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 * HOME
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 * Liquid Chromatography
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 * Nexera Analytical SFC / Nexera UC


NEXERA ANALYTICAL SFC

Supercritical Fluid Chromatography System

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SUPERCRITICAL FLUID CHROMATOGRAPHY SYSTEM
(WITH OPTIONAL SUPERCRITICAL FLUID EXTRACTION CAPABILITIES)

 

 

Request More SFC Information

 


HIGH SPEED OF ANALYSIS, SENSITIVITY, AND RESOLUTION

Supercritical CO2 enables high resolution chromatographic analysis, and the SFE
system performs highly efficient sample extraction. The two can be performed on
a single system (SFE/SFC system) or separately as needed by the user

 


HIGH RECOVERY RATE OF PREPARATIVE PURIFICATION WITH EXCELLENT OPERABILITY

Reliable small volume fractionation is ensured through Shimadzu’s unique
collection technology.

 


FULLY AUTOMATED ON-LINE SAMPLE PREPARATION, ANALYSIS AND FRACTIONATION

Target compounds are automatically extracted, analyzed, and fractionated.

 

 

Supercritical fluid chromatography (SFC) is a separation method that uses
supercritical CO2 as the mobile phase. The benefits of supercritical CO2 are the
low polarity similar to n-hexane, the lower viscosity, and the high diffusion
coefficient, which offers potential advanced separation methods that are
different from conventional HPLC separation. Thanks to this feature, SFC enables
unique analyses, such as high resolution chromatography, simultaneous analysis
of compounds over a wide polarity range, and improvement of MS detection
sensitivity.

For preparative scale, Nexera Prep SFC is Here




FEATURES

 * Higher Resolution
   The analysis time can be effectively shortened because an excellent
   chromatographic resolution can be maintained even at higher flow rates than
   those typically used for HPLC.
 * Available for Both UHPLC and SFC Analysis Using a Single System
   Separation results can be quickly obtained during method development by
   screening with both SFC and UHPLC.
 * Small Volume Fractionation
   By using a fraction collector, small-volume fractionation is also possible
   (ex: 96 well MTP's.)
 * Fully Automated On-Line Extraction and Separation
   Target compounds are extracted from solid samples, and then automatically
   transferred to SFC.
 * Nexera Analytical SFC Reduces Environmental Impact
   By using SFC, the consumption of organic solvent is reduced by 94.2%,
   compared to the normal-phase.

Learn more


LATEST WEBINAR

 * 2023-07-31
   
   Harnessing the Power of Collaboration: Shimadzu’s SFC Journey
   
    * Supercritical Fluid Chromatography (SFC) Systems
   
   Join us as we discuss the collaborative process that led from the
   introduction of Shimadzu’s Nexera UC analytical SFC systems to the
   Pharma-focused creation and launch of the Nexera UC Prep semi-preparative SFC
   systems. We will explore the uses of SFC and see how the Shimadzu lineup has
   been shaped to meet the needs of Pharma SFC users through their direct input
   into instrument and software design and development.

Learn more


VIDEOS

 * SFC Is As Easy As HPLC
   
    * Supercritical Fluid Chromatography (SFC) Systems
   
   Today’s SFC systems are setting new standards for performance and ease of
   use. Yet many chromatographers still haven’t made the switch. Why They’ve
   likely heard many of the common myths about this remarkable technology! And
   there are quite a few!

 * Harnessing the Power of Collaboration: Shimadzu’s SFC Journey
   
   Join us as we discuss the collaborative process that led from the
   introduction of Shimadzu’s Nexera UC analytical SFC systems to the
   Pharma-focused creation and launch of the Nexera UC Prep semi-preparative SFC
   systems. We will explore the uses of SFC and see how the Shimadzu lineup has
   been shaped to meet the needs of Pharma SFC users through their direct input
   into instrument and software design and development.

 * Nexera UC Supercritical Fluid Extraction/Chromatograph System Narration
   Eddition
   
    * Liquid Chromatography
   
   

 * Simplifying Medicinal Chemistry Workflows Using Shimadzu Nexera UC Prep
   
    * Liquid Chromatography
   
   Medicinal chemists need to quickly purify a wide range of drug candidates and
   intermediates. The Shimadzu Nexera UC Prep semi-preparative supercritical
   fluid chromatography system delivers outstanding performance in a compact
   footprint to provide you with the fastest, most accurate and most reliable
   results.
   

Read more
Show Less
Learn More


DOWNLOADS

Download the latest brochure.

Nexera UC Nexera UC Prep [ PDF / 3.41MB ]

Solutions for Medicinal Chemistry [ PDF / 4.14MB ]

Metabolomics Product Portfolio - Selection Guide Metabolite Analysis [ PDF /
2.99MB ]




APPLICATIONS

Documents Date Creation Date
AOAC-2020-Analysis of PFAS compounds in Fish Tissue Using Offline Supercritical
Fluid Extraction and LC-MS/MS [ PDF / 300.65KB ]

2020-08-21

Efficient Scouting of Chiral Separation Conditions Using LabSolutions MD [ PDF /
1.2MB ]

2024-03-26

Simultaneous Analysis of Carboxylic Anhydrides and Hydrolysates Using
Supercritical Fluid Chromatography [ PDF / 3.01MB ]

2023-07-11

Preparative Purification of Aroma Components Using a Supercritical Fluid
chromatograph [ PDF / 354.56KB ]

2023-03-15

Learn more




TECHNICAL DOCUMENTS

Documents Date Creation Date
Oxygen heterocyclic compounds profile evaluation in cold-pressed Citrus
essential oils using supercritical fluid chromatography coupled to photodiode
array dete [ PDF / 137.03KB ]

2024-05-22

Multiple Analytical Techniques For Carotenoid Analysis In Capsicum Cultivars [
PDF / 1.26MB ]

2023-10-24

An Improvement in Preparative SFC Effieciency Utilizing Online SFE-SFC System as
a “Solid Autosampler” [ PDF / 585.66KB ]

2023-09-27

Learn more




MANUALS

Documents Date Creation Date
Instruction Manual - Nexera UC Piping Kit - [ PDF / 1.41MB ]

2023-04-01

Nexera UC System Guide [ PDF / 12.17MB ]

2022-11-01

SFE-30A Instruction Manual - Supercritical Fluid Extraction Unit [ PDF / 14.21MB
]

2020-07-08

Learn more




NEWS / EVENTS

 * HPLC 2024
   
   July 20-25
   Hilton Denver City Center, Denver Ballroom
   Denver, Colorado
   
   
    * EVENTS
   
   July 20, 2024

 * Shimadzu Scientific Instruments Opens R&D Center
   
   These forward-focused R&D centers will enable us to closely collaborate with
   customers and stakeholders to develop products that meet tomorrow’s
   analytical laboratory needs and swiftly deliver these solutions to the
   marketplace.
   
    * OTHERS
   
   April 18, 2024

 * National American Chemical Society (Spring) 2024
   
   March 18-20
   Ernest N. Morial Convention Center
   New Orleans, Louisiana
   Booth # 2931
   
   
    * EVENTS
   
   March 18, 2024

 * Shimadzu Scientific Instruments and Telescope Innovations Initiate Technology
   Partnership
   
   The partners aim to integrate SSI’s High-Performance Liquid Chromatography
   (“HPLC”) systems with Telescope’s flagship product, the DirectInject-LC.
   
    * COLLABORATIONS
   
   February 29, 2024

 * New Nexera™ XS inert UHPLC System Eliminates Challenges of High-Concentration
   Mobile Phases to Achieve High Sensitivity and Reliability
   
    * PRODUCTS
   
   June 20, 2022

 * Cannabis Science Conference West 2022
   
   May 18 2022 - May 22 2022
   
    * EVENTS
   
   May 18, 2022

Learn more


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SUSTAINABILITY INITIATIVES

 * 2 Zero hunger

 * 3 Good health and well-being



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 * Specs
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