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WORLD.ORG® COVID-19 Research


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Studies: Long COVID & Epstein-Barr Virus Reactivation; MMR Vaccine & COVID-19

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 * MMR Vaccine
 * Long COVID/Epstein-Barr Virus
 * MoreOther Projects

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LONG COVID / EPSTEIN-BARR VIRUS REACTIVATION

ABSTRACT: Coronavirus disease 2019 (COVID-19) patients sometimes experience
long-term symptoms following resolution of acute disease, including fatigue,
brain fog, and rashes. Collectively these have become known as long COVID. Our
aim was to first determine long COVID prevalence in 185 randomly surveyed
COVID-19 patients and, subsequently, to determine if there was an association
between occurrence of long COVID symptoms and reactivation of EpsteinBarr virus
(EBV) in 68 COVID-19 patients recruited from those surveyed. We found the
prevalence of long COVID symptoms to be 30.3% (56/185), which included 4
initially asymptomatic COVID-19 patients who later developed long COVID
symptoms. Next, we found that 66.7% (20/30) of long COVID subjects versus 10%
(2/20) of control subjects in our primary study group were positive for EBV
reactivation based on positive titers for EBV early antigen-diffuse (EA-D) IgG
or EBV viral capsid antigen (VCA) IgM. The difference was significant (p <
0.001, Fishers exact test). A similar ratio was observed in a secondary group of
18 subjects 2190 days after testing positive for COVID-19, indicating
reactivation may occur soon after or concurrently with COVID-19 infection. These
findings suggest that many long COVID symptoms may not be a direct result of the
SARS-CoV-2 virus but may be the result of COVID-19 inflammation-induced EBV
reactivation. Read Full Study: NIH Website, Pathogens

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MMR VACCINE & COVID-19 SEVERITY

ABSTRACT: The measles-mumps-rubella (MMR) vaccine has been theorized to provide
protection against coronavirus disease 2019 (COVID-19). Our aim was to determine
whether any MMR IgG titers are inversely correlated with severity in recovered
COVID-19 patients previously vaccinated with MMR II. We divided 80 subjects into
two groups, comparing MMR titers to recent COVID-19 severity levels. The MMR II
group consisted of 50 subjects who would primarily have MMR antibodies from the
MMR II vaccine, and a comparison group of 30 subjects consisted of those who
would primarily have MMR antibodies from sources other than MMR II, including
prior measles, mumps, and/or rubella illnesses. There was a significant inverse
correlation (rs=0.71, p < 0.001) between mumps virus titers (mumps titers) and
COVID-19 severity within the MMR II group. There were no significant
correlations between mumps titers and severity in the comparison group, between
mumps titers and age in the MMR II group, or between severity and measles or
rubella titers in either group. Within the MMR II group, mumps titers of 134 to
300arbitrary units (AU)/ml (n = 8) were found only in those who were
functionally immune or asymptomatic; all with mild symptoms had mumps titers
below 134AU/ml (n = 17); all with moderate symptoms had mumps titers below
75AU/ml (n = 11); all who had been hospitalized and had required oxygen had
mumps titers below 32AU/ml (n = 5). Our results demonstrate that there is a
significant inverse correlation between mumps titers from MMR II and COVID-19
severity. Read Full Study: NIH Website, mBio

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OTHER PROJECTS BY WORLD.ORG®

 * Fossil Fuel Reduction - Save Energy, Save Money
 * Rescue Me!
 * Endangered Plant Propagation Center

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