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PFIZER SEEKS OK OF UPDATED COVID VACCINE BOOSTER FOR FALL

By LAURAN NEERGAARDyesterday


FILE - A health worker administers a dose of a Pfizer COVID-19 vaccine during a
vaccination clinic in Reading, Pa., Sept. 14, 2021. Pfizer asked U.S. regulators
Monday, Aug. 22, 2022, to authorize its combination COVID-19 vaccine that adds
protection against the newest omicron mutants — a key step toward opening a fall
booster campaign. (AP Photo/Matt Rourke, File)

Pfizer asked U.S. regulators Monday to authorize its combination COVID-19
vaccine that adds protection against the newest omicron relatives — a key step
toward opening a fall booster campaign.

The Food and Drug Administration ordered vaccine makers to tweak their shots to
target BA.4 and BA.5 that are better than ever at dodging immunity from earlier
vaccination or infection.

Pfizer and its partner BioNTech aim to offer updated boosters to people 12 and
older, and shots could begin within weeks if the FDA quickly clears the modified
vaccine — a step not expected to require waiting on new studies.

Moderna is expected to file a similar application soon for updated boosters for
adults. The U.S. has a contract to buy 105 million of the Pfizer doses and 66
million Moderna ones, assuming FDA gives the green light.

“It’s going to be really important that people this fall and winter get the new
shots. It’s designed for the virus that’s out there,” White House COVID-19
coordinator Dr. Ashish Jha said last week.

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For now at least. BA.5 currently is causing nearly all COVID-19 infections in
the U.S. and much of the world. There’s no way to know if it still will be a
threat this winter -- or if another mutant will have replaced it.


COVID-19

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WVA HOSPITAL RECEIVING $313K IN PANDEMIC RELIEF FUNDS

The vaccines currently used in the U.S. still offer strong protection against
severe disease and death, especially if people have gotten their recommended
boosters. But those vaccines target the coronavirus strain that spread in early
2020 and their effectiveness against infection has dropped markedly as new
mutants came along, particularly the super-contagious omicron family.

How would combo shots work? Sort of like a second-generation vaccine. Both the
Pfizer and Moderna vaccines contain the genetic instructions for the spike
protein that coats the coronavirus, to train the immune system to recognize the
real virus. The new combo doses will contain instructions for both the original
spike target and the spike mutations carried by BA.4 and BA.5.

The news comes after Britain a week ago became the first in the world to
authorize a different update to Moderna’s COVID-19 vaccines -- shots that add
protection against the original omicron that struck last winter.

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European regulators also are considering the original omicron versions by
Moderna and Pfizer. The U.S. opted not to use that earlier tweak -- setting up a
fall where different countries will be using different versions of booster shots
to rev up protection against another possible winter surge.

In the U.S., the FDA will be relying heavily on scientific testing of prior
tweaks to the vaccine recipe — rather than a study of the newest boosters that
could take months — to decide whether to fast-track updated shots for fall.

Pfizer previously announced results from a study that found its earlier omicron
tweak significantly revved up antibodies capable of fighting the first omicron
version, called BA.1, and to a lesser degree the genetically distinct BA.4 and
BA.5 omicron relatives. Its application to the FDA contains that data plus
animal testing of the newest recipe update.

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It’s similar to how flu vaccines are updated every year without having to
undergo large studies.

Pfizer and BioNTech expect to start a trial using the BA.4 and BA.5 boosters in
the coming weeks, to shed additional light on how well tweaked shots work.
Moderna has begun a similar study although full results wouldn’t be available
before a fall booster campaign.

“It’s clear that none of these vaccines are going to completely prevent
infection,” said Dr. Rachel Presti of Washington University in St. Louis, a
researcher with the Moderna trial.

But prior studies of variant booster candidates show “you still get a broader
immune response giving a variant booster than giving the same booster” again,
which should be helpful even if a newer omicron relative emerges, she added.

Pfizer and Moderna don’t make the only U.S. vaccine options. Novavax makes a
more traditional, protein-based shot — and U.S. health authorities just expanded
its use for people as young as 12. Novavax also plans to offer a variant update
later in the year.

___

The Associated Press Health and Science Department receives support from the
Howard Hughes Medical Institute’s Department of Science Education. The AP is
solely responsible for all content.

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