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C PEPTIDE RESEARCHES



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 * COFILIN AS THE MASTER REGULATOR OF THE KEY COVID INFLAMMATORY TRIGGER NLRP3
   AND MICROGLIA ACTIVITY AS WELL AS OF THE SHANK3 PROTEIN EFFECTS: POSSIBLE
   THERAPEUTIC IMPLICATIONS FOR THE BRAIN AND THE BODY AFFECTED BY COVID-19
   INFECTION
   
   The NLRP3 inflammasome was identified as one of the most important
   inflammatory and apoptosis triggers in covid patients. i Its role in the
   inflammatory brain pathology caused by covid19 is also established. For
   example, the spike protein can increase the production of NRLP3 protein in
   microglia. ii The importance of this fact is highlighted by…
   
   July 25, 2021
   
   


 * THE SPIKE PROTEINS OF COVID-19 HAVE A STRONG NEUROTOXIC EFFECT WITH SEVERE
   CONSEQUENCES
   
   The following is what Brazilian researchers came up with when studying
   tadpoles. On the one hand, the protein fragments that make up the spike
   proteins increased oxidative stress, and on the other hand, they increased
   the activity of the so-called acetylcholinesterase, thereby excessively
   degrading acetylcholine from the nervous system and other cells. (1) The
   latter…
   
   January 24, 2021
   
   


 * POSSIBLE IMPACT OF INTRANASAL PROINSULIN C-PEPTIDE ON THE COURSE OF COVID-19
   INFECTION: THE ROLE OF THE CHOLINERGIC ANTI-INFLAMMATORY PATHWAY MEASURED BY
   HEART RATE VARIABILITY (HRV) AND THE IMPORTANCE OF MICROGLIA, THE RESIDENT
   IMMUNE CELLS IN THE BRAIN
   
   The increase of the inflammatory markers CRP and Il-6 predict the unfavorable
   course of the covid-19 infection. (1) (2) The decrease of HRV by more than
   40% precedes a 50% increase in CRP during the next 72 hours according to a
   small study. (3) The sudden decrease of HRV may signal the weakening or
   collapse…
   
   January 16, 2021
   
   


 * AUTISM AND THE POTENTIAL ROLE OF PROINSULIN C PEPTIDE IN BRAIN DEVELOPMENT:
   POSSIBILITIES FOR INTERVENTION
   
   Proinsulin c peptide is produced in placental tissue even in mothers with
   diabetes type 1 (T1D). This may mask the lack of c peptide production for the
   fetus in the body of the mothers. [i] Although the brain is also producing
   insulin and c peptide independently of the pancreas, the lack of c-peptide
   secreted by…
   
   July 20, 2020
   
   


 * COVID-19: RESTORING ENDOGENOUS NITRIC OXIDE (NO) RELATED HOMEOSTASIS MAY BE
   AN EFFECTIVE AND NATURAL WAY TO DECREASE REPLICATION OF COVID-19
   
   NO seems to inhibit the replication cycle of severe acute respiratory
   coronavirus. [i] It is expected that this can be exploited in some way for
   COVID-19 also.[ii] It is important to note that among the various biological
   effects of proinsulin c peptide the activation of NO production is especially
   well researched. C-peptide increases nitric oxide…
   
   June 24, 2020
   
   


 * COVID-19: POTENTIAL RISKS OF ALUMINUM ADJUVANT OF VACCINES FOR THE CENTRAL
   NERVOUS SYSTEM AND THE POSSIBLE BENEFICIAL EFFECT OF CENTRAL PROINSULIN C
   PEPTIDE
   
   According to recent epidemiologic data, BCG vaccination may provide some
   protection against COVID-19 infection and may reduce the severity of it. (1)
   However, it is alarming that achieving high levels of neutralizing antibodies
   to the spike protein of SARS-CoV-2 is proposed to be achieved by aluminum
   adjuvant formulations of traditional vaccine formulations. (2) It is…
   
   June 21, 2020
   
   


 * COVID-19: THE LACK OF PROINSULIN C-PEPTIDE MAY BE THE MAIN CAUSE OF THE
   SIGNIFICANTLY HIGHER MORTALITY RATE OF PATIENTS WITH TYPE 1 DIABETES MELLITUS
   COMPARED TO TYPE 2 DIABETES
   
   According to the largest study to this date, people with Type 1 diabetes had
   3,5 times the odds of dying in hospital with Covid-19 compared to those
   without diabetes. The odds for Type 2 diabetes of dying in hospital with
   COVID-19 is much smaller. It is 2,03 compared to those without diabetes. The
   difference is…
   
   June 1, 2020
   
   


 * COVID-19: O-GLCNAC AND AMPKΑ AS TARGETS OF PROINSULIN C PEPTIDE FOR
   PREVENTING CYTOKINE STORM
   
   Dysregulated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling can promote
   cytokine storm induced by a viral infection. Higher levels of blood glucose
   correlate with higher levels of proinflammatory cytokines. It can impair the
   host defense mechanism of the immune cells. (1) (2) Proinsulin c-peptide
   regulates and balances O-GlcNAc signaling that may be also increased by high
   glucose level. In…
   
   May 10, 2020
   
   


 * COVID-19: METHODS OF VAGUS NERVE STIMULATION THAT MAY IMPROVE THE HOST
   DEFENSE SYSTEM AGAINST VIRAL ATTACKS
   
   A case study on COVID-19 related respiratory symptoms suggests that
   electrical non-invasive vagus nerve stimulation might provide clinical
   benefits in patients with COVID-19. It may ease chest tightness and shortness
   of breath. (1) It is a remarkable fact that the risk groups of the COVID-19
   patients with poor outcome have a relatively low vagal tone…
   
   May 5, 2020
   
   


 * MAY IT BE THAT CENTRAL/ INTRANASAL PROINSULIN C-PEPTIDE HAS A FAVORABLE
   EFFECT BY ITS HRV INCREASING ABILITY ON MOST OF THE CLINICAL MARKERS OF THE
   POOR OUTCOME OF COVID-19? (IL-6, D-DIMER, LYMPHOCYTES)
   
   IL-6: Heart rate variability (HRV) is in inverse relationship with IL-6:
   Relationship between Heart Rate Variability, Interleukin-6, and Soluble
   Tissue Factor in Healthy Subjects:
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8/ D-dimer: D-dimer is in
   inverse relationship with endothelial progenitor cells and edothelial
   progenitor cells are positively associated with HRV or parasympathetic tone
   at least in patients with hypertension. : Lower…
   
   April 29, 2020
   
   

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C peptide Researches