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NEUROSPECTRUM™360: UNLEASH YOUR BRAIN’S POTENTIAL™




CARRICK INSTITUTE IS PROUD TO OFFER A SYNERGISTIC NUTRITIONAL FORMULATION
DESIGNED TO STABILIZE AND OPTIMIZE NEUROLOGICAL FUNCTION.

WHILE NEUROSPECTRUM™360 IS DESIGNED FOR BRAIN RECOVERY, IT ALSO PROVIDES AN
EXCELLENT MULTIVITAMIN MINERAL SUPPLEMENT FOR HEALTHY ADULTS AND CHILDREN.


RESEARCH BACKED

NeuroSpectrum™360 is a NutraTek™ enhanced micronutrient formulation, which means
it is backed by extensive clinical research.
Now over 30 medical journal publications show that NeuroSpectrum™360 is an
effective micronutrient therapy for neurological stability and recovery.†


COMPREHENSIVE

NeuroSpectrum™360 includes all the vitamins and minerals science has shown are
essential for humans, at levels required to stabilize and optimize neurological
function.*
Research and clinical outcomes on NutraTek™ based micronutrient formulations†
show that they are safe for children and adults. It is also GMO-free,
sugar-free, gluten-free and vegan.


EXCEPTIONAL BALANCE

NeuroSpectrum™360 is not a mega-dose of nutrients. Rather it is a carefully
balanced combination of research-backed nutrients at the levels clinically
proven to support neurological health.† The broad-spectrum synergy of essential
nutrients in this formulation is a key component to its success.


CLINICALLY EFFECTIVE

High quality ingredients and specialized processing make NeuroSpectrum™360 much
more powerful than over-the-counter supplements, making it ideal for therapeutic
use.* Physicians who use this combination of micronutrients with their patients
have consistently reported positive clinical outcomes.†






ALLERGEN-FREE

Rest assured that NeuroSpectrum™360 is top 8 allergen-free as well as
sugar-free, soy-free and vegan.


13 VITAMINS

All 13 vitamins are present in clinical levels – balanced to each other to
deliver maximum synergistic effect*.


16 MINERALS

The 16 key minerals essential for every human process are microground and
chelated for ultimate absorption.


PROPRIETARY BLEND

The 16 key minerals essential for every human process are microground and
chelated for ultimate absorption.


30+ INDEPENDENT MEDICAL JOURNAL PUBLICATIONS BACK CLINICAL MICRONUTRIENTS

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Read The Studies



STUDY: RAT BRAIN REGROWTH




Researchers at the world-renowned Canadian Centre for Behavioural Neuroscience
conducted a series of controlled studies with rats fed a predecessor version of
NeuroSpectrum™360† to test its effects on brain injuries and brain-related
disorders.

Neuroscientists removed either the entire frontal lobe or part of the parietal
lobe of the brain in treatment animals, and then the neural tissue was regrown
with either the standard lab rat diet or with the treatment diet enhanced with
the micronutrient formula. Brain recovery was significantly enhanced in the
micronutrient-fed rats over those receiving the standard diet. Impressively, on
certain cognitive, behavioral, and motor tasks the micronutrient-fed treatment
group scored as well as the control rats!

Post-mortem analyses revealed that in both surgery and control animals the
micronutrient treatment increased cortical thickness and dendritic length,
supporting the use of micronutrient formulations for human brain trauma recovery
in conjunction with brain rehabilitation therapies.

[Factors influencing frontal cortex development and recovery from early frontal
injury. Halliwell C, Comeau W, Gibb R, Frost DO, Kolb B. Developmental
Neurorehabilitation. 2009;12(5):269-78.]†

Try it Now

Over 30 independent medical journal publications support the clinical use of
broad spectrum micronutrients for the treatment of a wide range of brain-related
disorders.

Further, the American Psychiatric Association recently published a
textbook which specifically mentions the safety and effectiveness of the
NutraTek™ enhanced formulation also known as NeuroSpectrum™360.


Clinicians: Apply for Physician Pricing


QUESTIONS?

We have compiled the most frequently asked questions for your convenience.
FAQ
Patients & Clinicians Order Now.



RESEARCH SUMMARY

Over 30 independent medical journal publications back the NeuroSpectrum™360
formulation.†
Download PDF



MICRONUTRIENT THERAPY: POWERFUL CLINICAL RESULTS

PATIENTS WHO ARE RECOVERING FROM TRAUMATIC BRAIN INJURY OR WHO ARE SUFFERING
FROM DEBILITATING MOOD DISORDERS HAVE BEEN SHOWN TO BENEFIT FROM CLINICAL
MICRONUTRIENT THERAPY.*

Dr. Julia Rucklidge, who has done extensive research on David Hardy’s NutraTek™
enhanced formulations† 
shares some of her findings on the TEDx stage in Christchurch, New Zealand: 




MANY HEALTHCARE PROFESSIONALS ARE RECOMMENDING NEUROSPECTRUM™360 TO PATIENTS
BECAUSE OF THE OVERWHELMING CLINICAL OUTCOMES BACKING NUTRATEK™ ENHANCED
FORMULATIONS.†

Clinicians: Apply for Physician Pricing


RESEARCH: MEDICAL JOURNAL PUBLICATIONS

This broad-spectrum approach has been extensively researched and has been shown
to be incredibly powerful.

NeuroSpectrum™360 is part of a family of products co-formulated by David Hardy
of Hardy Nutritionals® and powered by NutraTek™ Technology.
The published independent research on David Hardy’s formulations are below.†

Brain Injury - Micronutrient formulation greatly improves brain function in
rats.

Researchers at the world-renowned Canadian Centre for Behavioural Neuroscience
conducted a series of controlled studies with rats fed a micronutrient blend
co-formulated by David Hardy to test its effects on brain injuries and
brain-related disorders. Neuroscientists removed either the entire frontal lobe
or part of the parietal lobe of the brain in treatment animals, and then the
neural tissue was regrown with either the standard lab rat diet or with the
treatment diet enhanced with the micronutrient formula. Brain recovery was
significantly enhanced in the micronutrient-fed rats over those receiving the
standard diet. Impressively, on certain cognitive, behavioral, and motor tasks
the micronutrient-fed treatment group scored as well as the control rats!
Post-mortem analyses revealed that in both surgery and control animals the
micronutrient treatment increased cortical thickness and dendritic length,
supporting the use of micronutrient formulations for human brain trauma recovery
in conjunction with brain rehabilitation therapies.
[Factors influencing frontal cortex development and recovery from early frontal
injury. Halliwell C, Comeau W, Gibb R, Frost DO, Kolb B. Developmental
Neurorehabilitation. 2009;12(5):269-78.]†

Vitamin-mineral treatment improves aggression and emotional regulation in
children with ADHD: a fully blinded, randomized, placebo-controlled trial.

BACKGROUND:
Evaluation of broad-spectrum micronutrient (vitamins and minerals) treatment for
childhood ADHD has been limited to open-label studies that highlight beneficial
effects across many aspects of psychological functioning.

METHOD:
This is the first fully blinded randomized controlled trial of medication-free
children (n = 93) with ADHD (7-12 years) assigned to either micronutrients (n =
47) or placebo (n = 46) in a 1:1 ratio, for 10 weeks. All children received
standardized ADHD assessments. Data were collected from clinicians, parents,
participants and teachers across a range of measures assessing ADHD symptoms,
general functioning and impairment, mood, aggression and emotional regulation.

RESULTS:
Intent-to-treat analyses showed significant between-group differences favouring
micronutrient treatment on the Clinical Global Impression-Improvement (ES =
0.46), with 47% of those on micronutrients identified as ‘much’ to ‘very much’
improved versus 28% on placebo. No group differences were identified on
clinician, parent and teacher ratings of overall ADHD symptoms (ES ranged
0.03-0.17). However, according to clinicians, 32% of those on micronutrients
versus 9% of those on placebo showed a clinically meaningful improvement on
inattentive (OR = 4.9; 95% CI: 1.5-16.3), but no group differences on
improvement in hyperactive-impulsive symptoms (OR = 1.0; 95% CI: 0.4-2.5). Based
on clinician, parent and teacher report, those on micronutrients showed greater
improvements in emotional regulation, aggression and general functioning
compared to placebo (ES ranged 0.35-0.66). There were two dropouts per group, no
group differences in adverse events and no serious adverse events identified.
Blinding was successful with guessing no better than chance.

CONCLUSIONS:
Micronutrients improved overall function, reduced impairment and improved
inattention, emotional regulation and aggression, but not hyperactive/impulsive
symptoms, in this sample of children with ADHD. Although direct benefit for core
ADHD symptoms was modest, with mixed findings across raters, the low rate of
adverse effects and the benefits reported across multiple areas of functioning
indicate micronutrients may be a favourable option for some children,
particularly those with both ADHD and emotional dysregulation. Trial registered
with the Australian New Zealand Clinical Trials Registry ACTRN12613000896774.
[Vitamin-mineral treatment improves aggression and emotional regulation in
children with ADHD: a fully blinded, randomized, placebo-controlled trial.
Rucklidge JJ, Eggleston MJF, Johnstone JM, Darling K, Frampton CM. J Child
Psychol Psychiatry. 2017 Oct 2.]

[Factors influencing frontal cortex development and recovery from early frontal
injury. Halliwell C, Comeau W, Gibb R, Frost DO, Kolb B. Developmental
Neurorehabilitation. 2009;12(5):269-78.]†

ADHD Double-blind study: Micronutrient formulation is an effective and safe
treatment for adult ADHD.

A micronutrient formulation co-developed by NeuroSpectrum®360 formulator David
Hardy, showed “statistically robust improvements” in the first-ever double-blind
study to test the effectiveness and safety of a multivitamin-mineral treatment
for adult ADHD. Researchers from the University of Canterbury and the University
of Otago, New Zealand, randomized 80 adults diagnosed with ADHD to take either
the micronutrient formulation or a placebo for 8 weeks. Most of the study
participants had at least one psychiatric diagnosis in addition to ADHD,
including multiple anxiety disorders, major depressive disorder, dysthymia,
bipolar disorder, reading disability, and alcohol/substance misuse or
dependence. The nutrient group reported more than double the improvement in
attention, hyperactivity, and impulsivity symptoms, compared with the placebo
group (p=0.009). Clinical psychologists rated more than twice as many people in
the nutrient group than the placebo group ‘very much’ or ‘much’ improved in
overall symptoms. They also rated moderate and severely depressed participants
in the nutrient group as having nearly double the improvement in depression
symptoms (p=0.039). Researchers found that the micronutrients were completely
safe; there were no differences in side effects between the two groups.
[Vitamin–mineral treatment of attention-deficit hyperactivity disorder in
adults: double-blind randomised placebo-controlled trial.
Rucklidge JJ, Frampton CMA, Gorman B, Boggis A. The British Journal of
Psychiatry. 2014 Feb;204(2): doi: 10.1192/bjp.bp.113.132126 [Epub ahead of
print]†

Safety and tolerability of Micronutrient formulations.

Scientists compiled safety data from all published and unpublished studies that
used a micronutrient formulation co-developed by Hardy Nutritionals® founder
David Hardy which has been widely researched in the mental health field.
Biological safety data from six sources, including 144 children and adults,
showed no occurrences of clinically meaningful negative outcomes/effects or
abnormal blood tests that could be attributed to toxicity. Adverse event
information from six studies involving 157 children and adults included reports
of minor, transitory headache and nausea. Only one of the studies permitted a
direct comparison between tolerability of the micronutrient treatment and
medications: children and adults treated with micronutrients showed
significantly fewer adverse events and significantly less weight gain compared
with those taking medications.
[Systematic review of safety and tolerability of a complex micronutrient formula
used in mental health.†
Simpson JS, Crawford SG, Goldstein ET, Field C, Burgess E, Kaplan BJ. BioMed
Central Psychiatry. 2011 Apr 18;11:62.]

Database analysis: Micronutrient formulation greatly improves bipolar symptoms
in 358 adults.

Scientists analyzed data from 358 adults with a diagnosis of bipolar disorder
who took a micronutrient formulation co-developed by Hardy Nutritionals® founder
David Hardy for 6 months or more. The adults’ overall symptom severity was 41%
lower than baseline after 3 months, and 45% lower after 6 months. In addition,
at 6 months, 53% of adults experienced greater than 50% improvement in symptoms,
with 32% of adults experiencing greater than 75% improvement in symptoms.
Symptom improvements at 6 months suggested that benefits of micronutrient
treatment were not attributable to placebo or expectancy effects. Of those
taking psychiatric medications, nearly half were able to discontinue them over a
6-month period. The remainder reduced their medication usage by 54% during the
same time period. Adults who gradually eliminated their medications and took
full recommended levels of the vitamin-mineral formulation experienced the
greatest improvements in symptoms.†
[Database analysis of adults with bipolar disorder consuming a micronutrient
formula.
Gately D, Kaplan BJ. Clinical Medicine Insights: Psychiatry. 2009 Apr;4:3-16.]

A randomised trial of nutrient supplements to minimise psychological stress
after a natural disasterToggle Title
After devastating flooding in southern Alberta in June 2013, we attempted to
replicate a New Zealand randomised trial that showed that micronutrient
(minerals, vitamins) consumption after the earthquakes of 2010-11 resulted in
improved mental health. Residents of southern Alberta were invited to
participate in a study on the potential benefit of nutrient supplements
following a natural disaster. Fifty-six adults aged 23-66 were randomised to
receive a single nutrient (vitamin D, n=17), a few-nutrients formula (B-Complex,
n=21), or a broad-spectrum mineral/vitamin formula (BSMV, n=18). Self-reported
changes in depression, anxiety and stress were monitored for six weeks. Although
all groups showed substantial decreases on all measures, those consuming the
B-Complex and the BSMV formulas showed significantly greater improvement in
stress and anxiety compared with those consuming the single nutrient, with large
effect sizes (Cohen’s d range 0.76-1.08). There were no group differences
between those consuming the B-Complex and BSMV. The use of nutrient formulas
with multiple minerals and/or vitamins to minimise stress associated with
natural disasters is now supported by three studies. Further research should be
carried out to evaluate the potential population benefit that might accrue if
such formulas were distributed as a post-disaster public health measure.†
[A randomised trial of nutrient supplements to minimise psychological stress
after a natural disaster
Kaplan BJ, Rucklidge JJ, Romijn AR, Dolph M. Psychiatry Res. 2015 Aug
30;228(3):373-9.]
 
Micronutrient formulation reduces depression, anxiety, and stress in 17
earthquake survivors with ADHD.

A 7.1-magnitude earthquake in Christchurch, New Zealand created a natural
experiment for measuring the protective effects of a micronutrient formulation
co-developed by Hardy Nutritionals® founder David Hardy on mood, anxiety and
stress. Prior to the earthquake, researchers had assessed mood, anxiety and
stress levels in a group of 33 adults diagnosed with attention deficit
hyperactivity disorder, and they chose to repeat the same measures after the
earthquake. Scores showed that the 16 participants taking micronutrients were
more resilient to the effects of the earthquake than the 17 individuals not
taking any supplement. This effect was particularly marked for depression
scores.
[Post-earthquake psychological functioning in adults with
attention-deficit/hyperactivity disorder: positive effects of micronutrients on
resilience.†
Rucklidge JJ, Blampied, NM. New Zealand Journal of Psychology. 2011;40(4):51]

Database analysis: Micronutrient formulation greatly improves bipolar and ADHD
symptoms in 161 children and adolescents.

Scientists analyzed data from 120 children with pediatric bipolar disorder who
were treated with a micronutrient formulation co-developed† by Hardy
Nutritionals® founder David Hardy for at least 6 months. 24% of these children
also had a diagnosis of attention deficit hyperactivity disorder (ADHD). Their
results were compared with an additional 41 children who were diagnosed with
ADHD alone. Children with a bipolar diagnosis showed a 59% decline in symptoms,
whereas children with ADHD showed a 40% decrease in symptoms. The duration of
symptom reduction suggests that benefits of micronutrient treatment were not
attributable to placebo or expectancy effects. Of those taking psychiatric
medications, more than half were able to completely discontinue them over a
6-month period. Medication use by the remainder of children was reduced by 74%
during the same time period.
[Database analysis of children and adolescents with bipolar disorder consuming a
micronutrient formula.
Rucklidge JJ, Gately D, Kaplan BJ. BioMed Central Psychiatry. 2010 Sep
28;10:74.]

Micronutrient formulation greatly improves ADHD and other psychiatric disorders
(PTSD) in 14 adults.

Researchers documented the impact of a micronutrient formulation co-developed†
by Hardy Nutritionals® founder David Hardy in the treatment of 14
medication-free adults with attention deficit hyperactivity disorder. The
adults’ additional psychiatric diagnoses included major depressive disorder,
bipolar disorder II, generalized anxiety disorder, social phobia, obsessive
compulsive disorder, post-traumatic stress disorder, panic disorder with
agoraphobia, and psychotic disorder not otherwise specified. During 8 weeks of
micronutrient treatment, mood and hyperactivity/impulsivity symptoms normalized.
Researchers also noted significant improvements on measures of anxiety,
attention, stress, and quality of life. In follow-up, those who continued to
take the micronutrients for 2-6 months experienced sustained or improved symptom
relief.
[Effect of micronutrients on behavior and mood in adults with ADHD: evidence
from an 8-week open label trial with natural extension.
Rucklidge J, Taylor M, Whitehead K. Journal of Attention Disorders. 2011
Jan;15(1):79-91.]

Database analysis: Micronutrient formulation greatly improves bipolar and ADHD
symptoms in 161 children and adolescents.

Scientists analyzed data from 120 children with pediatric bipolar disorder who
were treated with a micronutrient formulation co-developed† by Hardy
Nutritionals® founder David Hardy for at least 6 months. 24% of these children
also had a diagnosis of attention deficit hyperactivity disorder (ADHD). Their
results were compared with an additional 41 children who were diagnosed with
ADHD alone. Children with a bipolar diagnosis showed a 59% decline in symptoms,
whereas children with ADHD showed a 40% decrease in symptoms. The duration of
symptom reduction suggests that benefits of micronutrient treatment were not
attributable to placebo or expectancy effects. Of those taking psychiatric
medications, more than half were able to completely discontinue them over a
6-month period. Medication use by the remainder of children was reduced by 74%
during the same time period.
[Database analysis of children and adolescents with bipolar disorder consuming a
micronutrient formula.
Rucklidge JJ, Gately D, Kaplan BJ. BioMed Central Psychiatry. 2010 Sep
28;10:74.]

Micronutrient formulation stabilizes mood in 11 bipolar adults.

Researchers treated 11 adults diagnosed with various types of bipolar disorder
for an average of 44 weeks with a micronutrient formulation co-developed† by
Hardy Nutritionals® founder David Hardy. The adults’ additional diagnoses
included attention deficit hyperactivity disorder, dysthymic disorder, and
obsessive-compulsive disorder. The adults experienced a 55% reduction in
depression symptoms, a 60% reduction in mania symptoms, and a 66% reduction in
general psychiatric symptoms. Their psychiatric medication use decreased by more
than 50%. The only reported side effect, nausea, was infrequent, minor, and
transitory.
[Effective mood stabilization with a chelated mineral supplement: an open-label
trial in bipolar disorder.
Kaplan BJ, Simpson JS, Ferre RC, Gorman CP, McMullen DM, Crawford SG. The
Journal of Clinical Psychiatry. 2001 Dec;62(12):936-44.]

Micronutrient formulation greatly improves mood, behavior, and anxiety disorders
in 9 children.

Researchers treated nine unselected children with mood and behavioral problems
with a micronutrient formulation co-developed† by Hardy Nutritionals® founder
David Hardy. The children’s psychiatric diagnoses included attention deficit
hyperactivity disorder, bipolar disorder, depression, oppositional defiant
disorder, obsessive-compulsive disorder, generalized anxiety disorder, Asperger
syndrome, and Prader-Willi syndrome. After a minimum of 8 weeks of micronutrient
treatment, the children’s behavior improved significantly in the following
areas: anxious and depressed mood, thought problems, interpersonal relationship
problems, attention problems, social problems, withdrawn behavior, disruptive
behavior, delinquent behavior, aggressive behavior, and self-harm behavior.
[Improved mood and behavior during treatment with a mineral-vitamin supplement:
an open-label case series of children.
Kaplan BJ, Fisher JE, Crawford SG, Field CJ, Kolb B. Journal of Child and
Adolescent Psychopharmacology. 2004 Spring;14(1):115-22.]

Successful treatment of bipolar disorder II and ADHD with a micronutrient
formula: a case study.

Researchers documented the effects of a micronutrient formulation co-developed†
by Hardy Nutritionals® founder David Hardy on psychiatric and neurocognitive
functioning in a naturalistic off-on-off-on design. A 21-year old female with
bipolar II disorder, attention deficit hyperactivity disorder (ADHD), social
anxiety, and panic disorder began taking a vitamin-mineral formulation following
a documented 8-year history of ongoing psychiatric symptoms that were not well
managed by medications. After 8 weeks on the formula, she showed significant
improvements in mood, anxiety, and hyperactivity/impulsivity. She then chose to
come off the formula. After 8 weeks, her depression scores returned to
pre-treatment levels, and anxiety and ADHD symptoms worsened dramatically. When
the formula was reintroduced, all psychiatric symptoms showed gradual
improvements. After one year, she was in remission of all mental illness
diagnoses. Her neurocognitive changes mirrored behavioral changes, showing
improved processing speed, variability in response, and verbal memory.
[Successful treatment of bipolar disorder II and ADHD with a micronutrient
formula: a case study.
Rucklidge JJ, Harrison R. CNS Spectrums. 2010 May;15(5):289-95.]

Treatment of mood lability and explosive rage with minerals and vitamins: two
case studies in children.

Researchers describe two medication-free boys with unstable mood and explosive
rage who took a micronutrient formulation co-developed† by Hardy Nutritionals®
founder David Hardy followed by reversal and re-treatment. The boys’ diagnoses
included pervasive developmental disorder with Asperger characteristics,
attention deficit hyperactivity disorder, obsessive-compulsive disorder, and
autism. Both boys benefited significantly from the micronutrient formula: mood,
angry outbursts, delinquent behavior, social and attention problems, and
anxious/obsessional symptoms improved when initially treated, returned when they
discontinued treatment, and remitted when the micronutrient treatment was
reintroduced. During a follow-up of over 2 years, both boys continued to be
stable while taking the micronutrient treatment.
[Treatment of mood lability and explosive rage with minerals and vitamins: two
case studies in children.
Kaplan BJ, Crawford SG, Gardner B, Farrelly G. Journal of Child and Adolescent
Psychopharmacology. 2002 Fall;12(3):205-19.]

Feasibility of a nutritional supplement as treatment for pediatric bipolar
spectrum disorders.

Researchers investigated the therapeutic effects of a micronutrient formulation
co-developed† by Hardy Nutritionals® founder David Hardy in 7 children with
bipolar disorder. The children’s additional psychiatric diagnoses included
attention deficit hyperactivity disorder, oppositional defiant disorder, major
depressive disorder, generalized anxiety disorder, conduct disorder, and
obsessive-compulsive disorder. The children experienced a 37% decrease in
depression scores and a 45% decrease in mania scores over 8 weeks. Side effects
were minor and transient—mostly temporary gastric discomfort.
[Feasibility of a nutritional supplement as treatment for pediatric bipolar
spectrum disorders.
Frazier EA, Fristad MA, Arnold LE. Journal of Alternative and Complementary
Medicine. 2012 Jul;18(7):678-85.]

Can micronutrients improve neurocognitive functioning in adults with ADHD and
severe mood dysregulation? A pilot study.

Researchers studied the impact of a micronutrient formulation co-developed† by
Hardy Nutritionals® founder David Hardy on neurocognitive functioning in 14
adults with attention deficit hyperactivity disorder (ADHD) and severe mood
dysregulation over an 8-week period. Significant improvement was observed in the
ADHD-micronutrient group, but not the control group, across a range of verbal
abilities, including verbal learning, verbal cognitive flexibility and fluency,
and verbal inhibition. These neurocognitive improvements were large and
consistent with improved psychiatric functioning.
[Can micronutrients improve neurocognitive functioning in adults with ADHD and
severe mood dysregulation? A pilot study.
Rucklidge JJ, Harrison R, Johnstone J. Journal of Alternative and Complementary
Medicine. 2011 Dec;17(12):1125-31.]

Use of micronutrients attenuates cannabis and nicotine abuse as evidenced from a
reversal design: a case study.

Scientists observed while conducting previous studies that many study
participants whose psychiatric symptoms were treated successfully with a
micronutrient formulation co-developed† by Hardy Nutritionals® founder David
Hardy tended to reduce or eliminate use of alcohol, cigarettes and cannabis on
their own. This study details one case in which on-off micronutrient use
resulted in off-on cigarette and cannabis smoking as well as off-on psychiatric
symptoms. Micronutrients provide the necessary precursors and cofactors for
adequate neurotransmitter production and regulation. In this way, micronutrients
assist with mood regulation, help reduce anxiety, and directly affect brain
reward circuitry, all of which can help individuals to successfully stop drug
use.
[Use of micronutrients attenuates cannabis and nicotine abuse as evidenced from
a reversal design: a case study.
Harrison R, Rucklidge JJ, Blampied N. Journal of Psychoactive Drugs. 2013
Jun;45(2):168-178.]

Micronutrients reduce stress and anxiety following a 7.1 earthquake in adults
with Attention-Deficit/Hyperactivity Disorder

The role of good nutrition for resilience in the face of stress is a topic of
interest, but difficult to study. A 7.1 earthquake took place in the midst of
research on a micronutrient treatment for Attention-Deficit/Hyperactivity
Disorder (ADHD), providing a unique opportunity to examine whether individuals
with ADHD taking micronutrients demonstrated more emotional resilience
post-earthquake than individuals with ADHD not taking micronutrients.
Thirty-three adults with ADHD were assessed twice following the earthquake using
a measure of depression, anxiety and stress also completed at some point
pre-earthquake (baseline). Seventeen were not taking micronutrients at the time
of the earthquake (control group), 16 were (micronutrient group). While there
were no between-group differences one week post-quake (Time 1), at two weeks
post-quake (Time 2), the micronutrient group reported significantly less anxiety
and stress than the controls (effect size 0.69). These between group differences
could not be explained by other variables, such as pre-earthquake measures of
emotions, demographics, psychiatric status, and personal loss or damage
following the earthquake. The results suggest micronutrients may increase
resilience to ongoing stress and anxiety associated with a highly stressful
event in individuals with ADHD and are consistent with controlled studies
showing benefit of micronutrients for mental health.
[Micronutrients reduce stress and anxiety following a 7.1 earthquake in adults
with Attention-Deficit/Hyperactivity Disorder
Rucklidge JJ, Johnstone J, Harrison R, Boggis A. 2011. Psychiatry Research,
189:281-87.]

Moderators of treatment response in adults with ADHD treated with a
vitamin-mineral supplement

Dr. Julia Rucklidge conducted nutrient assays on study participants in her 8
week double-blind RCT using micronutrient treatment for adult ADHD. Using this
extensive data set, she performed a post-hoc analysis of the original study in
an attempt to determine if blood levels of nutrients in adult ADHD patients
could be used to predict whether or not they would respond to micronutrient
treatment. The blood markers measured were Vitamin D, Vitamin B12, Folate, Iron,
Zinc, Copper, and Ferritin.

[Moderators of treatment response in adults with ADHD treated with a
vitamin-mineral supplement
Rucklidge JJ, Johnstone J, Gorman B, Boggis A, Frampton CM. Prog
Neuropsychopharmacol Biol Psychiatry. 2014 Apr 3;50:163-71.
doi:10.1016/j.pnpbp.2013.12.014. Epub 2013 Dec 26. PubMed PMID: 24374068.]†

Clinically Significant Symptom Reduction in Children with
Attention-Deficit/Hyperactivity Disorder Treated with Micronutrients: An
Open-Label Reversal Design Study

In January 2014, The British Journal of Psychiatry published the results of a
double-blind controlled trial which provided evidence of efficacy for
micronutrients† (vitamins and minerals) in the treatment of ADHD symptoms in
adults, with a reassuring safety profile.
As a follow-up to the adult trial, and pilot study for a RCT in childhood ADHD,
the Journal of Child and Adolescent Psychopharmacology recently published the
results of a study which treated 14 children with
Attention-Deficit/Hyperactivity Disorder (ADHD) using micronutrients† instead of
medication.
The study demonstrated the clinical benefit, feasibility, and safety of
broad-spectrum micronutrients in the treatment of childhood ADHD.
In the recently published study, medication-free children were treated with a
micronutrient formula† for eight weeks and then taken off it for four weeks—with
the on-off cycle repeating itself over a six-month period.
[Clinically Significant Symptom Reduction in Children with
Attention-Deficit/Hyperactivity Disorder Treated with Micronutrients: An
Open-Label Reversal Design Study
Gordon HA, Rucklidge JJ, Blampied NM, Johnstone JM. J Child Adolesc
Psychopharmacol. 2015 Dec;25(10):783-98. doi: 10.1089/cap.2015.0105. PubMed
PMID: 26682999; PubMed Central PMCID: PMC4702182.]

Micronutrient formulation outperforms Berocca Performance in reducing
depression, anxiety, and stress in 91 earthquake survivors.

Following a 6.3-magnitude earthquake in Christchurch, New Zealand, researchers
randomized 91 earthquake survivors to take one of two vitamin-mineral formulas
(Berocca Performance or a micronutrient formulation co-developed† by Hardy
Nutritionals® founder David Hardy. Then they measured symptoms of
situation-induced depression, anxiety, and stress in these individuals, as well
as 25 additional people who took no supplement (a control group). After 4 weeks,
20% of the control group, 43% of the Berocca Performance group, and 74% of the
group taking the micronutrients showed significant improvement in depression,
anxiety, and stress symptoms. Researchers concluded that this study supports
micronutrients as an inexpensive and practical treatment for acute stress
following a natural disaster, with a slight advantage to higher doses.

[Shaken but unstirred? Effects of micronutrients on stress and trauma after an
earthquake: RCT evidence comparing formulas and doses.
Rucklidge JJ, Andridge R, Gorman B, Blampied N, Gordon H, Boggis A. Human
Psychopharmacology. 2012 Sep;27(5):440-54.]

Micronutrient formulation greatly improves ADHD and other psychiatric disorders
in 14 adults.

Researchers documented the impact of a micronutrient formulation co-developed†
by Hardy Nutritionals® founder David Hardy in the treatment of 14
medication-free adults with attention deficit hyperactivity disorder. The
adults’ additional psychiatric diagnoses included major depressive disorder,
bipolar disorder II, generalized anxiety disorder, social phobia, obsessive
compulsive disorder, post-traumatic stress disorder, panic disorder with
agoraphobia, and psychotic disorder not otherwise specified. During 8 weeks of
micronutrient treatment, mood and hyperactivity/impulsivity symptoms normalized.
Researchers also noted significant improvements on measures of anxiety,
attention, stress, and quality of life. In follow-up, those who continued to
take the micronutrients for 2-6 months experienced sustained or improved symptom
relief.
[Effect of micronutrients on behavior and mood in adults with ADHD: evidence
from an 8-week open label trial with natural extension. Rucklidge J, Taylor M,
Whitehead K. Journal of Attention Disorders. 2011 Jan;15(1):79-91.]

Micronutrient formulation greatly improves mood, behavior, and anxiety disorders
in 9 children.

Researchers treated nine unselected children with mood and behavioral problems
with a micronutrient formulation co-developed† by Hardy Nutritionals® founder
David Hardy. The children’s psychiatric diagnoses included attention deficit
hyperactivity disorder, bipolar disorder, depression, oppositional defiant
disorder, obsessive-compulsive disorder, generalized anxiety disorder, Asperger
syndrome, and Prader-Willi syndrome. After a minimum of 8 weeks of micronutrient
treatment, the children’s behavior improved significantly in the following
areas: anxious and depressed mood, thought problems, interpersonal relationship
problems, attention problems, social problems, withdrawn behavior, disruptive
behavior, delinquent behavior, aggressive behavior, and self-harm behavior.
[Improved mood and behavior during treatment with a mineral-vitamin supplement:
an open-label case series of children.
Kaplan BJ, Fisher JE, Crawford SG, Field CJ, Kolb B. Journal of Child and
Adolescent Psychopharmacology. 2004 Spring;14(1):115-22.]†

Successful treatment of OCD with a micronutrient formula following partial
response to Cognitive Behavioral Therapy (CBT): a case study.

Researchers detail an off-on-off-on trial of an 18-year-old male diagnosed with
obsessive-compulsive disorder (OCD) and Asperger’s disordera who took a
micronutrient formulation co-developed† by Hardy Nutritionals® founder David
Hardy. The young man first underwent cognitive behavioral therapy (CBT) for one
year with a modest response. Within a year thereafter, his anxiety became severe
again and he began to experience major depression. After 8 weeks of using a
vitamin-mineral formulation, his mood stabilized, his anxiety reduced, and his
obsessions were in remission. Treatment was then discontinued for 8 weeks,
during which time his obsessions, anxiety, and mood worsened. Reintroduction of
the micronutrient formula again improved mood, obsession and anxiety symptoms
within 8 weeks. After taking the formulation for 6 months longer, he experienced
further improvements in mood and anxiety symptoms.
[Successful treatment of OCD with a micronutrient formula following partial
response to Cognitive Behavioral Therapy (CBT): a case study.
Rucklidge JJ. Journal of Anxiety Disorders. 2009 Aug;23(6):836-40.]†

Multinutrient supplement as treatment: literature review and case report of a
12-year-old boy with bipolar disorder.

Researchers describe a 12-year-old boy who was diagnosed at age 6 with bipolar
disorder. His diagnosis evolved to include psychotic features, generalized
anxiety disorder and obsessive-compulsive disorder. Although he was treated with
psychiatric medications for 6 years, he continued to experience many
debilitating mood, anxiety, and obsessive-compulsive symptoms. During treatment
with a micronutrient formulation co-developed† by Hardy Nutritionals® founder
David Hardy, the boy’s global functioning notably improved. He began interacting
more appropriately with peers, remained calm and playful throughout most of the
day, slept throughout the night, remained focused and efficient while completing
schoolwork, and experienced decreased compulsions. Eventually, his
hallucinations also ceased and all diagnoses fully remitted. His symptoms
remained stable during a 14-month follow-up period.
[Multinutrient supplement as treatment: literature review and case report of a
12-year-old boy with bipolar disorder.
Frazier EA, Fristad MA, Arnold LE. Journal of Child and Adolescent
Psychopharmacology. 2009 Aug;19(4):453-60.]†

Efficacy and cost of micronutrient treatment of childhood psychosis.

An 11-year-old boy with a 3-year history of mental illness and psychiatric
medication treatment was transitioned to a micronutrient formulation
co-developed† by Hardy Nutritionals® founder David Hardy. The boy was diagnosed
with multiple psychiatric disorders, including obsessive-compulsive disorder,
generalized anxiety disorder, social anxiety disorder, and psychosis—not
otherwise specified. The boy’s anxiety, obsessive-compulsive, and psychotic
symptoms decreased significantly when he took the vitamin-mineral formulation,
and his progress was maintained through a 4-year follow-up. A cost comparison
revealed that the boy’s micronutrient treatment cost less than 1% of his former
inpatient mental health care.
[Efficacy and cost of micronutrient treatment of childhood psychosis.
Rodway M, Vance A, Watters A, Lee H, Bos E, Kaplan BJ. BMJ Case Reports. 2012
Nov 9;2012.]†

Feasibility of a nutritional supplement as treatment for pediatric bipolar
spectrum disorders.

Researchers investigated the therapeutic effects of a micronutrient formulation
co-developed by Hardy Nutritionals® founder David Hardy in 7 children with
bipolar disorder. The children’s additional psychiatric diagnoses included
attention deficit hyperactivity disorder, oppositional defiant disorder, major
depressive disorder, generalized anxiety disorder, conduct disorder, and
obsessive-compulsive disorder. The children experienced a 37% decrease in
depression scores and a 45% decrease in mania scores over 8 weeks. Side effects
were minor and transient—mostly temporary gastric discomfort.
[Feasibility of a nutritional supplement as treatment for pediatric bipolar
spectrum disorders.
Frazier EA, Fristad MA, Arnold LE. Journal of Alternative and Complementary
Medicine. 2012 Jul;18(7):678-85.]†

Effect of Micronutrients on Insomnia in Adults: A Multiple-Baseline Study

Insomnia is a debilitating condition causing psychological distress and
frequently comorbid with other mental health conditions. This study examined the
effect of 8 weeks of treatment by broad spectrum micronutrients on insomnia
using a multiple-baseline-across-participants open-label trial design. Seventeen
adults were randomized to 1-, 2-, or 3-week baseline periods (14 completed).
Self-report measures were the Consensus Sleep Diary–Morning (CSD-M), the
Pittsburgh Insomnia Rating Scale (PIRS), and the Depression, Anxiety, Stress
Scale (DASS). Baselines were generally stable. Treatment completers reported
reliable and clinically significant change in insomnia severity (PIRS), in
depression, stress, and anxiety (DASS), and on at least two aspects of sleep
measured by the CDS-M. All completers were treatment-compliant, and side effects
were minimal. Nutritional supplementation is shown to be a novel, beneficial
treatment for insomnia in adults. Follow-up research using placebo-controlled
designs as well as comparisons to cognitive-behavioral and other treatments is
recommended.
[Effect of Micronutrients on Insomnia in Adults: A Multiple-Baseline Study
Joanna Lothian, Neville M. Blampied, Julia J. Rucklidge. Clinical Psychological
Science. May 23, 2016.doi:10.1177/2167702616631740]†

Micronutrient formulation outperforms medications in 88 patients with autism.

Researchers compared psychiatric medication and micronutrient treatment
approaches in 88 children with autism spectrum disorder. The micronutrient group
(taking predominately a micronutrient formulation co-developed by Hardy
Nutritionals® founder David Hardy improved significantly more than the
medication group in key ways, including notably reduced irritability, anger, and
intensity of self-injurious behaviors. The micronutrient-treated group also had
dramatically lower treatment side-effects.
[Micronutrients versus standard medication management in autism: a naturalistic
case-control study. Mehl-Madrona L, Leung B, Kennedy C, Paul S, Kaplan BJ.
Journal of Child and Adolescent Psychopharmacology. 2010 Apr;20(2):95-103.]†




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*THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FDA AND ARE NOT INTENDED TO
CURE, TREAT OR PREVENT ANY DISEASE OR DISORDER.
COPYRIGHT 2018 CARRICK INSTITUTE

†REFERS TO NEUROSPECTRUM™360 AND PRE-2013 VERSIONS OF EMPOWERPLUS, CO-FORMULATED
BY NUTRATEK™ FOUNDER DAVID HARDY.

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any disease or disorder. †Refers to Neurospectrum™360 and pre-2013 versions of
of Empowerplus, co-formulated by Nutratek™ founder David Hardy.
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