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* HSE University
* Faculty of Computer Science
* ABZ meeting
HSE University
A, B AND Z: THE STRUCTURE, FUNCTION AND GENETICS OF Z-DNA AND Z-RNA
MAY 19TH, 2021 [ONLINE]
Starting time: 5:00 am PDT / 6:00 am MDT / 7:00 am CDT / 8:00 am EDT / 1:00 pm
BST /2:00 pm CEST / 3:00 pm MSK / 9:00 pm JST
Free Registration
In celebration of 50 years of discoveries on Z-DNA and Z-RNA, we invite
researchers to the inaugural ABZ meeting ("A, B and Z: The Structure, Function
and Genetics of Z-DNA and Z-RNA") to be held on May 19th, 2021. This year's
meeting will be virtual.
We will feature speakers from many different fields to increase awareness of the
many innovative approaches available to further advance the field. Our aim to
build community and to foster multidisciplinary collaborations.
SPECIAL ISSUE
WE ALSO ACCEPT ABSTRACTS FOR A JOINT SPECIAL ISSUE IN MOLECULES, 'Z-DNA AND
Z-RNA: FROM PHYSICAL STRUCTURE TO BIOLOGICAL FUNCTION'. THE DEADLINE IS OCTOBER
1ST, 2021.
PROGRAM AND ORGANIZING COMMITTEE
ALAN HERBERT
InsideOutBio, Inc., USA
QUENTIN VICENS
University of Colorado, USA
KAREN VASQUEZ
University of Texas, USA
BEAT VÖGELI
University of Colorado, USA
MARIA POPTSOVA
Higher School of Economics, Russia
SERGEY KARAPETYAN
Higher School of Economics, Russia
SPEAKERS
ALAN HERBERT
InsideOutBio, Inc., USA
JAN REHWINKEL
University of Oxford, UK
BERTRAM JACOBS
Arizona State University, USA
QUENTIN VICENS
University of Colorado, USA
BEAT VÖGELI
University of Colorado, USA
SIDDHARTH BALACHANDRAN
Fox Chase Cancer Center, USA
KAREN VASQUEZ
University of Texas, USA
YUKIO KAWAHARA
Osaka University, Japan
ANDREW OBERST
University of Washington, USA
JONATHAN MAELFAIT
Ghent University, Belgium
ZEV BRYANT
Stanford University, USA
MARIA POPTSOVA
Higher School of Economics, Russia
TONY SUN
Rockefeller University, USA
THIRUMALA-DEVI KANNEGANTI
St. Jude Children's Research Hospital, USA
MANOLIS PASPARAKIS
University of Cologne, Germany
DAVID STEPHEN PISETSKY
Duke University, USA
SEOK-CHEOL HONG
Korea University, Korea
QINGDE WANG
University of Pittsburgh, USA
BREAKOUT ROOMS
Thematical breakout rooms with moderators (below) will be available during the
conference. Additionally several rooms will be open as free-communications
rooms.
Z-HISTORY
SHUGUANG ZHANG
MIT, USA
ZENETICS&DISEASE
GULIANG WANG
University of Texas, USA
Z-STRUCTURE
CATHERINE MUSSELMAN
University of Colorado, USA
Z-BINDING PROTEINS
HEATHER KOEHLER
Emory University, USA
PROGRAM
8:00-10:00
AM (EDT)
SESSION I
ALAN HERBERT, INSIDEOUTBIO, INC., USA
Moderator
--------------------------------------------------------------------------------
ALAN HERBERT, INSIDEOUTBIO, INC., USA
8:00 AM (EDT) Introduction
--------------------------------------------------------------------------------
SEOK-CHEOL HONG, KOREA UNIVERSITY, KOREA
8:20 AM (EDT) Sequence-dependent cost for Z-form shapes both torsion-driven and
protein-induced B-Z transitions
--------------------------------------------------------------------------------
YUKIO KAWAHARA, OSAKA UNIVERSITY, JAPAN
8:40 AM (EDT) Deciphering the biological significance of ADAR1–Z-RNA
interactions
--------------------------------------------------------------------------------
MANOLIS PASPARAKIS, UNIVERSITY OF COLOGNE, GERMANY
9:00 AM (EDT) Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and
inflammation
--------------------------------------------------------------------------------
JAN REHWINKEL, UNIVERSITY OF OXFORD, UK
9:20 AM (EDT) Recognition of Z-RNA by ADAR1 limits interferon response
--------------------------------------------------------------------------------
THIRUMALA-DEVI KANNEGANTI, PANOPTOSI ST. JUDE CHILDREN'S RESEARCH HOSPITAL, USA
9:40 AM (EDT) ZBP1-PANoptosome: Discovery of ZBP1 as an innate immune sensor of
RNA virus that drives inflammatory cell death
--------------------------------------------------------------------------------
BERTRAM JACOBS, ARIZONA STATE UNIVERSITY, USA
10:00 AM (EDT) Poxvirus induced zRNA as a pathogen associated molecular pattern
--------------------------------------------------------------------------------
10:40 AM - 1:00
PM (EDT)
SESSION II
MARIA POPTSOVA, HSE UNIVERSITY, RUSSIA
Moderator
--------------------------------------------------------------------------------
ALAN HERBERT, INSIDEOUTBIO, INC., USA
10:40 AM (EDT) Flipons
--------------------------------------------------------------------------------
JONATHAN MAELFAIT, GHENT UNIVERSITY, BELGIUM
11:00 AM (EDT) Z-RNA in autoinflammatory disease
--------------------------------------------------------------------------------
DAVID STEPHEN PISETSKY, DUKE UNIVERSITY, USA
11:20 AM (EDT) The Binding of Anti-DNA Antibodies to Z-DNA and other non-B DNA
Conformations
--------------------------------------------------------------------------------
KAREN VASQUEZ, UNIVERSITY OF TEXAS, USA
11:40 AM (EDT) Z-DNA-induced genetic instability in cancer
--------------------------------------------------------------------------------
ZEV BRYANT, STANFORD UNIVERSITY, USA
12:00 PM (EDT) Single-molecule mechanics of alternative structure formation in
supercoiled DNA
--------------------------------------------------------------------------------
MARIA POPTSOVA, HSE UNIVERSITY, RUSSIA
12:20 PM (EDT) Deep-learning approach to Z-DNA prediction
--------------------------------------------------------------------------------
QINGDE WANG, UNIVERSITY OF PITTSBURGH, USA
12:40 PM (EDT) Validation of the neuroinflammatory effect of the P193A mutation
in Z-binding domain of ADAR1 in mouse models
1:00-2:00
PM (EDT)
BREAK OUT SOCIAL
2:00-4:00
PM (EDT)
SESSION III
BEAT VÖGELI, UNIVERSITY OF COLORADO, USA
Moderator
--------------------------------------------------------------------------------
ANDREW OBERST, UNIVERSITY OF WASHINGTON, USA
2:00 PM (EDT) Regulation and sensing of endogenous RNA by ADAR1 and ZBP1
--------------------------------------------------------------------------------
ED MOCARSKI, EMORY UNIVERSITY SCHOOL OF MEDICINE, USA
2:20 PM (EDT) Vaccinia Virus E3 Prevents Sensing of Z-RNA to Block
ZBP1-dependent Necroptosis
--------------------------------------------------------------------------------
TONY SUN, ROCKEFELLER UNIVERSITY, USA
2:40 PM (EDT) Decoupled expression of ADAR1 isoforms reveals unique A-to-I RNA
edit sites associated with presence of the Zα domain
--------------------------------------------------------------------------------
SIDDHARTH BALACHANDRAN, FOX CHASE CANCER CENTER, USA
3:00 PM (EDT) The A-Z of influenza activated necroptosis
--------------------------------------------------------------------------------
QUENTIN VICENS, UNIVERSITY OF COLORADO, USA
3:20 PM (EDT) RNAs in Z-form: Revealing the RNA Underworld
--------------------------------------------------------------------------------
BEAT VÖGELI, UNIVERSITY OF COLORADO, USA
3:40 PM (EDT) ADAR1-induced Z-conformation in non-CG RNA
--------------------------------------------------------------------------------
4:00-4:45
PM (EDT)
CLOSING & NEXT STEPS DISCUSSION
KAREN VASQUEZ UNIVERSITY OF TEXAS, USA
Moderator
THERE ARE 10 MINUTE SLOTS AVAILABLE FOR LATE BREAKING PRESENTATIONS
CONTACTS
E-mail: info@abz.bio
* Dr. Quentin Vicens
Department of Biochemistry and Molecular Genetics, and RNA BioScience
Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
E-mail: quentin.vicens@cuanschutz.edu
* Dr. Beat Vögeli
Department of Biochemistry and Molecular Genetics, University of Colorado
Anschutz Medical Campus, Aurora, CO, USA
E-mail: beat.vogeli@cuanschutz.edu
* Dr. Karen M. Vasquez
Division of Pharmacology and Toxicology, University of Texas at Austin, Dell
Pediatric Research Institute, Austin, TX, USA
E-mail: karen.vasquez@austin.utexas.edu
* Dr. Maria Poptsova
Faculty of Computer Science, Big Data and Information Retrieval School, HSE
University, Moscow, Russia
E-mail: mPoptsova@hse.ru
* Dr. Alan Herbert
Discovery, InsideOutBio, Inc., Charlestown, MA, USA
E-mail: alan.herbert@insideoutbio.com
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