to download eBooks
for free – Links muito importantes para baixar e-Books gratuitamente). You can
do the downloads of the documents about it!! Você pode fazer os downloads destes
2 documentos sobre este assunto!! @ List of so many links of this blog and the
documents about it to do the downloads!! The Era of Modernity -> We live in a
time when many companies, laboratories and industries from the most varied
sectors and locations in the area of human health are increasingly improving the
techniques and technologies in the diagnosis, prevention and treatment of
various diseases, including those that are fatal and silent (go unnoticed by the
person). However, with all this scientific and technological advance in this
sector of society, unfortunately a large number of people around the world
acquire numerous diseases of various degrees and stages, causing a large number
of deaths daily. This contradiction and ambiguity occurs because there is an
enormous difficulty in understanding the different biological and physiological
mechanisms by which these diseases manifest themselves in people for a long
time. The person’s genetics and their age are one of the related factors. with
the morbidity and mortality of diseases, as it is known, in the over time, the
human body accumulates many factors at the cell phone and there is also the
natural wear and tear of it, as per example, the number of heartbeats in a
certain interval of time, obviously. As many people say, the human body can be
equivalent in a certain way to a machine that when passing of time, your organs
(parts) will wear out due to the numerous internal and external factors, and
thus life expectancy human tends to decay. Of course efficient drugs, medical
devices for detection (diagnosis), prognosis and treatment of diseases, vaccines
and therapeutic substances are great allies in the best quality of life and life
expectancy person’s. An increasingly efficient personalized medicine with
certainty is of great importance for human health too, taking into account the
patient’s age and genetics, consequently. Obviously, this quest for perfection
and high degree of efficiency in the development of new therapeutic substances,
medicines, vaccines and medical devices involve many factors, among which the
political, financial, research, professional training, construction or
improvement of new pharmaceutical laboratories, companies and industries, among
others. The breaking of paradigms and major challenges are extremely important
for Science, without a shadow of a doubt. Professors, scientists, researchers
and students must have great motivation and reference to obtain better results
from their scientific work for society. This point has to be highlighted because
unfortunately many health professionals are not well valued even in financial
levels. Public authorities must be fully aware of this fact, obviously.
Otherwise, the long-awaited scientific discoveries by society will take longer
than “normal” to emerge. A matter of great importance to be discussed is the
possibility of emergence of certain diseases (unknown diseases) in some country,
several countries or even in all countries of the world. The complicated issue
of this is the enormous difficulty of predict these diseases, as an example, it
is worth remembering the emergence of COVID-19. The acquisition of very
efficient technologies for this purpose, in case of detection of a possible
possibility of the emergence of a disease unknown by the world scientific
community, even more if this is fatal, it is of paramount importance for
everyone. Beyond of the detection (diagnosis) of this type of disease, it is
vital importance the existence of great technologies capable of preventing
(preventing the disease from manifesting in the person) and even doing an
excellent prognosis and treatment. The world scientific community needs to unite
more and more in all its aspects for human interdependence to be very effective
and thus the results obtained from research and projects they will be much
better and satisfying for all mankind. With of course, the full and exact
understanding of these types of diseases to avoid morbidity and mortality is
very difficult, however, impossible. The human being has already conquered many
things that were said by many people as impossible to be reached, like a lot of
people know. The dissemination of knowledge and information from a reliable
source is also of great value, of course, because as many already know, it is
from there that many people learn about this information and knowledge conveyed
by the Internet, radio and/or television and so on. progress of a country and
even of the whole world, depending on the circumstances and the reach reached of
diffusion (sharing) is reached more quickly. For a long time, research and
academic projects have been fundamental for the technical-scientific and
socioeconomic development of a country. That’s why more detailed and effective
scientific research and projects are great allies to world progress. High-impact
innovations are the ”soul” of world scientific progress. The era of Modernity
has made life much easier for many people in several countries. The other side
of the coin and balance of this era is that unfortunately there are still many
people living in extreme poverty. presenting a terrible quality of life and life
expectancy. In this sense, Science in all its aspects needs to achieve all
sectors of society, including those countries where the of the most varied types
of resources prevails. The authorities policies need to act much more in this
field of society world, because many problems, including violence and hunger,
arise due to the scarcity of financial resources in these locations, for
example. Therefore, the most active and the protagonists in this era of
Modernity in many countries urgently need to look, analyze and deeply reflect
the big problems of several types in other countries without discrimination and
without disrespect, because the Science needs to progress in all countries in a
more fair. The right to a decent life is everyone’s right, no matter which
country that the person is living in! Each country has made and makes its
history! Unfortunately, there have been many injustices throughout history! The
world needs to be more united, more and more! health and peace for all! @ Other
relevant documents to do the downloads @ The diffusion of relevant information
and knowledge is essential for a country progress always!! A difusão de
relevantes informações e conhecimentos é sempre essencial para o progresso de um
país!! @ Thank You!! Obrigado!!
https://science1984.wordpress.com/2021/12/25/what-levels-of-influence-does-the-internet-have-on-peoples-lives-in-its-various-aspects-the-fact-is-that-many-situations-that-occurred-and-occur-daily-in-the-internet-environment-would-never-occur/
– What levels of influence does the Internet have on people’s lives in its
various aspects? The fact is that many situations that occurred and occur daily
in the Internet environment would never occur in these people’s lives, due to
several interconnected factors, since this virtual world is very complex and
dynamic and is very linked to imagination and assumptions, for example.
Depending on the circumstance and other factors, a lot of information that one
person typed for another, he would not speak or read what he typed. Obviously
the Internet has its very good and important side in people’s lives in many
aspects. However, it has its negative and dark side in several interconnected
issues, coming to be dangerous in the lives of many people, unfortunately. The
Internet has two sides of the coin, one positive and one negative. Furthermore,
as many of you already know, there is a huge amount of money directly and/or
indirectly related to the Internet, which is strongly linked to the economy of a
certain place. As you already know, the Internet originated from the great ideas
and thoughts of people and since then, a lot has changed and has been changing
constantly, causing each time another significant increase in the number of
Internet users in various parts of the world. There are several types of
influences in different intensities that the Internet can cause in people’s
lives, depending, for example, on the types of website content that people
access and their frequency of access, as well as there are different means of
communication, such as the writing, speaking, writing something, and others.
Certainly, there are sites that are much better than others in various subjects,
causing a different type of behavior and view of the Internet user on this site.
As many say, there is a virtual world very different from the real world.
Obviously, the different technologies developed by people have impacts of
different degrees on people’s lives, bringing different types of consequences,
for example, very constructive and very negative and dangerous. Another very
obvious thing is that not always what happened and/or happens in the present in
the virtual environment happened and/or will happen in a personal contact
between 2 people in certain circumstances, for example. Therefore, it is
necessary to be very careful when browsing the Internet, as there are a lot of
sites of different types, some much better than others on the same topic,
causing different degrees of influence on people’s minds and actions at
different time intervals, depending a lot on the usage time of a certain
website, for example. Much Health and Peace for You Always!! #probability
#reader #time #pioneer #USA #pioneers #ideas #people #person #thoughts #thinking
#memory #tempo #probabilities #website #videos #links #websites #video #photo
#images #photos #names #name #DifferentInfluences #HumanMind #Feelings
#intentions #goal #objectives #tests #work #Internet #HumanInterdependence #test
#life #speak #sincerity #virtual #real #HumanMinds #actions #life #health
#probabilities #virtuality #reality #countries #economy #world @ YouTubeVideo –
@ Who invented the Internet? And Why? Quem inventou a internet? E por que?
https://www.youtube.com/watch?v=21eFwbb48sE www.youtube.com &
https://www.youtube.com/watch?v=KF6sLCeBj0s Como a internet funciona? – Glad You
Asked T1 – How does the Internet work?
https://science1984.wordpress.com/2022/12/14/66091/ – Probabilities -> More
Interactions of Many Types -> Groups of Retired People on Social Networks –
Email Lists of Retired People Who Worked in Excellent Research and Teaching
Centers of the World @ Probabilidade(s) -> Maiores Interações de Muitos Tipos ->
Grupos de Pessoas Aposentadas em Redes Sociais – Lista de Emails de Pessoas
Aposentadas que Trabalharam em Excelentes Centros de Pesquisa e Ensino do Mundo
@ ´´What happens in the digital world does not always happen in human life
without the internet, obviously ´´. Rodrigo Nunes Cal @ ´´Nem sempre o que
ocorre no mundo digital ocorre na vida humana sem a internet, obviamente´´.
Rodrigo Nunes Cal
https://science1984.wordpress.com/2023/01/08/100-cem-sem-no-sem-dna-cell-no-thinking-reading-pensamentos-chat-leituras-no-time-tempo-nos-tempos-times-cem-100-pensamentos-leituras-no-papel-paper-https-science1984-w/
-@ 100 – cem – sem – no (sem) DNA/Cell – no
thinking/reading/pensamento(s)/chat/leitura(s) – No time/tempo – No(s)
tempo(s)/time(s) – cem (100) pensamentos/leituras – no papel/paper
https://science1984.wordpress.com/2022/07/30/internet-history-pionner-pionners-work-world/
https://science1984.wordpress.com/2022/12/07/goals-of-this-blog-e-mails-probabilities-reading-leituras-usa-authorities-team-times-tempos-memory-law-lei/
www.wikipedia.org www.usa.gov www.fbi.gov www.cia.gov www.forbes.com
www.wordpress.com www.stripe.com www.nature.com www.nejm.com www.nobelprize.org
www.ucla.edu www.harvard.edu www.mit.edu www.stanford.edu https://www.cam.ac.uk/
https://www.ox.ac.uk/ https://ki.se/ www.bbc.com www.bloomberg.com www.cnn.com
https://www.wsj.com/ https://www.uspto.gov/ www.nih.gov www.cdc.gov www.fda.gov
www.pfizer.com www.gmail.com www.yahoo.com www.google.com www.youtube.com
www.twitter.com www.facebook.com www.facebook.com/scientificblog
www.linkedin.com www.instagram.com www.yale.edu www.cornell.edu www.duke.edu
www.famerp.br www.uftm.edu.br www.ita.br www.embraer.com www.gov.br/pt-br
www.unesp.br https://www5.usp.br/ https://www.unifesp.br/ https://ufmg.br/
www.ufrgs.br https://portal.uel.br/home/
https://www5.pucsp.br/paginainicial/www.ufscar.br https://www.gov.br/pf/pt-br
https://www.stj.jus.br/sites/portalp/Inicio
https://pt.semrush.com/blog/top-100-sites-mais-visitados/
https://www.whitehouse.gov/contact/
https://science1984.wordpress.com/2022/12/14/66104/ > ´´Obstacles are
opportunities in disguise.´´ Deepak Chopra
https://science1984.wordpress.com/2022/12/14/66086/ – Time/Tempo – Action/Ação –
Influence/Influência – Internet/Person/People/Pessoa(s) –
Probabilities/Possibilidades – Laws/Leis –
Money/Dinheiro/Price/Preço/Justice/Justiça – Intentions/Intenções –
Facts/Fato(s) – Life/Vida(s)/Lives/Health/Saúde – World History – Tempo de
Vida/Lifetime
https://science1984.wordpress.com/2022/12/13/graphics-comparisons-my-dissertation-relevant-reference-human-and-animal-researches-ages-age-person-people-analysis-of-influence-of-many-biological-factors-related-to-relation-among-health/
-Graphic Comparisons – Reference – Human and Animal Researches – Ages/Age –
Person/People – Study of factors related to relation among health, time,
diseases and death.
https://science1984.wordpress.com/2022/12/13/cell-dna-time-life-lives/ –
Cell/DNA/People – Person/Age/Ages – DNA/RNA – Human Life/Health – Times – Human
Lives
https://science1984.wordpress.com/2022/12/13/there-was-no-statistically-significant-difference-and-now-nao-houve-diferenca-estatistica-significativa-e-agora-editorial-20-march-2019-nature-567/
– ´´There was no statistically significant difference. And now? ´´Não houve
diferença estatística significativa. E agora?´´ @ EDITORIAL 20 MARCH 2019 –
Nature 567, 283 (2019) -> ´´It’s time to talk about ditching statistical
significance – Looking beyond a much used and abused measure would make science
harder, but better.´´ É hora de falar sobre a redução da significância
estatística – Olhar além de uma medida muito usada e abusada tornaria a ciência
mais difícil, mas melhor. ´´If researchers do discard statistical significance,
what should they do instead? They can start by educating themselves about
statistical misconceptions. Most important will be the courage to consider
uncertainty from multiple angles in every study. When working out which methods
to use, researchers should also focus as much as possible on actual problems.
People who will duel to the death over abstract theories on the best way to use
statistics often agree on results when they are presented with concrete
scenarios.´´ & WHAT DOES STATISTICALLY SIGNIFICANT MEAN? by Jeff Sauro, PhD |
October 21, 2014 @ Wikipedia Links about Time, Ageing, Age and Nobel Foundation
& Nobel Prize Website – www.nobelprize.org @ OTHER VERY IMPORTANT INFORMATION @
https://www.nature.com/articles/d41586-019-00857-9 @
https://www.nature.com/articles/d41586-019-00874-8
https://www.tandfonline.com/doi/full/10.1080/00031305.2019.1583913
https://science1984.wordpress.com/2022/12/09/as-many-people-know-not-every-theory-can-be-fully-or-partially-applied-in-practice-always-keep-in-mind-wanting-to-improve-the-society-in-some-way-whatever-it-may-be-rodrigo-nunes-cal/
– ´´As many people know, not every theory can be fully or partially applied in
practice. Always keep in mind wanting to improve the society in some way,
whatever it may be´´. Rodrigo Nunes Cal @ ´´Como muitos já sabem, nem toda
teoria consegue ser totalmente ou parcialmente aplicada na prática. Tenha sempre
em mente em querer melhorar a sociedade de alguma forma, seja ela qual for´´.
Rodrigo Nunes Cal @ https://www.genome.gov/ www.usa.gov www.nobelprize.org
www.forbes.com www.fbi.gov @ Internet #image #foto(s) #photo #images #age
#idade(s) #probabilities #probabilidades #person #feelings #sentimentos
#thinking #thoughts #actions #pensamento(s) #ações #time #future #tempo #present
#presente #futuro #past #passado #people #visão #vision #país #country #cidade
#city #memory #memória #mente #leitura #reading #life #vida #saúde #mind #health
#pessoas #pessoa #friends #friend #family #world Internet #image #foto(s) #photo
#images #age #idade(s) #probabilities #probabilidades #person #feelings
#sentimentos #thinking #thoughts #actions #pensamento(s) #ações #time #future
#tempo #present #presente #futuro #past #passado #people #visão #vision #país
#country #cidade #city #memory #memória #mente #leitura #reading #life #vida
#saúde #mind #health #pessoas #pessoa #friends #friend #family #world
#ChangeOfOpinion #MudançaDeOpinião #LifeFacts #FatosDaVida @ ´´The external
temperature of the planet affects to the internal temperature of the planet, the
difference between the internal and external temperature produce the magnetic
field force. If this difference of temperature reduces, the magnetic field
decreases reducing the rotational velocity of the planet and also reduce the
inclination. If the inclination reduces, also the sun-rays with higher energy
can enter in the planet producing the increase of the external temperature. And
it happens exponentially, and can be applied to all bodies also to the Sun. I
applied it to the Sun, venus, Earth, Mars Jupiter and Saturn with satisfactory
results´´. Joan Carles Testagorda Garcia joancarles@hotmail.es Astrophysisc –
Quantum Physics, Mathematics. @
https://www.nytimes.com/international/section/opinion @
https://www.nytimes.com/international/section/opinion www.cnn.com www.bbc.com
www.usa.gov #opinion #opinião #OpinionChange #MudançaDeOpinião #assunto #subject
#person #pessoas #people #person #AllProbabilities #TodasProbabilidades
#Internet #Vision #visão #communication #comunicação
https://science1984.wordpress.com/2022/11/28/i-used-to-believe-that-conversation-was-the-key-to-everything-but-actually-understanding-it-is-because-you-can-say-everything-that-bothers-you-but-if-the-other-doesnt-understand-it/
´´I used to believe that conversation was the key to everything. But today
comprehension it is. Because you can say everything that bothers you, but if the
other doesn't understand, it's over.´´
https://science1984.wordpress.com/2022/11/14/animal-and-human-testing-testes-em-animais-e-em-humanos/
– Animal and human testing @ Phases of clinical research – Clinical research is
conducted on drug candidates, vaccine candidates, new medical devices, and new
diagnostic assays @ Highly Cited Researchers (h>100) according to their Google
Scholar Citations public profiles – 15th Edition – second week of March 2022 @
Sharing interesting and important informations is a very important act because
it helps in the diffusion of them in the world. Of course, it has to be true and
not fake news.
https://science1984.wordpress.com/2022/10/09/not-always-what-we-think-refers-to-what-we-are-doing-and-or-what-we-want-to-do-in-the-future-ask-yourself-mentally-or-not-about-anything-whatever-the-subject-with-your-very-sincere-a/
-> ´´Not always what we think refers to what we are doing and/or what we want to
do”. Rodrigo Nunes Cal @ ´´Nem sempre o que pensamos refere-se àquilo que
estamos fazendo e/ou que queremos fazer´´. Rodrigo Nunes Cal
https://science1984.wordpress.com/2022/07/30/the-human-expectancy-of-life-needs-to-increase-so-much-faster-more-and-more-with-very-efficient-researches-and-projects-resulting-in-new-vaccines-therapeutical-substances-medical-devices-and-drugs/
– ´´The human expectancy of life in the world needs to increase so much faster
more and more with very efficient scientific researches and projects resulting
in new ideas, references, vaccines, therapeutical substances, medical devices,
drugs, prevention, diagnostic, prognostic and treatment methods, for example´´.
Rodrigo Nunes Cal @
https://science1984.wordpress.com/2018/11/15/hi-rodrigo-we-are-the-globo-tv-international-relationship-center-congratulations-to-you-for-all-the-works-you-are-doing-with-your-studies-its-very-good-to-know-about-it-thanks-for-sh/
@ www.google.com www.time.com www.gmail.com www.yahoo.com www.usa.gov
www.nih.gov www.wikipedia.org www.wordpress.com www.genome.gov
www.nobelprize.org www.harvard.edu www.mit.edu www.columbia.edu www.nasa.gov
www.ucla.edu www.stanford.edu www.princeton.edu www.yale.edu www.duke.edu
www.cornell.edu www.nyu.edu www.caltech.edu www.nyt.com www.wsj.com
www.reuters.com www.youtube.com www.bloomberg.com www.ft.com www.nasdaq.com
www.forbes.com www.exame.com www.famerp.br www.uftm.edu.br www.ita.br
www.cia.gov www.fbi.gov www.facebook.com www.instagram.com www.linkedin.com
www.twitter.com www.amazon.com www.spacex.com www.tesla.com www.microsoft.com
www.alibaba.com www.apple.com www.stripe.com www.wellsfargo.com
www.worldbank.org
https://science1984.wordpress.com/2022/08/10/you-have-a-very-impressive-career-ahead-of-you-very-good-worki-agree-with-you-100-we-dont-live-long-enough-ill-be-60-next-month-and-i-have-at-least-100-years-of/
– ´´You have a very impressive career ahead of you. Very good work´´I agree with
you 100%. We don´t live long enough. I´ll be 60 next month and I have at least
100 years of work I need to do.´´ no joke… There´s always too much todo and I´ve
lost so many good friends over the years. good people…´´ -> Messgaes for me from
my Facebook Friend Alan House ´´I am a Software Engineer and have had my own
business since 1982´´
https://science1984.wordpress.com/2022/08/06/facebook-messages-for-me-from-american-college-of-medical-genetics-and-genomics-acmg-after-ive-sent-it-messages-about-this-blog-thank-you-good-luck-in-your-work-thanks-for-reach/
– Facebook messages for me from American College of Medical Genetics and
Genomics (ACMG) after I´ve sent it messages about this blog: ´´Thank you. Good
luck in your work! Thanks for reaching out and we wish you all the best with
your blog.´´ – American College of Medical Genetics and Genomics -> Telephone:
301-718-9603 Fax: 301-718-9604 E-mail: acmg@acmg.net 7101 Wisconsin Avenue –
Suite 1101 Bethesda, MD 20814 @ www.google.com www.apple.com www.amazon.com
www.forbes.com www.nih.gov www.usa.gov www.gmail.com www.yahoo.com
www.youtube.com www.harvard.edu www.mit.edu www.nasa.gov www.princeton.edu
www.columbia.edu www.caltech.edu www.yale.edu www.cornell.edu www.duke.edu
www.pfizer.com www.linkedin.com www.microsoft.com www.twitter.com
www.nobelprize.org www.wordpress.com www.stripe.com www.facebook.com
www.facebook.com/scientificblog www.cnn.com www.bbc.com www.fbi.gov www.cdc.gov
www.fda.gov www.cia.gov www.alibaba.com www.spacex.com www.tesla.com
www.timeshighereducation.com www.wikipedia.org www.exame.com www.ita.br
www.famerp.br www.uftm.edu.br www.embraer.com www.instagram.com www.whatsapp.com
www.ox.ac.uk www.ki.se www.u-tokyo.ac.jp www.wellsfargo.com www.bloomberg.com
www.nasdaq.com www.washingtonpost.com www.ft.com www.ucla.edu
https://science1984.wordpress.com/2022/08/14/61244/ Sempre serei do bem. I´ll
always be a good person. @ World History – História Mundial – 100 Genes – No
Gene/Sem gene – Numbers/DNA -Read/Listen/Speak/Type/Write – Country
https://science1984.wordpress.com/2022/08/24/61708/ – DNA/Cell –
100-Pensamento(s) – Thinking – Read
@%?https://www.goodreads.com/author/quotes/7221234.Elon_Musk
https://science1984.wordpress.com/2022/08/27/the-first-step-is-to-establish-that-something-is-possible-then-probability-will-occur-elon-musk-o-primeiro-passo-e-estabelecer-que-algo-e-possivel-entao-a-probabilidade/
– “The first step is to establish that something is possible then probability
will occur.” Elon Musk @ “O primeiro passo é estabelecer que algo é possível,
então a probabilidade ocorrerá.” Elon Musk & Probability – Thinking – Facts –
Speak – Listen – Write – Type – Actions – Think – Reading – Life – Health – Mind
– Person – People – Minds – Same Times – Same Time – Different Probabilities –
Real Fact – Intentions – Objectives – Feelings – Time – Question – Deep
Self-Reflection – Affirmation – Learning – Human Errors – Information – Human
Rights – Human Evolution – World Progress – Human Longevity – Pionners – Work –
Prices – Money – Laws – Cities – Countries – Motivation – Logic Analysis Of The
Different Times – Television – Internet – Radio – Cell – Live – Different Lives
– DNA – Subject – Reflections – Imaginations – Future – Probabilities –
Different Times – Different Thoughts – Same Thoughts – Mind Inductions –
Telepathy – Very High Coincidences – Mind Reading – Human Interdependence –
Superations – Negatives Facts – Positive Facts – World History – Internet
History – Human Brains – Human Brain – Respect – Human Qualities – Internet
Pionner – Internet Pionners – Computer Pionner – Cell Phone Pionner – Medical
Devices Pionners – Books – eBooks – Free eBooks – Different Intensities of
Determined Subjects – World Contributions – Names – Name – Supositions – Nome –
Nomes – Internet – Time – Times – Thinking – Pensamento(s) – Thoughts – Progress
– New Ideas – Novas Ideias – Novos Projetos – New Projects – New Research –
Novas Pesquisas – Citations – References – Knowledge – Different Countries –
Different and Same Departments – Information – People – Person – Human Longevity
– New Scientific Discoveries – Scientific Community – USA Authorities – Internet
Pionner – First Idea – Work – Live – Life – Future Generations – Different Jobs
– Investigations – Personal History – Team – Govern – Police – Researches –
Projects – Ideas – Imagination – Different Jobs – Very High Importance of the
Human life – Very High Importance of Human Lives – Messages – Meeting – Meetings
– Scientific Events – Relevant Researches – Excellent References – Message –
Technologies – Graphics – Data – Origin – Notebooks – Computers – Authorities –
Logic – Future Facts – Place – Level of Importance – RANKING – Internet Content
– Website Content – Websites – Different Communication – Blog Content – Links –
Videos – Photos – Images – Analysis – Different Countries – Understanding –
Friends – Friend – Future Times – Past Times – Present Time – Normal Facts of
Human Life
https://science1984.wordpress.com/2022/10/16/the-17-equations-that-changed-the-world-andy-kiersz-mar-31-2016-601-pm-https-www-businessinsider-com-equations-that-changed-the-world-2016-3-www-google-com-www-forbes-com-www-gmail-com-www/
- The 17 equations that changed the world - Andy Kiersz - Mar 31, 2016, 6:01 PM
https://www.businessinsider.com/equations-that-changed-the-world-2016-3
www.google.com www.forbes.com www.gmail.com www.yahoo.com www.usa.gov
www.nih.gov www.wikipedia.org www.nobelprize.org www.wordpress.com
www.youtube.com www.facebook.com www.twitter.com www.linkedin.com
www.instagram.com www.amazon.com www.tesla.com www.nasa.gov www.harvard.edu
www.mit.edu www.stanford.edu www.ucla.edu www.caltech.edu www.yale.edu
www.columbia.edu www.cnn.com www.bbc.com www.cornell.edu www.princeton.edu
www.alibaba.com www.facebook.com/scientificblog www.fbi.gov www.cia.gov
www.fda.gov www.cdc.gov www.pfizer.com www.apple.com www.microsoft.com
www.duke.edu www.famerp.br www.ita.br www.uftm.edu.br www.embraer.com
www.pubmed.ncbi.nlm.nih.gov www.nature.com www.nejm.com www.gov.br
https://lattes.cnpq.br
https://science1984.wordpress.com/2022/09/14/the-world-needs-to-improve-so-much-faster-with-very-efficient-ideas-researches-and-projects-resulting-in-new-drugs-therapeutic-substances-medical-devices-vaccines-and-others-unfortunately-there/
– The world needs to improve so much faster with very efficient researches and
projects, resulting in new drugs, medical devices, vaccines, therapeutic
substances and others things. Unfortunately there are fatal diseases and/or
unknown diseases
https://science1984.wordpress.com/2022/09/07/human-mind-mente-vidas-life-lives/
EU/I – Pensamento(s) da(s) Pessoa(s) – Thinking of the Person/People
www.gmail.com www.yahoo.com
https://science1984.wordpress.com/2022/09/29/but-science-is-the-collection-of-natures-answers-the-humanities-the-collection-of-mens-thoughts-sir-gavin-de-beer-https-science1984-wordpress-com-2022-09-29-s/
´´But science is the collection of nature’s answers; the humanities the
collection of men’s thoughts.´´ — Sir Gavin de Beer
https://science1984.wordpress.com/2022/09/29/science-quotes-answer-quotes/
https://science1984.wordpress.com/2022/08/06/acmg-for-me-by-facebook-thank-you-good-luck-in-your-work-thanks-for-reaching-out-and-we-wish-you-all-the-best-with-your-blog-genetics-cell-dna-researches-ideas/
ACMG for me by Facebook -> ´´Thank you. Good luck in your work! Thanks for
reaching out and we wish you all the best with your blog.´´ @ #Genetics #Cell
#DNA #Research #Ideas #Projects #Efficiency #HumanLongevity #Age #Ages #Time
#Times #Life #Lives #Work #Blog #Internet #Reading #Feelings #Health #Mind
#Minds #Contributions #People #Person #Links #Videos #Images #Data #Websites
#SocialNetworks #Speak #thinking #Thoughts #Write #Type #Pioneers #Pioneer
#Communication #Progress #Country #Countries #Cities #City #Economy #Price
#Information #Money #Knowledge #Prices #Probability #Click #Clicks #Text #Texts
#Intentions #Goal #Objectives #ScientificCommunity #WorldInnovation #Graphics
#Dissertations #Monographs #References #Citations #ImpactFactors #Journals
#TrueFacts #Science #ScientificDiscoveries #Hope #FutureGenerations #Evolution
#HardWork #Analysis #Investigation #Ranking
https://science1984.wordpress.com/2021/11/29/message-that-my-facebook-friend-roger-weiss-who-works-at-nasa-sent-for-me-very-best-success-with-your-blog-and-research-some-of-positive-feedbacks-i-received-about-this-blog/
– Message that Roger Weiss who works at NASA sent for me by Facebook: ´´Very
best success with your blog and research´´ @ Some of positive feedbacks I´ve
received about this blog by LinkedIn and Facebook @ Statistics about this blog
in this day (12/01/2021) and others periods & YouTube Video (George Church on
reversing aging | ApplySci @ Harvard) @ Relevant Links, YouTube Videos (Internet
Pioneers), Websites, Social Networks and Images @& ´´Nothing is better than
reading and gaining more and more knowledge.” — Stephen Hawking
https://science1984.wordpress.com/2020/03/07/fome-e-o-fator-que-leva-a-celula-tumoral-a-migrar-pelo-corpo-diz-pesquisador-hunger-is-the-factor-that-causes-the-tumor-cell-to-migrate-through-the-body-says-researcher-genome-sequencing-key-to/
– Twitter message for me from @IEEEorg about this blog: ´´Thanks for your hard
work!´´ @ Nature 567, 283 (2019) doi: 10.1038/d41586-019-00874-8 – EDITORIAL 20
MARCH 2019 – ´´It’s time to talk about ditching statistical significance Looking
beyond a much used and abused measure would make science harder, but better. If
researchers do discard statistical significance, what should they do instead?
They can start by educating themselves about statistical misconceptions. Most
important will be the courage to consider uncertainty from multiple angles in
every study. Logic, background knowledge and experimental design should be
considered alongside P values and similar metrics to reach a conclusion and
decide on its certainty. Researchers should seek to analyse data in multiple
ways to see whether different analyses converge on the same answer.´´ @ Fome é o
fator que leva a célula tumoral a migrar pelo corpo, diz pesquisador – Hunger is
the factor that causes the tumor cell to migrate through the body, says
researcher #@ Genome Sequencing: Key to solving India’s rare diseases problem &
CRISPR treatment inserted directly into the body for first time – Experiment
tests a gene-editing therapy for a hereditary blindness disorder @ Coronavirus
disease 2019 (COVID-19): News and Information – Massachusetts General Hospital &
´´Não houve diferença estatística significativa. E agora?´´ @ ´´WHAT DOES
STATISTICALLY SIGNIFICANT MEAN?´´ by Jeff Sauro, PhD | October 21, 2014 @ OTHER
VERY IMPORTANT INFORMATION OF THE WORLD LIKE WEBSITES, LINKS AND IMAGES & The
graphics I did about ´´my´´ dissertation that can be great reference for many
types of future researches. Os gráficos que fiz sobre ´´minha´´ dissertação que
podem ser ótima referência para futuras pesquisas de vários tipos @
https://inano.au.dk/about/research-groups/gothelf-lab
https://inano.au.dk/open-positions/open-phd-positions
https://science1984.wordpress.com/2020/12/31/twitter-messages-for-me-from-my-twitter-follower-joe-w-joewer32145-who-is-mechanical-engineer-at-nasa-nasa-about-my-research-i-told-my-colleague-about-your-researchhe-thinks/
– Twitter messages for me from my Twitter follower Joe W. @joewer32145 who is
mechanical engineer at NASA @nasa about my research ´´I told my colleague about
your research´´He thinks you will be relevant in one of our research centres
´´It all depends on you´´You are a bright young man´´Okay´´I will communicate
with you tomorrow noon´´ @ Other Twitter message for me about the message I sent
to the doctor Rasu Shrestha @RasuShrestha ´´Thanks for sharing the link to your
blog Rodrigo! All the best to you in 2021.´´ @ My Facebook Page, Curriculum
Lattes and YouTube Channel – My Social Networks and E-mails Accounts & Images,
links, other Twitter messages and Great websites @ Many people liked the
comments I did about Tweets of other people. Images about it are available in
this Blog @ Image and link about the most powerful computers in the World –
Top500: Japan’s Fugaku Still the World’s Fastest Supercomputer @ Images about my
new Twitter Followers @ ´´The wise man never says everything he thinks, but he
always thinks everything he says´´. Aristotle @ ´´O sábio nunca diz tudo o que
pensa, mas pensa sempre tudo o que diz.´´ Aristóteles & Instagram message for me
about this blog from Karolinska Institutet Students
https://www.instagram.com/kistudents/ ´´Thank you for your message and for
sharing your blog with us. As an account, we unfortunately cannot share this
external content with our audience, but we appreciate that you reached out, and
we wish you the best of luck! Kind wishes, Gerda 😊 Same to you! Gerda´´.
Instagram message I sento to Karolinska Institutet Students: If possible, visit
and share my https://science1984.wordpress.com because this blog content is very
good with very quality and importance to the world. I do not earn any money from
it. Many people worldwide have visited it and liked it such as renowned
professors, scientists and/or researchers around the world!! The people need to
live better and longer, more and more!! So, this blog sharing is fundamental to
the world progress always!! Inform to your friends to do the same and so on!!
Let´s make a very big positive chain of dissemination of it!! Thanks for your
attention!! Sorry for anything. #probability #time #reader #countries #city
#cities #country Best regards !! Thank You !!! Best wishes always for you, your
friends and family!! @ ´´The difficulty in concentrating can have both internal
causes, such as a mental disorder, and external causes, such as the work
environment or cell phone. ” @ ´´A dificuldade para se concentrar pode ter tanto
causas internas, como um transtorno da mente, quanto causas externas, como
ambiente de trabalho ou celular. ´´- Twitter messages for me from my Twitter
follower Joe W. @joewer32145 who is mechanical engineer at NASA @nasa about my
research ´´I told my colleague about your research´´He thinks you will be
relevant in one of our research centres ´´It all depends on you´´You are a
bright young man´´Okay´´I will communicate with you tomorrow noon´´ @ Other
Twitter message for me about the message I sent to the doctor Rasu Shrestha
@RasuShrestha ´´Thanks for sharing the link to your blog Rodrigo! All the best
to you in 2021.´´ @ My Facebook Page, Curriculum Lattes and YouTube Channel – My
Social Networks and E-mails Accounts & Images, links, other Twitter messages and
Great websites @ Many people liked the comments I did about Tweets of other
people. Images about it are available in this Blog @ Image and link about the
most powerful computers in the World – Top500: Japan’s Fugaku Still the World’s
Fastest Supercomputer @ Images about my new Twitter Followers @
https://science1984.wordpress.com/2019/04/06/facebook-messages-for-me-dear-mr-rodrigo-cal-thank-you-very-much-for-your-message-and-the-information-about-your-research-it-is-very-important-information-in-xx/
– Facebook messages for me from Oxford Union: ´´Dear Mr. Rodrigo Cal!´´ ´´Thank
you very much for your message and the information about your research. It is
very important information in XXI century. The Academic Union of Oxford has a
lot of projects in all kinds of the scientific areas. This year our team is
preparing projects for Medical Universities all over the world. Please follow
our news to know the most actual conferences and events in scientific and
educational area! Best regards! Julia May, Manager of the Academic Union,
Oxford´´ @ Some websites about animal researches &@ ´´The Academic Union is an
international academic association of over 200 University Chancellors,
Scientists and Researchers. The committees and the Union as a whole pursue the
ideals of Academic Excellence, Innovation and Accessibility and are committed to
disseminating these core values through its worldwide community.The primary aim
of the Union is to consolidate the efforts of scientists, educators,
industrialists, and manufacturers on science, education and business integration
and development in the XXIst century.´´ @
https://science1984.wordpress.com/2018/11/15/hi-rodrigo-we-are-the-globo-tv-international-relationship-center-congratulations-to-you-for-all-the-works-you-are-doing-with-your-studies-its-very-good-to-know-about-it-thanks-for-sh/
– ´´Hi Rodrigo. We are the Globo TV International Relationship Center.
Congratulations to you for all the works you are doing with your studies. It’s
very good to know about it. Thanks for sharing your messages with us. Before we
go ahead with our conversation, could you please answer some questions? In which
country do you live and by which provider do you subscribe our TV channel? We
await for your response.´´ #time www.google.com www.usa.gov www.forbes.com
www.exame.com www.nobelprize.org www.harvard.edu www.mit.edu www.stanford.edu
www.facebook.com www.twitter.com www.youtube.com www.gmail.com www.yahoo.com
www.instagram.com www.linkedin.com #history #country #countries #communication
#analysis #investigations #intentions #mind #feelings #health #life #age #ages
#name #cities #city #person #blog #system #people #work #lives #contribuitions
#importance #respect #subject #subjects #goal #objectives #reading #speak #type
#listen #DifferentThings #DifferentTechnologies #DifferentInluences
#FutureGenerations #longevity @
https://globointernacional.globo.com/Paginas/sinais.aspx
https://falecomaredeglobo.globo.com/- ´´Hi Rodrigo. We are the Globo TV
International Relationship Center. Congratulations to you for all the works you
are doing with your studies. It’s very good to know about it. Thanks for sharing
your messages with us. Before we go ahead with our conversation, could you
please answer some questions? In which country do you live and by which provider
do you subscribe our TV channel? We await for your response.´´ #time
www.google.com www.usa.gov www.forbes.com www.exame.com www.nobelprize.org
www.harvard.edu www.mit.edu www.stanford.edu www.facebook.com www.twitter.com
www.youtube.com www.gmail.com www.yahoo.com www.instagram.com www.linkedin.com
#history #country #countries #communication #analysis #investigations
#intentions #mind #feelings #health #life #age #ages #name #cities #city #person
#blog #system #people #work #lives #contribuitions #importance #respect #subject
#subjects #goal #objectives #reading #speak #type #listen #DifferentThings
#DifferentTechnologies #DifferentInluences #FutureGenerations #longevity @
https://globointernacional.globo.com/Paginas/sinais.aspx ´´No passado, eu achava
que a conversa era a chave de tudo. Mas na verdade, a compreensão que é, pois
você pode falar tudo o que te incomoda e se o outro não entender, já era.´´
https://science1984.wordpress.com/2022/11/28/antigamente-eu-acreditava-que-a-conversa-era-a-chave-de-tudo-mas-na-verdade-a-compreensao-que-e-porque-voce-pode-falar-tudo-o-que-te-incomoda-porem-se-o-outro-nao-entender-ja-era/
https://science1984.wordpress.com/2022/04/24/different-types-of-internet-connections-submarine-cable-map-https-www-submarinecablemap-com-https-www2-telegeography-com/
Different Types of Internet Connections @ Submarine Cable Map –
https://www.submarinecablemap.com/ @ https://www2.telegeography.com/
https://science1984.wordpress.com/2022/01/28/genetic-engineering-images-links-websites-and-youtube-videos-01-28-2022/
– Genetic Engineering -> Images, Links, Websites and YouTube Videos (01/28/2022)
https://science1984.wordpress.com/2022/01/31/graphics-bigchallenge-feedbacks-database-scientificcommunity-person-people-age-ages-genetics-time-of-life-of-each-person-in-the-world-reading-present-past-future-internetmessage/
– Graphics @# ´´My´´Dissertation &# ´´My´´Monograph @ # BigChallenge – World
#Feedbacks #DataBase # ScientificCommunity #PERSON #PEOPLE #AGE #AGES #GENETICS
– DATA & Thinking – Time of Life of Each Person in the World – Diseases – Fatal
diseases – Reflections – Unknown Diseases – Rare Diseases – Times @ Indetermined
Time – Physical Immortality @ #reading #present #past #future # InternetMessages
#statistics #facts #research #genetics #age # HumanExpectancyOfLife #ages
#person #AGE #PEOPLE #Genetics #HumanLongevity # WorldHistory # InternetHistory
#Energies #time #life #I #EU #Interpretations # reading #Computer #people
researches #professors #scientists #students #doctors #researchers #
ExcellentResearchCenters #Countries #articles #efficiency #projects #tests
#laboratories #work #intentions #ScientificDiscoveries #PharmaceuticalIndustries
#reference #Biostatistics #biochemistry #physiology #MolecularBiology #DNA #Read
#Cells #DifferentTimes #LIFE #lives #contribuitions #society #FutureGenerations
#HEALTH ##TIME #HumanCell #DifferentTechnologies #GeneticEngineering #Science
#Technologies #Innovations #drugs #vaccines #InternetImages
#TherapeuticalSubstances #ideas #world #WorldInnovation www.science1984.com
www.wordpress.com www.usa.gov www.nobelprize.org
https://science1984.wordpress.com/2022/01/23/52592/ – Graphics of ´´my´´
dissertation and my monograph # WorldInnovation #Time # Feedbacks #Reading @
Others Data https://science1984.wordpress.com/2019/12/25/29845/ – What Happens
in an Internet Minute in 2019? @#probability #probabilidade #reading #chat
#leitura #tempo #respeito #world #word #name #nome #click #assunto #issue
#content #conteúdo #idade #age #respect #investigations #investigações #pesquisa
#researches #análise #equipe #team #analysis #ranking #sponsors #marketing
#money #time #people #pessoas #pessoa #emails #e-mail #website #site #links
#pergunta #question #afirmation #afirmação #leitor #reader #melhoria
#improvement #videos #photos #images #MentalHealth #SaúdeMental #Health #Saúde
#longevity #feelings #sentimentos #memory #memória @ LinkedIn message for me
from my LinkedIn contact Professor Dr. Bankole Johnson, Executive Chairman of
the Global Institutes on Addiction, and Founder and Chief Medical Officer of
Adial Pharmaceuticals. He was Chair of the Department of Psychiatry, University
of Maryland School of Medicine @ My LinkedIn Contacts
https://science1984.wordpress.com/2019/12/15/29333/ – Memory/Memória(s) – I/EU @
Videos/Chat/Website/Brazil/Site(s)/HighPopularity/GrandePopularidade –
Probability/Read my Messages in my Email Accounts about this Chat – USA/Brazil
Authorities – True Facts about this Chat – Probabilities/Possibilidades –
Intentions/Intenções – Leitura das minhas mensagens sobre este chat nas minhas
contas de emails – Patrocinadores/Sponsors – Influence of this Chat in the Human
Mind – High necessity of improvement in this chat – Grandes Iniciativas – Great
Initiatives – Alta necessidade de melhorias neste chat – Saúde mental das
pessoas – Mental health of people – Time – Tempo(s) – Times – País – Country –
Cidade(s) – City – Cities – Economy – Economia – Saúde Pública – Public Health –
Doença/Disease – Sentimentos/Feelings – Ações/Actions @ This Blog Contributions
to the World Society and World Progress Now and Always #
InternetHistory/Pioneers/ReconhecimentoDoTrabalho/WorkRecognition – Vida(s) –
Lives – Life – Vida – Internet – Trabalho – Teams – Equipes – Futuras Gerações –
Future Generations – Human Longevity – Longevidade Humana &# Artificially
cloaked viral nanovaccine for cancer immunotherapy -> Nature Communications
volume 10, Article number: 5747 (2019) @ 3 MILLION BITCOIN IN 2 SECONDS: GOOGLE
QUANTUM COMPUTER @ VACCINES RESEARCH – DRUG DEVELOPMENT – DISEASE TESTING –
VACCINE CANDIDATES – POTENTIAL POST-INFECTION THERAPIES – EFFECTIVE VACCINE –
CLINICAL RESEARCH – POTENTIAL THERAPEUTICS DRUGS – INDUSTRY RESEARCHERS
https://science1984.wordpress.com/2019/08/24/mri-scans-improve-prostate-cancer-detection-using-mri-scans-to-target-biopsies-is-more-effective-at-detecting-prostate-cancers-that-are-likely-to-need-treatment-than-standard-ultrasound-guided-biopsi/
– MRI scans improve prostate cancer detection. Using MRI scans to target
biopsies is more effective at detecting prostate cancers that are likely to need
treatment than standard ultrasound guided biopsies alone, according to research
published in JAMA Network Open. @ Most important 21st century innovation | Arun
Majumdar | TEDxStanford & Learn data science for beginners (How to learn data
science for free)? @ Top 10 Technologies To Learn In 2020 | Trending
Technologies In 2020 | Top IT Technologies | Edureka @ Understanding DevOps @
Prostate Cancer: Evolving Paradigms: From Biopsy to Treatment @ Prostate Cancer
101 | #UCLAMDChat Chat @ What Everyone Should Know About Prostate Cancer @ Very
Important Videos
https://science1984.wordpress.com/2019/06/17/ja-que-rola-a-zueira-ha-muito-tempo-em-um-site-ok-tudo-bem-since-it-has-been-mess-a-long-time-at-a-website-ok-it-is-all-right-policiafederal-fbi-email-leitura-reading-internet-emails-wor/
- Já que rola a zueira há muito tempo em um site, ok. Tudo bem. Since it has
been mess a long time at a website, ok. It is all right. Por Um Mundo Melhor
Sempre! For A Better World Forever ! @ Turning Drug Delivery Inside Out How
spherical nucleic acid (SNA) technology may solve the challenge of delivering
oligonucleotides into cells @ ´´Chaos theory is a branch of mathematics focusing
on the study of chaos—states of dynamical systems whose apparently-random states
of disorder and irregularities are often governed by deterministic laws that are
highly sensitive to initial conditions.[1][2]´´ @ VERY IMPORTANT SOCIAL
NETWORKS, WEBSITES, LINKS AND IMAGES OF THE WORLD #time #intentions #blog
#country #countries #system #technologies #DifferentTechnologies #reality
#DifferentPerceptions #mind #actions #influences #person #people #history
#improvement #reading #respect #age #ages #researches #innovation #reference
#affirmation #question #discussion #Science #energy #longevity #feelings #life
#health
https://science1984.wordpress.com/2019/01/22/chinese-facial-recognition-will-take-over-the-world-in-2019-michael-k-spencer-medium-member-since-apr-2018-blockchain-mark-consultant-tech-futurist-prolific-writer-wechat-mikekevinspencer-https/
Chinese Facial Recognition Will Take over the World in 2019 – Michael K. Spencer
Medium member since Apr 2018 Blockchain Mark Consultant, tech Futurist, prolific
writer. WeChat: mikekevinspencer
https://medium.com/futuresin/chinese-facial-recognition-will-take-over-the-world-in-2019-520754a7f966?fbclid=IwAR0nUeBlb3hvxdKL4tjNM2A2oXVrs260bjhhx9AM3p6lfitu6IVlJ_NjFw4
https://science1984.wordpress.com/2018/12/20/15362/ #emails #incerteza
#uncertain #Time #reading #leitura #imagination #video #chat #website #respect
#melhorias #assunto #issue #improve #fact #patrocinadores #sponsors #Tempo
#collaborations #USA #estratégiasmaisfáceis #mynotebook #firststrategy
#MyBlogGoal #easierstrategies #Print #intelligence #VeryBigChallenge #internet
https://science1984.wordpress.com/2018/10/20/our-administrator-chats-with-astronaut-nick-hague-osiris-rex-brakes-for-a-certain-asteroid-and-what-landing-site-is-right-for-our-next-mission-to-mars-a-few-of-the-sto/
´´Our administrator chats with astronaut Nick Hague, OSIRIS-REx “brakes” for a
certain asteroid, and what landing site is right for our next mission to Mars? A
few of the stories to tell you about – This Week at NASA!´´ #TIME
https://www.facebook.com/ThisWeekAtNASA/ https://www.nasa.gov/
https://science1984.wordpress.com/2018/08/15/us-court-issues-injunction-against-open-access-publisher-omics/
US Court Issues Injunction Against Open-Access Publisher OMICS –
https://www.the-scientist.com/the-nutshell/us-court-issues-injunction-against-open-access-publisher-omics-30581
& Researchers Develop Wearable Microfluidic Cytometer – Link – Image @ Twitter
Chat @ TECHNOLOGY
https://science1984.wordpress.com/2023/01/08/internet-pioneers-17-equations-that-changed-the-world-history-of-the-world/
– Internet Pioneers – 17 Equations that Changed the World – History of the World
– www.darpa.mil
https://science1984.wordpress.com/2019/06/17/ja-que-rola-a-zueira-ha-muito-tempo-em-um-site-ok-tudo-bem-since-it-has-been-mess-a-long-time-at-a-website-ok-it-is-all-right-policiafederal-fbi-email-leitura-reading-internet-emails-wor/
https://science1984.wordpress.com/2019/06/17/ja-que-rola-a-zueira-ha-muito-tempo-em-um-site-ok-tudo-bem-since-it-has-been-mess-a-long-time-at-a-website-ok-it-is-all-right-policiafederal-fbi-email-leitura-reading-internet-emails-wor/
– 10/29/2023 -Today/Hoje -@(?) Este chat faz parte de um site muito popular no
Brasil – This chat is part of a very popular website in Brazil # Muita incerteza
de quem a pessoa entra em contato nesse chat # A lot of uncertainty about who
the person contacts in this chat # Muita gente do Brasil usa este chat desde
muito tempo # Many people from Brazil have been using this chat for a long time
# Ausência de qualquer tipo de cadastro neste chat informando pelo menos a idade
do usuário do chat – Absence of any type of registration in this chat informing
at least the age of the chat user # Presença de diferentes situações
desrespeitosas de várias intensidades levando ao regresso do Brasil,
prejudicando a saúde pública à nível mental e físico # @ Presence of different
disrespectful situations of various intensities leading to the return of Brazil,
harming public health at a mental and physical level #@ Presença de diferentes
crimes praticados por pessoas nesse chat desde muito tempo. É claro que há uma
possibilidade de ocorrência de coincidência e/ou alta coincidência (dependendo
do tamanho da cidade, por exemplo) num possível encontro envolvendo uma simples
conversa entre 2 ou mais pessoas que trocaram mensagens nesse chat em que houve
uma denúncia por meio deste chat em relação à outra pessoa e esta pode fazer
infelizmente uma retaliação até por meio de alguma amizade, ocasionando
situações muito perigosas para si mesmo e até para a família da pessoa e amigos.
Infelizmente há muitos criminosos de vários tipos no Brasil desde muito tempo –
Presence of different crimes committed by people in this chat since a long time.
Of course, there is a possibility of coincidence and/or high coincidence
(depending on the size of the city, for example) in a possible meeting involving
a simple conversation between 2 or more people who exchanged messages in this
chat in which there was a report through this chat in relation to the other
person and this person can unfortunately retaliate even through some friendship,
causing very dangerous situations for themselves and even for the person’s
family and friends. Unfortunately, there have been many criminals of various
types in Brazil for a long time. & # No tópico de cidades, o assunto principal
desde muito tempo neste chat é sobre assunto relacionado à maiores de idade # In
the topic of cities, the main topic for a long time in this chat has been topics
related to adults. @ Muitas pessoas que usam este chat afirmam certas situações
para outra pessoas ao invés de perguntar, gerando desrespeito, obviamente. #
Many people who use this chat state certain situations to other people instead
of asking, obviously generating disrespect. # Não há histórico de conversas
neste chat desde muito tempo, o que poderia facilitar muitos aspectos para as
pessoas que usam este chat – There is no conversation history in this chat for a
long time, which could make many aspects easier for people using this chat #&
Obviamente, o Brasil e demais países precisam investir em novas tecnologias, por
exemplo, com o objetivo de melhorar a saúde das pessoas, a nível físico e
mental. Como muitos sabem, a saúde mental é um tema de grande importância
global, ocasionando diferentes níveis de motivação nas pessoas, depressão,
ansiedade, estresse, medo, entre outros exemplos, podendo ocasionar diferentes
tipos de doenças nas pessoas de diferentes intensidades e frequências. @
Obviously, Brazil and other countries need to invest in new technologies, for
example, with the aim of improving people’s health, physically and mentally. As
many know, mental health is a topic of great global importance, causing
different levels of motivation in people, depression, anxiety, stress, fear,
among other examples, which can cause different types of diseases in people of
different intensities and frequencies. Obviously, Brazil and other countries
need to invest in new technologies, for example, with the aim of improving
people’s health, physically and mentally. As many know, mental health is a topic
of great global importance, causing different levels of motivation in people,
depression, anxiety, stress, fear, among other examples, and can cause different
types of illnesses in people of different intensities and frequencies. @ Name –
Nome(s) – Names – Some People – Algumas Pessoas – This Chat/Este Chat – Email
Accounts – Minhas Contas de Email – Sobre Este Chat – About this Chat –
Possibilidades – Probabilities – Leituras – Reading – Autoridades Policiais –
Police Authorities – Political Authorities – Autoridades Políticas –
Governo/Govern – Trabalho/Work – Respect – Respeito – Vida – Life – Saúde/Health
– Money/Dinheiro – Intentions – Memory – Person – People – Memória – Intenções –
Pessoa(s) – Forbes – Ranking – Países – Countries – Cidade – City – Very
Different Chat – Very Different Technologies – Chat Muito Diferente –
Tecnologias Muito Diferentes – For a better world always in all ways ! Por um
mundo sempre melhor de todas as formas ! @ Turning Drug Delivery Inside Out How
spherical nucleic acid (SNA) technology may solve the challenge of delivering
oligonucleotides into cells & ´´Chaos theory is a branch of mathematics focusing
on the study of chaos—states of dynamical systems whose apparently-random states
of disorder and irregularities are often governed by deterministic laws that are
highly sensitive to initial conditions.[1][2]´´ @ VERY IMPORTANT SOCIAL
NETWORKS, WEBSITES, LINKS AND IMAGES OF THE WORLD @ #time #intentions #blog
#country #countries #system #technologies #DifferentTechnologies #reality
#DifferentPerceptions #mind #actions #influences #person #people #history
#improvement #melhorias #vidas #lives #reading #respect #age #ages #researches
#innovation #reference #affirmation #question #discussion #Science #energy
#longevity #feelings #life #health – Probability/Possibilidade (Email lists I
did in 2015 and 2022) @ Email message and/or other situation: Who was the person
who made the e-mail lists in the years of 2015 and/or 2022? @ As already
mentioned by me on this Blog, few people didn’t like the fact that I put each
person’s email address on the email list I created in 2022, informing me to
unsubscribe. Therefore, there is a probability that someone will use an email
list that I created and that someone who received an email message will also not
like that their email was added to the email list (in this case, I created the
email list in the year 2015 and 2022). Therefore, to avoid any type of problems
for myself and other people, I will not send anyone any of the email lists I
created, both the 2015 and the 2022 ones. As many know, the pioneering of the
Internet took place in the USA, Therefore, this country has every right to
decide everything regarding this issue, which is very important in several
global aspects. It was a lot of hard work to create these email lists (2015 and
2022). I don’t want to be harmed in any way by this. The laws on this subject
always have to be highly respected by people around the world for global
progress. @ Conforme já mencionado por mim neste Blog, poucas pessoas não
gostaram de eu ter colocado o email de cada uma na lista de emails que fiz em
2022, me informando para eu cancelar a inscrição. Portanto, há uma probabilidade
de alguém usar alguma lista de emails que fiz e alguma pessoa que recebeu alguma
mensagem de email também não gostar que colocaram o email dela na lista de
emails (no caso, eu que fiz a lista de emails no ano de 2015 e 2022). Portanto,
para evitar qualquer tipo de problemas para mim e também para outras pessoas,
não irei enviar para algúem nenhuma das listas de emails que fiz, tanto a de
2015 como a de 2022. Como muitos sabem, o pioneirismo da Internet ocorreu nos
EUA, portanto, este país tem todo o direito de decidir tudo do que se trata este
assunto que é muito importante em vários aspectos mundiais. Foi um trabalho
muito árduo fazer estas listas de emails (2015 e 2022). Não quero de nenhuma
forma me prejudicar com isso. As leis sobre este assunto sempre tem que serem
muito respeitadas pelas pessoas no mundo todo para o progresso mundial. &
Feelings – Health – I/EU – Person/Pessoa – People/Pessoas – Thinking – Thoughts
– Time/Tempo – Actions – Quality of Life – Times – Life – Countries – Human
Lives – Human Relations – Internet @ Internet Society – Society & Different
Types of Communication – World History – Scientific Discoveries
https://science1984.wordpress.com/2023/01/08/probabilities-e-mail-content-no-money-email-message-and-or-other-situation-who-was-the-person-who-made-the-e-mail-lists-feelings-i-person-people-thinking-thoughts-time-actions/
– Internet – Gene – sem gene – cem genes – 100 genes – 100 – gene(s) – No Gene –
No(s) Gene(s) – No Internet – 100 – Sem Internet – Vida(s) Humana(s) – Human
Life – Grau(s) de Influência(s) – Level of Influence – No Communication – Sem
Comunicação – Internet History – Test – Teste(s) – Tests – Internet Pioneer –
UCLA/Stanford/Darpa – Internet Pioneers – Pioneiro(s) da Internet – País(es) –
USA – Time/Tempo – Country – World – Countries – City – Cities – Person (Pessoa)
– Other Person (Outra Pessoa) – Distance – Distância(s) – World – History –
World History – History – Internet Society – Internet – Society – Internet
Origin – Origem da Internet – Pioneiro(s) da Internet – Times – Time(s) –
Tempo(s) – Human Lives – Human Memory – Memória(s) Humana(s) – Futuro – Future –
Now – Agora – Passado – Past – Presente – Present – Idade(s) – Age – Ages –
Human Longevity – Longevidade Humana @ President Biden Hosts a Bilateral Meeting
with President Xi Jinping of China The White House – 2,06 mi de inscritos –
11/15/2023 (Today/Hoje) -> https://www.youtube.com/watch?v=XQnjwLKBX0M
https://science1984.wordpress.com/2018/12/20/15362/ Hi Rodrigo,´´ ´´I visited
your blog and found it very insightful. I appreciate the effort you put into
sharing valuable content.´´
https://www.linkedin.com/in/nandan-kumar-duddukuri-8801133b/ Chief Scientific
Officer at Innatura Scientific Pvt. Ltd Fala sobre #medicine, #drugdiscovery,
#pharmaceuticals, ##leadoptimization e ##customchemicalsynthesisFala sobre
hashtag medicine, hashtag drugdiscovery, hashtag pharmaceuticals, hashtag
hashtag leadoptimization e hashtag hashtag customchemicalsynthesis Innatura
Scientific Pvt. Ltd Hyderabad, Telanganá, Índia Informações de contato 3.823
seguidores + de 500 conexões Amr El-Refaey BS Pharm, BCBBS, MBA, CMI Level 7
Certificate, Amber YaelSylvia Balazs, e mais 53 conexões em comum Sobre ´´I am a
chemist with over 10 years of experience in the biotech and pharmaceutical
industries, including over 10 years of managing small molecule drug discovery
projects with interdisciplinary teams. My experience includes progressing to the
candidate drug stage.´´ ´´I am actively building new business-to-business(B2B)
networks across Europe and North America through a large and expanding
international network. I am promoting drug discovery services with a creative
approach to new opportunities, including custom synthesis, medicinal chemistry,
pre-clinical and clinical synthesis of new chemical entities (NCEs), and
hit-to-lead optimization through fragment-based drug design.´´ ´´At Innatura
Scientific, we specialize in custom chemical synthesis services and have
extensive experience in the field of medicinal chemistry. Our expertise includes
the synthesis of compounds at scales ranging from milligrams to multiple
kilograms, as well as the production of drug intermediates, active
pharmaceutical ingredients (API), and impurities.´´ ´´We are particularly
interested in exploring business opportunities in the research and development
of PROTACs (Proteolysis-Targeting Chimera) and promoting our custom chemical
synthesis services worldwide. We are seeking to collaborate with biotech and
pharmaceutical companies, as well as academic teams, to exchange knowledge and
expertise in this field. Our goal is to work together to develop new PROTACs and
support the discovery of new therapeutics.´´ ´´Additionally, we offer
custom-targeted fluorescent probe services to help accelerate the discovery of
new drugs.´´ ´´We believe that through collaboration, we can bring new and
innovative solutions to the field of drug discovery. We look forward to the
opportunity to work with leading companies and academic teams to achieve this
goal.´´ ´´Our service models include fee-for-service (FFS), purchase orders
(PO), full-time equivalent (FTE), and contract manufacturing. We are supported
by a scientific advisory board from reputable institutions worldwide.´´
´´Specialties: Project management, medicinal chemistry, synthetic chemistry,
outsourced chemistry, pharmacology, telomerase inhibitor design, in vivo therapy
experiments, pharmacokinetics, oncology, anti-aging, and structure-based drug
design.´´ ´´Skills: Drug Development, Scientific Writing, Pharmacology, Patent
Law, Validation, Good Manufacturing Practice (GMP), Good Laboratory Practice
(GLP), Cancer, Life Sciences, Purification, Organic Chemistry, Laboratory
Skills, Analytical Chemistry, Research and Development (R&D), Business
Development.´´ Internet – World History/Time(s)/Data – Gene/Gene(s)/Genes – 100
– Sem Gene/No DNA/Sem DNA – Sem Genes – Cem Genes – 100 Genes – No Human Gene –
Nos genes – No human genes – No(s) Gene(s) – No Human Cell – Sem Célula Humana –
Sem Células Humanas/Sem Célula Humana – Cem Células Humanas – 100 human cells –
100 Células Humanas – No RNA/Sem RNA – No gene – No Internet/Sem Internet –
Vida(s) Humana(s) – Human Life – Grau(s) de Influência(s) – Level of Influence –
Level of Importance/Nível de Importância – No Communication – Sem Comunicação –
Internet History – Test – Teste(s)/Teste – Tests – Internet Pioneers –
UCLA/Stanford/Darpa – Pioneiros da Internet – Origin of the Internet – País(es)
– USA – Time(s)/Tempo(s) – Country – World – Countries – City/Cities –
Economy/Economia – Person/Pessoa – Other Person/Outra Pessoa –
Distance/Distância(s) – Probabilidade de Leitura – Probability of Reading –
Probabilities of Facts/Probabilidades de Fatos – World – History – World History
– History – Internet Society – Internet – Society – Internet Origin – Origem da
Internet – Time(s) – Tempo(s) – Human Lives – Human Memory – Memória(s)
Humana(s) – Futuro – Future – Now – Agora – Passado – Past – Presente – Present
– Idade(s) – Age – Ages – Human Longevity – Longevidade Humana @ President Biden
Hosts a Bilateral Meeting with President Xi Jinping of China The White House –
2,06 mi de inscritos – 11/15/2023 (Today/Hoje) ->
https://www.youtube.com/watch?v=XQnjwLKBX0M www.nih.gov www.cdc.gov www.fda.gov
www.pfizer.com www.wordpress.com www.wikipedia.org www.google.com www.gmail.com
www.youtube.com www.yahoo.com www.stripe.com www.forbes.com www.ft.com
www.cnn.com www.bbc.com www.nyt.com www.wsj.com www.timeshighereducation.com
www.nasa.gov www.genome.gov www.harvard.edu www.mit.edu www.caltech.edu
www.columbia.edu www.yale.edu www.duke.edu www.famerp.br www.uftm.edu.br
www.nasdaq.com www.fbi.gov www.cia.gov www.bankofamerica.com www.linkedin.com
www.twitter.com www.instagram.com www.facebook.com www.spacex.com www.tesla.com
www.ita.br www.embraer.com www.amazon.com www.princeton.edu www.whitehouse.gov
www.usa.gov www.exame.com www.washingtonpost.com www.reuters.com www.abc.com
www.wellsfargo.com www.worldbank.org www.nyu.edu www.cornell.edu www.nature.com
www.nejm.com www.nobelprize.org
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* I did very interesting, innovative, important and detailed graphics about
variations of all mice weights of different ages during all experimental time
of ´´my´´ dissertation. They´re available in this blog and they´re relevant
to the scientific community!! The diffusion of relevant knowledge and
information is always essential for the world progress. Scientific
discoveries need to emerge urgently!! @ Images, Texts, Links, Videos and
Websites
* In less than 2 years I was invited by Internet through direct messages to
participate in 77 very important scientific events in 32 cities in different
countries because I have participated of very important researches in Brazil
(my dissertation and my monograph). Data about it, like images, websites and
links are available in this Blog. Unfortunately there´re fatal diseases
without efficient drugs and total prevention methods
* It has a very big amount of relevant links, websites, texts, images and
YouTube Videos about human health and animal models for human diseases, such
as cardiovascular diseases, for example. It has a huge amount of very
important world data. This blog content is very good with a very high quality
and importance to the world! So, this blog sharing is relevant to the
society. #@& #HumanLongevity #DNA #Cell #Communication
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researchers, professors and/or scientists! The human expectancy of life needs
to increase so much faster by more efficient scientific research and
projects! Discovering how the initial stages of certain diseases work is of
huge importance for Science! Promoting Science like Scientific News is a very
important act to humanity in many aspects, for sure!
* About me and this blog #@ This blog goal is contribute significantly to the
world progress now and always! # @ Data about this blog statistics # I´ve
received positive feedbacks about this blog by LinkedIn, Twitter and
Facebook! Many of them are in this blog! & Animal and Human Research –
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