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FDA-APPROVED STUDY TO INVESTIGATE THERAPEUTIC POTENTIAL OF MUSHROOM-DERIVED
PSILOCIN AND PSILOCYBIN

Thu / Jul 7th

by Lukas Barfield

230
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Filament Health has begun its Phase 1 study investigating naturally-derived
psilocin and psilocybin, the first such study ever approved by the FDA.

Full story after the jump.

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Filament Health, a clinical-stage natural psychedelic drug development company,
has announced the start of a first-of-its-kind study in which psilocin and
psilocybin derived from mushrooms — rather than constituents created in a lab —
will be administered to patients.  

Overseen by Dr. Joshua Woolley at the University of California San Francisco’s
(UCSF) Translational Psychedelic Research Program (TrPR), the Phase 1 study is
approved federally by the Food and Drug Administration (FDA) and will
examine the effects of naturally-derived psychedelic substances.  

The trial will use three of Filament’s botanical drug candidates and assesses
the physiological and psychological effects of orally administered psilocybin,
orally administered psilocin, and sublingually administered psilocin to healthy
adults over a series of doses.   

> “We are incredibly proud to have reached this milestone in an FDA-approved
> trial. We look forward to increasing the scientific understanding of potential
> benefits and applications for natural psychedelic medicines, and to getting
> these treatments to those in need.”  — CEO and Co-Founder Benjamin Lightburn,
> in a statement

In the past, drug makers have been unable to properly synthesize psilocin
instead of its pro-drug form psilocybin. The hope is that naturally-derived
psilocin may offer greater consistency, increased bioavailability, faster onset
time, and lessened side effects, according to the press release. 

“We are excited to conduct the first trial of naturally sourced psilocybin and
the first modern trial of psilocin from any source,” Dr. Joshua Woolley,
MD/Ph.D., director of TrPR and the study’s principal investigator, said in a
statement. “This trial will provide crucial information about the effects and
mechanisms of these compounds that could allow for greatly enhanced
psychedelic-assisted therapy.” 

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--------------------------------------------------------------------------------

Authored By:


LUKAS BARFIELD



Lukas is a freelance writer and medical cannabis activist who lives in Tacoma.
When he’s not writing about cannabis or working to bring a better medical
cannabis system to Washington, he likes to DJ, play adaptive sports and
volunteer in his Tacoma community. He supports national legalization and the
opening up of the medical cannabis market in all 50 states.


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