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28-7 Logo toggle menu * Home * Science * About Us * Careers * News * Contact BOLD STEPS TOWARD A NEW DIRECTION We are explorers leading the revolution in RNA drug discovery to develop an entirely new class of therapies. We are identifying the chemical motifs to potently and selectively modulate RNA regulatory networks to treat the most challenging diseases. OUR THERAPIES RESTORE BALANCE We have set our first sights on cancer, an incredibly difficult disease to cure, dynamically evolving against the drugs used to treat it. Despite annual approvals of new cancer therapies, cancer remains the second leading cause of death in the U.S.1 Unfortunately, relapse is common. Over time, a cancer can activate multiple processes to become more and more aggressive, and potentially resist multi-drug regimens.2 1 Centers for Disease Control, 2017 2 Hanahan & Weinberg, Cell, 2011 MANY PATHWAYS TO CANCER Evading growth suppressors Avoiding immune destruction Enabling replicative immortality Tumor- promoting inflammation Activating Invasion & metastasis Induction of angiogenesis Genome instability & mutation Resisting cell death Deregulating cellular energetics Sustaining proliferative signaling OUR MULTI-PATHWAY THERAPEUTIC STRATEGY Most cancer drugs work by shutting down a single cellular pathway to halt or slow the growth of a cancer cell. However, cancer cells use many oncogenic pathways to maintain their aggressive growth and can activate new pathways over time. These cellular pathways may also be used, but to a lesser extent, by healthy cells, so patients may suffer from potentially severe drug toxicities by the very drugs intended to treat their cancer. Our therapeutic goal is fundamentally different. Our first program is designed to amplify multiple pathways that maintain a cell’s normal, differentiated phenotype. In a cancer cell context, activating these pathways reverses tumor growth. In other words, we are fighting cancer by restoring a healthy state. LEARN MORE ABOUT OUR UNIQUE STRATEGY Explore Your browser does not support the video tag. * Home * Science * About Us * Careers * News * Contact * Privacy * Terms of Use Copyright © 2019 28/7 – All rights reserved