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North America Analytical and Measuring Instruments * * About Shimadzu * Sales Rep Locator * Store * Global Links * Register * Sign in North America Analytical and Measuring Instruments * HOME * PRODUCTS * INDUSTRIES * RESOURCES * SERVICE/SUPPORT * NEWS/EVENTS * NEWS/EVENTS * CASE STUDIES * CASE STUDIES * ABOUT SHIMADZU * Request More Info Main menu 0 JavaScript Disabled Our website uses JavaScript. Please confirm that JavaScript is enabled in your browser. * HOME * Products * Liquid Chromatography * HPLC/UHPLC/SFC Systems * Nexera Analytical SFC / Nexera UC NEXERA ANALYTICAL SFC Supercritical Fluid Chromatography System Share Share * X (Twitter) * Facebook * LinkedIn Add Bookmark * Contact a Sales Rep * Request More Info * Tech Support * Request a Virtual Demo * Overview * Features * Applications * Specs * Downloads * Configuration * Columns * Options * Case Studies * Support SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEM (WITH OPTIONAL SUPERCRITICAL FLUID EXTRACTION CAPABILITIES) Request More SFC Information HIGH SPEED OF ANALYSIS, SENSITIVITY, AND RESOLUTION Supercritical CO2 enables high resolution chromatographic analysis, and the SFE system performs highly efficient sample extraction. The two can be performed on a single system (SFE/SFC system) or separately as needed by the user HIGH RECOVERY RATE OF PREPARATIVE PURIFICATION WITH EXCELLENT OPERABILITY Reliable small volume fractionation is ensured through Shimadzu’s unique collection technology. FULLY AUTOMATED ON-LINE SAMPLE PREPARATION, ANALYSIS AND FRACTIONATION Target compounds are automatically extracted, analyzed, and fractionated. Supercritical fluid chromatography (SFC) is a separation method that uses supercritical CO2 as the mobile phase. The benefits of supercritical CO2 are the low polarity similar to n-hexane, the lower viscosity, and the high diffusion coefficient, which offers potential advanced separation methods that are different from conventional HPLC separation. Thanks to this feature, SFC enables unique analyses, such as high resolution chromatography, simultaneous analysis of compounds over a wide polarity range, and improvement of MS detection sensitivity. For preparative scale, Nexera Prep SFC is Here FEATURES * Higher Resolution The analysis time can be effectively shortened because an excellent chromatographic resolution can be maintained even at higher flow rates than those typically used for HPLC. * Available for Both UHPLC and SFC Analysis Using a Single System Separation results can be quickly obtained during method development by screening with both SFC and UHPLC. * Small Volume Fractionation By using a fraction collector, small-volume fractionation is also possible (ex: 96 well MTP's.) * Fully Automated On-Line Extraction and Separation Target compounds are extracted from solid samples, and then automatically transferred to SFC. * Nexera Analytical SFC Reduces Environmental Impact By using SFC, the consumption of organic solvent is reduced by 94.2%, compared to the normal-phase. Learn more LATEST WEBINAR * 2023-07-31 Harnessing the Power of Collaboration: Shimadzu’s SFC Journey * Supercritical Fluid Chromatography (SFC) Systems Join us as we discuss the collaborative process that led from the introduction of Shimadzu’s Nexera UC analytical SFC systems to the Pharma-focused creation and launch of the Nexera UC Prep semi-preparative SFC systems. We will explore the uses of SFC and see how the Shimadzu lineup has been shaped to meet the needs of Pharma SFC users through their direct input into instrument and software design and development. Learn more VIDEOS * SFC Is As Easy As HPLC * Supercritical Fluid Chromatography (SFC) Systems Today’s SFC systems are setting new standards for performance and ease of use. Yet many chromatographers still haven’t made the switch. Why They’ve likely heard many of the common myths about this remarkable technology! And there are quite a few! * Harnessing the Power of Collaboration: Shimadzu’s SFC Journey Join us as we discuss the collaborative process that led from the introduction of Shimadzu’s Nexera UC analytical SFC systems to the Pharma-focused creation and launch of the Nexera UC Prep semi-preparative SFC systems. We will explore the uses of SFC and see how the Shimadzu lineup has been shaped to meet the needs of Pharma SFC users through their direct input into instrument and software design and development. * Nexera UC Supercritical Fluid Extraction/Chromatograph System Narration Eddition * Liquid Chromatography * Simplifying Medicinal Chemistry Workflows Using Shimadzu Nexera UC Prep * Liquid Chromatography Medicinal chemists need to quickly purify a wide range of drug candidates and intermediates. The Shimadzu Nexera UC Prep semi-preparative supercritical fluid chromatography system delivers outstanding performance in a compact footprint to provide you with the fastest, most accurate and most reliable results. Read more Show Less Learn More DOWNLOADS Download the latest brochure. Nexera UC Nexera UC Prep [ PDF / 3.41MB ] Solutions for Medicinal Chemistry [ PDF / 4.14MB ] Metabolomics Product Portfolio - Selection Guide Metabolite Analysis [ PDF / 2.99MB ] APPLICATIONS Documents Date Creation Date AOAC-2020-Analysis of PFAS compounds in Fish Tissue Using Offline Supercritical Fluid Extraction and LC-MS/MS [ PDF / 300.65KB ] 2020-08-21 Efficient Scouting of Chiral Separation Conditions Using LabSolutions MD [ PDF / 1.2MB ] 2024-03-26 Simultaneous Analysis of Carboxylic Anhydrides and Hydrolysates Using Supercritical Fluid Chromatography [ PDF / 3.01MB ] 2023-07-11 Preparative Purification of Aroma Components Using a Supercritical Fluid chromatograph [ PDF / 354.56KB ] 2023-03-15 Learn more TECHNICAL DOCUMENTS Documents Date Creation Date Oxygen heterocyclic compounds profile evaluation in cold-pressed Citrus essential oils using supercritical fluid chromatography coupled to photodiode array dete [ PDF / 137.03KB ] 2024-05-22 Multiple Analytical Techniques For Carotenoid Analysis In Capsicum Cultivars [ PDF / 1.26MB ] 2023-10-24 An Improvement in Preparative SFC Effieciency Utilizing Online SFE-SFC System as a “Solid Autosampler” [ PDF / 585.66KB ] 2023-09-27 Learn more MANUALS Documents Date Creation Date Instruction Manual - Nexera UC Piping Kit - [ PDF / 1.41MB ] 2023-04-01 Nexera UC System Guide [ PDF / 12.17MB ] 2022-11-01 SFE-30A Instruction Manual - Supercritical Fluid Extraction Unit [ PDF / 14.21MB ] 2020-07-08 Learn more NEWS / EVENTS * HPLC 2024 July 20-25 Hilton Denver City Center, Denver Ballroom Denver, Colorado * EVENTS July 20, 2024 * Shimadzu Scientific Instruments Opens R&D Center These forward-focused R&D centers will enable us to closely collaborate with customers and stakeholders to develop products that meet tomorrow’s analytical laboratory needs and swiftly deliver these solutions to the marketplace. * OTHERS April 18, 2024 * National American Chemical Society (Spring) 2024 March 18-20 Ernest N. Morial Convention Center New Orleans, Louisiana Booth # 2931 * EVENTS March 18, 2024 * Shimadzu Scientific Instruments and Telescope Innovations Initiate Technology Partnership The partners aim to integrate SSI’s High-Performance Liquid Chromatography (“HPLC”) systems with Telescope’s flagship product, the DirectInject-LC. * COLLABORATIONS February 29, 2024 * New Nexera™ XS inert UHPLC System Eliminates Challenges of High-Concentration Mobile Phases to Achieve High Sensitivity and Reliability * PRODUCTS June 20, 2022 * Cannabis Science Conference West 2022 May 18 2022 - May 22 2022 * EVENTS May 18, 2022 Learn more BLOG SUSTAINABILITY INITIATIVES * 2 Zero hunger * 3 Good health and well-being * Overview * Features * Applications * Specs * Downloads * Configuration * Columns * Options * Case Studies * Support This Website uses cookies to ensure you a better browsing experience and to analyze our traffic. We also share information about your use of our Website with our Parent company, distributors, and analytics partners. Click "Accept" to continue to browse the site, we will assume that you will consent to receive cookies from this site. More Information Accept Contact SHIMADZU * Contact a Sales Rep * Request More Info * Tech Support * Request a Virtual Demo * PRODUCTS * INDUSTRIES * RESOURCES * SERVICE/SUPPORT * NEWS/EVENTS * CASE STUDIES SUBSCRIBE TO NEWSLETTER FOLLOW US * * * * * * PRIVACY POLICY * TERMS OF USE * EMPLOYMENT * SITE MAP Copyright © Shimadzu Scientific Instruments. All Rights Reserved * * *