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you for your patience..

 * * Original Article Autism and Prenatal Exposure to Antiseizure Medication S.
     Hernández-Díaz and Others
     
     In a population-based study, prenatal exposure to topiramate, valproate, or
     lamotrigine was linked with an increased risk of autism. After adjustment
     for confounders, only valproate exposure was linked with increased risk.
     
     Mar 21
     
     Editorial Risks of Fetal Exposure to Topiramate
 * * Original Article Ribociclib + Endocrine Therapy in Early Breast Cancer D.
     Slamon and Others
     
     In patients with stage II or III early breast cancer, the addition of
     ribociclib to adjuvant hormonal therapy resulted in a significant
     improvement in 3-year invasive disease–free survival.
     
     Mar 21
   * Perspective Fundamentals of Medical Ethics Physicians, Spirituality, and
     Compassionate Care D.P. Sulmasy
     
     The ethical principles of beneficence and respect for patients as whole
     persons may require doctors to inquire about patients’ spiritual and
     religious needs and refer them to a chaplain as appropriate.
     
     Mar 16

 * * Perspective Double Take Alzheimer’s Disease — Managing Stages of Dementia
     N.A. Chin and Others
     
     This Double Take video reviews the stages of Alzheimer’s disease as well as
     pharmacologic and nonpharmacologic management for each stage.
     
     Mar 21
   * Perspective “What’s Lymphoma?” B. Vipler
     
     The immediate release of test results to patients, mandated by the 21st
     Century Cures Act, has some unfortunate unintended consequences for
     patients and their clinicians.
     
     Mar 16
 * * Perspective The Plight of DEI Leaders A. Maybank
     
     As leaders of diversity, equity, and inclusion efforts within academic,
     medical, and corporate institutions strive to improve equity and health for
     all, they are facing attacks from all sides.
     
     Mar 20
   * Perspective Podcast: Not Otherwise Specified Whatever it Takes
     
     This podcast episode takes a sobering look at the mental health of U.S.
     medical students and trainees, in an era when the pressures can be
     intolerable but the culture still treats depression as weakness.
     
     Mar 21

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ORIGINAL RESEARCH

 * * Original Article Gene Therapy for Giant Axonal Neuropathy D.X.
     Bharucha-Goebel and Others
     
     In a phase 1 study involving children with giant axonal neuropathy,
     intrathecal administration of an adeno-associated virus containing a GAN
     transgene resulted in some improvement in motor function scores.
     
     Mar 21
 * * Original Article Anti–Interleukin-23 in Immunodeficiency A. Cheng and
     Others
     
     Investigators identified autoantibodies against interleukin-23 (with or
     without anti–interleukin-12) in patients with a variety of opportunistic
     infections, especially in those with thymoma.
     
     Mar 21
     
     Editorial Anti–Interleukin-23 Autoantibodies and Severe Infections
   
   * Original Article Ribociclib + Endocrine Therapy in Early Breast Cancer D.
     Slamon and Others
     
     In patients with stage II or III early breast cancer, the addition of
     ribociclib to adjuvant hormonal therapy resulted in a significant
     improvement in 3-year invasive disease–free survival.
     
     Mar 21

 * * Original Article Blood-Based Test for Colorectal Cancer Screening D.C.
     Chung and Others
     
     In a cohort at average risk for colorectal cancer, a cell-free DNA
     blood-based test had 83% sensitivity for colorectal cancer, 90% specificity
     for advanced neoplasia, and 13% sensitivity for advanced precancerous
     lesions.
     
     Mar 14
     
     Editorial Improving Noninvasive Colorectal Cancer Screening
     Editorial Cell-free DNA for Colorectal Cancer Screening
     Original Article Next-Generation Multitarget Stool DNA Test for Colorectal
     Cancer Screening
 * * Correspondence Kidney Injury and Hair Straightening with Glyoxylic Acid T.
     Robert and Others
     
     This letter describes a woman with recurrent episodes of acute kidney
     injury due to oxalate nephropathy after hair-straightening procedures and
     provides evidence that glyoxylic acid is responsible.
     
     Mar 21

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CLINICAL PRACTICE AND REVIEW

 * * Case Records of the Massachusetts General Hospital A Man with a Fall Z.
     Sargsyan and Others
     
     An 84-year-old man was evaluated at the hospital for a fall and admitted
     for treatment of a presumed urinary tract infection. On hospital day 4,
     severe chest pain developed. What is the diagnosis?
     
     Mar 21
   * Review Article Cerebral Cavernous Malformations E.R. Smith
     
     Cerebral cavernous malformations occur in 0.5% of the population; 85% are
     sporadic, and 15% are familial or radiation-induced. Several genetic
     variants, including variants in CCM, drive their development.
     
     Mar 14
   * Perspective What I Do Not Tell the Medical Student E. Andrist
     
     What do we tell medical students who are wowed by senior physicians’ power
     and control over patients’ conditions and outcomes when we know this power
     and control are largely illusory?
     
     Mar 21
 * * Review Article Wearable Digital Health Technologies in Medicine Wearable
     Digital Health Technologies in Clinical Care G.S. Ginsburg, R.W. Picard,
     and S.H. Friend
     
     The authors address the issues that must be confronted if we are to
     integrate the use of wearable digital health technologies into clinical
     care in a way that provides an enduring benefit to patients.
     
     Mar 21
   * Case Records of the Massachusetts General Hospital A Man with Cardiac
     Arrest, Cardiogenic Shock, and Hypoxemia R.O. Roswell and Others
     
     A 55-year-old man had an out-of-hospital cardiac arrest. An evaluation
     showed 2-mm ST-segment elevations in the inferior leads on
     electrocardiography, cardiogenic shock, and a new systolic murmur. What is
     the diagnosis?
     
     Mar 14

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78-year-old man with a 65-pack-year history of smoking and underlying emphysema
who presents with muscle weakness, a rash over the dorsum of the hands favoring
the knuckles, and an elevated creatine kinase level?

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 * Testing of respiratory muscle strength
 * MRI of the thymus
 * Nerve-conduction studies
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COMMENTARY

 * Perspective Mar 21 Physicians, Spirituality, and Compassionate Care
   D.P. Sulmasy
 * Perspective Mar 20 The Plight of DEI Leaders
   A. Maybank
 * Editorial Mar 21 Risks of Fetal Exposure to Topiramate
   K.J. Meador
 * Editorial Mar 21 Thymoma, Autoimmunity, and Susceptibility to Infection
   M.G. Netea and F.L. van de Veerdonk
 * Perspective Mar 21 “What’s Lymphoma?”
   B. Vipler
 * Perspective Mar 21 What I Do Not Tell the Medical Student
   E. Andrist


CORRESPONDENCE

 * Kidney Injury and Hair-Straightening Products Containing Glyoxylic Acid
 * A Placebo-Controlled Trial of PCI for Stable Angina
 * Nirsevimab for Prevention of RSV Hospitalizations in Infants
 * Sparsentan versus Irbesartan in Focal Segmental Glomerulosclerosis
 * Recombinant Influenza Vaccine in Adults under 65 Years of Age

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 * Original Article Mar 14, 2024
   A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening
   D. C. Chung and Others
 * Images in Clinical Medicine Mar 14, 2024
   Spontaneous Oral Purpura in Immune Thrombocytopenia
   J. L. Drivenes and A. Bygum

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{* #signInForm *}
{* signInEmailAddress *} {* currentPassword *}
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{* /signInForm *}


FORGOT PASSWORD

Enter the email address associated with your account then click Continue. We
will email you a link to a page where you can easily create a new password.

{* #forgotPasswordForm *}
{* forgotPasswordEmailAddress *} {* captcha *}

{* /forgotPasswordForm *}


CREATE NEW PASSWORD

We've sent an email with instructions to create a new password. Your existing
password has not been changed.

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To reset your password, enter a new password twice and click the 'Reset
Password' button.

{* #changePasswordFormNoAuth *} {* newPassword *} {* newPasswordConfirm *}

{* /changePasswordFormNoAuth *}

Your password has been reset. You will need to sign in again using your new
password to access site content and features.



{* #resetPasswordForm *}
The link that you followed to reset your password has expired.

Enter the email address associated with your account then click Continue. We
will email you a link to a page where you can easily create a new password.

{* signInEmailAddress *}

{* /resetPasswordForm *}

If the address matches an existing account, you will receive an email with
instructions to reset your password.





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