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NEXT GENERATION SEQUENCINGGENOMICS


USE OF ARTIFICIAL INTELLIGENCE IN AUTOMATION OF PHARMACOVIGILANCE


HOW AI IS TRANSFORMING THE PHARMA INDUSTRY


CONTINUOUS VS. BATCH MANUFACTURING


ADVANCED MODEL PREDICTIVE CONTROL SYSTEM OF CONTINUOUS BIOPHARMACEUTICAL
MANUFACTURING PROCESS


ADAPTING CONTAINMENT STRATEGIES TO FUTURE-PROOF THE MANUFACTURE OF STERILE DRUG
PRODUCTS


VIRAL GENE THERAPY – HOW CAN THE INDUSTRY DRIVE DOWN THE COST OF GOODS TO BETTER
SERVE THE PATIENTS?


CHOOSE CAREFULLY: THE POTENTIAL OF CONTINUOUS FLOW CHEMISTRY IN API SYNTHESIS


PHARMACEUTICAL 3D PRINTING


GENE THERAPY FOR CANCER & IMMUNOLOGY


DECENTRALIZATION - THE FUTURE OF CLINICAL TRIALS


IGA-MEDIATED INFLAMMATORY DISORDERS


USING QUANTITATIVE SYSTEMS PHARMACOLOGY MODELLING TO ACCELERATE DRUG DEVELOPMENT


ADVANCES IN MRNA THERAPEUTICS AND VACCINES

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26

May 2023



TME PHARMA PROVIDES POSITIVE CLINICAL UPDATE AND 14-MONTH SURVIVAL DATA FROM
GLORIA EXPANSION ARM EVALUATING NOX-A12 IN COMBINATION WITH RADIOTHERAPY AND
BEVACIZUMAB IN GLIOBLASTOMA

ME Pharma NV Euronext Growth Paris ALTME a biotechnology company focused on
developing novel therapies for treatment of cancer by targeting the tumor
microenvironment TME announces clinical update on survival of newly diagnosed
glioblastoma patients in the GLORIA expansion arm evaluating NOXA TME Ph...




26

May 2023



BIORAY HAS FILED AN IND FOR BRY812, A NOVEL ANTIBODY-DRUG CONJUGATE TARGETING
LIV-1

BioRay Pharmaceutical Co hereafter referred to as BioRay announced that the
Investigational New Drug IND application for the clinical trial of its
proprietary product BRY a novel antibody drug ADC targeting human LIV for the
treatment of advanced malignancies has been accepted by China National Med...




26

May 2023



PFIZER’S PAXLOVID™ RECEIVES FDA APPROVAL FOR ADULT PATIENTS AT HIGH RISK OF
PROGRESSION TO SEVERE COVID-19

Pfizer Inc NYSE PFE announced today that the US Food and Drug Administration FDA
approved PAXLOVID nirmatrelvir tablets and ritonavir tablets for the treatment
of mildtomoderate COVID in adults who are at high risk for progression to severe
COVID including hospitalization or death PAXLOVID has been...




26

May 2023



HI-BIO RECEIVES FDA ORPHAN DRUG DESIGNATION FOR FELZARTAMAB FOR THE TREATMENT OF
MEMBRANOUS NEPHROPATHY

Human Immunology Biosciences HIBio a clinicalstage biotechnology company
developing targeted therapies for patients with severe immunemediated diseases
IMDs today announced that the US Food and Drug Administration FDA has granted
orphan drug designation ODD for felzartamab the companys investigation...




26

May 2023



MILVEXIAN GRANTED U.S. FDA FAST TRACK DESIGNATION FOR ALL THREE INDICATIONS
UNDER EVALUATION IN PHASE 3 LIBREXIA PROGRAM: ISCHEMIC STROKE, ACUTE CORONARY
SYNDROME AND ATRIAL FIBRILLATION

The Janssen Pharmaceutical Companies of Johnson Johnson today announced that all
three prospective indications for milvexian an investigational oral factor XIa
FXIa inhibitor being developed in collaboration with Bristol Myers Squibb have
now been granted Fast Track Designation by the US Food and D...




25

May 2023



10X GENOMICS LAUNCHES VISIUM CYTASSIST GENE AND PROTEIN EXPRESSION ASSAY

x Genomics Inc Nasdaq TXG a leader in single cell and spatial biology announced
today the commercial availability of a new Visium CytAssist Gene and Protein
Expression product to expand the breadth of the Visium CytAssist spatial
analysis capabilities







PRESS RELEASESREAD MORE...




26

May 2023



EMOLECULES ACQUIRES SPECS COMPOUND HANDLING B.V.

EMolecules Inc an industry leading chemical compound searchandfulfillment
platform for early discovery chemistry research today announced the acquisition
of Specs Compound Handling BV Specs




26

May 2023



JNANA THERAPEUTICS ANNOUNCES MILESTONE ACHIEVED UNDER FIRST COLLABORATION WITH
ROCHE

Jnana Therapeutics a clinicalstage biotechnology company leveraging its
nextgeneration chemoproteomics platform to discover medicines for
challengingtodrug targets announces the achievement of a milestone from its
first collaboration agreement with Roche SIXRO ROG OTCQX RHHBY




26

May 2023



DEBIOPHARM PARTNERS WITH GENEDATA TO DIGITALIZE TRANSLATIONAL RESEARCH

Genedata the leading provider of enterprise software solutions for
biopharmaceutical RD today announced that Debiopharm a Swissbased global
biopharmaceutical company is adopting Genedata Profiler as its single point of
access to translational research data to accelerate its RD activities and bring
l...




26

May 2023



AION LABS, IN CONTINUED PARTNERSHIP WITH BIOMED X, LAUNCHES NEW GLOBAL CALL FOR
APPLICATIONS: IDENTIFICATION OF ACTIVE SMALL MOLECULES FOR DRUG DISCOVERY

AION Labs a firstofitskind innovation lab spearheading the adoption of AI
technologies and computational science to solve therapeutic challenges and
German independent research institute BioMed X announced today the launch of its
latest global call for applications to identify AI and machine learnin...




26

May 2023



GINKGO BIOWORKS AND CENTRIENT PHARMACEUTICALS ANNOUNCE EXPANSION OF PARTNERSHIP
FOLLOWING SUCCESS OF INITIAL PROJECT TO BRING SUSTAINABLE INNOVATION TO THE
GENERIC API SPACE

Centrient Pharmaceuticals Centrient the global businesstobusiness leader in
sustainable antibiotics nextgeneration statins and antifungals and Ginkgo
Bioworks NYSE DNA which is building the leading platform for cell programming
and biosecurity today announced they are expanding their existing partne...




25

May 2023



VOYAGEUR PHARMACEUTICALS PARTNERS WITH RAIN CAGE CARBON TO REVOLUTIONIZE MEDICAL
IMAGING WITH NANOCARBON-BASED CONTRAST DRUGS

Voyageur Pharmaceuticals Ltd TSXV VM USA VYYRF Voyageur or the Corporation
announces it has entered into a groundbreaking development and license agreement
with Rain Cage Carbon Inc Rain Cage This strategic partnership aims to
revolutionize the field by developing and manufacturing cuttingedge nanoc...






EVENTSREAD MORE...




05 - 08

Jun 2023



BIO INTERNATIONAL CONVENTION

Boston, United States


12 - 13

Jun 2023



PRE-FILLED SYRINGES WEST COAST

San Diego, CA, USA


12 - 13

Jun 2023



PHARMACEUTICAL MANUFACTURING & PACKAGING CONGRESS

Geneva, Switzerland


13 - 15

Jun 2023



FCE PHARMA – INTERNATIONAL

Sao Paulo, Latin America


14 - 15

Jun 2023



RNA THERAPEUTICS USA

San Diego, CA, USA


19 - 21

Jun 2023



CPHI & PMEC CHINA

Shanghai, China


20 - 21

Jun 2023



CANNA PHARMA 2023

Philadelphia, United States


12 - 14

Jul 2023



CPHI SOUTH EAST ASIA

Bangkok, Thailand






TOP ARTICLES


 * 1
   
   
   ALZHEIMER'S DRUG PIPELINE: PAST, PRESENT, AND FUTURE BIOLOGIC THERAPIES
   
   RONNY PRIEFER
   
   PROFESSOR, MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES UNIVERSITY
   
   CHAEHUI SUE
   
   PHARMACY STUDENT, MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES
   UNIVERSITY


 * 2
   
   
   CANCER CELL-MEMBRANE-COATED NANOCARRIERS IN CANCER DIAGNOSIS AND TREATMENT:
   FROG-LEAPING INTO THE FUTURE
   
   RYAN VARGHESE
   
   STUDENT AND RESEARCHER, DEPARTMENT OF PHARMACEUTICAL CHEMISTRY, POONA COLLEGE
   OF PHARMACY, BHARATI VIDYAPEETH UNIVERSITY
   
   GARGI DIGHOLKAR
   
   POONA COLLEGE OF PHARMACY, BHARATI VIDYAPEETH UNIVERSITY
   
   JAINAM KARSIYA
   
   CLINICAL PHARMACIST AND MEDICAL AFFAIRS EXECUTIVE, RIVER ROUTE CREATIVE GROUP
   LLP
   
   DILEEP KUMAR
   
   POONA COLLEGE OF PHARMACY, BHARATI VIDYAPEETH (DEEMED TO BE) UNIVERSITY;
   DEPARTMENT OF ENTOMOLOGY, UNIVERSITY OF CALIFORNIA; UC DAVIS COMPREHENSIVE
   CANCER CENTER, UNIVERSITY OF CALIFORNIA. ELECTRONIC ADDRESS:
   DILEEP.0@GMAIL.COM


 * 3
   
   
   ARTIFICIAL INTELLIGENCE IN CLINICAL TRIALS
   
   ASHWIN KUCHEKAR
   
   ASSOCIATE PROFESSOR AND THE HEAD OF CAREER SERVICES AND PLACEMENT AT THE
   SCHOOL OF PHARMACY
   
   REVA RAJENDRA JOSHI
   
   MASTERS STUDENT AT THE MIT WORLD PEACE UNIVERSITY SCHOOL OF PHARMACY


 * 4
   
   
   MONKEY POX: A VIRAL DISEASE CREATING TREPIDATION BUT NOT PANDEMIC
   
   MANSI ATHALYE
   
   ASSISTANT PROFESSOR, DEPARTMENT OF PHARMACEUTICS AT L. M. COLLEGE OF PHARMACY
   
   PARAG TARAPADA
   
   B. PHARM STUDENT, PHARMACY SECTION, L. M. COLLEGE OF PHARMACY
   
   NIJA PATEL
   
   B. PHARM STUDENT, PHARMACY SECTION, L. M. COLLEGE OF PHARMACY


 * 5
   
   
   FORMULATION OF SESAMOL LOADED MANNOSE SURFACE CONJUGATED SMART LIPID
   PARTICLES: ASSESSMENT OF SERUM LIVER INJURY MARKERS
   
   VIPUL SANSARE
   
   DEPARTMENT OF PHARMACEUTICS, INDIRA INSTITUTE OF PHARMACY, INDIA
   
   PRASHANT GURAV
   
   DEPARTMENT OF PHARMACEUTICS, INDIRA INSTITUTE OF PHARMACY, INDIA
   
   MANISH KUMAR GUPTA
   
   SCHOOL OF PHARMACEUTICAL SCIENCES, JAIPUR NATIONAL UNIVERSITY, INDIA


KNOWLEDGE BANK


 * ARTICLES
   
   
   ADVANCES IN MRNA THERAPEUTICS AND VACCINES
   
   Medicine is the testament to the virtue of human innovation a collective
   desire to reduce the burden of disease and an ever evolving journey to
   enhance the quality of human health
   
   
   ALZHEIMER'S DRUG PIPELINE: PAST, PRESENT, AND FUTURE BIOLOGIC THERAPIES
   
   Alzheimers disease AD is the most common type of dementia This is a
   progressive neurodegenerative disorder whereby cognitive and social abilities
   deteriorate over time and functioning suffers In the United States alone
   million individuals aged and older have AD with being years old or older The
   prevalence of AD is believed to be between and among the million persons with
   dementia globally
   
   
   CANCER CELL-MEMBRANE-COATED NANOCARRIERS IN CANCER DIAGNOSIS AND TREATMENT:
   FROG-LEAPING INTO THE FUTURE
   
   Cancer is one of the deadliest diseases known to exist in humans and is
   undoubtedly the leading cause of mortality worldwide The limited efficacy of
   the drug and the harmful side effects of conventional cancer therapy such as
   surgical therapy chemoradiotherapy and immunotherapy present a significant
   obstacle This leads to the development of new technologies
   
   
   ARTIFICIAL INTELLIGENCE IN CLINICAL TRIALS
   
   Artificial intelligence is a field of engineering and science that focus on
   making intelligent machines Artificial intelligence is a top technology that
   is reshaping the pharmaceutical industrys future For ages the pharmaceutical
   industry has been developing cures and treatments Traditionally medication
   design and manufacture took many years extensive clinical studies and skyhigh
   pricesThis has be...
   
   
   MONKEY POX: A VIRAL DISEASE CREATING TREPIDATION BUT NOT PANDEMIC
   
   Monkeypox is a viral disease that can be infected in humans and other animals
   by monkey pox virus It is the zoonotic virus that belongs to the genus
   Orthopoxvirus The variola virus which causes smallpox belongs to the same
   genus Monkey pox is infected in humans as two types first is the West African
   type and the second is the central African Congo Basin type
   
   
   FORMULATION OF SESAMOL LOADED MANNOSE SURFACE CONJUGATED SMART LIPID
   PARTICLES: ASSESSMENT OF SERUM LIVER INJURY MARKERS
   
   Liver diseases affect millions of populationworldwide which are difficult to
   treat with conventional drug deliveryBartneck et al World health organization
   has reported to of liver cirrhosisglobally due to alcohol consumption and
   more than million cases of chronic hepatitisinfections in Numerous drugs have
   been investigated for the treatment


 * RESEARCH INSIGHTS
   
   
   INTEGRATED BIOINFORMATICS AND STATISTICAL APPROACHES TO EXPLORE MOLECULAR
   BIOMARKERS FOR BREAST CANCER DIAGNOSIS, PROGNOSIS AND THERAPIES
   
   Integrated bioinformatics and statistical approaches are now playing the
   vital role in identifying potential molecular biomarkers more accurately in
   presence of huge number of alternatives for disease diagnosis prognosis and
   therapies by reducing time and cost compared to the wetlab based experimental
   procedures


 * TECHNO TRENDS
   
   
   NEW MEDICATION FOR TREATMENT OF ADULTS WITH SEVERE ALOPECIA AREATA (AA)
   
   OLUMIANT baricitinib a novel drug from Eli Lilly Company and Incyte has been
   introduced for the treatment of individuals with severe alopecia areata AA
   The proposed drug has yet to be approved by European regulators If approved
   Olumiant will be the first centrally sanctioned oral medicine


ADVISORY BOARD

Tamara Miller

Juris Hmelnickis

David Contorno

Svetlana Busiguina

Eiman Shafa

Nigel Cryer FRSC

.

Hector Alejandro Andonie

.

Josipa Ljubicic

.

JOAQUÍN D. CAMPBELL

.

Hoda Gamal

.

Amine Bekkali

.

Pinheiro Neto João

.


EDITORIAL SECTION


 * STRATEGY
   
   
   AN OVERVIEW OF CLINICAL OVERVIEW
   
   A Clinical Overview is an integrated document intended to provide critical
   analysis of Pharmacology Efficacy and Safety of the pharmaceutical agent in
   humans It is one of the important documents of Module of the Common Technical
   Document CTD ie Module which refers to the data provided in the comprehensive
   clinical summary the individual clinical study reports presen...


 * RESEARCH DEVELOPMENT
   
   
   IGA-MEDIATED INFLAMMATORY DISORDERS
   
   In current drug development we are educated and trained to follow identical
   development strategies that have been proven to be successful in the past and
   assume a guaranteed success for the future


 * CLINICAL TRIALS
   
   
   GENE THERAPY FOR CANCER & IMMUNOLOGY
   
   After the s and the development of recombinant DNA techniques tests showed
   that foreign genes are able to correct disease phenotypes and genetic defects
   in mammalian cells while the use of gene transfer methods has facilitated the
   effective demonstration of phenotype correction in vitro and in vivo


 * MANUFACTURING
   
   
   CONTINUOUS VS. BATCH MANUFACTURING
   
   In batch processing a subsequent batch can be processed only after the
   current batch has been completed


 * INFORMATION TECHNOLOGY
   
   
   USE OF ARTIFICIAL INTELLIGENCE IN AUTOMATION OF PHARMACOVIGILANCE
   
   With rapid digitalization and increased research in the sector the
   pharmaceutical industry has experienced a remarkable development in the last
   three years opening doors for innovative routes of therapy for humankind


 * EXPERT TALK
   
   
   NEXT GENERATION SEQUENCING - GENOMICS
   
   The genomic sequencing approach allows for a comprehensive analysis of human
   DNA for gene sequence changes enabling the detection of cancer associated...




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