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Select
Condition Indication
* Moderate-to-Severe Eczema (Ages 6+ Months)
* Moderate-to-Severe Asthma (Ages 6+ Years)
* Chronic Rhinosinusitis with Nasal Polyposis
(Ages 18+ Years)
* Eosinophilic Esophagitis (Ages 12+ Years
weighing at least 88 lb (40 kg))
* Prurigo Nodularis (Ages 18+ Years)

* ESPAÑOL
*
* Página de inicio de franquicias
* Eczema moderado a grave (6 meses de edad o más)
* Asma moderada a grave (6 años de edad o más)

* --------------------------------------------------------------------------------
* DUPIXENT Pricing
Information
* Patient Prescribing
Information
* PATIENT INFORMATION
* Patient Information - English
* Patient Information - Spanish

* --------------------------------------------------------------------------------

* PRESCRIBING INFORMATION
* Prescribing Information - English
* Prescribing Information - Spanish

* --------------------------------------------------------------------------------

* PRE-FILLED SYRINGE INSTRUCTIONS FOR USE
* 200mg Dose - English
* 200mg Dose - Spanish
* 300mg Dose - English
* 300mg Dose - Spanish

* --------------------------------------------------------------------------------

* PRE-FILLED PEN INSTRUCTIONS FOR USE
* 200mg Dose - English
* 200mg Dose - Spanish
* 300mg Dose - English
* 300mg Dose - Spanish

* --------------------------------------------------------------------------------
* For Healthcare
Professionals
* Copay Offer

* FOR U.S. RESIDENTS ONLY

* PATIENT SUPPORT,
COST & SAVINGS

* Copay Card
* Pricing and Insurance
* DUPIXENT MyWay®
Program
* Taking
Dupixent

* Injection Support Center
* Injection Reminders and Tips
* FREQUENTLY
ASKED QUESTIONS
* Español
* Página de inicio de franquicias
* Eczema moderado a grave (6 meses de edad
o más)
* Asma moderada a grave (6 años de edad o más)
* DUPIXENT Pricing Information
* For Healthcare Professionals
* Copay Offer

CHOOSE YOUR CONDITION:

Uncontrolled Moderate-to-Severe

ECZEMA (ATOPIC DERMATITIS OR AD)

Ages 6+ Months

Add-on Maintenance Treatment for Uncontrolled Moderate-to-Severe Eosinophilic or
Oral Steroid Dependent

ASTHMA Ages 6+ Years

DUPIXENT is not used to treat sudden breathing problems

Add-on Maintenance Treatment for Uncontrolled

CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS (CRSwNP)

Ages 18+ Years

EOSINOPHILIC ESOPHAGITIS (EoE)

Ages 12+ Years weighing
at least 88 lb (40 kg)

PRURIGO NODULARIS (PN)

Ages 18+ Years

Choose A condition

Uncontrolled Moderate-to-Severe

ECZEMA (ATOPIC DERMATITIS OR AD)

Ages 6+ Months

Add-on Maintenance Treatment for Uncontrolled Moderate-to-Severe Eosinophilic or
Oral Steroid Dependent

ASTHMA Ages 6+ Years

DUPIXENT is not used to treat sudden breathing problems

Add-on Maintenance Treatment for Uncontrolled

CHRONIC RHINOSINUSITIS WITH NASAL POLYPOSIS (CRSwNP)

Ages 18+ Years

EOSINOPHILIC ESOPHAGITIS (EoE)

Ages 12+ Years weighing
at least 88 lb (40 kg)

PRURIGO NODULARIS (PN)

Ages 18+ Years

DISCOVER WHAT'S
POSSIBLE WITH DUPIXENT

DUPIXENT IS APPROVED FOR 5 INDICATIONS.

WHY DUPIXENT

DUPIXENT is a biologic. This means that it is a type of specialty medicine that
is processed in the body differently than oral or
topical medications. Biologics are used to treat a variety of conditions,
including chronic inflammatory diseases that affect
your immune system. To be effective and work in the body properly, most
biologics are delivered by injection.

THINGS TO CONSIDER WHEN TALKING TO YOUR DOCTOR:

HELPS REDUCE INFLAMMATION

DUPIXENT helps block a key source of inflammation
by targeting a root cause of your condition.

NOT A STEROID OR IMMUNOSUPPRESSANT

DUPIXENT doesn’t broadly suppress
the immune system.

CONTINUOUSLY TREATS EVEN
IN BETWEEN SYMPTOMS

DUPIXENT is a proactive treatment that helps
keep you one step ahead of your symptoms.

NO INITIAL OR ROUTINE BLOOD WORK
REQUIRED, PER PRESCRIBING INFORMATION

SAVINGS & PATIENT SUPPORT

DUPIXENT MyWay® is a patient support program designed to help you get access to
DUPIXENT and help eligible patients cover the out-of-pocket costs of DUPIXENT.
The DUPIXENT MyWay program also provides useful tools and resources to help you
stay on track with your treatment.

THE DUPIXENT MYWAY COPAY CARD

The DUPIXENT MyWay Copay Card may help eligible
patients cover the out-of-pocket cost of DUPIXENT. If
you’re eligible, you can sign up online or by phone and
your card will be sent to you via email. Terms &
Restrictions apply.

CHECK COPAY
CARD ELIGIBILITY

THE DUPIXENT MYWAY PROGRAM

The DUPIXENT MyWay patient support program is here
to help you at every step of your DUPIXENT treatment
journey. Enrolled patients receive:

* One-on-one support from our DUPIXENT MyWay
support team
* Help understanding insurance coverage
* Financial assistance (for eligible patients only)
* Help scheduling deliveries
* Virtual, over-the-phone, or home injection training

Access DUPIXENT MyWay

STAY CONNECTED
WITH DUPIXENT

Sign up now to receive emails and resources
designed to help patients, caregivers,
and
information seekers throughout the
DUPIXENT treatment journey.

SIGN UP
Choose your condition:
* Uncontrolled moderate-to-severe eczema
* Uncontrolled moderate-to-severe eosinophilic
or oral steroid dependent asthma
* Uncontrolled chronic rhinosinusitis
with nasal polyposis (CRSwNP)
* Eosinophilic esophagitis (EoE)
* Prurigo nodularis (PN)

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Transcript

I grew up in a very small town—one stop light, if you blink you might miss it.
Very quaint. The small-town environment lends to the type of work that I do,
more one-on-one with our patients.

My name is Shari and I’m a registered nurse with DUPIXENT MyWay.

I chose to be a nurse because I wanted to help people, and I believe that people
should be in service to others.

Being a nurse for DUPIXENT MyWay is very rewarding. I really enjoy the patient
interaction. I’m ready to make a difference. I’m ready to help our patients to
have the confidence to proceed with their journey.

Our nurses work remotely from our homes. So, we step into our offices, we’re
going into a nice relaxing environment.

When our patients call in, they get to speak to a real person, a experienced
clinician who can provide them support along their journey.

We provide general product support and education, as well as supplemental
injection training, and injection and refill reminder calls.

Every day is different depending on the type of calls that we have. Some of the
common questions we get: “How much is it going to cost me?” “When will I get
started?” “How do I take my DUPIXENT injections when I’m traveling?”

We have multiple resources available for patients. We have the ability to send
out package inserts that include all the important safety information for
DUPIXENT. For patients wanting a copay card, they can access that by visiting
our product website at DUPIXENT.com.

One of my favorite parts of providing nursing care to our patients is being able
to walk them through their journey, hold their hand through the process, just to
give them confidence along the way and we always want them to know that they
have our support.

LAURIE, Field Nurse

I’m Laurie. I’m a registered nurse with DUPIXENT MyWay. I’ve been with DUPIXENT
MyWay since the very beginning.

I give supplemental injection training to the patient and the patient’s
caregiver.

When I was very young, I knew that I wanted to be a nurse. I wanted to go out
and make a difference and help people.

When I get the order for the patient, I get really excited. I travel to see the
patients—sometimes for hours. I make sure that I gather all of the things that I
may need to help the experienced person, and then the person that’s never even
touched a needle.

I think it’s very important for me as a nurse to go and teach these patients.
Not only to teach them how to give themselves the medicine, but also to just
come and give them encouragement, and show them kindness and patience.

When I go to see the patient, I can’t wait to travel, no matter how far it is. I
have a training kit that has a training syringe in it. And that helps us so that
we can practice before we do the real thing.

I can’t wait to go and meet them, and see where they are in their life, and be
excited for them.

I help them to relax. Sometimes they can just take a deep breath, we’ll go slow,
think about their favorite place, think about something that reminds them and
makes them happy and calms them down.

I went to this patient’s house and he seemed very standoffish. You could tell
that the patient was just not comfortable. He was anxious, he wouldn’t give me
eye contact. So, I asked the parents, “would it be OK if I just come back the
next day?"

I think it’s very important to just be patient. Make it into their routine and
let them go at their own pace. We have time. They have set aside this time for
us to learn. And for me to teach.

Sometimes at the end of the training, I’ll get some questions about, “You know,
we did great today, but what else? What if when you leave, I don’t know what to
do and it’s time for me to give myself my injection again?” I can refer the
patient to the DUPIXENT website for more resources and there’s also a Nurse
Educator phone number.

I like to go out and do this job. It’s just really neat. It’s neat to go in and
get to know people.

DUP.23.04.0076

Transcript

DUPIXENT® (dupilumab)—a medicine with special storage requirements—is what’s
known as a specialty medicine.

That means it may be delivered to you by a specialty pharmacy instead of your
local pharmacy.

That also means you can expect the process for getting your prescription filled
to be different from other medicines you may pick up from your local pharmacy.

It will go something like this:

First, your doctor writes a prescription for DUPIXENT. Be sure to ask your
doctor about enrolling in DUPIXENT MyWay®, which can provide additional support
for you. You or your doctor can download the enrollment form on DUPIXENT.com or
call 1-844-DUPIXENT, option 1 to enroll.

Next, your prescription may have to be authorized by insurance. This is called
prior authorization and is common for specialty medicines.

Your insurance company will work with your doctor to get any additional medical
information they need.

It might feel like this part takes a while, but hang in there.

If you have enrolled in DUPIXENT MyWay, you will receive a welcome call from a
Nurse Educator while your insurance benefits are being confirmed. Once DUPIXENT
is approved by your insurer, a specialty pharmacy works with you to schedule the
shipments of DUPIXENT to your home or other preferred location, so be sure to
answer their calls to prevent delays.

They will not ship your medicine without first confirming delivery details with
you.

And while everyone’s working through the details, look to DUPIXENT MyWay for
additional support.

You can connect with DUPIXENT MyWay Nurse Educators by phone to receive
supplemental injection training, help scheduling deliveries and prescription
refills, or help navigating financial support options, such as copay assistance.

As a reminder, with all of these folks helping to get you off to good start with
DUPIXENT, you may receive phone calls from your doctor’s office, specialty
pharmacy, and a DUPIXENT MyWay Nurse Educator.

Remember to quickly respond to these calls to avoid delays in receiving
DUPIXENT. So, now you know what to expect from prescription to delivery.

For more information on how to properly store DUPIXENT after delivery, please
review the DUPIXENT Instructions for Use at DUPIXENT.com.

TRANSCRIPT

VO:

DUPIXENT® (dupilumab) is a prescription medicine used to treat people aged 6
years and older with moderate-to-severe atopic dermatitis (eczema) that is not
well controlled with prescription therapies used on the skin (topical), or who
cannot use topical therapies. DUPIXENT can be used with or without topical
corticosteroids. It is not known if DUPIXENT is safe and effective in children
with atopic dermatitis under 6 years of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in
DUPIXENT®.

Please see additional Important Safety Information throughout this video and
adjacent links for Full Prescribing Information.

Before starting DUPIXENT, you should talk to your doctor about all the medical
conditions you have or medications you are taking.

You and your doctor should also discuss the potential benefits and risks of
treatment with DUPIXENT including the most common side effects such as injection
site reactions and some serious side effects such as allergic reactions,
including anaphylaxis, and eye problems.

There is no cure for atopic dermatitis. DUPIXENT can help reduce the signs and
symptoms of eczema. Patients’ individual results with DUPIXENT may vary.

MAX:

I prefer self-injection just because I feel like it’s more controlled when I do
it.

ANA:

Max had his initial dose of 2 injections under the skin at the doctor’s office.
She gave him one injection, and she taught him how to self-inject the second. I
thought that we would go back there every 2 weeks to have the injection
administered, but he picked it up, and he was very comfortable doing it, and
he’s been self-injecting at home ever since.

ANA:

I think it’s great that he can self-inject. It’s great that he can do it at
home. We have a scheduled time that he does it. But... I can’t even look.

MAX:

She doesn’t handle it very well. She gets really anxious when I’m doing it.

ANA:

I, myself, am not comfortable with needles, and I – you know, maybe it’s because
it’s my son – I still get queasy, and I have to look away. I can’t, but he is
ok.

Important Safety Information
and Indications

Do not use if you are allergic to dupilumab or to any of the ingredients in
DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical
conditions, including if you:

* have eye problems.
* have a parasitic (helminth) infection.
* are scheduled to receive any vaccinations. You should not receive a “live
vaccine” right before and during treatment with DUPIXENT.
* are pregnant or plan to become pregnant. It is not known whether DUPIXENT
will harm your unborn baby.
* A pregnancy registry for women who take DUPIXENT during pregnancy collects
information about the health of you and your baby. To enroll or get more
information call 1-877-311-8972 or go
to https://mothertobaby.org/ongoing-study/dupixent/.
* are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT
passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or
inhaled corticosteroid medicines; have asthma and use an asthma medicine; or
have atopic dermatitis, CRSwNP, or EoE, and also have asthma. Do not change or
stop your corticosteroid medicine or other asthma medicine without talking to
your healthcare provider. This may cause other symptoms that were controlled by
the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

* Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes
be severe. Stop using DUPIXENT and tell your healthcare provider or get
emergency help right away if you get any of the following signs or symptoms:
breathing problems or wheezing, swelling of the face, lips, mouth, tongue or
throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives,
joint pain, general ill feeling, itching, skin rash, swollen lymph nodes,
nausea or vomiting, or cramps in your stomach-area.
* Eye problems. Tell your healthcare provider if you have any new or worsening
eye problems, including eye pain or changes in vision, such as blurred
vision. Your healthcare provider may send you to an ophthalmologist for an
exam if needed.
* Inflammation of your blood vessels. Rarely, this can happen in people with
asthma who receive DUPIXENT. This may happen in people who also take a
steroid medicine by mouth that is being stopped or the dose is being lowered.
It is not known whether this is caused by DUPIXENT. Tell your healthcare
provider right away if you have: rash, chest pain, worsening shortness of
breath, a feeling of pins and needles or numbness of your arms or legs, or
persistent fever.
* Joint aches and pain. Some people who use DUPIXENT have had trouble walking
or moving due to their joint symptoms, and in some cases needed to be
hospitalized. Tell your healthcare provider about any new or worsening joint
symptoms. Your healthcare provider may stop DUPIXENT if you develop joint
symptoms.

The most common side effects include:

* Atopic dermatitis: injection site reactions, eye and eyelid inflammation,
including redness, swelling, and itching, sometimes with blurred vision, cold
sores in your mouth or on your lips, and high count of a certain white blood
cell (eosinophilia).
* Asthma: injection site reactions, pain in the throat (oropharyngeal pain),
high count of a certain white blood cell (eosinophilia), and parasitic
(helminth) infections.
* Chronic rhinosinusitis with nasal polyposis: injection site reactions, eye
and eyelid inflammation, including redness, swelling, and itching, sometimes
with blurred vision, high count of a certain white blood cell (eosinophilia),
trouble sleeping (insomnia), toothache, gastritis, and joint pain
(arthralgia).
* Eosinophilic esophagitis: injection site reactions, upper respiratory tract
infections, cold sores in your mouth or on your lips, and joint pain
(arthralgia).

Tell your healthcare provider if you have any side effect that bothers you or
that does not go away. These are not all the possible side effects of DUPIXENT.
Call your doctor for medical advice about side effects. You are encouraged to
report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an
injection given under the skin (subcutaneous injection). Your healthcare
provider will decide if you or your caregiver can inject DUPIXENT. Do not try to
prepare and inject DUPIXENT until you or your caregiver have been trained by
your healthcare provider. In children 12 years of age and older, it’s
recommended DUPIXENT be administered by or under supervision of an adult. In
children under 12 years of age, DUPIXENT should be given by a caregiver.

Please see accompanying full Prescribing Information including Patient
Information.

Indications

DUPIXENT is a prescription medicine used:

* to treat adults and children 6 months of age and older with
moderate-to-severe atopic dermatitis (eczema) that is not well controlled
with prescription therapies used on the skin (topical), or who cannot use
topical therapies. DUPIXENT can be used with or without topical
corticosteroids. It is not known if DUPIXENT is safe and effective in
children with atopic dermatitis under 6 months of age.
* with other asthma medicines for the maintenance treatment of
moderate-to-severe eosinophilic or oral steroid dependent asthma in adults
and children 6 years of age and older whose asthma is not controlled with
their current asthma medicines. DUPIXENT helps prevent severe asthma attacks
(exacerbations) and can improve your breathing. DUPIXENT may also help reduce
the amount of oral corticosteroids you need while preventing severe asthma
attacks and improving your breathing. DUPIXENT is not used to treat sudden
breathing problems. It is not known if DUPIXENT is safe and effective in
children with asthma under 6 years of age.
* with other medicines for the maintenance treatment of chronic rhinosinusitis
with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It
is not known if DUPIXENT is safe and effective in children with chronic
rhinosinusitis with nasal polyposis under 18 years of age.
* to treat adults and children 12 years of age and older, who weigh at least 88
pounds (40 kg), with eosinophilic esophagitis (EoE). It is not known if
DUPIXENT is safe and effective in children with eosinophilic esophagitis
under 12 years of age and who weigh at least 88 pounds (40 kg).

Transcript

VO: DUPIXENT is a prescription medicine used:

* to treat people aged 6 years and older with moderate-to-severe atopic
dermatitis (eczema) that is not well controlled with prescription therapies
used on the skin (topical), or who cannot use topical therapies. DUPIXENT can
be used with or without topical corticosteroids. It is not known if DUPIXENT
is safe and effective in children with atopic dermatitis under 6 years of
age.
* with other asthma medicines for the maintenance treatment of
moderate-to-severe eosinophilic or oral steroid dependent asthma in people
aged 12 years and older whose asthma is not controlled with their current
asthma medicines. DUPIXENT helps prevent severe asthma attacks
(exacerbations) and can improve your breathing. DUPIXENT may also help reduce
the amount of oral corticosteroids you need while preventing severe asthma
attacks and improving your breathing. DUPIXENT is not used to treat sudden
breathing problems. It is not known if DUPIXENT is safe and effective in
children with
* with other medicines for the maintenance treatment of chronic rhinosinusitis
with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It
is not known if DUPIXENT is safe and effective in children with chronic
rhinosinusitis with nasal polyposis under 18 years of age.

Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in
DUPIXENT®.

Please see additional Important Safety Information throughout this video and
adjacent links for full Prescribing Information asthma under 12 years of age.

Before starting DUPIXENT, you should talk to your doctor about all the medical
conditions you have and medications you are taking.

You and your doctor should also discuss the potential benefits and risks of
treatment with DUPIXENT including the most common side effects such as injection
site reactions, and some serious side effects such as allergic reactions
including anaphylaxis, eye problems and inflammation of your blood vessels.

JENNIFER: If you’re thinking about trying DUPIXENT, I would say, talk to your
doctor, get connected with DUPIXENT MyWay, and make sure you’ve got a support
system out there cheering you on. manage the disease.

RACHEL: I highly recommend getting a good physician that you can talk to that
you trust, and have that open communication. Develop a good treatment plan
together and advocate for yourself.

KRISTY: Know that there is DUPIXENT MyWay. There's always someone there to
support you and that they're on your side. If any concerns arise or you have any
problems, that there will always be someone there to help you.

CHLOE: It was so nice knowing that I could call that number anytime to talk to a
nurse or whoever to give me more information to find out more about DUPIXENT,
whether it was payment or how to inject or anything like that.

SUE: I don’t even think about giving myself an injection anymore. It’s just like
putting on makeup or brushing your hair. It’s just there.

But everybody’s different. I know it can be kind of nerve-wracking, it’s so
worth it.

JACQUE: There's help out there for you now. The advice I would give someone
starting DUPIXENT is to ask all the questions that you have. Talk to your
doctor.

Be optimistic. Be persistent and look forward to the possibilities that lie
ahead of you with DUPIXENT.

VO: Do not use if you are allergic to dupilumab or to any of the ingredients in
DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical
conditions, including if you:

* have eye problems
* have a parasitic (helminth) infection
* are scheduled to receive any vaccinations. You should not receive a “live
vaccine” if you are treated with DUPIXENT.

Transcript

Let’s take a second to get situated before we begin our breathing exercise.

Find a spot where you can be still and quiet. Get into a comfortable position.
This can be seated, standing, or laying down. Pause for just a moment before you
begin.

Now, close your eyes and settle your mind.

Focus on your body relaxing as you settle into position. Relax your muscles;
start with your toes, work upward to your arms and then your head. Transition
your focus to your breath.

Slowly take a deep breath. Let your stomach expand [pause], and now your rib
cage, and your chest. Pause for just a moment.

Exhale at the same pace as the inhale. Allow the breath to come steadily out of
your nose until your lungs are completely empty.

Pay attention when you breathe in. First your stomach rises, then your rib cage,
finally your chest. Notice each of them fall as you breathe out: chest, rib
cage, stomach.

Feel your body respond as you continue to breathe.

This can be done for as long as you like. You can repeat this any time you are
feeling anxious to help calm yourself.

ORE:
I like when my dad does my injection for me. He was trained by my doctor.

YETUNDE:
Ore’s dermatologist trained us on how to do the injection under the skin, and
then when we contacted DUPIXENT MyWay, they sent a nurse to the house to give
additional training to make sure that we were comfortable giving the injection.

ORE:
I feel like one day I will do it myself, but I think right now assisted
injection is better.

YETUNDE:
I do remember her dad asking, “Are you sure that you’re comfortable with this,”
it being an injection under the skin, and she was. I’m the one that cringes with
needles, but she does great.

ORE:
I see the injection as something that I just have to do, and it doesn’t freak me
out as much as it did in the beginning. I don’t really get scared anymore.

Voice-over (VO):
Important Safety Information

Do not use if you are allergic to dupilumab or to any of the ingredients in
DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical
conditions, including if you:

• have eye problems.

• have a parasitic (helminth) infection.

• are scheduled to receive any vaccinations. You should not receive a “live
vaccine” right before and during treatment with DUPIXENT.

• are pregnant or plan to become pregnant. It is not known whether DUPIXENT will
harm your unborn baby.

o A pregnancy registry for women who take DUPIXENT during pregnancy collects
information about the health of you and your baby. To enroll or get more
information call 1-877-311-8972 or go to
https://mothertobaby.org/ongoing-study/dupixent/.

• are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT
passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical or
inhaled corticosteroid medicines or if you have atopic dermatitis and asthma and
use an asthma medicine. Do not change or stop your corticosteroid medicine or
other asthma medicine without talking to your healthcare provider. This may
cause other symptoms that were controlled by the corticosteroid medicine or
other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

• Allergic reactions. DUPIXENT can cause allergic reactions that can sometimes
be severe. Stop using DUPIXENT and tell your healthcare provider or get
emergency help right away if you get any of the following signs or symptoms:
breathing problems or wheezing, swelling of the face, lips, mouth, tongue, or
throat, fainting, dizziness, feeling lightheaded, fast pulse, fever, hives,
joint pain, general ill feeling, itching, skin rash, swollen lymph nodes, nausea
or vomiting, or cramps in your stomach-area.

• Eye problems. Tell your healthcare provider if you have any new or worsening
eye problems, including eye pain or changes in vision, such as blurred vision.
Your healthcare provider may send you to an ophthalmologist for an eye exam if
needed.

• Joint aches and pain. Some people who use DUPIXENT have had trouble walking or
moving due to their joint symptoms, and in some cases needed to be hospitalized.
Tell your healthcare provider about any new or worsening joint symptoms. Your
healthcare provider may stop DUPIXENT if you develop joint symptoms.

The most common side effects in patients with eczema include injection site
reactions, eye and eyelid inflammation, including redness, swelling, and
itching, sometimes with blurred vision, cold sores in your mouth or on your
lips, and high count of a certain white blood cell (eosinophilia).

Tell your healthcare provider if you have any side effect that bothers you or
that does not go away. These are not all possible side effects of DUPIXENT. Call
your doctor for medical advice about side effects. You are encouraged to report
negative side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an
injection given under the skin (subcutaneous injection). Your healthcare
provider will decide if you or your caregiver can inject DUPIXENT. Do not try to
prepare and inject DUPIXENT until you or your caregiver have been trained by
your healthcare provider. In children 12 years of age and older, it’s
recommended DUPIXENT be administered by or under supervision of an adult. In
children 6 months to less than 12 years of age, DUPIXENT should be given by a
caregiver.

Please see adjacent links for full Prescribing Information including Patient
Information.

Important Safety Information
and Indications

Do not use if you are allergic to dupilumab or to any of the ingredients in
DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical
conditions, including if you:

* have eye problems.
* have a parasitic (helminth) infection.
* are scheduled to receive any vaccinations. You should not receive a “live
vaccine” right before and during treatment with DUPIXENT.
* are pregnant or plan to become pregnant. It is not known whether DUPIXENT
will harm your unborn baby.
* A pregnancy registry for women who take DUPIXENT during pregnancy collects
information about the health of you and your baby. To enroll or get more
information call 1-877-311-8972 or go to
https://mothertobaby.org/ongoing-study/dupixent/.
* are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT
passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or
inhaled corticosteroid medicines; have asthma and use an asthma medicine; or
have atopic dermatitis, chronic rhinosinusitis with nasal polyposis,
eosinophilic esophagitis, or prurigo nodularis and also have asthma. Do not
change or stop your corticosteroid medicine or other asthma medicine without
talking to your healthcare provider. This may cause other symptoms that were
controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

The most common side effects include:

* Eczema: injection site reactions, eye and eyelid inflammation, including
redness, swelling, and itching, sometimes with blurred vision, cold sores in
your mouth or on your lips, and high count of a certain white blood cell
(eosinophilia).
* Asthma: injection site reactions, high count of a certain white blood cell
(eosinophilia), pain in the throat (oropharyngeal pain), and parasitic
(helminth) infections.
* Chronic Rhinosinusitis with Nasal Polyposis: injection site reactions, eye
and eyelid inflammation, including redness, swelling, and itching, sometimes
with blurred vision, high count of a certain white blood cell (eosinophilia),
gastritis, joint pain (arthralgia), trouble sleeping (insomnia), and
toothache.
* Eosinophilic Esophagitis: injection site reactions, upper respiratory tract
infections, cold sores in your mouth or on your lips, and joint pain
(arthralgia).
* Prurigo Nodularis: eye and eyelid inflammation, including redness, swelling,
and itching, sometimes with blurred vision, herpes virus infections, common
cold symptoms (nasopharyngitis), dizziness, muscle pain, and diarrhea.

Tell your healthcare provider if you have any side effect that bothers you or
that does not go away. These are not all the possible side effects of DUPIXENT.
Call your doctor for medical advice about side effects. You are encouraged to
report negative side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an
injection given under the skin (subcutaneous injection). Your healthcare
provider will decide if you or your caregiver can inject DUPIXENT. Do not try to
prepare and inject DUPIXENT until you or your caregiver have been trained by
your healthcare provider. In children 12 years of age and older, it’s
recommended DUPIXENT be administered by or under supervision of an adult. In
children 6 months to less than 12 years of age, DUPIXENT should be given by a
caregiver.

Please see accompanying adjacent links for full Prescribing Information
including Patient Information.

INDICATIONS

DUPIXENT is a prescription medicine used:

* to treat adults and children 6 months of age and older with
moderate-to-severe eczema (atopic dermatitis or AD) that is not well
controlled with prescription therapies used on the skin (topical), or who
cannot use topical therapies. DUPIXENT can be used with or without topical
corticosteroids. It is not known if DUPIXENT is safe and effective in
children with atopic dermatitis under 6 months of age.
* with other asthma medicines for the maintenance treatment of
moderate-to-severe eosinophilic or oral steroid dependent asthma in adults
and children 6 years of age and older whose asthma is not controlled with
their current asthma medicines. DUPIXENT helps prevent severe asthma attacks
(exacerbations) and can improve your breathing. DUPIXENT may also help reduce
the amount of oral corticosteroids you need while preventing severe asthma
attacks and improving your breathing. DUPIXENT is not used to treat sudden
breathing problems. It is not known if DUPIXENT is safe and effective in
children with asthma under 6 years of age.
* with other medicines for the maintenance treatment of chronic rhinosinusitis
with nasal polyposis (CRSwNP) in adults whose disease is not controlled. It
is not known if DUPIXENT is safe and effective in children with chronic
rhinosinusitis with nasal polyposis under 18 years of age.
* to treat adults and children 12 years of age and older, who weigh at least 88
pounds (40 kg), with eosinophilic esophagitis (EoE). It is not known if
DUPIXENT is safe and effective in children with eosinophilic esophagitis
under 12 years of age and who weigh at least 88 pounds (40 kg).
* to treat adults with prurigo nodularis (PN). It is not known if DUPIXENT is
safe and effective in children with prurigo nodularis under 18 years of age.

Important Safety Information
and Indications

Do not use if you are allergic to dupilumab or to any of the ingredients in
DUPIXENT®.

Before using DUPIXENT, tell your healthcare provider about all your medical
conditions, including if you:

* have eye problems.
* have a parasitic (helminth) infection.
* are scheduled to receive any vaccinations. You should not receive a “live
vaccine” right before and during treatment with DUPIXENT.
* are pregnant or plan to become pregnant. It is not known whether DUPIXENT
will harm your unborn baby.
* A pregnancy registry for women who take DUPIXENT during pregnancy collects
information about the health of you and your baby. To enroll or get more
information call 1-877-311-8972 or go to
https://mothertobaby.org/ongoing-study/dupixent/.
* are breastfeeding or plan to breastfeed. It is not known whether DUPIXENT
passes into your breast milk.

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you are taking oral, topical, or
inhaled corticosteroid medicines; have asthma and use an asthma medicine; or
have atopic dermatitis, chronic rhinosinusitis with nasal polyposis,
eosinophilic esophagitis, or prurigo nodularis and also have asthma. Do not
change or stop your corticosteroid medicine or other asthma medicine without
talking to your healthcare provider. This may cause other symptoms that were
controlled by the corticosteroid medicine or other asthma medicine to come back.

DUPIXENT can cause serious side effects, including:

The most common side effects include:

Tell your healthcare provider if you have any side effect that bothers you or
that does not go away. These are not all the possible side effects of DUPIXENT.
Call your doctor for medical advice about side effects. You are encouraged to
report negative side effects of prescription drugs to the FDA. Visit
www.fda.gov/medwatch, or call 1-800-FDA-1088.

Use DUPIXENT exactly as prescribed by your healthcare provider. It’s an
injection given under the skin (subcutaneous injection). Your healthcare
provider will decide if you or your caregiver can inject DUPIXENT. Do not try to
prepare and inject DUPIXENT until you or your caregiver have been trained by
your healthcare provider. In children 12 years of age and older, it’s
recommended DUPIXENT be administered by or under supervision of an adult. In
children 6 months to less than 12 years of age, DUPIXENT should be given by a
caregiver.

Please see accompanying adjacent links for full Prescribing Information
including Patient Information.

INDICATIONS

DUPIXENT is a prescription medicine used:

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Site Map
Legal Disclaimer Information Privacy Preference Center

Questions or comments?
Contact Sanofi US or Regeneron Pharmaceuticals, Inc. or call 1-844-387-4936 to
contact DUPIXENT MyWay®.

DUPIXENT® and DUPIXENT MyWay® are registered trademarks of Sanofi Biotechnology.

DUP.23.06.0135 Last Update: August 2023

Sanofi US is hosting this website on behalf of Sanofi and Regeneron
Pharmaceuticals, Inc.

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