ods.od.nih.gov Open in urlscan Pro
2607:f220:41a:431d::89bb:ad99  Public Scan

URL: https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/
Submission: On July 22 via api from US — Scanned from DE

Form analysis 2 forms found in the DOM

POST ./

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                <h1 id="ctl00_ctl00_cphMain_contentTitle" class="fsTitle">Zinc</h1>
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                  <h2>Table of Contents</h2>
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                    <li class="l1"><a href="#h1">Introduction</a></li>
                    <li class="l1"><a href="#h2">Recommended Intakes</a></li>
                    <li class="l1"><a href="#h3">Sources of Zinc</a></li>
                    <li class="l1"><a href="#h7">Zinc Intakes and Status</a></li>
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                    <li class="l1"><a href="#h28">Zinc and Healthful Diets</a></li>
                    <li><a href="#ref">References</a></li>
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              <p><em>This is a fact sheet intended for health professionals. For a reader-friendly overview of Zinc, see our</em> <a href="/factsheets/Zinc-Consumer/">consumer fact sheet on Zinc</a>.</p><!-- docid = 66 -->
              <p><em>For information on zinc and COVID-19, see <a href="/factsheets/list-all/#COVID19">Dietary Supplements in the Time of COVID-19</a>.</em></p>
              <h2 id="h1">Introduction</h2>
              <p>Zinc is an essential mineral that is naturally present in some foods, added to others, and available as a dietary supplement. Zinc is also found in many cold lozenges and some over-the-counter drugs sold as cold remedies.</p>
              <p>Zinc is involved in numerous aspects of cellular metabolism. It is required for the catalytic activity of approximately 100 enzymes [<a href="#en1" class="fscopy_nounderline">1</a>,<a href="#en2" class="fscopy_nounderline">2</a>] and
                it plays a role in immune function [<a href="#en3" class="fscopy_nounderline">3</a>,<a href="#en4" class="fscopy_nounderline">4</a>], protein synthesis [<a href="#en4" class="fscopy_nounderline">4</a>], wound healing
                [<a href="#en5" class="fscopy_nounderline">5</a>], DNA synthesis [<a href="#en2" class="fscopy_nounderline">2</a>,<a href="#en4" class="fscopy_nounderline">4</a>], and cell division [<a href="#en4" class="fscopy_nounderline">4</a>].
                Zinc also supports normal growth and development during pregnancy, childhood, and adolescence [<a href="#en6" class="fscopy_nounderline">6-8</a>] and is required for proper sense of taste and smell
                [<a href="#en9" class="fscopy_nounderline">9</a>]. A daily intake of zinc is required to maintain a steady state because the body has no specialized zinc storage system [<a href="#en10" class="fscopy_nounderline">10</a>].</p>
              <h2 id="h2">Recommended Intakes</h2>
              <p>Intake recommendations for zinc and other nutrients are provided in the Dietary Reference Intakes (DRIs) developed by the Food and Nutrition Board (FNB) at the Institute of Medicine of the National Academies (formerly National
                Academy of Sciences) [<a href="#en2" class="fscopy_nounderline">2</a>]. DRI is the general term for a set of reference values used for planning and assessing nutrient intakes of healthy people. These values, which vary by age and
                gender [<a href="#en2" class="fscopy_nounderline">2</a>], include the following:</p>
              <ul>
                <li>Recommended Dietary Allowance (RDA): Average daily level of intake sufficient to meet the nutrient requirements of nearly all (97%–98%) healthy individuals; often used to plan nutritionally adequate diets for individuals.</li>
                <li>Adequate Intake (AI): Intake at this level is assumed to ensure nutritional adequacy; established when evidence is insufficient to develop an RDA.</li>
                <li>Estimated Average Requirement (EAR): Average daily level of intake estimated to meet the requirements of 50% of healthy individuals; usually used to assess the nutrient intakes of groups of people and to plan nutritionally
                  adequate diets for them; can also be used to assess the nutrient intakes of individuals.</li>
                <li>Tolerable Upper Intake Level (UL): Maximum daily intake unlikely to cause adverse health effects.</li>
              </ul>
              <p>The current RDAs for zinc are listed in Table 1 [<a href="#en2" class="fscopy_nounderline">2</a>]. For infants aged 0 to 6 months, the FNB established an AI for zinc that is equivalent to the mean intake of zinc in healthy, breastfed
                infants.</p>
              <table border="1">
                <caption>Table 1: Recommended Dietary Allowances (RDAs) for Zinc [<a href="#en2" class="fscopy_nounderline">2</a>]</caption>
                <thead>
                  <tr>
                    <th scope="col">Age</th>
                    <th scope="col">Male</th>
                    <th scope="col">Female</th>
                    <th scope="col">Pregnancy</th>
                    <th scope="col">Lactation</th>
                  </tr>
                </thead>
                <tbody>
                  <tr>
                    <td scope="row">0–6 months</td>
                    <td align="right">2 mg*</td>
                    <td align="right">2 mg*</td>
                    <td align="right"></td>
                    <td align="right"></td>
                  </tr>
                  <tr>
                    <td scope="row">7–12 months</td>
                    <td align="right">3 mg</td>
                    <td align="right">3 mg</td>
                    <td align="right"></td>
                    <td align="right"></td>
                  </tr>
                  <tr>
                    <td scope="row">1–3 years</td>
                    <td align="right">3 mg</td>
                    <td align="right">3 mg</td>
                    <td align="right"></td>
                    <td align="right"></td>
                  </tr>
                  <tr>
                    <td scope="row">4–8 years</td>
                    <td align="right">5 mg</td>
                    <td align="right">5 mg</td>
                    <td align="right"></td>
                    <td align="right"></td>
                  </tr>
                  <tr>
                    <td scope="row">9–13 years</td>
                    <td align="right">8 mg</td>
                    <td align="right">8 mg</td>
                    <td align="right"></td>
                    <td align="right"></td>
                  </tr>
                  <tr>
                    <td scope="row">14–18 years</td>
                    <td align="right">11 mg</td>
                    <td align="right">9 mg</td>
                    <td align="right">12 mg</td>
                    <td align="right">13 mg</td>
                  </tr>
                  <tr>
                    <td scope="row">19+ years</td>
                    <td align="right">11 mg</td>
                    <td align="right">8 mg</td>
                    <td align="right">11 mg</td>
                    <td align="right">12 mg</td>
                  </tr>
                </tbody>
              </table>
              <p style="padding-top: 0px;">* Adequate Intake (AI)</p>
              <h2 id="h3">Sources of Zinc</h2>
              <h4>Food</h4>
              <p>A wide variety of foods contain zinc (Table 2) [<a href="#en2" class="fscopy_nounderline">2</a>]. Oysters contain more zinc per serving than any other food, but red meat and poultry provide the majority of zinc in the American diet.
                Other good food sources include beans, nuts, certain types of seafood (such as crab and lobster), whole grains, fortified breakfast cereals, and dairy products
                [<a href="#en2" class="fscopy_nounderline">2</a>,<a href="#en11" class="fscopy_nounderline">11</a>].</p>
              <p>Phytates—which are present in whole-grain breads, cereals, legumes, and other foods—bind zinc and inhibit its absorption
                [<a href="#en2" class="fscopy_nounderline">2</a>,<a href="#en12" class="fscopy_nounderline">12</a>,<a href="#en13" class="fscopy_nounderline">13</a>]. Thus, the bioavailability of zinc from grains and plant foods is lower than that
                from animal foods, although many grain- and plant-based foods are still good sources of zinc [<a href="#en2" class="fscopy_nounderline">2</a>].</p>
              <table border="1">
                <caption style="text-align: left;">Table 2: Zinc Content of Selected Foods [<a href="#en11" class="fscopy_nounderline">11</a>]</caption>
                <thead>
                  <tr>
                    <th scope="col">Food</th>
                    <th scope="col">Milligrams (mg)<br> per serving</th>
                    <th scope="col">Percent DV*</th>
                  </tr>
                </thead>
                <tbody>
                  <tr>
                    <td scope="row">Oysters, cooked, breaded and fried, 3 ounces</td>
                    <td align="right">74.0</td>
                    <td align="right">673</td>
                  </tr>
                  <tr>
                    <td scope="row">Beef chuck roast, braised, 3 ounces</td>
                    <td align="right">7.0</td>
                    <td align="right">64</td>
                  </tr>
                  <tr>
                    <td scope="row">Crab, Alaska king, cooked, 3 ounces</td>
                    <td align="right">6.5</td>
                    <td align="right">59</td>
                  </tr>
                  <tr>
                    <td scope="row">Beef patty, broiled, 3 ounces</td>
                    <td align="right">5.3</td>
                    <td align="right">48</td>
                  </tr>
                  <tr>
                    <td scope="row">Lobster, cooked, 3 ounces</td>
                    <td align="right">3.4</td>
                    <td align="right">31</td>
                  </tr>
                  <tr>
                    <td scope="row">Pork chop, loin, cooked, 3 ounces</td>
                    <td align="right">2.9</td>
                    <td align="right">26</td>
                  </tr>
                  <tr>
                    <td scope="row">Baked beans, canned, plain or vegetarian, ½ cup</td>
                    <td align="right">2.9</td>
                    <td align="right">26</td>
                  </tr>
                  <tr>
                    <td scope="row">Breakfast cereal, fortified with 25% of the DV for zinc, 1 serving</td>
                    <td align="right">2.8</td>
                    <td align="right">25</td>
                  </tr>
                  <tr>
                    <td scope="row">Chicken, dark meat, cooked, 3 ounces</td>
                    <td align="right">2.4</td>
                    <td align="right">22</td>
                  </tr>
                  <tr>
                    <td scope="row">Pumpkin seeds, dried, 1 ounce</td>
                    <td align="right">2.2</td>
                    <td align="right">20</td>
                  </tr>
                  <tr>
                    <td scope="row">Yogurt, fruit, low fat, 8 ounces</td>
                    <td align="right">1.7</td>
                    <td align="right">15</td>
                  </tr>
                  <tr>
                    <td scope="row">Cashews, dry roasted, 1 ounce</td>
                    <td align="right">1.6</td>
                    <td align="right">15</td>
                  </tr>
                  <tr>
                    <td scope="row">Chickpeas, cooked, ½ cup</td>
                    <td align="right">1.3</td>
                    <td align="right">12</td>
                  </tr>
                  <tr>
                    <td scope="row">Cheese, Swiss, 1 ounce</td>
                    <td align="right">1.2</td>
                    <td align="right">11</td>
                  </tr>
                  <tr>
                    <td scope="row">Oatmeal, instant, plain, prepared with water, 1 packet</td>
                    <td align="right">1.1</td>
                    <td align="right">10</td>
                  </tr>
                  <tr>
                    <td scope="row">Milk, low-fat or non fat, 1 cup</td>
                    <td align="right">1.0</td>
                    <td align="right">9</td>
                  </tr>
                  <tr>
                    <td scope="row">Almonds, dry roasted, 1 ounce</td>
                    <td align="right">0.9</td>
                    <td align="right">8</td>
                  </tr>
                  <tr>
                    <td scope="row">Kidney beans, cooked, ½ cup</td>
                    <td align="right">0.9</td>
                    <td align="right">8</td>
                  </tr>
                  <tr>
                    <td scope="row">Chicken breast, roasted, skin removed, ½ breast</td>
                    <td align="right">0.9</td>
                    <td align="right">8</td>
                  </tr>
                  <tr>
                    <td scope="row">Cheese, cheddar or mozzarella, 1 ounce</td>
                    <td align="right">0.9</td>
                    <td align="right">8</td>
                  </tr>
                  <tr>
                    <td scope="row">Peas, green, frozen, cooked, ½ cup</td>
                    <td align="right">0.5</td>
                    <td align="right">5</td>
                  </tr>
                  <tr>
                    <td scope="row">Flounder or sole, cooked, 3 ounces</td>
                    <td align="right">0.3</td>
                    <td align="right">3</td>
                  </tr>
                </tbody>
              </table>
              <p style="padding-top: 0px;">* DV = Daily Value. The U.S. Food and Drug Administration (FDA) developed DVs to help consumers compare the nutrient contents of foods and dietary supplements within the context of a total diet. The DV for
                zinc is 11 mg for adults and children aged 4 years and older [<a href="#en14" class="fscopy_nounderline">14</a>]. FDA does not require food labels to list zinc content unless zinc has been added to the food. Foods providing 20% or
                more of the DV are considered to be high sources of a nutrient, but foods providing lower percentages of the DV also contribute to a healthful diet.</p>
              <p>The U.S. Department of Agriculture’s (USDA’s)
                <a href="https://fdc.nal.usda.gov/" target="external">FoodData Central</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a>
                [<a href="#en11" class="fscopy_nounderline">11</a>] lists the nutrient content of many foods and provides a comprehensive list of foods containing zinc arranged by <a href="/pubs/usdandb/Zinc-Content.pdf">nutrient content</a> and by
                <a href="/pubs/usdandb/Zinc-Food.pdf">food name</a>.</p>
              <h4>Dietary supplements</h4>
              <p>Supplements contain several forms of zinc, including zinc gluconate, zinc sulfate, and zinc acetate. The percentage of elemental zinc varies by form. For example, approximately 23% of zinc sulfate consists of elemental zinc; thus,
                220 mg of zinc sulfate contains 50 mg of elemental zinc. The elemental zinc content appears in the Supplement Facts panel on the supplement container. Research has not determined whether differences exist among forms of zinc in
                absorption, bioavailability, or tolerability.</p>
              <p>In addition to standard tablets and capsules, some zinc-containing cold lozenges are labeled as dietary supplements.</p>
              <h4>Other sources</h4>
              <p>Zinc is present in several products, including some labeled as homeopathic medications, sold over the counter for the treatment and prevention of colds. Numerous case reports of anosmia (loss of the sense of smell), in some cases
                long-lasting or permanent, have been associated with the use of zinc-containing nasal gels or sprays [<a href="#en15" class="fscopy_nounderline">15</a>,<a href="#en16" class="fscopy_nounderline">16</a>]. In June 2009, the FDA warned
                consumers to stop using three zinc-containing intranasal products because they might cause anosmia [<a href="#en17" class="fscopy_nounderline">17</a>]. The manufacturer recalled these products from the marketplace. Currently, these
                safety concerns have not been found to be associated with cold lozenges containing zinc.</p>
              <p>Zinc is also present in some denture adhesive creams at levels ranging from 17–34 mg/g [<a href="#en18" class="fscopy_nounderline">18</a>]. While use of these products as directed (0.5–1.5 g/day) is not of concern, chronic, excessive
                use can lead to zinc toxicity, resulting in copper deficiency and neurologic disease. Such toxicity has been reported in individuals who used 2 or more standard 2.4 oz tubes of denture cream per week
                [<a href="#en18" class="fscopy_nounderline">18</a>,<a href="#en19" class="fscopy_nounderline">19</a>]. Many denture creams have now been reformulated to eliminate zinc.</p>
              <h2 id="h7">Zinc Intakes and Status</h2>
              <p>Most infants (especially those who are formula fed), children, and adults in the United States consume recommended amounts of zinc according to two national surveys, the 1988–1991 National Health and Nutrition Examination Survey
                (NHANES III) [<a href="#en20" class="fscopy_nounderline">20</a>] and the 1994 Continuing Survey of Food Intakes of Individuals (CSFII) [<a href="#en21" class="fscopy_nounderline">21</a>].</p>
              <p>However, some evidence suggests that zinc intakes among older adults might be marginal. An analysis of NHANES III data found that 35%–45% of adults aged 60 years or older had zinc intakes below the estimated average requirement of
                6.8 mg/day for elderly females and 9.4 mg/day for elderly males. When the investigators considered intakes from both food and dietary supplements, they found that 20%–25% of older adults still had inadequate zinc intakes
                [<a href="#en22" class="fscopy_nounderline">22</a>].</p>
              <p>Zinc intakes might also be low in older adults from the 2%–4% of U.S. households that are food insufficient (sometimes or often not having enough food) [<a href="#en23" class="fscopy_nounderline">23</a>]. Data from NHANES III
                indicate that adults aged 60 years or older from food-insufficient families had lower intakes of zinc and several other nutrients and were more likely to have zinc intakes below 50% of the RDA on a given day than those from
                food-sufficient families [<a href="#en24" class="fscopy_nounderline">24</a>].</p>
              <h2 id="h8">Zinc Deficiency</h2>
              <p>Zinc deficiency is characterized by growth retardation, loss of appetite, and impaired immune function. In more severe cases, zinc deficiency causes hair loss, diarrhea, delayed sexual maturation, impotence, hypogonadism in males,
                and eye and skin lesions [<a href="#en2" class="fscopy_nounderline">2</a>,<a href="#en8" class="fscopy_nounderline">8</a>,<a href="#en25" class="fscopy_nounderline">25</a>,<a href="#en26" class="fscopy_nounderline">26</a>]. Weight
                loss, delayed healing of wounds, taste abnormalities, and mental lethargy can also occur
                [<a href="#en5" class="fscopy_nounderline">5</a>,<a href="#en8" class="fscopy_nounderline">8</a>,<a href="#en27" class="fscopy_nounderline">27-31</a>]. Many of these symptoms are non-specific and often associated with other health
                conditions; therefore, a medical examination is necessary to ascertain whether a zinc deficiency is present.</p>
              <p>Zinc nutritional status is difficult to measure adequately using laboratory tests [<a href="#en2" class="fscopy_nounderline">2</a>,<a href="#en32" class="fscopy_nounderline">32</a>,<a href="#en33" class="fscopy_nounderline">33</a>]
                due to its distribution throughout the body as a component of various proteins and nucleic acids [<a href="#en34" class="fscopy_nounderline">34</a>]. Plasma or serum zinc levels are the most commonly used indices for evaluating zinc
                deficiency, but these levels do not necessarily reflect cellular zinc status due to tight homeostatic control mechanisms [<a href="#en8" class="fscopy_nounderline">8</a>]. Clinical effects of zinc deficiency can be present in the
                absence of abnormal laboratory indices [<a href="#en8" class="fscopy_nounderline">8</a>]. Clinicians consider risk factors (such as inadequate caloric intake, alcoholism, and digestive diseases) and symptoms of zinc deficiency (such
                as impaired growth in infants and children) when determining the need for zinc supplementation [<a href="#en2" class="fscopy_nounderline">2</a>].</p>
              <h2 id="h9">Groups at Risk of Zinc Inadequacy</h2>
              <p>In North America, overt zinc deficiency is uncommon [<a href="#en2" class="fscopy_nounderline">2</a>]. When zinc deficiency does occur, it is usually due to inadequate zinc intake or absorption, increased losses of zinc from the
                body, or increased requirements for zinc [<a href="#en27" class="fscopy_nounderline">27</a>,<a href="#en28" class="fscopy_nounderline">28</a>,<a href="#en35" class="fscopy_nounderline">35</a>]. People at risk of zinc deficiency or
                inadequacy need to include good sources of zinc in their daily diets. Supplemental zinc might also be appropriate in certain situations.</p>
              <h4>People with gastrointestinal and other diseases</h4>
              <p>Gastrointestinal surgery and digestive disorders (such as ulcerative colitis, Crohn’s disease, and short bowel syndrome) can decrease zinc absorption and increase endogenous zinc losses primarily from the gastrointestinal tract and,
                to a lesser extent, from the kidney
                [<a href="#en2" class="fscopy_nounderline">2</a>,<a href="#en27" class="fscopy_nounderline">27</a>,<a href="#en36" class="fscopy_nounderline">36</a>,<a href="#en37" class="fscopy_nounderline">37</a>]. Other diseases associated with
                zinc deficiency include malabsorption syndrome, chronic liver disease, chronic renal disease, sickle cell disease, diabetes, malignancy, and other chronic illnesses [<a href="#en38" class="fscopy_nounderline">38</a>]. Chronic diarrhea
                also leads to excessive loss of zinc [<a href="#en25" class="fscopy_nounderline">25</a>].</p>
              <h4>Vegetarians</h4>
              <p>The bioavailability of zinc from vegetarian diets is lower than from non-vegetarian diets because vegetarians do not eat meat, which is high in bioavailable zinc and may enhance zinc absorption. In addition, vegetarians typically eat
                high levels of legumes and whole grains, which contain phytates that bind zinc and inhibit its absorption [<a href="#en32" class="fscopy_nounderline">32</a>,<a href="#en39" class="fscopy_nounderline">39</a>].</p>
              <p>Vegetarians sometimes require as much as 50% more of the RDA for zinc than non-vegetarians [<a href="#en2" class="fscopy_nounderline">2</a>]. In addition, they might benefit from using certain food preparation techniques that reduce
                the binding of zinc by phytates and increase its bioavailability. Techniques to increase zinc bioavailability include soaking beans, grains, and seeds in water for several hours before cooking them and allowing them to sit after
                soaking until sprouts form [<a href="#en39" class="fscopy_nounderline">39</a>]. Vegetarians can also increase their zinc intake by consuming more leavened grain products (such as bread) than unleavened products (such as crackers)
                because leavening partially breaks down the phytate; thus, the body absorbs more zinc from leavened grains than unleavened grains.</p>
              <h4>Pregnant and lactating women</h4>
              <p>Pregnant women, particularly those starting their pregnancy with marginal zinc status, are at increased risk of becoming zinc insufficient due, in part, to high fetal requirements for zinc
                [<a href="#en40" class="fscopy_nounderline">40</a>]. Lactation can also deplete maternal zinc stores [<a href="#en41" class="fscopy_nounderline">41</a>]. For these reasons, the RDA for zinc is higher for pregnant and lactating women
                than for other women (see Table 1) [<a href="#en2" class="fscopy_nounderline">2</a>].</p>
              <h4>Older infants who are exclusively breastfed</h4>
              <p>Breast milk provides sufficient zinc (2 mg/day) for the first 4–6 months of life but does not provide recommended amounts of zinc for infants aged 7–12 months, who need 3 mg/day
                [<a href="#en2" class="fscopy_nounderline">2</a>,<a href="#en34" class="fscopy_nounderline">34</a>]. In addition to breast milk, infants aged 7–12 months should consume age-appropriate foods or formula containing zinc
                [<a href="#en2" class="fscopy_nounderline">2</a>]. Zinc supplementation has improved the growth rate in some children who demonstrate mild-to-moderate growth failure and who have a zinc deficiency
                [<a href="#en25" class="fscopy_nounderline">25</a>,<a href="#en42" class="fscopy_nounderline">42</a>].</p>
              <h4>People with sickle cell disease</h4>
              <p>Results from a large cross-sectional survey suggest that 44% of children with sickle cell disease have a low plasma zinc concentration [<a href="#en43" class="fscopy_nounderline">43</a>], possibly due to increased nutrient
                requirements and/or poor nutritional status [<a href="#en44" class="fscopy_nounderline">44</a>]. Zinc deficiency also affects approximately 60%–70% of adults with sickle cell disease
                [<a href="#en45" class="fscopy_nounderline">45</a>]. Zinc supplementation has been shown to improve growth in children with sickle cell disease [<a href="#en44" class="fscopy_nounderline">44</a>].</p>
              <h4>Alcoholics</h4>
              <p>Approximately 30%–50% of alcoholics have low zinc status because ethanol consumption decreases intestinal absorption of zinc and increases urinary zinc excretion [<a href="#en45" class="fscopy_nounderline">45</a>]. In addition, the
                variety and amount of food consumed by many alcoholics is limited, leading to inadequate zinc intake
                [<a href="#en2" class="fscopy_nounderline">2</a>,<a href="#en46" class="fscopy_nounderline">46</a>,<a href="#en47" class="fscopy_nounderline">47</a>,<a href="#en48" class="fscopy_nounderline">48</a>].</p>
              <h2 id="h16">Zinc and Health</h2>
              <h4>Immune function</h4>
              <p>Severe zinc deficiency depresses immune function [<a href="#en49" class="fscopy_nounderline">49</a>], and even mild to moderate degrees of zinc deficiency can impair macrophage and neutrophil functions, natural killer cell activity,
                and complement activity [<a href="#en50" class="fscopy_nounderline">50</a>]. The body requires zinc to develop and activate T-lymphocytes
                [<a href="#en2" class="fscopy_nounderline">2</a>,<a href="#en51" class="fscopy_nounderline">51</a>]. Individuals with low zinc levels have shown reduced lymphocyte proliferation response to mitogens and other adverse alterations in
                immunity that can be corrected by zinc supplementation [<a href="#en50" class="fscopy_nounderline">50</a>,<a href="#en52" class="fscopy_nounderline">52</a>]. These alterations in immune function might explain why low zinc status has
                been associated with increased susceptibility to pneumonia and other infections in children in developing countries and the elderly [<a href="#en53" class="fscopy_nounderline">53-56</a>].</p>
              <h4>Wound healing</h4>
              <p>Zinc helps maintain the integrity of skin and mucosal membranes [<a href="#en50" class="fscopy_nounderline">50</a>]. Patients with chronic leg ulcers have abnormal zinc metabolism and low serum zinc levels
                [<a href="#en57" class="fscopy_nounderline">57</a>], and clinicians frequently treat skin ulcers with zinc supplements [<a href="#en58" class="fscopy_nounderline">58</a>]. The authors of a systematic review concluded that zinc sulfate
                might be effective for treating leg ulcers in some patients who have low serum zinc levels [<a href="#en59" class="fscopy_nounderline">59</a>,<a href="#en60" class="fscopy_nounderline">60</a>]. However, research has not shown that the
                general use of zinc sulfate in patients with chronic leg ulcers or arterial or venous ulcers is effective [<a href="#en59" class="fscopy_nounderline">59</a>,<a href="#en60" class="fscopy_nounderline">60</a>].</p>
              <h4>Diarrhea</h4>
              <p>Acute diarrhea is associated with high rates of mortality among children in developing countries [<a href="#en61" class="fscopy_nounderline">61</a>]. Zinc deficiency causes alterations in immune response that probably contribute to
                increased susceptibility to infections, such as those that cause diarrhea, especially in children [<a href="#en50" class="fscopy_nounderline">50</a>].</p>
              <p>Studies show that poor, malnourished children in India, Africa, South America, and Southeast Asia experience shorter courses of infectious diarrhea after taking zinc supplements [<a href="#en62" class="fscopy_nounderline">62</a>].
                The children in these studies received 4–40 mg of zinc a day in the form of zinc acetate, zinc gluconate, or zinc sulfate [<a href="#en62" class="fscopy_nounderline">62</a>].</p>
              <p>In addition, results from a pooled analysis of randomized controlled trials of zinc supplementation in developing countries suggest that zinc helps reduce the duration and severity of diarrhea in zinc-deficient or otherwise
                malnourished children [<a href="#en63" class="fscopy_nounderline">63</a>]. Similar findings were reported in a meta-analysis published in 2008 and a 2007 review of zinc supplementation for preventing and treating diarrhea
                [<a href="#en64" class="fscopy_nounderline">64</a>,<a href="#en65" class="fscopy_nounderline">65</a>]. The effects of zinc supplementation on diarrhea in children with adequate zinc status, such as most children in the United States,
                are not clear.</p>
              <p>The World Health Organization and UNICEF now recommend short-term zinc supplementation (20 mg of zinc per day, or 10 mg for infants under 6 months, for 10–14 days) to treat acute childhood diarrhea
                [<a href="#en61" class="fscopy_nounderline">61</a>].</p>
              <a name="change"></a>
              <h4>The common cold</h4>
              <p>Researchers have hypothesized that zinc could reduce the severity and duration of cold symptoms by directly inhibiting rhinovirus binding and replication in the nasal mucosa and suppressing inflammation
                [<a href="#en66" class="fscopy_nounderline">66</a>,<a href="#en67" class="fscopy_nounderline">67</a>]. In studies examining the effects of zinc on the common cold, zinc is usually administered in a lozenge or syrup that temporarily
                “sticks” to the mouth and throat, placing the zinc in contact with the rhinovirus in those areas.</p>
              <p>The results from clinical trials that examined the effects of zinc on the common cold have been inconsistent. However, overall, zinc in lozenge or syrup form appears to reduce the duration, but not the severity, of symptoms when
                taken shortly after a person develops a cold
                [<a href="#en68" class="fscopy_nounderline">68</a>,<a href="#en69" class="fscopy_nounderline">69</a>,<a href="#en70" class="fscopy_nounderline">70</a>,<a href="#en71" class="fscopy_nounderline">71</a>].</p>
              <p>In one randomized, double-blind, placebo-controlled clinical trial, 50 adults within 24 hours of developing the common cold took a zinc acetate lozenge (13.3 mg zinc) or placebo every 2–3 wakeful hours for as long as they had cold
                symptoms. In comparison with placebo, the zinc lozenges significantly reduced the duration of colds by 3 days and the severity of cold symptoms (cough, nasal discharge, and muscle aches)
                [<a href="#en72" class="fscopy_nounderline">72</a>].</p>
              <p>In another clinical trial, 273 adults with experimentally induced colds took zinc gluconate lozenges that provided 13.3 mg zinc every 2 to 3 hours while awake, for a total of 6 lozenges per day for up to 14 days. The lozenges
                significantly reduced the duration of illness by 1 day in comparison with placebo but had no effect on symptom severity [<a href="#en73" class="fscopy_nounderline">73</a>]. However, the same administration schedule using zinc acetate
                lozenges (that provided 5.0 or 11.5 mg zinc) had no effect on either cold duration or severity. Neither zinc gluconate nor zinc acetate lozenges affected the duration or severity of cold symptoms in 281 adults with natural (not
                experimentally induced) colds in another trial [<a href="#en73" class="fscopy_nounderline">73</a>].</p>
              <p>A 2021 systematic review and meta-analysis included 28 randomized controlled trials (including the three described above) with a total of 5,446 participants (mostly adults younger than 65 years) who had a community-acquired viral
                respiratory tract infection or were inoculated with a rhinovirus [<a href="#en68" class="fscopy_nounderline">68</a>]. Most trials provided zinc in the form of zinc acetate or gluconate lozenges at total daily doses of 45 mg to 300 mg
                for up to 2 weeks, but some trials used nasal sprays or gels. In participants who used zinc supplements, symptoms resolved an average of 2 days earlier than in those who received placebo. Symptoms on the third day were also milder in
                participants who used zinc, but average daily symptom severity did not differ between those who were and were not treated with zinc supplements.</p>
              <p>Findings were similar in earlier analyses, including a 2017 meta-analysis of 7 randomized controlled trials with a total of 575 individuals aged 11 to 69 years [<a href="#en70" class="fscopy_nounderline">70</a>]. Participants started
                taking either zinc lozenges (in the form of zinc acetate or zinc gluconate) every 2 to 3 hours while awake, for total daily doses of 80 to 207 mg zinc, or placebo within 1 to 3 days of developing a cold. In participants taking zinc
                lozenges, colds were 33% shorter than in those taking placebo. Similarly, a 2012 systematic review and meta-analysis included 17 trials with a total of 2,121 participants (mostly adults, but four trials included children aged 1 year
                and older) that administered zinc, mainly in the form of zinc gluconate lozenges, zinc acetate lozenges, or zinc sulfate syrup, for 3 to 14 days or until symptoms were resolved [<a href="#en71" class="fscopy_nounderline">71</a>]. Zinc
                doses and administration schedules varied but ranged from about 4.5 mg every 1 to 1.5 hours to 23.7 mg every 2 hours during waking hours. Overall, cold symptoms lasted a mean of 1.65 days less in those who took zinc than in the
                placebo group. However, the analysis showed no significant difference in severity of symptoms between the zinc and placebo groups. An earlier systematic review concluded that use of total daily zinc lozenge doses of over 75 mg reduced
                the duration of the common cold, whereas lower doses did not [<a href="#en69" class="fscopy_nounderline">69</a>].</p>
              <p>More large, high-quality clinical trials are needed to determine the optimal dosage, formulation, and administration schedule before a general recommendation can be made regarding the use of zinc supplements for the common cold
                [<a href="#en69" class="fscopy_nounderline">69</a>,<a href="#en70" class="fscopy_nounderline">70</a>,<a href="#en71" class="fscopy_nounderline">71</a>].</p>
              <h4>Age-related macular degeneration</h4>
              <p>Researchers have suggested that both zinc and antioxidants delay the progression of age-related macular degeneration (AMD) and vision loss, possibly by preventing cellular damage in the retina
                [<a href="#en74" class="fscopy_nounderline">74</a>,<a href="#en75" class="fscopy_nounderline">75</a>]. In a population-based cohort study in the Netherlands, high dietary intake of zinc as well as beta carotene, vitamin C, and vitamin
                E was associated with reduced risk of AMD in elderly subjects [<a href="#en76" class="fscopy_nounderline">76</a>]. However, the authors of a systematic review and meta-analysis published in 2007 concluded that zinc is not effective
                for the primary prevention of early AMD [<a href="#en77" class="fscopy_nounderline">77</a>], although zinc might reduce the risk of progression to advanced AMD.</p>
              <p>The Age-Related Eye Disease Study (AREDS), a large, randomized, placebo-controlled, clinical trial (n = 3,597), evaluated the effect of high doses of selected antioxidants (500 mg vitamin C, 400 IU vitamin E, and 15 mg beta-carotene)
                with or without zinc (80 mg as zinc oxide) on the development of advanced AMD in older individuals with varying degrees of AMD [<a href="#en75" class="fscopy_nounderline">75</a>]. Participants also received 2 mg copper to prevent the
                copper deficiency associated with high zinc intakes. After an average follow-up period of 6.3 years, supplementation with antioxidants plus zinc (but not antioxidants alone) significantly reduced the risk of developing advanced AMD
                and reduced visual acuity loss. Zinc supplementation alone significantly reduced the risk of developing advanced AMD in subjects at higher risk but not in the total study population. Visual acuity loss was not significantly affected
                by zinc supplementation alone.</p>
              <p>A follow-up AREDS2 study confirmed the value of this supplement in reducing the progression of AMD over a median follow-up period of 5 years [<a href="#en78" class="fscopy_nounderline">78</a>]. AREDS2 found that a formulation
                providing 25 mg zinc (about one-third the amount in the original formulation) provided the same protective effect against developing advanced AMD. However, because AREDS2 had fewer participants than the original AREDS study, and fewer
                than half took the lower zinc formula, the researchers view this finding as preliminary. They recommend use of an AREDS formulation providing 80 mg zinc
                [<a href="#en79" class="fscopy_nounderline">79</a>,<a href="#en80" class="fscopy_nounderline">80</a>].</p>
              <p>Two other small clinical trials evaluated the effects of supplementation with 200 mg zinc sulfate (providing 45 mg zinc) for 2 years in subjects with drusen or macular degeneration. Zinc supplementation significantly reduced visual
                acuity loss in one of the studies [<a href="#en81" class="fscopy_nounderline">81</a>] but had no effect in the other [<a href="#en82" class="fscopy_nounderline">82</a>].</p>
              <p>A Cochrane review concluded that the evidence supporting the use of antioxidant vitamins and zinc for AMD comes primarily from the AREDS study [<a href="#en74" class="fscopy_nounderline">74</a>]. Individuals who have or are
                developing AMD should talk to their healthcare provider about taking a zinc-containing AREDS supplement.</p>
              <h4>Interactions with iron and copper</h4>
              <p>Iron-deficiency anemia is a serious world-wide public health problem. Iron fortification programs have been credited with improving the iron status of millions of women, infants, and children. Fortification of foods with iron does
                not significantly affect zinc absorption. However, large amounts of supplemental iron (greater than 25 mg) might decrease zinc absorption
                [<a href="#en2" class="fscopy_nounderline">2</a>,<a href="#en83" class="fscopy_nounderline">83</a>]. Taking iron supplements between meals helps decrease its effect on zinc absorption
                [<a href="#en83" class="fscopy_nounderline">83</a>].</p>
              <p>High zinc intakes can inhibit copper absorption, sometimes producing copper deficiency and associated anemia [<a href="#en84" class="fscopy_nounderline">84</a>,<a href="#en85" class="fscopy_nounderline">85</a>]. For this reason,
                dietary supplement formulations containing high levels of zinc, such as the one used in the AREDS study [<a href="#en75" class="fscopy_nounderline">75</a>], sometimes contain copper.</p>
              <h2 id="h23">Health Risks from Excessive Zinc</h2>
              <p>Zinc toxicity can occur in both acute and chronic forms. Acute adverse effects of high zinc intake include nausea, vomiting, loss of appetite, abdominal cramps, diarrhea, and headaches
                [<a href="#en2" class="fscopy_nounderline">2</a>]. One case report cited severe nausea and vomiting within 30 minutes of ingesting 4 g of zinc gluconate (570 mg elemental zinc) [<a href="#en86" class="fscopy_nounderline">86</a>].
                Intakes of 150–450 mg of zinc per day have been associated with such chronic effects as low copper status, altered iron function, reduced immune function, and reduced levels of high-density lipoproteins
                [<a href="#en87" class="fscopy_nounderline">87</a>]. Reductions in a copper-containing enzyme, a marker of copper status, have been reported with even moderately high zinc intakes of approximately 60 mg/day for up to 10 weeks
                [<a href="#en2" class="fscopy_nounderline">2</a>]. The doses of zinc used in the AREDS study (80 mg per day of zinc in the form of zinc oxide for 6.3 years, on average) have been associated with a significant increase in
                hospitalizations for genitourinary causes, raising the possibility that chronically high intakes of zinc adversely affect some aspects of urinary physiology [<a href="#en88" class="fscopy_nounderline">88</a>].</p>
              <p>The FNB has established ULs for zinc (Table 3). Long-term intakes above the UL increase the risk of adverse health effects [<a href="#en2" class="fscopy_nounderline">2</a>]. The ULs do not apply to individuals receiving zinc for
                medical treatment, but such individuals should be under the care of a physician who monitors them for adverse health effects.</p>
              <table border="1">
                <caption style="text-align: left;">Table 3: Tolerable Upper Intake Levels (ULs) for Zinc [<a href="#en2" class="fscopy_nounderline">2</a>]</caption>
                <thead>
                  <tr>
                    <th scope="col">Age</th>
                    <th scope="col">Male</th>
                    <th scope="col">Female</th>
                    <th scope="col">Pregnant</th>
                    <th scope="col">Lactating</th>
                  </tr>
                </thead>
                <tbody>
                  <tr>
                    <td>0–6 months</td>
                    <td align="right">4 mg</td>
                    <td align="right">4 mg</td>
                    <td align="right"></td>
                    <td align="right"></td>
                  </tr>
                  <tr>
                    <td>7–12 months</td>
                    <td align="right">5 mg</td>
                    <td align="right">5 mg</td>
                    <td align="right"></td>
                    <td align="right"></td>
                  </tr>
                  <tr>
                    <td>1–3 years</td>
                    <td align="right">7 mg</td>
                    <td align="right">7 mg</td>
                    <td align="right"></td>
                    <td align="right"></td>
                  </tr>
                  <tr>
                    <td>4–8 years</td>
                    <td align="right">12 mg</td>
                    <td align="right">12 mg</td>
                    <td align="right"></td>
                    <td align="right"></td>
                  </tr>
                  <tr>
                    <td>9–13 years</td>
                    <td align="right">23 mg</td>
                    <td align="right">23 mg</td>
                    <td align="right"></td>
                    <td align="right"></td>
                  </tr>
                  <tr>
                    <td>14–18 years</td>
                    <td align="right">34 mg</td>
                    <td align="right">34 mg</td>
                    <td align="right">34 mg</td>
                    <td align="right">34 mg</td>
                  </tr>
                  <tr>
                    <td>19+ years</td>
                    <td align="right">40 mg</td>
                    <td align="right">40 mg</td>
                    <td align="right">40 mg</td>
                    <td align="right">40 mg</td>
                  </tr>
                </tbody>
              </table> &nbsp; <h2 id="h24">Interactions with Medications</h2>
              <p>Zinc supplements have the potential to interact with several types of medications. A few examples are provided below. Individuals taking these medications on a regular basis should discuss their zinc intakes with their healthcare
                providers.</p>
              <h4>Antibiotics</h4>
              <p>Both quinolone antibiotics (such as Cipro®) and tetracycline antibiotics (such as Achromycin® and Sumycin®) interact with zinc in the gastrointestinal tract, inhibiting the absorption of both zinc and the antibiotic
                [<a href="#en89" class="fscopy_nounderline">89</a>,<a href="#en90" class="fscopy_nounderline">90</a>]. Taking the antibiotic at least 2 hours before or 4–6 hours after taking a zinc supplement minimizes this interaction
                [<a href="#en91" class="fscopy_nounderline">91</a>].</p>
              <h4>Penicillamine</h4>
              <p>Zinc can reduce the absorption and action of penicillamine, a drug used to treat rheumatoid arthritis [<a href="#en92" class="fscopy_nounderline">92</a>]. To minimize this interaction, individuals should take zinc supplements at
                least 2 hours before or after taking penicillamine [<a href="#en90" class="fscopy_nounderline">90</a>].</p>
              <h4>Diuretics</h4>
              <p>Thiazide diuretics such as chlorthalidone (Hygroton®) and hydrochlorothiazide (Esidrix® and HydroDIURIL®) increase urinary zinc excretion by as much as 60% [<a href="#en93" class="fscopy_nounderline">93</a>]. Prolonged use of
                thiazide diuretics could deplete zinc tissue levels, so clinicians should monitor zinc status in patients taking these medications.</p>
              <h2 id="h28">Zinc and Healthful Diets</h2>
              <p>The federal government’s 2020–2025 <em>Dietary Guidelines for Americans</em> notes that “Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily
                through foods. … In some cases, fortified foods and dietary supplements are useful when it is not possible otherwise to meet needs for one or more nutrients (e.g., during specific life stages such as pregnancy).”</p>
              <p>For more information about building a healthy dietary pattern, refer to the
                <em><a href="https://www.dietaryguidelines.gov" target="external">Dietary Guidelines for Americans</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a></em>
                and the U.S. Department of Agriculture’s
                <em><a href="https://www.choosemyplate.gov/" target="external">MyPlate.</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a></em>
              </p>
              <p>The <em>Dietary Guidelines for Americans</em> describes a healthy dietary pattern as one that:</p>
              <ul>
                <li>Includes a variety of vegetables; fruits; grains (at least half whole grains); fat-free and low-fat milk, yogurt, and cheese; and oils. <dl>
                    <dd>Whole grains and milk products are good sources of zinc. Many ready-to-eat breakfast cereals are fortified with zinc.</dd>
                  </dl>
                </li>
                <li>Includes a variety of protein foods such as lean meats; poultry; eggs; seafood; beans, peas, and lentils; nuts and seeds; and soy products. <dl>
                    <dd>Oysters, red meat, and poultry are excellent sources of zinc. Baked beans, chickpeas, and nuts (such as cashews and almonds) also contain zinc.</dd>
                  </dl>
                </li>
                <li>Limits foods and beverages higher in added sugars, saturated fat, and sodium.</li>
                <br>
                <li>Limits alcoholic beverages.</li>
                <br>
                <li>Stays within your daily calorie needs.</li>
              </ul>
              <section id="ctl00_ctl00_cphMain_cphPageContent_ctlfs_divCitations">
                <h2 id="ref">References</h2>
                <ol>
                  <li id="en1">Sandstead HH. Understanding zinc: recent observations and interpretations. J Lab Clin Med 1994;124:322-7. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/8083574?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en2">Institute of Medicine, Food and Nutrition Board.
                    <a href="http://search.nap.edu/nap-cgi/de.cgi?term=Dietary+Reference+Intakes+for+Vitamin+A%2C+Vitamin+K%2C+Arsenic%2C+Boron%2C+Chromium%2C+Copper%2C+Iodine%2C+Iron%2C+Manganese%2C+Molybdenum%2C+Nickel%2C+Silicon%2C+Vanadium%2C+and+Zinc.&amp;x=13&amp;y=10" target="external">Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a>.
                    Washington, DC: National Academy Press, 2001.</li>
                  <li id="en3">Solomons NW. Mild human zinc deficiency produces an imbalance between cell-mediated and humoral immunity. Nutr Rev 1998;56:27-8.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9481116?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en4">Prasad AS. Zinc: an overview. Nutrition 1995;11:93-9. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/7749260?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en5">Heyneman CA. Zinc deficiency and taste disorders. Ann Pharmacother 1996;30:186-7. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/8835055?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en6">Simmer K, Thompson RP. Zinc in the fetus and newborn. Acta Paediatr Scand Suppl 1985;319:158-63. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/3868917?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en7">Fabris N, Mocchegiani E. Zinc, human diseases and aging. Aging (Milano) 1995;7:77-93. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/7548268?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en8">Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol 2006;20:3-18.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/16632171?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en9">Prasad AS, Beck FW, Grabowski SM, Kaplan J, Mathog RH. Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects. Proc Assoc Am Physicians
                    1997;109:68-77. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9010918?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en10">Rink L, Gabriel P. Zinc and the immune system. Proc Nutr Soc 2000;59:541-52. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/11115789?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en11">U.S. Department of Agriculture, Agricultural Research Service.
                    <a href="https://fdc.nal.usda.gov/" target="external">FoodData Central</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a>,
                    2019.</li>
                  <li id="en12">Sandstrom B. Bioavailability of zinc. Eur J Clin Nutr 1997;51 (1 Suppl):S17-9. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9023474?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en13">Wise A. Phytate and zinc bioavailability. Int J Food Sci Nutr 1995;46:53-63. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/7712343?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en14">U.S. Food and Drug Administration.
                    <a href="https://www.federalregister.gov/documents/2016/05/27/2016-11867/food-labeling-revision-of-the-nutrition-and-supplement-facts-labels" target="external">Food Labeling: Revision of the Nutrition and Supplement Facts Labels.</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a>
                    2016.</li>
                  <li id="en15">Jafek BW, Linschoten MR, Murrow BW. Anosmia after intranasal zinc gluconate use. Am J Rhinol 2004;18:137-41. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/15283486?dopt=Abstract" target="external">PubMed abstract</a>]
                  </li>
                  <li id="en16">Alexander TH, Davidson TM. Intranasal zinc and anosmia: the zinc-induced anosmia syndrome. Laryngoscope 2006;116:217-20.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/16467707?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en17">U.S. Food and Drug Administration. Warnings on Three Zicam Intranasal Zinc Products.
                    [<a href="http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm166931.htm" target="external">http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm166931.htm</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a>]
                  </li>
                  <li id="en18">Nations SP, Boyer PJ, Love LA, Burritt MF, Butz JA, Wolfe GI, Hynan LS, Reisch J, Trivedi JR. Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease. Neurology. 2008 Aug
                    26;71(9):639-43. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/18525032?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en19">Spain RI, Leist TP, De Sousa EA. When metals compete: a case of copper-deficiency myeloneuropathy and anemia. Nat Clin Pract Neurol. 2009 Feb;5(2):106-11.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/19194390?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en20">Alaimo K, McDowell MA, Briefel RR, et al. Dietary intake of vitamins, minerals, and fiber of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1,
                    1986-91.
                    <a href="http://www.cdc.gov/nchs/data/ad/ad258.pdf" target="external">Advance data from vital and health statistics no 258</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a>.
                    Hyattsville, Maryland: National Center for Health Statistics. 1994.</li>
                  <li id="en21">Interagency Board for Nutrition Monitoring and Related Research. Third Report on Nutrition Monitoring in the United States. Washington, DC: U.S. Government Printing Office, 1995.</li>
                  <li id="en22">Ervin RB, Kennedy-Stephenson J. Mineral intakes of elderly adult supplement and non-supplement users in the third national health and nutrition examination survey. J Nutr 2002;132:3422-7.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/12421862?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en23">Ribar DS, Hamrick KS. Dynamics of Poverty and Food Sufficiency. Food Assistance and Nutrition Report Number 36, 2003. Washington, DC: U.S. Department of Agriculture, Economic Research Service.
                    [<a href="http://www.ers.usda.gov/publications/fanrr36/fanrr36.pdf" target="external">http://www.ers.usda.gov/publications/fanrr36/fanrr36.pdf</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a>]
                  </li>
                  <li id="en24">Dixon LB, Winkleby MA, Radimer KL. Dietary intakes and serum nutrients differ between adults from food-insufficient and food-sufficient families: Third National Health and Nutrition Examination Survey, 1988-1994. J
                    Nutr 2001;131:1232-46. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/11285332?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en25">Prasad AS. Zinc deficiency: its characterization and treatment. Met Ions Biol Syst 2004;41:103-37. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/15206115?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en26">Wang LC, Busbey S. Images in clinical medicine. Acquired acrodermatitis enteropathica. N Engl J Med 2005;352:1121.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/15784665?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en27">Hambidge KM, Mild zinc deficiency in human subjects. In: Mills CF, ed. Zinc in Human Biology. New York, NY: Springer-Verlag, 1989:281-96.</li>
                  <li id="en28">King JC, Cousins RJ. Zinc. In: Shils ME, Shike M, Ross AC, Caballero B, Cousins, RJ, eds. Modern Nutrition in Health and Disease, 10th ed. Baltimore, MD: Lippincott Williams &amp; Wilkins, 2005:271-85.</li>
                  <li id="en29">Krasovec M, Frenk E. Acrodermatitis enteropathica secondary to Crohn’s disease. Dermatology 1996;193:361-3. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/8993972?dopt=Abstract" target="external">PubMed abstract</a>]
                  </li>
                  <li id="en30">Ploysangam A, Falciglia GA, Brehm BJ. Effect of marginal zinc deficiency on human growth and development. J Trop Pediatr 1997;43:192-8.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9283119?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en31">Nishi Y. Zinc and growth. J Am Coll Nutr 1996;15:340-4. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/8829089?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en32">Hunt JR. Bioavailability of iron, zinc, and other trace minerals from vegetarian diets. Am J Clin Nutr 2003;78 (3 Suppl):633S-9S.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/12936958?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en33">Van Wouwe JP. Clinical and laboratory assessment of zinc deficiency in Dutch children. A review. Biol Trace Elem Res 1995;49:211-25.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/8562288?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en34">Hambidge KM, Krebs NF. Zinc deficiency: a special challenge. J Nutr 2007;137:1101-5. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/17374687?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en35">Prasad AS. Zinc deficiency in women, infants and children. J Am Coll Nutr 1996;15:113-20. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/8778139?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en36">Naber TH, van den Hamer CJ, Baadenhuysen H, Jansen JB. The value of methods to determine zinc deficiency in patients with Crohn’s disease. Scand J Gastroenterol 1998;33:514-23.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9648992?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en37">Valberg LS, Flanagan PR, Kertesz A, Bondy DC. Zinc absorption in inflammatory bowel disease. Dig Dis Sci. 1986 Jul;31(7):724-31.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/2873002?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en38">Prasad AS. Zinc deficiency. BMJ 2003;326:409-10. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/12595353?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en39">American Dietetic Association, Dietitians of Canada. Position of the American Dietetic Association and Dietitians of Canada: vegetarian diets. J Am Diet Assoc 2003;103:748-65.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/12778049?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en40">Caulfield LE, Zavaleta N, Shankar AH, Merialdi M. Potential contribution of maternal zinc supplementation during pregnancy to maternal and child survival. Am J Clin Nutr 1998;68 (2 Suppl):499S-508S.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9701168?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en41">Krebs NF. Zinc supplementation during lactation. Am J Clin Nutr 1998;68 (2 Suppl):509S -12S. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9701169?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en42">Brown KH, Allen LH, Peerson J. Zinc supplementation and children’s growth: a meta-analysis of intervention trials. Bibl Nutr Dieta 1998;54:73-6.</li>
                  <li id="en43">Leonard MB, Zemel BS, Kawchak DA, Ohene-Frempong K, Stallings VA. Plasma zinc status, growth, and maturation in children with sickle cell disease. J Pediatr 1998;132:467-71.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9544903?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en44">Zemel BS, Kawchak DA, Fung EB, Ohene-Frempong K, Stallings VA. Effect of zinc supplementation on growth and body composition in children with sickle cell disease. Am J Clin Nutr 2002;75:300-7.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/11815322?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en45">Prasad AS. Zinc deficiency in patients with sickle cell disease. Am J Clin Nutr 2002;75:181-2. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/11815307?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en46">Kang YJ, Zhou Z. Zinc prevention and treatment of alcoholic liver disease. Mol Aspects Med 2005;26:391-404. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/16099027?dopt=Abstract" target="external">PubMed abstract</a>]
                  </li>
                  <li id="en47">Menzano E, Carlen PL. Zinc deficiency and corticosteroids in the pathogenesis of alcoholic brain dysfunction—a review. Alcohol Clin Exp Res 1994;18:895-901.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/7978102?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en48">Navarro S, Valderrama R, To-Figueras J, Gimenez A, Lopez JM, Campo E, et al. Role of zinc in the process of pancreatic fibrosis in chronic alcoholic pancreatitis. Pancreas 1994;9:270-4.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/8190729?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en49">Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998;68:447S-63S.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9701160?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en50">Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 2007;51:301-23.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/17726308?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en51">Beck FW, Prasad AS, Kaplan J, Fitzgerald JT, Brewer GJ. Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am J Physiol 1997;272:E1002-7.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9227444?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en52">Prasad AS. Effects of zinc deficiency on Th1 and Th2 cytokine shifts. J Infect Dis 2000;182 (Suppl):S62-8. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/10944485?dopt=Abstract" target="external">PubMed abstract</a>]
                  </li>
                  <li id="en53">Bahl R, Bhandari N, Hambidge KM, Bhan MK. Plasma zinc as a predictor of diarrheal and respiratory morbidity in children in an urban slum setting. Am J Clin Nutr 1998;68 (2 Suppl):414S-7S.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9701154?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en54">Brooks WA, Santosham M, Naheed A, Goswami D, Wahed MA, Diener-West M, et al. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population
                    in Bangladesh: randomised controlled trial. Lancet 2005;366:999-1004. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/16168782?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en55">Meydani SN, Barnett JB, Dallal GE, Fine BC, Jacques PF, Leka LS, et al. Serum zinc and pneumonia in nursing home elderly. Am J Clin Nutr 2007;86:1167-73.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/17921398?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en56">Black RE. Zinc deficiency, infectious disease and mortality in the developing world. J Nutr 2003;133:1485S-9S.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/12730449?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en57">Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Agren MS. Zinc in wound healing: theoretical, experimental, and clinical aspects. Wound Repair Regen 2007;15:2-16.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/17244314?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en58">Anderson I. Zinc as an aid to healing. Nurs Times 1995;91:68, 70. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/7644377?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en59">Wilkinson EA, Hawke CI. Does oral zinc aid the healing of chronic leg ulcers? A systematic literature review. Arch Dermatol 1998;134:1556-60.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9875193?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en60">Wilkinson EA, Hawke CI. Oral zinc for arterial and venous leg ulcers. Cochrane Database Syst Rev 2000;(2):CD001273.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/10796629?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en61">World Health Organization and United Nations Children Fund. Clinical management of acute diarrhoea. WHO/UNICEF Joint Statement, August, 2004. [<a href="http://www.unicef.org/nutrition/files/ENAcute_Diarrhoea_reprint.pdf" target="external">
http://www.unicef.org/nutrition/files/ENAcute_Diarrhoea_reprint.pdf</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a>]
                  </li>
                  <li id="en62">Black RE. Therapeutic and preventive effects of zinc on serious childhood infectious diseases in developing countries. Am J Clin Nutr 1998;68:476S-9S.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9701163?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en63">Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, et al. Therapeutic effects of oral zinc in acute and persistent diarrhea in children in developing countries: pooled analysis of randomized controlled
                    trials. Am J Clin Nutr 2000;72:1516-22. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/11101480?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en64">Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea. Pediatrics 2008;121:326-36.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/18245424?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en65">Fischer Walker CL, Black RE. Micronutrients and diarrheal disease. Clin Infect Dis 2007;45 (1 Suppl):S73-7. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/17582575?dopt=Abstract" target="external">PubMed abstract</a>]
                  </li>
                  <li id="en66">Hulisz D. Efficacy of zinc against common cold viruses: an overview. J Am Pharm Assoc (2003) 2004;44:594-603. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/15496046?dopt=Abstract" target="external">PubMed abstract</a>]
                  </li>
                  <li id="en67">Caruso TJ, Prober CG, Gwaltney JM Jr. Treatment of naturally acquired common colds with zinc: a structured review. Clin Infect Dis 2007;45:569-74.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/17682990?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en68">Hunter J, Arentz S, Goldenberg J, Yang G, Beardsley J, Myers SP, Mertz D, Leeder S. Zinc for the prevention or treatment of acute viral respiratory tract infections in adults: a rapid systematic review and
                    meta-analysis of randomised controlled trials. BMJ Open 2021;11:e047474. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/34728441?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en69">Hemilä H. Zinc lozenges may shorten the duration of colds: a systematic review. Open Respir Med J. 2011;5:51-8.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/21769305?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en70">Hemilä H. Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM Open 2017;8:2054270417694291.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/28515951?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en71">Science M, Johnstone J, Roth DE, Guyatt G, Loeb M. Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. CMAJ 2012;184:E551-61.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/22566526?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en72">Prasad AS, Beck FW, Bao B, Snell D, Fitzgerald JT. Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients
                    with common cold treated with zinc acetate. J Infect Dis 2008 ;197:795-802. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/18279051?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en73">Turner RB, Cetnarowski WE. Effect of treatment with zinc gluconate or zinc acetate on experimental and natural colds. Clin Infect Dis 2000;31:1202-8.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/11073753?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en74">Evans JR. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev 2006;(2):CD000254.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/16625532?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en75">Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision
                    loss: AREDS report no. 8. Arch Ophthalmol 2001;119:1417-36. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/11594942?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en76">van Leeuwen R, Boekhoorn S, Vingerling JR, Witteman JC, Klaver CC, Hofman A, et al. Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA 2005;294:3101-7.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/16380590?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en77">Chong EW, Wong TY, Kreis AJ, Simpson JA, Guymer RH. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ 2007;335:755.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/17923720?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en78">The Age-Related Eye Disease Study 2 (AREDS2) Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.
                    JAMA 2013;309:2005-15. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/23644932?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en79">National Eye Institute. <a href="https://www.nei.nih.gov/research/clinical-trials/age-related-eye-disease-studies-aredsareds2/aredsareds2-frequently-asked-questions">AREDS/AREDS2 Frequently Asked Questions</a>. 2020.
                  </li>
                  <li id="en80">National Eye Institute. <a href="https://www.nei.nih.gov/research/clinical-trials/age-related-eye-disease-studies-aredsareds2/about-areds-and-areds2">AREDS/AREDS2 Clinical Trials</a>. 2020.</li>
                  <li id="en81">Newsome DA, Swartz M, Leone NC, Elston RC, Miller E. Oral zinc in macular degeneration. Arch Ophthalmol 1988;106:192-8.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/3277606?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en82">Stur M, Tittl M, Reitner A, Meisinger V. Oral zinc and the second eye in age-related macular degeneration. Invest Ophthalmol Vis Sci 1996;37:1225-35.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/8641826?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en83">Whittaker P. Iron and zinc interactions in humans. Am J Clin Nutr 1998;68:442S-6S. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9701159?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en84">Broun ER, Greist A, Tricot G, Hoffman R. Excessive zinc ingestion. A reversible cause of sideroblastic anemia and bone marrow depression. JAMA 1990;264:1441-3.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/2094240?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en85">Willis MS, Monaghan SA, Miller ML, McKenna RW, Perkins WD, Levinson BS, et al. Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination. Am J Clin Pathol 2005;123:125-31.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/15762288?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en86">Lewis MR, Kokan L. Zinc gluconate: acute ingestion. J Toxicol Clin Toxicol 1998;36:99-101. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/9541053?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en87">Hooper PL, Visconti L, Garry PJ, Johnson GE. Zinc lowers high-density lipoprotein-cholesterol levels. J Am Med Assoc 1980;244:1960-1.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/7420708?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en88">Johnson AR, Munoz A, Gottlieb JL, Jarrard DF. High dose zinc increases hospital admissions due to genitourinary complications. J Urol 2007;177:639-43.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/17222649?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en89">Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones. 1995 update. Drug Saf 1995;12:314-33. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/7669261?dopt=Abstract" target="external">PubMed abstract</a>]
                  </li>
                  <li id="en90">Penttilä O, Hurme H, Neuvonen PJ. Effect of zinc sulphate on the absorption of tetracycline and doxycycline in man. Eur J Clin Pharmacol 1975;9:131-4.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/786686?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en91">
                    <a href="http://www.NaturalDatabase.com" target="external">Natural Medicines Comprehensive Database</a><a href="/About/exit_disclaimer.aspx" title="External Website"><img src="/images/Common/externallink.png" height="12" width="12" alt="external link disclaimer" class="externallink"></a>.
                    Zinc.</li>
                  <li id="en92">Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, Dick RD, Wang Y. Treatment of Wilson’s disease with zinc: XI. Interaction with other anticopper agents. J Am Coll Nutr 1993;12:26-30.
                    [<a href="https://www.ncbi.nlm.nih.gov/pubmed/8440814?dopt=Abstract" target="external">PubMed abstract</a>]</li>
                  <li id="en93">Wester PO. Urinary zinc excretion during treatment with different diuretics. Acta Med Scand 1980;208:209-12. [<a href="https://www.ncbi.nlm.nih.gov/pubmed/7001863?dopt=Abstract" target="external">PubMed abstract</a>]
                  </li>
                </ol>
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Home > Health Information > Dietary Supplement Fact Sheets > Zinc > Zinc -
Health Professional


ZINC

Fact Sheet for Health Professionals

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TABLE OF CONTENTS

 * Introduction
 * Recommended Intakes
 * Sources of Zinc
 * Zinc Intakes and Status
 * Zinc Deficiency
 * Groups at Risk of Zinc Inadequacy
 * Zinc and Health
 * Health Risks from Excessive Zinc
 * Interactions with Medications
 * Zinc and Healthful Diets
 * References
 * Disclaimer

This is a fact sheet intended for health professionals. For a reader-friendly
overview of Zinc, see our consumer fact sheet on Zinc.

For information on zinc and COVID-19, see Dietary Supplements in the Time of
COVID-19.


INTRODUCTION

Zinc is an essential mineral that is naturally present in some foods, added to
others, and available as a dietary supplement. Zinc is also found in many cold
lozenges and some over-the-counter drugs sold as cold remedies.

Zinc is involved in numerous aspects of cellular metabolism. It is required for
the catalytic activity of approximately 100 enzymes [1,2] and it plays a role in
immune function [3,4], protein synthesis [4], wound healing [5], DNA synthesis
[2,4], and cell division [4]. Zinc also supports normal growth and development
during pregnancy, childhood, and adolescence [6-8] and is required for proper
sense of taste and smell [9]. A daily intake of zinc is required to maintain a
steady state because the body has no specialized zinc storage system [10].


RECOMMENDED INTAKES

Intake recommendations for zinc and other nutrients are provided in the Dietary
Reference Intakes (DRIs) developed by the Food and Nutrition Board (FNB) at the
Institute of Medicine of the National Academies (formerly National Academy of
Sciences) [2]. DRI is the general term for a set of reference values used for
planning and assessing nutrient intakes of healthy people. These values, which
vary by age and gender [2], include the following:

 * Recommended Dietary Allowance (RDA): Average daily level of intake sufficient
   to meet the nutrient requirements of nearly all (97%–98%) healthy
   individuals; often used to plan nutritionally adequate diets for individuals.
 * Adequate Intake (AI): Intake at this level is assumed to ensure nutritional
   adequacy; established when evidence is insufficient to develop an RDA.
 * Estimated Average Requirement (EAR): Average daily level of intake estimated
   to meet the requirements of 50% of healthy individuals; usually used to
   assess the nutrient intakes of groups of people and to plan nutritionally
   adequate diets for them; can also be used to assess the nutrient intakes of
   individuals.
 * Tolerable Upper Intake Level (UL): Maximum daily intake unlikely to cause
   adverse health effects.

The current RDAs for zinc are listed in Table 1 [2]. For infants aged 0 to 6
months, the FNB established an AI for zinc that is equivalent to the mean intake
of zinc in healthy, breastfed infants.

Table 1: Recommended Dietary Allowances (RDAs) for Zinc [2] Age Male Female
Pregnancy Lactation 0–6 months 2 mg* 2 mg* 7–12 months 3 mg 3 mg 1–3 years 3 mg
3 mg 4–8 years 5 mg 5 mg 9–13 years 8 mg 8 mg 14–18 years 11 mg 9 mg 12 mg 13 mg
19+ years 11 mg 8 mg 11 mg 12 mg

* Adequate Intake (AI)


SOURCES OF ZINC

FOOD

A wide variety of foods contain zinc (Table 2) [2]. Oysters contain more zinc
per serving than any other food, but red meat and poultry provide the majority
of zinc in the American diet. Other good food sources include beans, nuts,
certain types of seafood (such as crab and lobster), whole grains, fortified
breakfast cereals, and dairy products [2,11].

Phytates—which are present in whole-grain breads, cereals, legumes, and other
foods—bind zinc and inhibit its absorption [2,12,13]. Thus, the bioavailability
of zinc from grains and plant foods is lower than that from animal foods,
although many grain- and plant-based foods are still good sources of zinc [2].

Table 2: Zinc Content of Selected Foods [11] Food Milligrams (mg)
per serving Percent DV* Oysters, cooked, breaded and fried, 3 ounces 74.0 673
Beef chuck roast, braised, 3 ounces 7.0 64 Crab, Alaska king, cooked, 3 ounces
6.5 59 Beef patty, broiled, 3 ounces 5.3 48 Lobster, cooked, 3 ounces 3.4 31
Pork chop, loin, cooked, 3 ounces 2.9 26 Baked beans, canned, plain or
vegetarian, ½ cup 2.9 26 Breakfast cereal, fortified with 25% of the DV for
zinc, 1 serving 2.8 25 Chicken, dark meat, cooked, 3 ounces 2.4 22 Pumpkin
seeds, dried, 1 ounce 2.2 20 Yogurt, fruit, low fat, 8 ounces 1.7 15 Cashews,
dry roasted, 1 ounce 1.6 15 Chickpeas, cooked, ½ cup 1.3 12 Cheese, Swiss, 1
ounce 1.2 11 Oatmeal, instant, plain, prepared with water, 1 packet 1.1 10 Milk,
low-fat or non fat, 1 cup 1.0 9 Almonds, dry roasted, 1 ounce 0.9 8 Kidney
beans, cooked, ½ cup 0.9 8 Chicken breast, roasted, skin removed, ½ breast 0.9 8
Cheese, cheddar or mozzarella, 1 ounce 0.9 8 Peas, green, frozen, cooked, ½ cup
0.5 5 Flounder or sole, cooked, 3 ounces 0.3 3

* DV = Daily Value. The U.S. Food and Drug Administration (FDA) developed DVs to
help consumers compare the nutrient contents of foods and dietary supplements
within the context of a total diet. The DV for zinc is 11 mg for adults and
children aged 4 years and older [14]. FDA does not require food labels to list
zinc content unless zinc has been added to the food. Foods providing 20% or more
of the DV are considered to be high sources of a nutrient, but foods providing
lower percentages of the DV also contribute to a healthful diet.

The U.S. Department of Agriculture’s (USDA’s) FoodData Central [11] lists the
nutrient content of many foods and provides a comprehensive list of foods
containing zinc arranged by nutrient content and by food name.

DIETARY SUPPLEMENTS

Supplements contain several forms of zinc, including zinc gluconate, zinc
sulfate, and zinc acetate. The percentage of elemental zinc varies by form. For
example, approximately 23% of zinc sulfate consists of elemental zinc; thus, 220
mg of zinc sulfate contains 50 mg of elemental zinc. The elemental zinc content
appears in the Supplement Facts panel on the supplement container. Research has
not determined whether differences exist among forms of zinc in absorption,
bioavailability, or tolerability.

In addition to standard tablets and capsules, some zinc-containing cold lozenges
are labeled as dietary supplements.

OTHER SOURCES

Zinc is present in several products, including some labeled as homeopathic
medications, sold over the counter for the treatment and prevention of colds.
Numerous case reports of anosmia (loss of the sense of smell), in some cases
long-lasting or permanent, have been associated with the use of zinc-containing
nasal gels or sprays [15,16]. In June 2009, the FDA warned consumers to stop
using three zinc-containing intranasal products because they might cause anosmia
[17]. The manufacturer recalled these products from the marketplace. Currently,
these safety concerns have not been found to be associated with cold lozenges
containing zinc.

Zinc is also present in some denture adhesive creams at levels ranging from
17–34 mg/g [18]. While use of these products as directed (0.5–1.5 g/day) is not
of concern, chronic, excessive use can lead to zinc toxicity, resulting in
copper deficiency and neurologic disease. Such toxicity has been reported in
individuals who used 2 or more standard 2.4 oz tubes of denture cream per week
[18,19]. Many denture creams have now been reformulated to eliminate zinc.


ZINC INTAKES AND STATUS

Most infants (especially those who are formula fed), children, and adults in the
United States consume recommended amounts of zinc according to two national
surveys, the 1988–1991 National Health and Nutrition Examination Survey (NHANES
III) [20] and the 1994 Continuing Survey of Food Intakes of Individuals (CSFII)
[21].

However, some evidence suggests that zinc intakes among older adults might be
marginal. An analysis of NHANES III data found that 35%–45% of adults aged 60
years or older had zinc intakes below the estimated average requirement of 6.8
mg/day for elderly females and 9.4 mg/day for elderly males. When the
investigators considered intakes from both food and dietary supplements, they
found that 20%–25% of older adults still had inadequate zinc intakes [22].

Zinc intakes might also be low in older adults from the 2%–4% of U.S. households
that are food insufficient (sometimes or often not having enough food) [23].
Data from NHANES III indicate that adults aged 60 years or older from
food-insufficient families had lower intakes of zinc and several other nutrients
and were more likely to have zinc intakes below 50% of the RDA on a given day
than those from food-sufficient families [24].


ZINC DEFICIENCY

Zinc deficiency is characterized by growth retardation, loss of appetite, and
impaired immune function. In more severe cases, zinc deficiency causes hair
loss, diarrhea, delayed sexual maturation, impotence, hypogonadism in males, and
eye and skin lesions [2,8,25,26]. Weight loss, delayed healing of wounds, taste
abnormalities, and mental lethargy can also occur [5,8,27-31]. Many of these
symptoms are non-specific and often associated with other health conditions;
therefore, a medical examination is necessary to ascertain whether a zinc
deficiency is present.

Zinc nutritional status is difficult to measure adequately using laboratory
tests [2,32,33] due to its distribution throughout the body as a component of
various proteins and nucleic acids [34]. Plasma or serum zinc levels are the
most commonly used indices for evaluating zinc deficiency, but these levels do
not necessarily reflect cellular zinc status due to tight homeostatic control
mechanisms [8]. Clinical effects of zinc deficiency can be present in the
absence of abnormal laboratory indices [8]. Clinicians consider risk factors
(such as inadequate caloric intake, alcoholism, and digestive diseases) and
symptoms of zinc deficiency (such as impaired growth in infants and children)
when determining the need for zinc supplementation [2].


GROUPS AT RISK OF ZINC INADEQUACY

In North America, overt zinc deficiency is uncommon [2]. When zinc deficiency
does occur, it is usually due to inadequate zinc intake or absorption, increased
losses of zinc from the body, or increased requirements for zinc [27,28,35].
People at risk of zinc deficiency or inadequacy need to include good sources of
zinc in their daily diets. Supplemental zinc might also be appropriate in
certain situations.

PEOPLE WITH GASTROINTESTINAL AND OTHER DISEASES

Gastrointestinal surgery and digestive disorders (such as ulcerative colitis,
Crohn’s disease, and short bowel syndrome) can decrease zinc absorption and
increase endogenous zinc losses primarily from the gastrointestinal tract and,
to a lesser extent, from the kidney [2,27,36,37]. Other diseases associated with
zinc deficiency include malabsorption syndrome, chronic liver disease, chronic
renal disease, sickle cell disease, diabetes, malignancy, and other chronic
illnesses [38]. Chronic diarrhea also leads to excessive loss of zinc [25].

VEGETARIANS

The bioavailability of zinc from vegetarian diets is lower than from
non-vegetarian diets because vegetarians do not eat meat, which is high in
bioavailable zinc and may enhance zinc absorption. In addition, vegetarians
typically eat high levels of legumes and whole grains, which contain phytates
that bind zinc and inhibit its absorption [32,39].

Vegetarians sometimes require as much as 50% more of the RDA for zinc than
non-vegetarians [2]. In addition, they might benefit from using certain food
preparation techniques that reduce the binding of zinc by phytates and increase
its bioavailability. Techniques to increase zinc bioavailability include soaking
beans, grains, and seeds in water for several hours before cooking them and
allowing them to sit after soaking until sprouts form [39]. Vegetarians can also
increase their zinc intake by consuming more leavened grain products (such as
bread) than unleavened products (such as crackers) because leavening partially
breaks down the phytate; thus, the body absorbs more zinc from leavened grains
than unleavened grains.

PREGNANT AND LACTATING WOMEN

Pregnant women, particularly those starting their pregnancy with marginal zinc
status, are at increased risk of becoming zinc insufficient due, in part, to
high fetal requirements for zinc [40]. Lactation can also deplete maternal zinc
stores [41]. For these reasons, the RDA for zinc is higher for pregnant and
lactating women than for other women (see Table 1) [2].

OLDER INFANTS WHO ARE EXCLUSIVELY BREASTFED

Breast milk provides sufficient zinc (2 mg/day) for the first 4–6 months of life
but does not provide recommended amounts of zinc for infants aged 7–12 months,
who need 3 mg/day [2,34]. In addition to breast milk, infants aged 7–12 months
should consume age-appropriate foods or formula containing zinc [2]. Zinc
supplementation has improved the growth rate in some children who demonstrate
mild-to-moderate growth failure and who have a zinc deficiency [25,42].

PEOPLE WITH SICKLE CELL DISEASE

Results from a large cross-sectional survey suggest that 44% of children with
sickle cell disease have a low plasma zinc concentration [43], possibly due to
increased nutrient requirements and/or poor nutritional status [44]. Zinc
deficiency also affects approximately 60%–70% of adults with sickle cell disease
[45]. Zinc supplementation has been shown to improve growth in children with
sickle cell disease [44].

ALCOHOLICS

Approximately 30%–50% of alcoholics have low zinc status because ethanol
consumption decreases intestinal absorption of zinc and increases urinary zinc
excretion [45]. In addition, the variety and amount of food consumed by many
alcoholics is limited, leading to inadequate zinc intake [2,46,47,48].


ZINC AND HEALTH

IMMUNE FUNCTION

Severe zinc deficiency depresses immune function [49], and even mild to moderate
degrees of zinc deficiency can impair macrophage and neutrophil functions,
natural killer cell activity, and complement activity [50]. The body requires
zinc to develop and activate T-lymphocytes [2,51]. Individuals with low zinc
levels have shown reduced lymphocyte proliferation response to mitogens and
other adverse alterations in immunity that can be corrected by zinc
supplementation [50,52]. These alterations in immune function might explain why
low zinc status has been associated with increased susceptibility to pneumonia
and other infections in children in developing countries and the elderly
[53-56].

WOUND HEALING

Zinc helps maintain the integrity of skin and mucosal membranes [50]. Patients
with chronic leg ulcers have abnormal zinc metabolism and low serum zinc levels
[57], and clinicians frequently treat skin ulcers with zinc supplements [58].
The authors of a systematic review concluded that zinc sulfate might be
effective for treating leg ulcers in some patients who have low serum zinc
levels [59,60]. However, research has not shown that the general use of zinc
sulfate in patients with chronic leg ulcers or arterial or venous ulcers is
effective [59,60].

DIARRHEA

Acute diarrhea is associated with high rates of mortality among children in
developing countries [61]. Zinc deficiency causes alterations in immune response
that probably contribute to increased susceptibility to infections, such as
those that cause diarrhea, especially in children [50].

Studies show that poor, malnourished children in India, Africa, South America,
and Southeast Asia experience shorter courses of infectious diarrhea after
taking zinc supplements [62]. The children in these studies received 4–40 mg of
zinc a day in the form of zinc acetate, zinc gluconate, or zinc sulfate [62].

In addition, results from a pooled analysis of randomized controlled trials of
zinc supplementation in developing countries suggest that zinc helps reduce the
duration and severity of diarrhea in zinc-deficient or otherwise malnourished
children [63]. Similar findings were reported in a meta-analysis published in
2008 and a 2007 review of zinc supplementation for preventing and treating
diarrhea [64,65]. The effects of zinc supplementation on diarrhea in children
with adequate zinc status, such as most children in the United States, are not
clear.

The World Health Organization and UNICEF now recommend short-term zinc
supplementation (20 mg of zinc per day, or 10 mg for infants under 6 months, for
10–14 days) to treat acute childhood diarrhea [61].

THE COMMON COLD

Researchers have hypothesized that zinc could reduce the severity and duration
of cold symptoms by directly inhibiting rhinovirus binding and replication in
the nasal mucosa and suppressing inflammation [66,67]. In studies examining the
effects of zinc on the common cold, zinc is usually administered in a lozenge or
syrup that temporarily “sticks” to the mouth and throat, placing the zinc in
contact with the rhinovirus in those areas.

The results from clinical trials that examined the effects of zinc on the common
cold have been inconsistent. However, overall, zinc in lozenge or syrup form
appears to reduce the duration, but not the severity, of symptoms when taken
shortly after a person develops a cold [68,69,70,71].

In one randomized, double-blind, placebo-controlled clinical trial, 50 adults
within 24 hours of developing the common cold took a zinc acetate lozenge (13.3
mg zinc) or placebo every 2–3 wakeful hours for as long as they had cold
symptoms. In comparison with placebo, the zinc lozenges significantly reduced
the duration of colds by 3 days and the severity of cold symptoms (cough, nasal
discharge, and muscle aches) [72].

In another clinical trial, 273 adults with experimentally induced colds took
zinc gluconate lozenges that provided 13.3 mg zinc every 2 to 3 hours while
awake, for a total of 6 lozenges per day for up to 14 days. The lozenges
significantly reduced the duration of illness by 1 day in comparison with
placebo but had no effect on symptom severity [73]. However, the same
administration schedule using zinc acetate lozenges (that provided 5.0 or 11.5
mg zinc) had no effect on either cold duration or severity. Neither zinc
gluconate nor zinc acetate lozenges affected the duration or severity of cold
symptoms in 281 adults with natural (not experimentally induced) colds in
another trial [73].

A 2021 systematic review and meta-analysis included 28 randomized controlled
trials (including the three described above) with a total of 5,446 participants
(mostly adults younger than 65 years) who had a community-acquired viral
respiratory tract infection or were inoculated with a rhinovirus [68]. Most
trials provided zinc in the form of zinc acetate or gluconate lozenges at total
daily doses of 45 mg to 300 mg for up to 2 weeks, but some trials used nasal
sprays or gels. In participants who used zinc supplements, symptoms resolved an
average of 2 days earlier than in those who received placebo. Symptoms on the
third day were also milder in participants who used zinc, but average daily
symptom severity did not differ between those who were and were not treated with
zinc supplements.

Findings were similar in earlier analyses, including a 2017 meta-analysis of 7
randomized controlled trials with a total of 575 individuals aged 11 to 69 years
[70]. Participants started taking either zinc lozenges (in the form of zinc
acetate or zinc gluconate) every 2 to 3 hours while awake, for total daily doses
of 80 to 207 mg zinc, or placebo within 1 to 3 days of developing a cold. In
participants taking zinc lozenges, colds were 33% shorter than in those taking
placebo. Similarly, a 2012 systematic review and meta-analysis included 17
trials with a total of 2,121 participants (mostly adults, but four trials
included children aged 1 year and older) that administered zinc, mainly in the
form of zinc gluconate lozenges, zinc acetate lozenges, or zinc sulfate syrup,
for 3 to 14 days or until symptoms were resolved [71]. Zinc doses and
administration schedules varied but ranged from about 4.5 mg every 1 to 1.5
hours to 23.7 mg every 2 hours during waking hours. Overall, cold symptoms
lasted a mean of 1.65 days less in those who took zinc than in the placebo
group. However, the analysis showed no significant difference in severity of
symptoms between the zinc and placebo groups. An earlier systematic review
concluded that use of total daily zinc lozenge doses of over 75 mg reduced the
duration of the common cold, whereas lower doses did not [69].

More large, high-quality clinical trials are needed to determine the optimal
dosage, formulation, and administration schedule before a general recommendation
can be made regarding the use of zinc supplements for the common cold
[69,70,71].

AGE-RELATED MACULAR DEGENERATION

Researchers have suggested that both zinc and antioxidants delay the progression
of age-related macular degeneration (AMD) and vision loss, possibly by
preventing cellular damage in the retina [74,75]. In a population-based cohort
study in the Netherlands, high dietary intake of zinc as well as beta carotene,
vitamin C, and vitamin E was associated with reduced risk of AMD in elderly
subjects [76]. However, the authors of a systematic review and meta-analysis
published in 2007 concluded that zinc is not effective for the primary
prevention of early AMD [77], although zinc might reduce the risk of progression
to advanced AMD.

The Age-Related Eye Disease Study (AREDS), a large, randomized,
placebo-controlled, clinical trial (n = 3,597), evaluated the effect of high
doses of selected antioxidants (500 mg vitamin C, 400 IU vitamin E, and 15 mg
beta-carotene) with or without zinc (80 mg as zinc oxide) on the development of
advanced AMD in older individuals with varying degrees of AMD [75]. Participants
also received 2 mg copper to prevent the copper deficiency associated with high
zinc intakes. After an average follow-up period of 6.3 years, supplementation
with antioxidants plus zinc (but not antioxidants alone) significantly reduced
the risk of developing advanced AMD and reduced visual acuity loss. Zinc
supplementation alone significantly reduced the risk of developing advanced AMD
in subjects at higher risk but not in the total study population. Visual acuity
loss was not significantly affected by zinc supplementation alone.

A follow-up AREDS2 study confirmed the value of this supplement in reducing the
progression of AMD over a median follow-up period of 5 years [78]. AREDS2 found
that a formulation providing 25 mg zinc (about one-third the amount in the
original formulation) provided the same protective effect against developing
advanced AMD. However, because AREDS2 had fewer participants than the original
AREDS study, and fewer than half took the lower zinc formula, the researchers
view this finding as preliminary. They recommend use of an AREDS formulation
providing 80 mg zinc [79,80].

Two other small clinical trials evaluated the effects of supplementation with
200 mg zinc sulfate (providing 45 mg zinc) for 2 years in subjects with drusen
or macular degeneration. Zinc supplementation significantly reduced visual
acuity loss in one of the studies [81] but had no effect in the other [82].

A Cochrane review concluded that the evidence supporting the use of antioxidant
vitamins and zinc for AMD comes primarily from the AREDS study [74]. Individuals
who have or are developing AMD should talk to their healthcare provider about
taking a zinc-containing AREDS supplement.

INTERACTIONS WITH IRON AND COPPER

Iron-deficiency anemia is a serious world-wide public health problem. Iron
fortification programs have been credited with improving the iron status of
millions of women, infants, and children. Fortification of foods with iron does
not significantly affect zinc absorption. However, large amounts of supplemental
iron (greater than 25 mg) might decrease zinc absorption [2,83]. Taking iron
supplements between meals helps decrease its effect on zinc absorption [83].

High zinc intakes can inhibit copper absorption, sometimes producing copper
deficiency and associated anemia [84,85]. For this reason, dietary supplement
formulations containing high levels of zinc, such as the one used in the AREDS
study [75], sometimes contain copper.


HEALTH RISKS FROM EXCESSIVE ZINC

Zinc toxicity can occur in both acute and chronic forms. Acute adverse effects
of high zinc intake include nausea, vomiting, loss of appetite, abdominal
cramps, diarrhea, and headaches [2]. One case report cited severe nausea and
vomiting within 30 minutes of ingesting 4 g of zinc gluconate (570 mg elemental
zinc) [86]. Intakes of 150–450 mg of zinc per day have been associated with such
chronic effects as low copper status, altered iron function, reduced immune
function, and reduced levels of high-density lipoproteins [87]. Reductions in a
copper-containing enzyme, a marker of copper status, have been reported with
even moderately high zinc intakes of approximately 60 mg/day for up to 10 weeks
[2]. The doses of zinc used in the AREDS study (80 mg per day of zinc in the
form of zinc oxide for 6.3 years, on average) have been associated with a
significant increase in hospitalizations for genitourinary causes, raising the
possibility that chronically high intakes of zinc adversely affect some aspects
of urinary physiology [88].

The FNB has established ULs for zinc (Table 3). Long-term intakes above the UL
increase the risk of adverse health effects [2]. The ULs do not apply to
individuals receiving zinc for medical treatment, but such individuals should be
under the care of a physician who monitors them for adverse health effects.

Table 3: Tolerable Upper Intake Levels (ULs) for Zinc [2] Age Male Female
Pregnant Lactating 0–6 months 4 mg 4 mg 7–12 months 5 mg 5 mg 1–3 years 7 mg 7
mg 4–8 years 12 mg 12 mg 9–13 years 23 mg 23 mg 14–18 years 34 mg 34 mg 34 mg 34
mg 19+ years 40 mg 40 mg 40 mg 40 mg

 


INTERACTIONS WITH MEDICATIONS

Zinc supplements have the potential to interact with several types of
medications. A few examples are provided below. Individuals taking these
medications on a regular basis should discuss their zinc intakes with their
healthcare providers.

ANTIBIOTICS

Both quinolone antibiotics (such as Cipro®) and tetracycline antibiotics (such
as Achromycin® and Sumycin®) interact with zinc in the gastrointestinal tract,
inhibiting the absorption of both zinc and the antibiotic [89,90]. Taking the
antibiotic at least 2 hours before or 4–6 hours after taking a zinc supplement
minimizes this interaction [91].

PENICILLAMINE

Zinc can reduce the absorption and action of penicillamine, a drug used to treat
rheumatoid arthritis [92]. To minimize this interaction, individuals should take
zinc supplements at least 2 hours before or after taking penicillamine [90].

DIURETICS

Thiazide diuretics such as chlorthalidone (Hygroton®) and hydrochlorothiazide
(Esidrix® and HydroDIURIL®) increase urinary zinc excretion by as much as 60%
[93]. Prolonged use of thiazide diuretics could deplete zinc tissue levels, so
clinicians should monitor zinc status in patients taking these medications.


ZINC AND HEALTHFUL DIETS

The federal government’s 2020–2025 Dietary Guidelines for Americans notes that
“Because foods provide an array of nutrients and other components that have
benefits for health, nutritional needs should be met primarily through foods. …
In some cases, fortified foods and dietary supplements are useful when it is not
possible otherwise to meet needs for one or more nutrients (e.g., during
specific life stages such as pregnancy).”

For more information about building a healthy dietary pattern, refer to the
Dietary Guidelines for Americans and the U.S. Department of Agriculture’s
MyPlate.

The Dietary Guidelines for Americans describes a healthy dietary pattern as one
that:

 * Includes a variety of vegetables; fruits; grains (at least half whole
   grains); fat-free and low-fat milk, yogurt, and cheese; and oils. Whole
   grains and milk products are good sources of zinc. Many ready-to-eat
   breakfast cereals are fortified with zinc.
 * Includes a variety of protein foods such as lean meats; poultry; eggs;
   seafood; beans, peas, and lentils; nuts and seeds; and soy products. Oysters,
   red meat, and poultry are excellent sources of zinc. Baked beans, chickpeas,
   and nuts (such as cashews and almonds) also contain zinc.
 * Limits foods and beverages higher in added sugars, saturated fat, and sodium.
   
   
 * Limits alcoholic beverages.
   
   
 * Stays within your daily calorie needs.


REFERENCES

 1.  Sandstead HH. Understanding zinc: recent observations and interpretations.
     J Lab Clin Med 1994;124:322-7. [PubMed abstract]
 2.  Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes
     for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron,
     Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC:
     National Academy Press, 2001.
 3.  Solomons NW. Mild human zinc deficiency produces an imbalance between
     cell-mediated and humoral immunity. Nutr Rev 1998;56:27-8. [PubMed
     abstract]
 4.  Prasad AS. Zinc: an overview. Nutrition 1995;11:93-9. [PubMed abstract]
 5.  Heyneman CA. Zinc deficiency and taste disorders. Ann Pharmacother
     1996;30:186-7. [PubMed abstract]
 6.  Simmer K, Thompson RP. Zinc in the fetus and newborn. Acta Paediatr Scand
     Suppl 1985;319:158-63. [PubMed abstract]
 7.  Fabris N, Mocchegiani E. Zinc, human diseases and aging. Aging (Milano)
     1995;7:77-93. [PubMed abstract]
 8.  Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc
     supplementation. J Trace Elem Med Biol 2006;20:3-18. [PubMed abstract]
 9.  Prasad AS, Beck FW, Grabowski SM, Kaplan J, Mathog RH. Zinc deficiency:
     changes in cytokine production and T-cell subpopulations in patients with
     head and neck cancer and in noncancer subjects. Proc Assoc Am Physicians
     1997;109:68-77. [PubMed abstract]
 10. Rink L, Gabriel P. Zinc and the immune system. Proc Nutr Soc
     2000;59:541-52. [PubMed abstract]
 11. U.S. Department of Agriculture, Agricultural Research Service. FoodData
     Central, 2019.
 12. Sandstrom B. Bioavailability of zinc. Eur J Clin Nutr 1997;51 (1
     Suppl):S17-9. [PubMed abstract]
 13. Wise A. Phytate and zinc bioavailability. Int J Food Sci Nutr
     1995;46:53-63. [PubMed abstract]
 14. U.S. Food and Drug Administration. Food Labeling: Revision of the Nutrition
     and Supplement Facts Labels. 2016.
 15. Jafek BW, Linschoten MR, Murrow BW. Anosmia after intranasal zinc gluconate
     use. Am J Rhinol 2004;18:137-41. [PubMed abstract]
 16. Alexander TH, Davidson TM. Intranasal zinc and anosmia: the zinc-induced
     anosmia syndrome. Laryngoscope 2006;116:217-20. [PubMed abstract]
 17. U.S. Food and Drug Administration. Warnings on Three Zicam Intranasal Zinc
     Products. [http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm166931.htm]
 18. Nations SP, Boyer PJ, Love LA, Burritt MF, Butz JA, Wolfe GI, Hynan LS,
     Reisch J, Trivedi JR. Denture cream: an unusual source of excess zinc,
     leading to hypocupremia and neurologic disease. Neurology. 2008 Aug
     26;71(9):639-43. [PubMed abstract]
 19. Spain RI, Leist TP, De Sousa EA. When metals compete: a case of
     copper-deficiency myeloneuropathy and anemia. Nat Clin Pract Neurol. 2009
     Feb;5(2):106-11. [PubMed abstract]
 20. Alaimo K, McDowell MA, Briefel RR, et al. Dietary intake of vitamins,
     minerals, and fiber of persons ages 2 months and over in the United States:
     Third National Health and Nutrition Examination Survey, Phase 1, 1986-91.
     Advance data from vital and health statistics no 258. Hyattsville,
     Maryland: National Center for Health Statistics. 1994.
 21. Interagency Board for Nutrition Monitoring and Related Research. Third
     Report on Nutrition Monitoring in the United States. Washington, DC: U.S.
     Government Printing Office, 1995.
 22. Ervin RB, Kennedy-Stephenson J. Mineral intakes of elderly adult supplement
     and non-supplement users in the third national health and nutrition
     examination survey. J Nutr 2002;132:3422-7. [PubMed abstract]
 23. Ribar DS, Hamrick KS. Dynamics of Poverty and Food Sufficiency. Food
     Assistance and Nutrition Report Number 36, 2003. Washington, DC: U.S.
     Department of Agriculture, Economic Research Service.
     [http://www.ers.usda.gov/publications/fanrr36/fanrr36.pdf]
 24. Dixon LB, Winkleby MA, Radimer KL. Dietary intakes and serum nutrients
     differ between adults from food-insufficient and food-sufficient families:
     Third National Health and Nutrition Examination Survey, 1988-1994. J Nutr
     2001;131:1232-46. [PubMed abstract]
 25. Prasad AS. Zinc deficiency: its characterization and treatment. Met Ions
     Biol Syst 2004;41:103-37. [PubMed abstract]
 26. Wang LC, Busbey S. Images in clinical medicine. Acquired acrodermatitis
     enteropathica. N Engl J Med 2005;352:1121. [PubMed abstract]
 27. Hambidge KM, Mild zinc deficiency in human subjects. In: Mills CF, ed. Zinc
     in Human Biology. New York, NY: Springer-Verlag, 1989:281-96.
 28. King JC, Cousins RJ. Zinc. In: Shils ME, Shike M, Ross AC, Caballero B,
     Cousins, RJ, eds. Modern Nutrition in Health and Disease, 10th ed.
     Baltimore, MD: Lippincott Williams & Wilkins, 2005:271-85.
 29. Krasovec M, Frenk E. Acrodermatitis enteropathica secondary to Crohn’s
     disease. Dermatology 1996;193:361-3. [PubMed abstract]
 30. Ploysangam A, Falciglia GA, Brehm BJ. Effect of marginal zinc deficiency on
     human growth and development. J Trop Pediatr 1997;43:192-8. [PubMed
     abstract]
 31. Nishi Y. Zinc and growth. J Am Coll Nutr 1996;15:340-4. [PubMed abstract]
 32. Hunt JR. Bioavailability of iron, zinc, and other trace minerals from
     vegetarian diets. Am J Clin Nutr 2003;78 (3 Suppl):633S-9S. [PubMed
     abstract]
 33. Van Wouwe JP. Clinical and laboratory assessment of zinc deficiency in
     Dutch children. A review. Biol Trace Elem Res 1995;49:211-25. [PubMed
     abstract]
 34. Hambidge KM, Krebs NF. Zinc deficiency: a special challenge. J Nutr
     2007;137:1101-5. [PubMed abstract]
 35. Prasad AS. Zinc deficiency in women, infants and children. J Am Coll Nutr
     1996;15:113-20. [PubMed abstract]
 36. Naber TH, van den Hamer CJ, Baadenhuysen H, Jansen JB. The value of methods
     to determine zinc deficiency in patients with Crohn’s disease. Scand J
     Gastroenterol 1998;33:514-23. [PubMed abstract]
 37. Valberg LS, Flanagan PR, Kertesz A, Bondy DC. Zinc absorption in
     inflammatory bowel disease. Dig Dis Sci. 1986 Jul;31(7):724-31. [PubMed
     abstract]
 38. Prasad AS. Zinc deficiency. BMJ 2003;326:409-10. [PubMed abstract]
 39. American Dietetic Association, Dietitians of Canada. Position of the
     American Dietetic Association and Dietitians of Canada: vegetarian diets. J
     Am Diet Assoc 2003;103:748-65. [PubMed abstract]
 40. Caulfield LE, Zavaleta N, Shankar AH, Merialdi M. Potential contribution of
     maternal zinc supplementation during pregnancy to maternal and child
     survival. Am J Clin Nutr 1998;68 (2 Suppl):499S-508S. [PubMed abstract]
 41. Krebs NF. Zinc supplementation during lactation. Am J Clin Nutr 1998;68 (2
     Suppl):509S -12S. [PubMed abstract]
 42. Brown KH, Allen LH, Peerson J. Zinc supplementation and children’s growth:
     a meta-analysis of intervention trials. Bibl Nutr Dieta 1998;54:73-6.
 43. Leonard MB, Zemel BS, Kawchak DA, Ohene-Frempong K, Stallings VA. Plasma
     zinc status, growth, and maturation in children with sickle cell disease. J
     Pediatr 1998;132:467-71. [PubMed abstract]
 44. Zemel BS, Kawchak DA, Fung EB, Ohene-Frempong K, Stallings VA. Effect of
     zinc supplementation on growth and body composition in children with sickle
     cell disease. Am J Clin Nutr 2002;75:300-7. [PubMed abstract]
 45. Prasad AS. Zinc deficiency in patients with sickle cell disease. Am J Clin
     Nutr 2002;75:181-2. [PubMed abstract]
 46. Kang YJ, Zhou Z. Zinc prevention and treatment of alcoholic liver disease.
     Mol Aspects Med 2005;26:391-404. [PubMed abstract]
 47. Menzano E, Carlen PL. Zinc deficiency and corticosteroids in the
     pathogenesis of alcoholic brain dysfunction—a review. Alcohol Clin Exp Res
     1994;18:895-901. [PubMed abstract]
 48. Navarro S, Valderrama R, To-Figueras J, Gimenez A, Lopez JM, Campo E, et
     al. Role of zinc in the process of pancreatic fibrosis in chronic alcoholic
     pancreatitis. Pancreas 1994;9:270-4. [PubMed abstract]
 49. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of
     altered resistance to infection. Am J Clin Nutr 1998;68:447S-63S. [PubMed
     abstract]
 50. Wintergerst ES, Maggini S, Hornig DH. Contribution of selected vitamins and
     trace elements to immune function. Ann Nutr Metab 2007;51:301-23. [PubMed
     abstract]
 51. Beck FW, Prasad AS, Kaplan J, Fitzgerald JT, Brewer GJ. Changes in cytokine
     production and T cell subpopulations in experimentally induced
     zinc-deficient humans. Am J Physiol 1997;272:E1002-7. [PubMed abstract]
 52. Prasad AS. Effects of zinc deficiency on Th1 and Th2 cytokine shifts. J
     Infect Dis 2000;182 (Suppl):S62-8. [PubMed abstract]
 53. Bahl R, Bhandari N, Hambidge KM, Bhan MK. Plasma zinc as a predictor of
     diarrheal and respiratory morbidity in children in an urban slum setting.
     Am J Clin Nutr 1998;68 (2 Suppl):414S-7S. [PubMed abstract]
 54. Brooks WA, Santosham M, Naheed A, Goswami D, Wahed MA, Diener-West M, et
     al. Effect of weekly zinc supplements on incidence of pneumonia and
     diarrhoea in children younger than 2 years in an urban, low-income
     population in Bangladesh: randomised controlled trial. Lancet
     2005;366:999-1004. [PubMed abstract]
 55. Meydani SN, Barnett JB, Dallal GE, Fine BC, Jacques PF, Leka LS, et al.
     Serum zinc and pneumonia in nursing home elderly. Am J Clin Nutr
     2007;86:1167-73. [PubMed abstract]
 56. Black RE. Zinc deficiency, infectious disease and mortality in the
     developing world. J Nutr 2003;133:1485S-9S. [PubMed abstract]
 57. Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Agren MS. Zinc in wound
     healing: theoretical, experimental, and clinical aspects. Wound Repair
     Regen 2007;15:2-16. [PubMed abstract]
 58. Anderson I. Zinc as an aid to healing. Nurs Times 1995;91:68, 70. [PubMed
     abstract]
 59. Wilkinson EA, Hawke CI. Does oral zinc aid the healing of chronic leg
     ulcers? A systematic literature review. Arch Dermatol 1998;134:1556-60.
     [PubMed abstract]
 60. Wilkinson EA, Hawke CI. Oral zinc for arterial and venous leg ulcers.
     Cochrane Database Syst Rev 2000;(2):CD001273. [PubMed abstract]
 61. World Health Organization and United Nations Children Fund. Clinical
     management of acute diarrhoea. WHO/UNICEF Joint Statement, August, 2004. [
     http://www.unicef.org/nutrition/files/ENAcute_Diarrhoea_reprint.pdf]
 62. Black RE. Therapeutic and preventive effects of zinc on serious childhood
     infectious diseases in developing countries. Am J Clin Nutr
     1998;68:476S-9S. [PubMed abstract]
 63. Bhutta ZA, Bird SM, Black RE, Brown KH, Gardner JM, Hidayat A, et al.
     Therapeutic effects of oral zinc in acute and persistent diarrhea in
     children in developing countries: pooled analysis of randomized controlled
     trials. Am J Clin Nutr 2000;72:1516-22. [PubMed abstract]
 64. Lukacik M, Thomas RL, Aranda JV. A meta-analysis of the effects of oral
     zinc in the treatment of acute and persistent diarrhea. Pediatrics
     2008;121:326-36. [PubMed abstract]
 65. Fischer Walker CL, Black RE. Micronutrients and diarrheal disease. Clin
     Infect Dis 2007;45 (1 Suppl):S73-7. [PubMed abstract]
 66. Hulisz D. Efficacy of zinc against common cold viruses: an overview. J Am
     Pharm Assoc (2003) 2004;44:594-603. [PubMed abstract]
 67. Caruso TJ, Prober CG, Gwaltney JM Jr. Treatment of naturally acquired
     common colds with zinc: a structured review. Clin Infect Dis
     2007;45:569-74. [PubMed abstract]
 68. Hunter J, Arentz S, Goldenberg J, Yang G, Beardsley J, Myers SP, Mertz D,
     Leeder S. Zinc for the prevention or treatment of acute viral respiratory
     tract infections in adults: a rapid systematic review and meta-analysis of
     randomised controlled trials. BMJ Open 2021;11:e047474. [PubMed abstract]
 69. Hemilä H. Zinc lozenges may shorten the duration of colds: a systematic
     review. Open Respir Med J. 2011;5:51-8. [PubMed abstract]
 70. Hemilä H. Zinc lozenges and the common cold: a meta-analysis comparing zinc
     acetate and zinc gluconate, and the role of zinc dosage. JRSM Open
     2017;8:2054270417694291. [PubMed abstract]
 71. Science M, Johnstone J, Roth DE, Guyatt G, Loeb M. Zinc for the treatment
     of the common cold: a systematic review and meta-analysis of randomized
     controlled trials. CMAJ 2012;184:E551-61. [PubMed abstract]
 72. Prasad AS, Beck FW, Bao B, Snell D, Fitzgerald JT. Duration and severity of
     symptoms and levels of plasma interleukin-1 receptor antagonist, soluble
     tumor necrosis factor receptor, and adhesion molecules in patients with
     common cold treated with zinc acetate. J Infect Dis 2008 ;197:795-802.
     [PubMed abstract]
 73. Turner RB, Cetnarowski WE. Effect of treatment with zinc gluconate or zinc
     acetate on experimental and natural colds. Clin Infect Dis 2000;31:1202-8.
     [PubMed abstract]
 74. Evans JR. Antioxidant vitamin and mineral supplements for slowing the
     progression of age-related macular degeneration. Cochrane Database Syst Rev
     2006;(2):CD000254. [PubMed abstract]
 75. Age-Related Eye Disease Study Research Group. A randomized,
     placebo-controlled, clinical trial of high-dose supplementation with
     vitamins C and E, beta carotene, and zinc for age-related macular
     degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol
     2001;119:1417-36. [PubMed abstract]
 76. van Leeuwen R, Boekhoorn S, Vingerling JR, Witteman JC, Klaver CC, Hofman
     A, et al. Dietary intake of antioxidants and risk of age-related macular
     degeneration. JAMA 2005;294:3101-7. [PubMed abstract]
 77. Chong EW, Wong TY, Kreis AJ, Simpson JA, Guymer RH. Dietary antioxidants
     and primary prevention of age related macular degeneration: systematic
     review and meta-analysis. BMJ 2007;335:755. [PubMed abstract]
 78. The Age-Related Eye Disease Study 2 (AREDS2) Research Group. Lutein +
     zeaxanthin and omega-3 fatty acids for age-related macular degeneration:
     the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.
     JAMA 2013;309:2005-15. [PubMed abstract]
 79. National Eye Institute. AREDS/AREDS2 Frequently Asked Questions. 2020.
 80. National Eye Institute. AREDS/AREDS2 Clinical Trials. 2020.
 81. Newsome DA, Swartz M, Leone NC, Elston RC, Miller E. Oral zinc in macular
     degeneration. Arch Ophthalmol 1988;106:192-8. [PubMed abstract]
 82. Stur M, Tittl M, Reitner A, Meisinger V. Oral zinc and the second eye in
     age-related macular degeneration. Invest Ophthalmol Vis Sci
     1996;37:1225-35. [PubMed abstract]
 83. Whittaker P. Iron and zinc interactions in humans. Am J Clin Nutr
     1998;68:442S-6S. [PubMed abstract]
 84. Broun ER, Greist A, Tricot G, Hoffman R. Excessive zinc ingestion. A
     reversible cause of sideroblastic anemia and bone marrow depression. JAMA
     1990;264:1441-3. [PubMed abstract]
 85. Willis MS, Monaghan SA, Miller ML, McKenna RW, Perkins WD, Levinson BS, et
     al. Zinc-induced copper deficiency: a report of three cases initially
     recognized on bone marrow examination. Am J Clin Pathol 2005;123:125-31.
     [PubMed abstract]
 86. Lewis MR, Kokan L. Zinc gluconate: acute ingestion. J Toxicol Clin Toxicol
     1998;36:99-101. [PubMed abstract]
 87. Hooper PL, Visconti L, Garry PJ, Johnson GE. Zinc lowers high-density
     lipoprotein-cholesterol levels. J Am Med Assoc 1980;244:1960-1. [PubMed
     abstract]
 88. Johnson AR, Munoz A, Gottlieb JL, Jarrard DF. High dose zinc increases
     hospital admissions due to genitourinary complications. J Urol
     2007;177:639-43. [PubMed abstract]
 89. Lomaestro BM, Bailie GR. Absorption interactions with fluoroquinolones.
     1995 update. Drug Saf 1995;12:314-33. [PubMed abstract]
 90. Penttilä O, Hurme H, Neuvonen PJ. Effect of zinc sulphate on the absorption
     of tetracycline and doxycycline in man. Eur J Clin Pharmacol 1975;9:131-4.
     [PubMed abstract]
 91. Natural Medicines Comprehensive Database. Zinc.
 92. Brewer GJ, Yuzbasiyan-Gurkan V, Johnson V, Dick RD, Wang Y. Treatment of
     Wilson’s disease with zinc: XI. Interaction with other anticopper agents. J
     Am Coll Nutr 1993;12:26-30. [PubMed abstract]
 93. Wester PO. Urinary zinc excretion during treatment with different
     diuretics. Acta Med Scand 1980;208:209-12. [PubMed abstract]


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Updated: December 7, 2021 History of changes to this fact sheet

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