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Allelica's latest results on clinical multi-ancestry PRS published in Nature
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EMPOWERING THE NEXT GENERATION OF CLINICAL GENOMICS

Talk with us

Allelica is a global life sciences company powering the healthcare and
pharmaceutical industries with comprehensive solutions for the development and
commercialization of clinical genetic tests. Uniquely positioned as innovators
in genetic risk prediction and experts in medical devices, Allelica offers a
cutting-edge quality management system, specifically designed to develop and
implement new genetics based assays.


WHAT WE DO


SEAMLESS ASSAY DEVELOPMENT FOR CLINICAL GENETICS

With an agile quality management system (QMS) built uniquely for clinical
genetic tests, Allelica provides healthcare providers, biotechs and
pharmaceutical companies with expertise and world class software for the
development and validation of new genetic tests, from conception to
commercialization.


COMPREHENSIVE SOLUTIONS FOR POLYGENIC RISK SCORE TESTING

Allelica is the leading provider of ancestry-specific clinical polygenic risk
score testing in the US and Europe. Through the implementation of cutting edge
microarray technology at partner medical laboratories, Allelica offers an end to
end testing solution for polygenic risk score (PRS), pharmacogenomics (PGx) and
carrier screening (CS).


SECURE & SCALABLE BIOINFORMATICS SOFTWARE

Available as an on-premise or cloud-based solution, Allelica’s suite of digital
tools enables laboratories to perform clinical PRS, Pharmacogenetics, and
Carrier Screening analyses in-house. In addition to flexible software access
options, Allelica offers multilingual, white label reporting for a range of our
customizable PRS, PGx and CS panels.


ALLELICA ISO CERTIFICATION




TRUSTED BY





"With this agreement, Merck confirms its strong commitment to advancing science
and technology in the area of cardiovascular disease"

Read more →

Antonio Messina, General Manager, Merck Biopharma


LATEST NEWS

Allelica multi-ancestry PRS published in Nature Communications

Results published by Allelica scientists in Nature Communications demonstrate
the clinical utility of polygenic risk scores across multiple ancestry
groups.The publication adds to growing evidence of the clinical value of PRS in
cardiovascular disease risk assessment, showing that adding PRS to traditional
models improves their precision and accuracy.

Baylor & Allelica present clinical workflow for PRS testing at ASHG

Allelica presented collaborative results with Baylor College of Medicine at the
American Society of Human Genetics Annual Meeting 2023. George Busby, Allelica
CSO, presented the results in the poster titled “Complete end-to-end workflow
for implementing clinical polygenic risk scores”.

Allelica launches the Allelica Precision Server

Allelica announces the release of the Allelica Precision Server (APS) for
CLIA-compliant, on-premises analysis and clinical reporting of polygenic risk
score, pharmacogenomics and carrier screening. APS is now available for medical
laboratories and healthcare providers.

Allelica participates in BiotechX Europe 2023

The Allelica team met with leaders in the pharmaceutical industry and
biotechnology at the annual BioTechX conference in Basel, Switzerland. PRS is
increasingly gaining traction among pharma and biotech companies for its ability
to stratify clinical trial populations and identify new drug targets.

PRS cost-effectiveness results published in Frontiers

Results published by Allelica researchers in Frontiers in Public Health reveal
that integrating PRS testing into workplace health programs cuts costs for
employers and improves quality of life for employees. Authors found that
Allelica's workplace program integrating PRS with the standard of care,
cardioriskSCORE, significantly outperformed programs without PRS.

Allelica delivers oral presentation, three poster presentations at ESHG 2023

The Allelica team showcased exciting PRS results at the European Society of
Human Genetics Conference 2023. Posters included: Low-coverage
genotyping-by-sequencing with accurate long HiFi reads and optimized imputation
(presented in collaboration with PacBio), Recalibrating polygenic risk scores to
country-specific incidence, and Analyses of polygenic risk scores that consider
individual-level admixture proportions outperform single ancestry approaches.

Clinical breast cancer PRS Results presented at ASCO 2023

Dr. Daniel Morganstern of Hartford Healthcare presented results integrating
Allelica’s multi-ancestry PRSs into risk assessments at the American Society of
Clinical Oncology Annual Meeting. Findings revealed the value PRS provides in
clinical risk assessments for breast cancer.

Allelica Research Published in the Journal of the American Heart Association

A health economics study [Integrating a Polygenic Risk Score for Coronary Artery
Disease as a Risk‐Enhancing Factor in the Pooled Cohort Equation: A
Cost‐Effectiveness Analysis Study] has been published in the Journal of the
American Heart Association. The study, performed by Allelica, in collaboration
with experts from Illumina and the University of Sydney, analyzed the
cost-effectiveness of PRS in heart disease risk assessments and found that PRS
is cost-saving in US health systems.

Allelica CAD PRS Research in Circulation

Allelica researchers identified a critical interaction between PRS for coronary
artery disease (CAD) and LDL cholesterol level. Their discovery has major
implications for clinical decision-making in primary prevention strategies. The
research is now available in the American Heart Association Journal,
Circulation.

Allelica Obtains ISO Certification

Allelica continues to set the industry standard of clinical-grade Polygenic Risk
Score analysis with the addition of two key ISO certifications. ISO 13485 and
ISO 9001 certify that Allelica applies medical device quality management
processes every step of the way.





OUR PRINCIPLES

Data Driven

Our products are developed and validated using world class datasets and
state-of-the-art technology to ensure the highest level of quality.

Scientific Rigor

We are a group of international scientists and researchers committed to
maintaining standards of academic excellence every step of the way.

Human-centricity

Everything we do works towards our common goal of providing tangible improvement
in preventive healthcare to help humans live a longer, healthier life.


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