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Important Safety Information
Medication Guide and Prescribing Information
 * DYANAVEL XR Tablet
 * DYANAVEL XR Liquid
 * QuilliChew ER
 * Quillivant XR

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 * About ADHD
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 * Savings & Support
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 * Explore Tris ADHD Products
   * DYANAVEL XR Tablet
   * DYANAVEL XR Liquid
   * QuilliChew ER
   * Quillivant XR

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INNOVATIONS IN ADHD.


INNOVATIONS FOR YOU.

Our unique technology is designed to release your ADHD medication consistently
through the day.

Learn more about the Tris family of ADHD treatment options below.




AMPHETAMINE TREATMENTS


METHYLPHENIDATE TREATMENTS

Once Daily DYANAVEL XR extended release
Once-daily tablet amphetamine
Learn more about
DYANAVEL XR tablet
DYANAVEL XR extended release oral suspension
Once-daily liquid amphetamine
Learn more about
DYANAVEL XR liquid


METHYLPHENIDATE TREATMENTS

QuilliChew ER, the only once-daily extended-release methylphenidate tablet
Once-daily tablet methylphenidate
Learn more about
QuilliChew ER
Quillivant XR, the first once-daily, long-acting* liquid methylphenidate
treatment
Once-daily liquid methylphenidate
Learn more about
Quillivant XR

DYANAVEL® XR (amphetamine), Quillivant XR® (methylphenidate HCI), and QuilliChew
ER® (methylphenidate HCI) are central nervous system (CNS) stimulant
prescription medicines used for the treatment of Attention Deficit Hyperactivity
Disorder (ADHD) in people 6 years and older. These medicines may help increase
attention and decrease impulsiveness and hyperactivity in people with ADHD.

It is not known if DYANAVEL XR, Quillivant XR, and QuilliChew ER are safe and
effective in children under 6 years of age.

DYANAVEL XR, Quillivant XR, and QuilliChew ER are federally controlled
substances (CII) because they can be a target for people who abuse prescription
medicines or street drugs. DYANAVEL XR, Quillivant XR, and QuilliChew ER have a
high chance for abuse and misuse and may lead to substance use problems,
including addiction. Keep these medicines in a safe place to prevent abuse and
misuse. Selling or giving away these medicines may harm others and is against
the law. See additional Important Safety Information below.


WHY CHOOSE TRIS ADHD MEDICATIONS?

Our medications are different because they use drug delivery technology that
combines fast-acting and long-lasting medication all-in-one. Our liquid and
tablet formulations are designed to release medication gradually over time for
smooth ADHD symptom control throughout the day with no crashes.


ADHD – A CAREGIVER’S PRACTICAL RESOURCE, A BOOKLET THAT PROVIDES HELPFUL
EDUCATIONAL INFORMATION ABOUT ADHD.

Sign up to receive a complimentary copy


EXPLORE YOUR ADHD TREATMENT OPTIONS

Child
Adolescent
Adult


THE YOUNG ADHD PATIENT

AGE: 6–12 YEARS | GRADE: 1st through 7th

WHAT MIGHT THIS ADHD PATIENT LOOK LIKE?

 * Needs help staying focused for the entire day, including morning, during and
   after school, and evening when helping out with chores at home
 * Is newly diagnosed with ADHD and/or has not taken ADHD medication before
 * Typically begins with a liquid methylphenidate medication vs an amphetamine

WHICH TRIS ADHD MEDICATION IS RIGHT FOR MY CHILD?

Only your child's doctor can help you decide which medication is right for your
child. This may involve an examination by the doctor, who may ask questions and
may perform tests to help with the diagnosis before deciding to prescribe
medication.

If your child is starting ADHD medication for the first time and prefers the
flexibility of a liquid, talk to your doctor about Quillivant XR®
(methylphenidate HCl).

Learn more about Quillivant XR

If you and your child's doctor decide that a methylphenidate is right for your
child and they prefer a tablet that can be swallowed whole or chewed, talk to
your doctor about QuilliChew ER® (methylphenidate HCl).

Learn more about QuilliChew ER

If your child is ready for an amphetamine medication, and prefers the
flexibility of a liquid, talk to your doctor about DYANAVEL® XR (amphetamine)
liquid.

Learn more about DYANAVEL XR liquid


THE ADOLESCENT ADHD PATIENT

AGE: 13 – 17 YEARS | GRADE: 8th through 12th

WHAT MIGHT THIS ADHD PATIENT LOOK LIKE?

 * Needs help staying focused for the entire day, which may include a busy
   schedule of schoolwork, afterschool activities, a part-time job, chores, and
   social activities
 * May have taken a methylphenidate ADHD medication before
 * Prefers personalized dosing options in either a tablet or liquid

WHICH TRIS ADHD MEDICATION IS RIGHT FOR MY CHILD?

Only your child's doctor can help you decide which medication is right for your
child. This may involve an examination by the doctor, who may ask questions and
may perform tests to help with the diagnosis before deciding to prescribe
medication.

If you and your child's doctor decide that a methylphenidate is right for your
child and they prefer a tablet that can be swallowed whole or chewed, talk to
your doctor about QuilliChew ER® (methylphenidate HCl).

Learn more about QuilliChew ER

If your child is ready for an amphetamine medication, and they prefer a tablet
that can be swallowed whole or chewed, talk to your doctor about DYANAVEL® XR
(amphetamine) tablet.

Learn more about DYANAVEL XR tablet


THE ADULT ADHD PATIENT

WHAT MIGHT THIS ADHD PATIENT LOOK LIKE?

YOUNG ADULT

AGE: 18 - 24 years
 * Needs help staying focused for the entire day, which may include college, a
   part-time or first full-time job, and social events
 * Has taken a methylphenidate or amphetamine ADHD medication before
 * Prefers personalized dosing options in either a tablet or liquid

ADULT

AGE: 25+ Years
 * Needs help staying focused for their entire day, which may include long
   hours, competing priorities, a demanding full-time job, errands, chores, and
   parenting/caring for family members
 * Has taken a methylphenidate or amphetamine ADHD medication before
 * Prefers personalized dosing options in either a tablet or liquid

WHICH TRIS ADHD MEDICATION IS RIGHT FOR ME?

Only your doctor can help you decide which medication is right for you. This may
involve an examination by the doctor, who may ask questions and may perform
tests to help with the diagnosis before deciding to prescribe medication.

If you are ready for an amphetamine medication, talk to your doctor about
DYANAVEL® XR (amphetamine) tablet.

Learn more about DYANAVEL XR tablet


CHOOSE A SAVINGS OFFER BASED ON THE PRODUCT THAT YOUR DOCTOR HAS PRESCRIBED*

DYANAVEL XR Tablet
Get savings card
OR
Quillivant XR • QuilliChew ER
DYANAVEL XR Liquid
Get savings card
Or text TRIS to TRIS4U (874748) for a Mobile Savings Card†

* Co-pay offer is subject to eligibility. Terms and Conditions apply.

† Mobile Terms and Conditions: coupon.trisadhd.com/terms. Message data rates may
apply.


IMPORTANT SAFETY INFORMATION & APPROVED USE



DYANAVEL® XR (amphetamine), Quillivant XR® (methylphenidate HCI), and QuilliChew
ER® (methylphenidate HCI) are federally controlled substances (CII) because they
can be a target for people who abuse prescription medicines or street drugs.
DYANAVEL XR, Quillivant XR, and QuilliChew ER have a high chance for abuse and
misuse and may lead to substance use problems, including addiction. Keep these
medicines in a safe place to prevent abuse and misuse. Selling or giving away
these medicines may harm others and is against the law. Your healthcare provider
should check you or your child’s risk for abuse, misuse, and addiction before
starting treatment with DYANAVEL XR, Quillivant XR, and QuilliChew ER and will
monitor you or your child during treatment. Tell your physician if you, your
child, or any family members have ever abused or been dependent on alcohol,
prescription medicines, or street drugs.

See Additional Important Safety Information.


IMPORTANT SAFETY INFORMATION & APPROVED USE

DYANAVEL® XR (amphetamine), Quillivant XR® (methylphenidate HCl), and QuilliChew
ER® (methylphenidate HCl) are federally controlled substances (CII) because they
can be a target for people who abuse prescription medicines or street drugs.
DYANAVEL XR, Quillivant XR, and QuilliChew ER have a high chance for abuse and
misuse and may lead to substance use problems, including addiction. Keep these
medicines in a safe place to prevent abuse and misuse. Selling or giving away
these medicines may harm others and is against the law.

Your healthcare provider should check you or your child’s risk for abuse,
misuse, and addiction before starting treatment with DYANAVEL XR, Quillivant XR,
and QuilliChew ER and will monitor you or your child during treatment. Tell your
physician if you, your child, or any family members have ever abused or been
dependent on alcohol, prescription medicines, or street drugs.

DYANAVEL XR, or Quillivant XR and QuilliChew ER, should not be taken if you or
your child are allergic to amphetamine or methylphenidate hydrochloride,
respectively, or any of the ingredients in these medicines, or are taking or
have taken within the past 14 days an anti-depression medicine called a
monoamine oxidase inhibitor or MAOI including the antibiotic linezolid and the
intravenous medicine methylene blue.

DYANAVEL XR, Quillivant XR, and QuilliChew ER can cause serious side effects.
Tell the doctor:

 * if you or your child have heart problems, heart defects, high blood pressure,
   or a family history of these problems. This is important because sudden death
   has occurred in children 6 to 17 years old with heart problems or defects,
   and sudden death, stroke, and heart attack have happened in adults. Your
   doctor should check you or your child carefully for heart problems before
   starting any of these medicines. Call the doctor right away if you or your
   child have any signs of heart problems such as chest pain, shortness of
   breath, or fainting while taking any of these medicines.
 * Since increases in blood pressure and heart rate may occur, the doctor should
   regularly check these during treatment.
 * if you or your child have mental problems, or a family history of suicide,
   bipolar illness, or depression. This is important because new or worsening
   behavior and thought problems or bipolar illness may occur. New symptoms such
   as seeing or hearing things that are not real, believing things that are not
   true, being suspicious, or having new manic symptoms may occur. Call the
   doctor right away if there are any new or worsening mental symptoms during
   treatment.
 * if you or your child have circulation problems in fingers and toes (called
   peripheral vasculopathy, including Raynaud’s phenomenon). Fingers or toes may
   feel numb, cool, painful, sensitive to temperature, and/or change color from
   pale, to blue, to red. Call the doctor right away if any signs of unexplained
   wounds appear on fingers or toes while taking DYANAVEL XR, Quillivant XR, or
   QuilliChew ER.
 * if your child is having slowing of growth (height and weight); Your child
   should have his or her height and weight checked often while taking DYANAVEL
   XR, Quillivant XR, or QuilliChew ER.
 * New or worsening tics or worsening Tourette’s syndrome. Tell your healthcare
   provider if you or your child get any new or worsening tics or worsening
   Tourette’s syndrome during treatment.
 * There have been cases of increased eye pressure and acute angle closure
   glaucoma, an emergency that results from a rapid increase in your eye
   pressure with Quillivant XR and QuilliChew ER. Call your healthcare provider
   right away if you or your child develop changes in your vision or eye pain,
   swelling, or redness.
 * if you or your child develop painful and prolonged erections (priapism), seek
   medical help right away. Priapism has occurred with methylphenidate
   (Quillivant XR and QuilliChew ER). Because priapism can cause long-lasting
   damage, it should be checked by a doctor right away.
 * if you or your child have symptoms of serotonin syndrome - agitation,
   hallucinations, coma, or other changes in mental status; fast heartbeat;
   sweating or fever; nausea, vomiting, diarrhea; high or low blood pressure;
   problems controlling movements or muscle twitching; muscle stiffness or
   tightness. Serotonin syndrome may occur when DYANAVEL XR is taken with
   certain other medicines and may be life-threatening. Stop DYANAVEL XR and
   call your doctor or go to the nearest hospital emergency room.
 * if you or your child have phenylketonuria (PKU). QuilliChew ER contains
   phenylalanine as part of the artificial sweetener, aspartame. The artificial
   sweetener may be harmful to people with PKU or who are allergic to
   phenylalanine.
 * if you or your child are pregnant or plan to become pregnant. It is not known
   if DYANAVEL XR, Quillivant XR, or QuilliChew ER will harm your unborn baby.
   There is a pregnancy registry for females who are exposed to DYANAVEL XR,
   Quillivant XR, or QuilliChew ER during pregnancy. The purpose of the registry
   is to collect information about the health of females exposed to DYANAVEL XR,
   Quillivant XR, or QuilliChew ER and their baby. If you or your child becomes
   pregnant during treatment with DYANAVEL XR, Quillivant XR, or QuilliChew ER,
   talk to your healthcare provider about registering with the National
   Pregnancy Registry for Psychostimulants at 1-866-961-2388 or visit
   https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/othermedications/.
 * You and your child should not breastfeed while you are taking DYANAVEL XR.
   You and your healthcare provider should decide if you will take Quillivant XR
   or QuilliChew ER or breastfeed.


COMMON SIDE EFFECTS OF AMPHETAMINE PRODUCTS INCLUDE:

 * dry mouth
 * nausea
 * extreme mood changes
 * decreased appetite
 * trouble sleeping
 * dizziness
 * weight loss
 * restlessness
 * increased heart rate
 * stomach pain


COMMON SIDE EFFECTS OF METHYLPHENIDATE PRODUCTS INLUDE:

 * decreased appetite
 * stomach pain
 * irritability
 * trouble sleeping
 * weight loss
 * mood swings
 * nausea
 * anxiety
 * fast heart beat
 * vomiting
 * dizziness
 * increased blood pressure
 * indigestion

Talk to your doctor if you or your child have any side effects that bother you
or do not go away.

Avoid drinking alcohol while taking DYANAVEL XR, Quillivant XR, or QuilliChew
ER.

You are encouraged to report side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

APPROVED USE

DYANAVEL XR, Quillivant XR, and QuilliChew ER are central nervous system (CNS)
stimulant prescription medicines used for the treatment of Attention Deficit
Hyperactivity Disorder (ADHD) in people 6 years and older. These medicines may
help increase attention and decrease impulsiveness and hyperactivity in people
with ADHD.

It is not known if DYANAVEL XR, Quillivant XR, and QuilliChew ER are safe and
effective in children under 6 years of age.

See Medication Guide for DYANAVEL XR, Quillivant XR, and QuilliChew ER.

See Full Prescribing Information for DYANAVEL XR, Quillivant XR, and QuilliChew
ER, including Boxed Warning about Abuse, Misuse and Addiction.

The health information contained herein is provided for educational purposes
only and is not intended to replace discussions with a healthcare professional.
All decisions regarding patient care must be made with a healthcare
professional, considering the unique characteristics of the patient.

This site is intended solely for US residents and is governed solely by US laws
and government regulations. Please see our online privacy policy for more
information. While Tris Pharma makes reasonable efforts to include accurate,
up-to-date information on the site, Tris Pharma makes no warranties or
representations as to its accuracy. Tris Pharma assumes no liability for any
errors or omissions in the content of the site.

visit trispharma.com
 * Site Map
 * Terms of Use
 * Privacy Policy
 * Contact Us
 * Unsubscribe

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DYANAVEL and LiquiXR are registered trademarks of Tris Pharma, Inc. Quillivant
XR and QuilliChew ER are registered trademarks of NextWave Pharmaceuticals, Inc.
All other trademarks are the property of their respective owners.
© 2023 Tris Pharma, Inc. All rights reserved.
DXR.1973.PR 10/23
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Ask your doctor to prescribe DYANAVEL® XR tablet - an amphetamine product used
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Please see Full Prescribing Information, including Boxed Warning about Abuse,
Misuse, and Addiction and Medication Guide.

DYANAVEL XR (amphetamine) is a central nervous system (CNS) stimulant
prescription medicine used for the treatment of Attention Deficit Hyperactivity
Disorder (ADHD) in people 6 years and older. DYANAVEL XR may help increase
attention and decrease impulsiveness and hyperactivity in people with ADHD.

Adderall is a registered trademark of Takeda Pharma, Inc.
DYANAVEL is a registered trademark of Tris Pharma, Inc.
© 2023 Tris Pharma, Inc. All rights reserved. DXR.2102.PR 11/23


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