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Text Content

Important Safety Information Prescribing Information Medication Guide En Español
Healthcare Professionals Site

En Español
Why RYBELSUS®?
 * Why RYBELSUS®?
 * RYBELSUS® Results
 * RYBELSUS® vs Other Diabetes Pills
 * How RYBELSUS® Works
 * Real RYBELSUS® Stories

Taking RYBELSUS®
 * Taking RYBELSUS®
 * How to Start RYBELSUS®
 * What to Expect With RYBELSUS®

Savings & Support
FAQs
About Type 2 Diabetes
 * About Type 2 Diabetes
 * What Is Type 2 Diabetes?
 * Type 2 Diabetes Lifestyle Tips

Search
Important Safety Information Prescribing Information Medication Guide En Español
Healthcare Professionals Site


Menu


Save on RYBELSUS®

RYBELSUS® Support Programs

Questions?

I can help

Please tell me what you're looking for

Save on RYBELSUS®

RYBELSUS® Support Programs

Questions?

I can help


HOW TO START
RYBELSUS®

It’s important to take RYBELSUS® as directed the same way, every day.

When taken as directed each day, RYBELSUS®, along with diet and exercise, may
help lower your blood sugar.

Learn more about starting RYBELSUS® and how to make it a part of your daily
routine.

Learn more about starting RYBELSUS® and how to make it a part of your daily
routine.

For RYBELSUS® to work as planned to lower blood sugar:

Take on an empty stomach when you first wake up.




An empty stomach means no food, drink, oral medications, vitamins, or
supplements.

Take with no more than 4 ounces of plain water.




Take RYBELSUS® with a sip of plain water, no more than 4 ounces.

Wait 30 minutes before eating, drinking, or taking other oral medications.



After 30 minutes, you can eat, drink, or take other oral medications, vitamins,
or supplements.

If you miss a dose, the missed dose should be skipped, and the next dose should
be taken the following day.

Discover the digital patient starter experience


You can visit the digital patient starter experience for all the information
about getting started with RYBELSUS® and much more!

LEARN MORE


How to properly store RYBELSUS®

The blue cap on the RYBELSUS® bottle is specially designed to keep your tablets
protected so they can work as planned to lower your blood sugar. It is important
that your RYBELSUS® tablets stay in the bottle with the cap on until you are
ready to take one.

For RYBELSUS® to work as planned to lower blood sugar:

Store tablets in the closed RYBELSUS® bottle until you are ready to take one.

Do not use a pill organizer or other container to store RYBELSUS® tablets.

Swallow tablet whole. Do not cut, crush, or chew.

--------------------------------------------------------------------------------

Store at room temperature 68°F to 77°F.

Store in a dry place away from moisture.

RYBELSUS® comes in a child-resistant bottle. Keep out of reach of children.

Establishing a wake-up routine with RYBELSUS®



Everyone has a different wake-up routine. Here's a tip to help you remember to
take RYBELSUS® when you first wake up: Keep your RYBELSUS® package and a small
glass of plain water on your nightstand.

When you wake up, take your medicine with a sip of plain water (no more than 4
ounces), and then wait 30 minutes before eating, drinking, or taking any other
oral medications. After 30 minutes, you can eat, drink, or take other oral
medications, vitamins, or supplements.

Texta READY to 21848 to sign up for support

RYBELSUS® Connect can help you establish a routine with text message reminders
and motivational messages.

aMessage and data rates may apply. Check with your mobile service provider.
Message frequency will be based on your selections. Text HELP to 21848 for help.
Text STOP to 21848 to quit. See Terms and Conditions of Use.

GET STARTED

Diabetes support when you need it

For one-on-one, live support from a Diabetes Health Coach, if you need it.

Call 1-833-ASK-A-CDE

(1-833-275-2233)

Monday – Friday, 9:00 AM – 6:00 PM ET

CALL NOW
NEXT: What to Expect With RYBELSUS®

Get your A1C DOWN with RYBELSUS®

Once-daily RYBELSUS® is proven to significantly lower A1C.


LEARN MORE

Pay as little as $10 for up to a 3-month RYBELSUS® prescriptiona

Check your insurance coverage and learn about ways to save.

START SAVING

aEligible, commercially insured patients only. For 3 mg dose, pay as little as
$10 each month. Restrictions apply.

Support to help you start and stay on RYBELSUS®

RYBELSUS® Connect offers support when and where you need it. Textb READY to
21848 to get started.


MORE INFO

aEligible, commercially insured patients only. For 3 mg dose, pay as little as
$10 each month. Restrictions apply.

bMessage and data rates may apply. Check with your mobile service provider.
Message frequency will be based on your selections. Text HELP to 21848 for help.
Text STOP to 21848 to quit. See Terms and Conditions of Use.

Indication and Important Safety Information

READ MORE COLLAPSE


WHAT IS RYBELSUS®?

RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used
along with diet and exercise to improve blood sugar (glucose) in adults with
type 2 diabetes.

 * RYBELSUS® is not recommended as the first choice of medicine for treating
   diabetes
 * It is not known if RYBELSUS® can be used in people who have had pancreatitis
 * RYBELSUS® is not for use in people with type 1 diabetes
 * It is not known if RYBELSUS® is safe and effective for use in children under
   18 years of age

Scroll to "What is RYBELSUS®?"


IMPORTANT SAFETY INFORMATION


WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT RYBELSUS®?

RYBELSUS® may cause serious side effects, including:

 * Possible thyroid tumors, including cancer. Tell your healthcare provider if
   you get a lump or swelling in your neck, hoarseness, trouble swallowing, or
   shortness of breath. These may be symptoms of thyroid cancer. In studies with
   rodents, RYBELSUS® and medicines that work like RYBELSUS® caused thyroid
   tumors, including thyroid cancer. It is not known if RYBELSUS® will cause
   thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma
   (MTC) in people

Do not use RYBELSUS® if:

 * you or any of your family have ever had MTC, or if you have an endocrine
   system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
 * you have had a serious allergic reaction to semaglutide or any of the
   ingredients in RYBELSUS®. See symptoms of serious allergic reaction in "What
   are the possible side effects of RYBELSUS®?"

Scroll to ISI


WHAT IS RYBELSUS®?

RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used
along with diet and exercise to improve blood sugar (glucose) in adults with
type 2 diabetes.

 * RYBELSUS® is not recommended as the first choice of medicine for treating
   diabetes
 * It is not known if RYBELSUS® can be used in people who have had pancreatitis
 * RYBELSUS® is not for use in people with type 1 diabetes
 * It is not known if RYBELSUS® is safe and effective for use in children under
   18 years of age


IMPORTANT SAFETY INFORMATION (CONT'D)

Before using RYBELSUS®, tell your healthcare provider if you have any other
medical conditions, including if you:

 * have or have had problems with your pancreas or kidneys
 * have a history of vision problems related to your diabetes
 * are pregnant or plan to become pregnant. It is not known if RYBELSUS® will
   harm your unborn baby. You should stop using RYBELSUS® 2 months before you
   plan to become pregnant. Talk to your healthcare provider about the best way
   to control your blood sugar if you plan to become pregnant or while you are
   pregnant
 * are breastfeeding or plan to breastfeed. Breastfeeding is not recommended
   during treatment with RYBELSUS®

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.
RYBELSUS® may affect the way some medicines work and some medicines may affect
the way RYBELSUS® works.


HOW SHOULD I TAKE RYBELSUS®?

 * Take RYBELSUS® exactly as your healthcare provider tells you to
 * Take RYBELSUS® by mouth on an empty stomach when you first wake up with a sip
   of plain water (no more than 4 ounces)
 * Do not split, crush, or chew. Swallow RYBELSUS® whole
 * After 30 minutes, you can eat, drink, or take other oral medicines
 * If you miss a dose of RYBELSUS®, skip the missed dose and go back to your
   regular schedule


WHAT ARE THE POSSIBLE SIDE EFFECTS OF RYBELSUS®?

RYBELSUS® may cause serious side effects, including:

 * inflammation of your pancreas (pancreatitis). Stop using RYBELSUS® and call
   your healthcare provider right away if you have severe pain in your stomach
   area (abdomen) that will not go away, with or without vomiting. You may feel
   the pain from your abdomen to your back
 * changes in vision. Tell your healthcare provider if you have changes in
   vision during treatment with RYBELSUS®  
 * low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be
   higher if you use RYBELSUS® with another medicine that can cause low blood
   sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood
   sugar may include: dizziness or lightheadedness, blurred vision, anxiety,
   irritability or mood changes, sweating, slurred speech, hunger, confusion or
   drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling
   jittery
 * kidney problems (kidney failure). In people who have kidney problems,
   diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration),
   which may cause kidney problems to get worse. It is important for you to
   drink fluids to help reduce your chance of dehydration
 * serious allergic reactions. Stop using RYBELSUS® and get medical help right
   away, if you have any symptoms of a serious allergic reaction, including
   swelling of your face, lips, tongue, or throat; problems breathing or
   swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid
   heartbeat
 * gallbladder problems. Gallbladder problems have happened in some people who
   take RYBELSUS®. Tell your healthcare provider right away if you get symptoms
   of gallbladder problems, which may include: pain in your upper stomach
   (abdomen), yellowing of skin or eyes (jaundice), fever, and clay-colored
   stools

The most common side effects of RYBELSUS® may include nausea, stomach
(abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation.
Nausea, vomiting, and diarrhea are most common when you first start RYBELSUS®.

Please see Prescribing Information and Medication Guide for RYBELSUS®.



RYBELSUS® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

 




IMPORTANT SAFETY INFORMATION


WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT RYBELSUS®?

RYBELSUS® may cause serious side effects, including:

 * Possible thyroid tumors, including cancer. Tell your healthcare provider if
   you get a lump or swelling in your neck, hoarseness, trouble swallowing, or
   shortness of breath. These may be symptoms of thyroid cancer. In studies with
   rodents, RYBELSUS® and medicines that work like RYBELSUS® caused thyroid
   tumors, including thyroid cancer. It is not known if RYBELSUS® will cause
   thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma
   (MTC) in people

Do not use RYBELSUS® if:

 * you or any of your family have ever had MTC, or if you have an endocrine
   system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
 * you have had a serious allergic reaction to semaglutide or any of the
   ingredients in RYBELSUS®. See symptoms of serious allergic reaction in "What
   are the possible side effects of RYBELSUS®?"


WHAT IS RYBELSUS®?

RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used
along with diet and exercise to improve blood sugar (glucose) in adults with
type 2 diabetes.

 * RYBELSUS® is not recommended as the first choice of medicine for treating
   diabetes
 * It is not known if RYBELSUS® can be used in people who have had pancreatitis
 * RYBELSUS® is not for use in people with type 1 diabetes
 * It is not known if RYBELSUS® is safe and effective for use in children under
   18 years of age


WHAT IS RYBELSUS®?

RYBELSUS® (semaglutide) tablets 7 mg or 14 mg is a prescription medicine used
along with diet and exercise to improve blood sugar (glucose) in adults with
type 2 diabetes.

 * RYBELSUS® is not recommended as the first choice of medicine for treating
   diabetes
 * It is not known if RYBELSUS® can be used in people who have had pancreatitis
 * RYBELSUS® is not for use in people with type 1 diabetes
 * It is not known if RYBELSUS® is safe and effective for use in children under
   18 years of age


IMPORTANT SAFETY INFORMATION

Before using RYBELSUS®, tell your healthcare provider if you have any other
medical conditions, including if you:

 * have or have had problems with your pancreas or kidneys
 * have a history of vision problems related to your diabetes
 * are pregnant or plan to become pregnant. It is not known if RYBELSUS® will
   harm your unborn baby. You should stop using RYBELSUS® 2 months before you
   plan to become pregnant. Talk to your healthcare provider about the best way
   to control your blood sugar if you plan to become pregnant or while you are
   pregnant
 * are breastfeeding or plan to breastfeed. Breastfeeding is not recommended
   during treatment with RYBELSUS®

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.
RYBELSUS® may affect the way some medicines work and some medicines may affect
the way RYBELSUS® works.


HOW SHOULD I TAKE RYBELSUS®?

 * Take RYBELSUS® exactly as your healthcare provider tells you to
 * Take RYBELSUS® by mouth on an empty stomach when you first wake up with a sip
   of plain water (no more than 4 ounces)
 * Do not split, crush, or chew. Swallow RYBELSUS® whole
 * After 30 minutes, you can eat, drink, or take other oral medicines
 * If you miss a dose of RYBELSUS®, skip the missed dose and go back to your
   regular schedule


WHAT ARE THE POSSIBLE SIDE EFFECTS OF RYBELSUS®?

RYBELSUS® may cause serious side effects, including:

 * inflammation of your pancreas (pancreatitis). Stop using RYBELSUS® and call
   your healthcare provider right away if you have severe pain in your stomach
   area (abdomen) that will not go away, with or without vomiting. You may feel
   the pain from your abdomen to your back
 * changes in vision. Tell your healthcare provider if you have changes in
   vision during treatment with RYBELSUS®  
 * low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be
   higher if you use RYBELSUS® with another medicine that can cause low blood
   sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood
   sugar may include: dizziness or lightheadedness, blurred vision, anxiety,
   irritability or mood changes, sweating, slurred speech, hunger, confusion or
   drowsiness, shakiness, weakness, headache, fast heartbeat, and feeling
   jittery
 * kidney problems (kidney failure). In people who have kidney problems,
   diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration),
   which may cause kidney problems to get worse. It is important for you to
   drink fluids to help reduce your chance of dehydration
 * serious allergic reactions. Stop using RYBELSUS® and get medical help right
   away, if you have any symptoms of a serious allergic reaction, including
   swelling of your face, lips, tongue, or throat; problems breathing or
   swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid
   heartbeat
 * gallbladder problems. Gallbladder problems have happened in some people who
   take RYBELSUS®. Tell your healthcare provider right away if you get symptoms
   of gallbladder problems, which may include: pain in your upper stomach
   (abdomen), yellowing of skin or eyes (jaundice), fever, and clay-colored
   stools

The most common side effects of RYBELSUS® may include nausea, stomach
(abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation.
Nausea, vomiting, and diarrhea are most common when you first start RYBELSUS®.

Please see Prescribing Information and Medication Guide for RYBELSUS®.



RYBELSUS® is a prescription medication.

You are encouraged to report negative side effects of prescription drugs to the
FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

 



 * Privacy Notice
 * Cookie Policy
 * Privacy Request
 * About Novo Nordisk
 * Site Map
 * Contact Us

RYBELSUS® is a registered trademark of Novo Nordisk A/S.
Novo Nordisk is a registered trademark of Novo Nordisk A/S.
All other trademarks, registered or unregistered, are the property of their
respective owners.
© 2023 Novo Nordisk   All rights reserved.   US22RYB01079   April 2023





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