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 * Patient Information
 * Important Safety Information
 * Healthcare Professionals Site
 * Medical Information 1-833-267-0545

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 * About Zokinvy
   * About progeria and PDPL
   * How ZOKINVY works
 * Zokinvy results
 * How Zokinvy is given
 * Eiger OneCare™ support
 * Resources

 * About Zokinvy
   * About progeria and PDPL
   * How ZOKINVY works
 * Zokinvy results
 * How Zokinvy is given
 * Eiger OneCare™ support
 * Resources

For U.S. Audiences Only

 * Patient Information
 * Important Safety Information
 * Healthcare Professionals Site
 * Medical Information 1-833-267-0545

Get More Of What Matters With Zokinvy®

Zokinvy is the first and only treatment to target the cause and symptoms of
progeria, also known as Hutchinson-Gilford progeria syndrome, and
processing-deficient progeroid laminopathies (PDPL) in young people 12 months of
age and older.

See How it Works

Michiel, 21, Belgium. Photo courtesy of The Progeria Research Foundation.




CONNECT WITH EIGER ONECARE™

Get in touch with your dedicated team of specialists to see what they can do for
your family.

Connect Now



LEARN ABOUT ZOKINVY

Zokinvy was studied in clinical trials to ensure its safety and effectiveness.

See the Results

LOOKING FOR MORE INFORMATION?

Get downloadable materials and links to advocacy groups on our resources page.

Learn More
Amen, 21, Togo. Photo courtesy of The Progeria Research Foundation.

IMPORTANT SAFETY INFORMATION

Do not take ZOKINVY if you are taking:

 * a strong or moderate CYP3A inhibitor or inducer
 * midazolam
 * lovastatin, simvastatin, and atorvastatin

Tell your healthcare provider about all the medicines you take, including
prescription and over-the-counter medicines, vitamins, and herbal supplements.
ZOKINVY and other medicines may affect each other, causing serious side effects.
Talk with your healthcare provider before taking any new medicines.

BEFORE TAKING ZOKINVY, TELL YOUR HEALTHCARE PROVIDER ABOUT ALL OF YOUR MEDICAL
CONDITIONS, INCLUDING IF YOU:

 * have kidney problems.
 * have eye problems.
 * are pregnant or plan to become pregnant. ZOKINVY can harm your unborn baby.
   Women who are able to become pregnant should use effective birth control
   (contraception) during treatment with ZOKINVY.
 * are breastfeeding or plan to breastfeed. It is not known if ZOKINVY can pass
   into your breast milk. Talk to your healthcare provider about the best way to
   feed your baby during treatment with ZOKINVY.

Do not give ZOKINVY to children under the age of 12 months because it has not
been studied in this age group.

HOW SHOULD I TAKE ZOKINVY?

 * Take ZOKINVY exactly as your healthcare provider tells you to.
 * Do not stop taking ZOKINVY without talking to your healthcare provider. Your
   healthcare provider may change your dose of ZOKINVY if needed.
 * Your healthcare provider will provide you with the dose you should be taking.
   The dose is based on body size (height and weight).
 * Take ZOKINVY 2 times a day with food.
 * Swallow ZOKINVY capsules whole with an adequate amount of water. Do not chew
   ZOKINVY capsules.
 * If you or your child cannot swallow the ZOKINVY capsule whole, see the
   detailed Instructions for Use that comes with ZOKINVY for information about
   how to prepare and give or take a dose of ZOKINVY by mixing the contents of a
   ZOKINVY capsule with either Ora-Blend SF, Ora-Plus, orange juice, or
   applesauce.
 * Each dose of ZOKINVY mixture must be prepared fresh and taken within about 10
   minutes of mixing.
 * Do not take ZOKINVY with any juice that contains grapefruit or Seville
   oranges. Seville oranges may also be called bitter or sour oranges.
 * If you miss a dose of ZOKINVY, take it as soon as possible up to 8 hours
   before your next scheduled dose with food. If it is less than 8 hours before
   your next dose of ZOKINVY, skip the missed dose and take ZOKINVY at your next
   regularly scheduled dose.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF ZOKINVY?

ZOKINVY may cause serious side effects, including:

Severe kidney problems. ZOKINVY may cause severe kidney problems. Your
healthcare provider will monitor your kidney function regularly during treatment
with ZOKINVY.

Eye problems. ZOKINVY may cause problems with night vision. Call your healthcare
provider right away if you develop any new changes in your vision.

The most common side effects of ZOKINVY include:

 * vomiting
 * diarrhea
 * decreased appetite
 * nausea
 * stomach-area (abdominal) pain
 * tiredness
 * increased liver enzyme blood test results

 * weight loss
 * constipation
 * muscle and joint (musculoskeletal) pain
 * upper respiratory tract infection

Call your healthcare provider if you continue to have nausea, vomiting, or
diarrhea that leads to loss of appetite and weight loss during your treatment
with ZOKINVY.

ZOKINVY may cause an increase in your blood pressure (hypertension). Your
healthcare provider will check your blood pressure during treatment with
ZOKINVY. Call your healthcare provider right away if you develop any symptoms of
high blood pressure including headaches, shortness of breath, nosebleeds,
flushing, tiredness, dizziness, vision problems, irregular heartbeat, or chest
pain.

ZOKINVY may cause fertility problems in women and men, which may affect your
ability to have children. Talk to your healthcare provider if you have concerns
about fertility. These are not all of the possible side effects of ZOKINVY.

You are encouraged to report negative side effects of prescription drugs to
Eiger BioPharmaceuticals, Inc. at 1-833-267-0545 or the FDA at 1-800-FDA-1088 or
www.fda.gov/medwatch.

For more information, please see the full Prescribing Information, including the
Patient Information.

WHAT IS Zokinvy® (lonafarnib)?

ZOKINVY (zoh-KIN-vee) is a prescription medicine used to treat
Hutchinson-Gilford Progeria Syndrome and some types of Progeroid Laminopathies
known as processing-deficient Progeroid Laminopathies. These illnesses are
caused when the body makes harmful proteins called progerin and progerin-like
proteins.

When used for Progeroid Laminopathies, ZOKINVY is only for those Progeroid
Laminopathies associated with the production of these harmful irregular
(progerin-like) proteins.



IMPORTANT SAFETY INFORMATION

Do not take ZOKINVY if you are taking:

 * a strong or moderate CYP3A inhibitor or inducer
 * midazolam
 * lovastatin, simvastatin, and atorvastatin

WHAT IS Zokinvy® (lonafarnib)?

ZOKINVY (zoh-KIN-vee) is a prescription medicine used to treat
Hutchinson-Gilford Progeria Syndrome and some types of Progeroid Laminopathies
known as processing-deficient Progeroid Laminopathies. These illnesses are
caused when the body makes harmful proteins called progerin and progerin-like
proteins.

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