learning.aaps.org
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https://learning.aaps.org/topclass/topclass.do?expand-OfferingDetails-viaTC=1-offeringId=229458
Submission: On March 04 via api from US — Scanned from DE
Submission: On March 04 via api from US — Scanned from DE
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Overcoming Obstacles in Development of a Test System for Fentanyl Induced
Respiratory Depression and
Added:02/06/2024 17:11
0 user reviews
--------------------------------------------------------------------------------
Opioid-related deaths have become an increasing concern for patients with
substances use disorders as well as the general public with severe respiratory
depression being generally accepted as one of the major factors in
opioid-related deaths. Despite this, little testing is done involving the
respiratory assessments of conscious animals exposed to fentanyl, limiting the
applicability to real world over-dose situations. Because of this, we are
developing a test system for assessing potential pharmacotherapies for fentanyl
induced respiratory depression and overdose toxicity. Our results present a
potential high-throughput test system for assessing medical countermeasures of
fentanyl-induced respiratory depression and overdose. This test system allows
for real time monitoring in alert and unrestrained animals and is capable of
assessing a multitude of prophylactic and rescue pharmaceuticals.
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ABOUT THIS ITEM
Opioid-related deaths have become an increasing concern for patients with
substances use disorders as well as the general public with severe respiratory
depression being generally accepted as one of the major factors in
opioid-related deaths. Despite this, little testing is done involving the
respiratory assessments of conscious animals exposed to fentanyl, limiting the
applicability to real world over-dose situations. Because of this, we are
developing a test system for assessing potential pharmacotherapies for fentanyl
induced respiratory depression and overdose toxicity. Our results present a
potential high-throughput test system for assessing medical countermeasures of
fentanyl-induced respiratory depression and overdose. This test system allows
for real time monitoring in alert and unrestrained animals and is capable of
assessing a multitude of prophylactic and rescue pharmaceuticals.
SPEAKER INFORMATION
Samuel Vance, MS
Samuel Vance received his Master’s in Toxicology from East Carolina University
where he studied the environmental and immunotoxicity of per and
poly-fluoroalkyl substances. He has nearly a decade of experience in toxicology
and respiratory physiology primarily focused in small animal models. Prior to
joining Lovelace Biomedical, Samuel worked at the U.S. Environmental Protection
Agency studying the respiratory health effects of military related exposures
including burn pit smoke, firearm and explosive particulate matter.
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