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I'M JAMES. THIS IS MY YEAR OF TRAVEL.




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MONOCLONAL ANTIBODY PRODUCTION PROCESS FLOW DIAGRAM

8/1/2023

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Ehrlich and Élie Metchnikoff received the 1908 Nobel Prize for Physiology or
Medicine for providing the theoretical basis for immunology.īy the 1970s,
lymphocytes producing a single antibody were known, in the form of multiple
myeloma – a cancer affecting B-cells. This underpinned the concept of monoclonal
antibodies and monoclonal drug conjugates. In the early 1900s, immunologist Paul
Ehrlich proposed the idea of a Zauberkugel – " magic bullet", conceived of as a
compound which selectively targeted a disease-causing organism, and could
deliver a toxin for that organism. In 2020, the administration of monoclonal
antibodies was authorized by several countries for treating moderate symptoms of
COVID-19. Monoclonal antibodies are being used on a clinical level for both the
diagnosis and therapy of several diseases. This capability has become an
investigative tool in biochemistry, molecular biology, and medicine. It is
possible to produce monoclonal antibodies that specifically bind to almost any
suitable substance they can then serve to detect or purify it. Bispecific
monoclonal antibodies can also be engineered, by increasing the therapeutic
targets of one monoclonal antibody to two epitopes. In contrast, polyclonal
antibodies bind to multiple epitopes and are usually made by several different
antibody-secreting plasma cell lineages.

Monoclonal antibodies can have monovalent affinity, binding only to the same
epitope (the part of an antigen that is recognized by the antibody). All
subsequent antibodies derived this way trace back to a unique parent cell. A
general representation of the method used to produce monoclonal antibodies Ī
monoclonal antibody ( mAb, more rarely called moAb) is an antibody produced from
a cell lineage made by cloning a unique white blood cell.


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