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SPEAK WITH AN ORIJIN® NURSE:

1-844-254-6272

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SPEAK WITH AN ORIJIN® NURSE:

1-844-254-6272

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STARTING PRKORSUVA®?

Chronic kidney disease (CKD)-associated itch—or pruritus—is the itching
experienced by some patients with CKD undergoing hemodialysis.


WHAT THE ORIJIN® PATIENT SUPPORT PROGRAM HAS TO OFFER:

If you have any questions or concerns about taking KORSUVA, talk to an ORIJIN
nurse. Our nursing professionals are here to help you with your journey. Get
counselling services from an ORIJIN nurse on:


HOW KORSUVA WILL BE ADMINISTERED


INFORMATION RELATED TO TREATING CKD-ASSOCIATED ITCH


WHAT TO EXPECT DURING YOUR TREATMENT


ORIJIN CAN ALSO HELP YOU WITH:


FINANCIAL ASSISTANCE


REIMBURSEMENT NAVIGATION


What is KORSUVA used for?
How does KORSUVA work?
What are the possible side effects from using KORSUVA?
What is KORSUVA used for?

What is KORSUVA used for?

KORSUVA is used to treat itching in adults with CKD on hemodialysis.
How does KORSUVA work?

How does KORSUVA work?

KORSUVA contains the active substance difelikefalin. KORSUVA works by relieving
the need for scratching yourself.
What are the possible side effects from using KORSUVA?

What are the possible side effects from using KORSUVA?

These are not all the possible side effects you may have when taking KORSUVA. If
you experience any side effects not listed here, tell your healthcare
professional. Common side effects (≥1% and <10%) include:
 * Sensation in the skin or mouth such as tingling prickling, burning or
   numbness, decreased feeling or sensitivity
 * Headache
 * Nausea, diarrhea
 * Change in how you walk (your gait) and falls
 * High blood potassium level (seen in blood tests)
 * Back pain

Talk to your healthcare professional if you experience dizziness, drowsiness, or
mental status changes (including feeling confused). Get immediate medical help
if you experience chest pain, shortness of breath due to heart weakness or
feeling of irregular heart beat. If you have a troublesome symptom or side
effect that is not listed here or becomes bad enough to interfere with your
daily activities, tell your healthcare professional.



RESOURCES


Want to know more about KORSUVA? Need more information about CKD-associated
itch? We’ve collected some resources that can help you!

Patient tools


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OTHER RESOURCES




THE KIDNEY FOUNDATION OFFERS INFORMATION, EDUCATIONAL MATERIALS, ASSISTANCE, AND
PEER SUPPORT.

Otsuka Canada Pharmaceutical Inc. does not operate and is not responsible for
the content on this third-party site. If you have any questions or concerns
about the products, services, or content on the linked third-party site, please
contact the third party directly.

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FAQ


What is KORSUVA used for?

KORSUVA is used to treat itching in adults with CKD on hemodialysis.

How does KORSUVA work?

KORSUVA contains the active substance difelikefalin. KORSUVA works by relieving
the need for scratching yourself.

How do I take KORSUVA?
Your healthcare professional will add KORSUVA into the venous line of the
dialysis circuit 3 times per week at the end of a hemodialysis session. No more
than 4 doses of KORSUVA per week should be given even if the number of
hemodialysis treatments in a week exceeds 4.
What are possible side effects from using KORSUVA?
These are not all the possible side effects you may have when taking KORSUVA. If
you experience any side effects not listed here, tell your healthcare
professional. Common side effects (≥1% and <10%) include:
 * Sensation in the skin or mouth such as tingling prickling, burning or
   numbness, decreased feeling or sensitivity
 * Headache
 * Nausea, diarrhea
 * Change in how you walk (your gait) and falls
 * High blood potassium level (seen in blood tests)
 * Back pain

Talk to your healthcare professional if you experience dizziness, drowsiness, or
mental status changes (including feeling confused). Get immediate medical help
if you experience chest pain, shortness of breath due to heart weakness or
feeling of irregular heart beat. If you have a troublesome symptom or side
effect that is not listed here or becomes bad enough to interfere with your
daily activities, tell your healthcare professional.
What should I tell my healthcare professional before receiving KORSUVA?
Before you receive KORSUVA, talk to your healthcare professional about any
health conditions or problems you may have, including if you:
 * Are pregnant, think you are pregnant or plan to become pregnant. It is not
   known if KORSUVA may harm your unborn baby
 * Are breastfeeding or plan to breastfeed. It is not known if KORSUVA can pass
   into your milk and harm your baby. Talk to your healthcare professional about
   the best way to feed your baby if you take KORSUVA
 * Have an increased potassium level in the blood
 * Have or have had heart weakness or a heart rhythm disorder
 * Have problems with your liver
 * Have reduced function of the blood-brain barrier (such as cancer in the brain
   or the central nervous system, or a disease of the central nervous system
   like multiple sclerosis or dementia) as this might increase your risk of side
   effects
 * Are using medicines that could increase the risk of drowsiness or dizziness,
   such as:

 * medicines that slow down brain activity such as those that help with sleep
   disturbances and anxiety
 * medicines to treat allergies, cold, nausea and/or vomiting called sedating
   antihistamines
 * strong painkillers, called opioid analgesics

Tell your healthcare professional about all the medicines you take, including
any drugs, vitamins, minerals, natural supplements, or alternative medicines.
What is CKD-associated itch?

Chronic kidney disease (CKD)-associated itch—or pruritus—is the itching
experienced by some patients with CKD undergoing hemodialysis.

Several factors are believed to contribute to the development of CKD-associated
itch, including:

 * Nerves misfiring

 * Sometimes you feel an itching sensation when your nerves are activated out of
   proportion or independent of any substance causing itch.

 * Immune system overacting

 * It could be due to an imbalance in your immune system which leads to more
   inflammation, causing your skin to itch.

 * KORSUVA is a registered trademark of Cara Therapeutics, Inc., used under
   licence by Otsuka Canada Pharmaceutical Inc.
 * ORIJIN is a registered trademark of, and the ORIJIN logo is a trademark of,
   Otsuka Canada Pharmaceutical Inc.
 * © Otsuka Canada Pharmaceutical Inc. All rights reserved.
 * OCPI-KOR-00015E

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