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Home About Reseach cores & servicesSummer internship program News & Events People Quick links OKRA Coordinating CenterSummer Internship ProgramUM KUHR Training NetworkUM Division of NephrologyWolverines for Life National Kidney Disease Education ProgramNational Kidney FoundationNIDDK Kidney Disease CentersPolycystic Kidney Disease Research Resource Consortium Request Services Michigan George M. O'Brien National Resource Center ADVANCING RESEARCH THROUGH INNOVATION AND COLLABORATION Work with usLearn about our centerView publications The George M. O'Brien Kidney National Resource Center at the University of Michigan is dedicated to accelerating advancements in kidney disease research by providing kidney researchers with specialized resources, tools, technologies, services, and expertise beyond those typically available in an individual lab or institutional core. We strive to improve the lives of patients with kidney diseases through our state-of-the-art facilities, cutting-edge technologies, and collaborative approach. Our center, funded the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), is a member of the George M. O'Brien Kidney Resource Alliance (OKRA) consortium. Discover OUR INNOVATIVE APPROACH We utilize a three-pronged approach to support all basic and patient-oriented kidney research investigators. MOLECULAR INVESTIGATION We enable investigators to investigate the molecular causes and endpoints of acute and chronic kidney diseases. MODERN SYSTEMS BIOLOGY APPROACHES We disseminate and support the most modern and powerful systems biological approaches for identifying novel biomarkers and targets for diagnosis and treatment of kidney diseases. ANALYSIS AND INTEGRATION Our expert analysis and integration of cohort and systems data through sophisticated bioinformatics and database integration help identify specific pathways and targets for treatments. RESEARCH CORES AND SERVICES ADMINISTRATIVE CORE (AC) Coordinate activities, distribute resources, and assess operations to support the Center's goals and objectives. Through an ongoing review process, we ensure the effectiveness and advancement of kidney research. APPLIED SYSTEMS BIOLOGY CORE (ASBC) Provide expert consulting services for data mining genome-wide renal data sets and unique sets of tools to assist in bridging the gap between deep biological and clinical understanding with large-scale molecular and clinical data sets. DATA ANALYTIC SERVICES CORE (DASC) Enhance the understanding of complex kidney diseases and the multi-scalar data sets that accompany systems-biology approaches to their functional implications regarding kidney disease development, diagnosis, progression and therapeutic potential. RESOURCE DEVELOPMENT CORE (RDC) Develop a unified platform and methods to integrate multidimensional data, cohort selection and clinical trial design. CONTACT University of Michigan Medical School 5100 Brehm Tower 1000 Wall Street Ann Arbor, MI 48105-5714 Phone: (734) 936-5645 Fax: (734) 232-8162 Email: dikmj@umich.edu WORK WITH US GET STARTED To get started, please fill out our Request for sevices or training form. One of our staff will respond within 5-7 business days. 1-HOUR CONSULTAION Your request will be reviewed. For projects, a consultation will be scheduled to review the project/experimental design and quote. EVALUATION We will evaluate your project to determine resources and cost. PLEASE NOTE: Highest priority for services is given to investigators a) who are conducting kidney-related research that is federally funded or b) those funded by DCC Pilot and Feasibility grants, or c) to early-career investigators who are starting careers in kidney research but who may not have yet obtained funding. The next highest priority is given to researchers who are conducting research in kidney disease supported by non-federal agencies or are conducting unfunded research to support the submission of federal grant applications. OUR LEADERSHIP Subramaniam Pennathur, MD Director, Administrative Core View profileView website Matthias Kretzler, MD Director, Applied Systems Biology Core View profileView website Brian Athey, PhD Director, Data Analytic Services Core View profileView website Salim Hayek, MD Director, Resource Development Core View profileView website LATEST PUBLICATIONS See all publications EXTRACORPOREAL IMMUNOMODULATION THERAPY IN ACUTE CHRONIC LIVER FAILURE WITH MULTIORGAN FAILURE: FIRST IN HUMAN USE Yessayan, Lenar T., et al. March 2024 , ASAIO Journal UNBIASED KIDNEY-CENTRIC MOLECULAR CATEGORIZATION OF CHRONIC KIDNEY DISEASE AS A STEP TOWARDS PRECISION MEDICINE Reznichenko, Anna, et al. January 2024 , Kidney International DEFINING THE MOLECULAR CORRELATE OF ARTERIOLAR HYALINOSIS IN KIDNEY DISEASE PROGRESSION BY INTEGRATION OF SINGLE CELL TRANSCRIPTOMIC ANALYSIS AND PATHOLOGY SCORING Menon, Rajasree, et al. August 2023 , medRxiv [preprint] CRABTREE EFFECT IN KIDNEY PROXIMAL TUBULE CELLS VIA LATE-STAGE GLYCOLYTIC INTERMEDIATES Darshi, Manjula, et al. March 2023 , iScience UPCOMING EVENTS See all events 09 April OKRA MEETING Tuesday, April 9, 2024 16 April GEORGE O'BRIEN KIDNEY CENTER RESEARCH SEMINAR TBD Tuesday, April 16, 2024 9:00 - 10:00 AM 23 April O'BRIEN RETREAT Tuesday, April 23, 2024 FEATURED NEWS & STORIES See more REQUEST FOR PILOT & FEASIBILITY GRANT APPLICATIONS FOR BASIC & CLINICAL RESEARCH OF KIDNEY DISEASE June 18, 2022 The intent of this pilot program is to provide seed money for researchers to obtain subsequent extramural funding. If funded, the proposed start date for the P&F grants will be January 1, 2023. WE RECENTLY FUNDED SEVERAL PILOT & FEASIBILITY AND SMALL GRANT AWARDS! June 3, 2019 Congratulations to all who got funded! UROP MENTEE AWARDED OUTSTANDING POSTER AWARD May 1, 2019 Nephrology had two Undergraduate Research Opportunity Program (UROP) students the past academic school year. Both presented in the annual UROP Research symposium April 24, 2019. Social media FEED > When using any core services, users agree to cite the George M. O’Brien Michigan Kidney Translational Resource Center, funded by NIH/NIDDK grant U54DK137314 in any publications and/or presentations resulting from the use of these core services. The George M. O'Brien National Resource Center at the University of Michigan is supported by grant U54-DK137314 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)