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Submitted URL: http://www.aaps.org/pharmsci360
Effective URL: https://www.aaps.org/aaps/pharmsci/annual-meeting
Submission: On March 04 via api from US — Scanned from NL
Effective URL: https://www.aaps.org/aaps/pharmsci/annual-meeting
Submission: On March 04 via api from US — Scanned from NL
Form analysis 1 forms found in the DOM
POST ./annual-meeting
<form method="post" action="./annual-meeting" onsubmit="javascript:return WebForm_OnSubmit();" id="MasterPageForm" class="form">
<div class="aspNetHidden">
<input type="hidden" name="ScriptManager1_TSM" id="ScriptManager1_TSM" value="">
<input type="hidden" name="StyleSheetManager1_TSSM" id="StyleSheetManager1_TSSM" value="">
<input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="">
<input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="">
<input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE"
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<h2>AAPS 2024 PHarmSCi 360</h2>
<span style="font-size: 1.6rem;"><span>October 20-23, 2024<br>Salt Palace Convention Center<br>Salt Lake City,
UT<br><span></span></span></span> <a href="https://www.aaps.org/aaps/pharmsci/ps360submit" class="btn btn-primary" target="_blank" rel="noopener">2024 Program Submission Information</a>
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<p><img src="https://higherlogicdownload.s3.amazonaws.com/AAPS/6ab7f0bc-b417-4a16-bedb-21afc588c1d6/UploadedImages/2023_PharmSci/Discovery_and_Basic_Research_Web_200x200.png" alt=""
data-mce-hlimagekey="d08ad7bb-3715-6c54-8740-725dff0eb3b8" data-mce-hlselector="#TinyMceContent_b21135dd-471c-ce72-1ce4-b992b43d8b72-tinyMceHtml" width="79" height="73"><strong><span style="font-size: 16pt;">Discovery and
Basic Research</span></strong></p>
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<p><strong>Theme 1: Leveraging AI in the Processes of Drug Discovery, Lead Validation, Preclinical Development, and Regulatory Submissions</strong></p>
<p><strong>Keywords:</strong> Artificial Intelligence (AI), Bioinformatics, Drug Discovery, Drug Repurposing, Machine Learning (ML), Metabolomics, Predictive Network Analysis, Proteomics, Regulatory Guidelines, Target
Identification.</p>
<p>Artificial Intelligence (AI) is playing a critical role in the metamorphosis of drug discovery and development -- expediting processes, refining decision-making, and optimizing resource allocation. The integration of AI is
transforming diverse phases of drug discovery, lead validation, and drug development by introducing innovative solutions for augmenting efficiency, precision, and swiftness during the preclinical stage. Furthermore, AI and
Machine Learning (ML) have enabled the repurposing of currently marketed drugs toward novel disease indications. AI-based approaches also include integration of “-omics” data sets into the drug discovery process, thereby
enabling predictions of novel therapeutic targets and indices of drug effectiveness. The overarching objective of this theme is to impart firsthand insights into approaches related to target identification and validation,
AI-based compound screening, on biological activities, and predictive model development. Specific emphasis will be given to predicting adverse effects. The theme will focus on how predictive modeling can be harnessed to
recognize new therapeutic indications for difficult-to-treat and rare diseases. Attention will be directed toward strategies to expedite preclinical discovery steps in alignment with the evolving requirements from regulatory
submissions. </p>
<p><br><strong>Theme 2: Challenges and Opportunities Associated with Targeted Therapeutics</strong></p>
<p><strong>Keywords:</strong> Antibody-Drug Conjugates, Cancer, Drug Delivery, Infectious Diseases, Intracellular Signaling, Molecular Pharmacology, Neurological Diseases, Precision Medicine, Targeted Therapeutics, Transporters,
Receptor-Mediated Transcytosis.</p>
<p>Targeted therapy has demonstrated improved efficacy and safety in a diverse array of medical conditions, particularly cancers, neurological diseases, and other ailments characterized by molecular or genetic irregularities.
The application of targeted therapeutics has now been extended to include functionalized antibodies and protein substitution, as well as small molecule and protein-based approaches for treating and mitigating human genetic and
acquired diseases. Additionally, gene editing and RNA-based therapeutics, such as SiRNAs, microRNAs, CRISPR, and antisense oligonucleotides (ASOs) directly target the mechanisms responsible for producing disease-associated
proteins. It is noteworthy that targeted modulation of immune responses has been successfully integrated into cancer vaccines and the management of various pathogenic infections. The overarching aim of this theme is to furnish
the audience with state-of-the-art advancements in drug targeting and precision medicine for the development of novel approaches to treat human diseases. </p>
<p><br><strong>Theme 3: Innovative Methodologies for Advancing Therapeutics from Bench to Bedside</strong></p>
<p><strong>Keywords:</strong> DNA Microarray, Drug Metabolism, Drug Transport, Imaging Modalities, Large Molecule Drugs, Organ-on-a-Chip, Pharmacokinetics, Single-Cell Technologies, Small Molecule Drugs.</p>
<p>The progression of therapeutics from the laboratory bench to the patient's bedside represents a multifaceted and dynamic undertaking, necessitating the deployment of innovative methodologies to rigorously ensure efficacy,
safety, and the seamless translation of scientific breakthroughs into tangible clinical applications. Within this context, emphasis is placed on advanced tools and technologies that significantly contribute to the development
of both small- and large-molecule drugs. Cutting-edge imaging modalities, such as positron emission tomography (PET) and magnetic resonance imaging (MRI), along with theranostic approaches as diagnostic tools to identify
specific biomarkers or disease characteristics, as well as the targeted delivery of therapeutic agents, are now routinely utilized in early-stage development of innovative therapeutic drugs. Additionally, DNA microarrays play
a crucial role in understanding the genetic basis of diseases and drug responses. Organ-on-a-chip platforms replicate the microenvironment and physiological conditions of human organs, offering insights into pharmacokinetic
properties of novel therapeutics. Furthermore, single-cell techniques provide valuable information on the therapeutic efficacy and metabolite profiling of new drugs, especially when cell heterogeneity is a concern. </p>
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<p><img src="https://higherlogicdownload.s3.amazonaws.com/AAPS/6ab7f0bc-b417-4a16-bedb-21afc588c1d6/UploadedImages/2023_PharmSci/Icon_Preclinical_Translational_200x200.png" alt=""
data-mce-hlimagekey="d08ad7bb-3715-6c54-8740-725dff0eb3b8" data-mce-hlselector="#TinyMceContent_b21135dd-471c-ce72-1ce4-b992b43d8b72-tinyMceHtml" width="79" height="73"> <strong><span style="font-size: 16pt;">Preclinical,
Clinical and Translational Sciences</span></strong></p>
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<p><strong>Theme 1: Translating the Translational Sciences - Different Understanding, Common Aim</strong></p>
<p><strong>Keywords:</strong> Translation, Preclinical Pharmacology, Clinical Development, Biomarkers, Patient Outcome.</p>
<p>Translational science is a multi-disciplinary field that focuses on applying knowledge from basic scientific research to practical advancements in healthcare. Translational sciences play a crucial role in expediting the
transformation of scientific insights into tangible benefits for patients, such as new drugs, therapies, and diagnostic tools. With that, this theme explores different types of translations that form the backbone of successful
drug discovery, development, and implementation. These include molecular and genetic translation, bridging the gap between preclinical studies to clinical research (Phase 1, Phase 2, Phase 3), and moving from clinical trials
to implementation in real world and global settings, ultimately leading to improvement in patient outcomes. <br> <br>This theme brings together scientists involved across the spectrum of translational research to
compare and discuss novel approaches, practical applications including case studies, and areas where such tools have been used successfully in practice.<br> </p>
<p><strong>Theme 2: Making Data Work for Us – Applying and Combining Empirical (AI/ML) and Mechanistic Modeling in the Preclinical, Clinical, and Post-Approval Realms</strong></p>
<p><strong>Keywords:</strong> Modeling and Simulation, PBPK/QSP, Mechanistic Models, Empirical Models, AI/ML, Digital Biomarkers. </p>
<p>This theme explores the gaps in making AI/ML successful in delivering breakthrough medicines and/or approaches/discoveries in the drug development field and debates the need to apply combined approaches to empirical and
mechanistic modeling. </p>
<p>This theme covers includes: virtual data / synthetic data / synthetic control (at preclinical and clinical levels); replacement of placebo/vehicle control in preclinical trials with computational models, replacement of
control group in clinical trials with computational models; data quality and datasets size and heterogeneity and its influence on the model quality, large datasets, Real World data and its use; empirical and mechanistic
(PBPK/QSP) models combined to solve problems – i.e. virtual BE studies; use of virtual data to dynamically adapt trial designs in real-time based on accumulated information.</p>
<p><br><strong>Theme 3: Advancing Vaccine Development: Utilizing the Power of Model-Based Approaches</strong></p>
<p><strong>Keywords:</strong> Model informed drug development, vaccines, immunogenicity prediction, dose optimization, QSP, real world data</p>
<p>Model-informed drug development is a key tool that is broadly used to support drug discovery and development as well as regulatory review. This theme centers on the application of model-informed approaches in vaccine
development and will highlight the strategic integration of clinical pharmacology tools, including dose/exposure-response analyses, mechanistic PK/PD modeling, model-based meta-analysis, and other quantitative approaches to
address challenges and inform decision-making across all stages of vaccine development. Applications will include (but are not limited to) optimization of dosing regimen and formulation components, informing dosing for special
populations, prediction of immunogenicity, and leveraging real world data for refinement (e.g. variants, long term safety). <br>Our aim is to bring together scientists from industry, academia and regulatory agencies in a
collaborative dialog that encourages the adoption of quantitative tools leading to the accelerated development of more effective and safer vaccines.</p>
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<p><img src="https://higherlogicdownload.s3.amazonaws.com/AAPS/6ab7f0bc-b417-4a16-bedb-21afc588c1d6/UploadedImages/2023_PharmSci/bioanalytics_no-words-Icon-02.png" alt="" data-mce-hlimagekey="d08ad7bb-3715-6c54-8740-725dff0eb3b8"
data-mce-hlselector="#TinyMceContent_b21135dd-471c-ce72-1ce4-b992b43d8b72-tinyMceHtml" width="79" height="73"><strong><span style="font-size: 16pt;">Bioanalytics</span></strong></p>
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<p><strong>Theme 1: Bioanalytical Lab Innovations</strong></p>
<p><strong>Keywords:</strong> Automation, Artificial Intelligence (AI), Machine Learning (ML), High Throughput, Assay Design, Predictive Outcomes, Devices, Platforms, Supply Chain, GLP, GCP, Clinical, Drug Development,
Troubleshooting, Validation, Bioanalytical, Therapeutic, Robotics, Cut-Point Analysis. </p>
<p>This theme explores new technologies -- including Artificial Intelligence (AI) and Machine Learning (ML) – and their applications to bioanalysis. It also explores platforms, robotics, and automation solutions for advancing
therapeutics in the bioanalytical lab. Topics include integration of robotics, microfluidics, and automation in high throughput platforms; assay design; automated sample processing; adaptation of 96 well assay format to 384
well format --case studies of development, validation, and analysis for non-standard therapeutics; solutions for GLP and GCP lab documentation using AI technologies; and innovative lab solutions for troubleshooting complex
therapeutics.</p>
<p><strong>Theme 2: Current Challenges in Bioanalytical Labs</strong></p>
<p><strong>Keywords:</strong> PK, PD, ADA, APA, NAb, Assays, Immunogenicity, PCR, Molecular, RT-PCR, dd-PCR, ELISPOT, Potency Assays, Domain Specificity, CAR-T, Cross-Validation, Biodistribution, Cell and Gene Therapy, ADCs,
AOCs, Oligonucleotides, RNA Therapeutics, Biologics, Multidomain Therapeutics, Critical Reagents, Genomics, Stability, Matrices, Surrogate, LCMS, LBA, Troubleshooting, Microsampling, Con-Conforming Modalities, Cut-Point
Analysis.</p>
<p>This theme explores current challenges for the bioanalytical lab’s assay development, validation, analysis, and assay lifecycle management. Topics include the selection of platforms for genomics-based molecular assays;
challenges for cell and gene therapy -- unique issues to the development of the ADCs, AOCs, and multi-domain therapeutics; hybrid approaches for the small molecule/complex therapeutic analysis; stability challenges and
critical reagent management for complex therapeutics; matrix selection; nontraditional samples in matrices such as whole blood, tissues, PMBC, cerebrospinal fluid etc.; patient-centric sampling and bioanalytical challenges and
approaches for personalized medicine; and troubleshooting-focused case studies. </p>
<p><strong>Theme 3: Regulatory Implications for Bioanalysis</strong></p>
<p><strong>Keywords:</strong> PCR, Molecular, RT-PCR, dd-PCR, ELISPOT, Domain Specificity, CAR-T, Cross-Validation, LCMS, LBA, Study Design and Implementation, Cell and Gene Therapy, Immunogenicity, Gaps, Regulatory, Biomarkers,
Clinical, Assays, Rare Diseases, Animal Models, Alternate Animal Models, Microsampling, Sample Logistics (China HGRA).</p>
<p>This theme explores the implications of the gaps in the current regulatory guidelines and incorporation of industry recommendations. Topics include biomarkers, hybrid LC/MS, cell and gene therapies and nucleic acid analysis;
incorporation of automation and Artificial Intelligence (AI); selection and testing of unique or rare matrices; cut point for rare diseases; outsourcing; study design and implementation through application of current guidance
and industry white papers; harmonization across regulatory authorities or where gaps in guidance exist; impacts and implementation of new regulatory guidance; and quality considerations when guidance is undefined. </p>
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<p><img src="https://higherlogicdownload.s3.amazonaws.com/AAPS/6ab7f0bc-b417-4a16-bedb-21afc588c1d6/UploadedImages/2023_PharmSci/Manufacturing_and_Bioprocessing_no-words-Icon-02.png" alt=""
data-mce-hlimagekey="d08ad7bb-3715-6c54-8740-725dff0eb3b8" data-mce-hlselector="#TinyMceContent_b21135dd-471c-ce72-1ce4-b992b43d8b72-tinyMceHtml" width="79" height="73"><strong><span style="font-size: 16pt;">Manufacturing and
Analytical Characterization</span></strong></p>
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<p><strong>Theme 1: Innovation in Pharmaceuticals/Biopharmaceuticals Manufacturing and Characterization</strong></p>
<p><strong>Keywords:</strong> Continuous manufacturing, single use technologies, modality agnostic flex facilities, green chemistry, sustainability, collaborative ecosystems, smart manufacturing, bioprocessing innovation,
pharmaceutical manufacturing 4.0, EU regulatory reform, cross-industry collaborations, disruptive innovation, industry-academia collaboration, federal funding for innovation, digital replicas, predictive modeling, ICH Q12 and
Q 14, capillary zone electrophoresis, isoelectric focusing, ion exchange, size exclusion (SEC), reversed phase (RP) or hydrophilic interaction liquid chromatography (HILIC), coupled with ultraviolet (UV), fluorescence, or mass
spectrometric (MS), LC MS/MS, SEC-MS, Drug release and dissolution. </p>
<p>The pharmaceutical and biopharmaceutical industries are experiencing a wave of innovations that are revolutionizing their traditional manufacturing and characterization. These innovations include continuous manufacturing,
single-use technologies, flexible facilities, modality-agnostic manufacturing systems, and modular manufacturing systems including use of robotics. Additionally, there is a growing emphasis on green chemistry and
sustainability in pharmaceutical and excipient industry.</p>
<p>Characterization techniques have evolved commensurate to the complex nature of novel formulations and manufacturing processes. These advanced techniques offer more accurate and rapid results, contributing to improved speed
and reliability throughout the entire product lifecycle. By embracing these disruptive innovations, the industry demonstrates its commitment to efficiency, adaptability, and sustainability. <br> <br>Moving forward,
the pharmaceutical industry, in collaboration with academia and regulatory, is actively embracing innovative technologies, sustainable practices, and adaptable manufacturing and testing methodologies. This theme provides a
forum for Innovations in small molecule, biologics, cellular therapies, oligonucleotides, and antibody drug conjugates manufacturing and characterization agnostic of their development and implementation stage.</p>
<p><br><strong>Theme 2: Digital Tools to Accelerate Drug Development, Manufacturing and Analysis</strong></p>
<p><strong>Keywords:</strong> Automation and Robotics, Simulation And Modeling Platforms To Increase Efficiency, Virtual Testing And Process Design, Digital Twins, Mini Piloting, Platform Ecosystem For DS and DP, Line of Sight
to Commercialization, Predictive Modeling for Manufacturing, Supply Chain Visibility (Enhanced Traceability And Visibility), Internet Of Things (IOT) Devices, Real-Time Data Collection, Analysis and Decision Making, Training
Simulations Using Virtual Reality (VR) and Augmented Reality (AR), Drug Repurposing -- Artificial Intelligence (AI) and Machine Learning (ML) to Identify New Uses, Regulatory Guidance For Digital Tools, Validation Of Digital
Tools, Model Maintenance, Safeguards for Digital Tools.</p>
<p>The pharmaceutical industry has wholeheartedly embraced a range of digital tools and platform technologies to expedite drug development, manufacturing, and analysis. These tools harness advanced technologies to enhance
efficiency, reduce costs, and improve overall processes. They also leverage historical learning from industry and academia. Key examples of these tools include computational drug design, training simulations, digital twins,
cloud computing, high-throughput experiments, crystal structure prediction, regulatory information management systems and standardization of submission data format. </p>
<p>By integrating these tools into the product lifecycle, the pharmaceutical industry can accelerate drug development, manufacturing, and analysis. These tools leverage data automation and advanced analytics to make processes
more efficient, cost-effective, and innovative, therefore taking drug to patients faster. They enable the industry to leverage vast amounts of data, leading to faster decision-making and improved outcomes. </p>
<p>The adoption of these tools represents a significant step forward in the pharmaceutical industry's quest for enhanced productivity and competitiveness. The track will also elaborate on the latest in regulatory guidance and
safeguards for digital tools.<br><br><strong>Theme 3: Challenges and Lessons Learned in Commercializing (Manufacturing and Product Quality Analysis) Novel Modalities</strong></p>
<p><strong>Keywords:</strong> Commercialization of Antibody-Drug Conjugates (ADC), Nano-Medicine, Protein Degradation Therapies (PROTACS), Cell Therapy, CRISPER, Bispecifics, Oral Peptide, RNA-Based Therapies, mRNA, SiRNA,
Antisense Oligonucleotides, Gene Therapy, Phage Therapy, 3D Printing In Drug Delivery, mRNA Vaccines, Abuse Deterrent Formulations, Life Cycle Management of Analytical Methods, Regulatory Strategy, Intellectual Property
Protection, Manufacturing Scalability, Cost of Goods and Manufacturing (COGM) Considerations, Long Term Sustainability and End to End (E2E) Product Lifecycle Management.<br><br>Over the past decade, pharmaceutical companies
have achieved remarkable success in commercializing novel therapies that have revolutionized patient safety and healthcare outcomes. These innovations include antibody-drug conjugates (ADC), nanomedicine, protein degradation
therapies (PROTACS), cell therapy, CRISPER, bispecifics, oral peptide, RNA-based therapies, mRNA, SiRNA, antisense oligonucleotides, gene therapy, phage therapy, 3D printing in drug delivery, mRNA vaccines and abuse deterrent
formulations. <br>These advancements have had a significant impact on improving global health, thanks to the collaborative efforts of industry, academia, and regulators in a rapidly changing environment. Manufacturing
facilities have been adapted to meet the unique requirements of these novel modalities, while new analytical characterization methods have been developed, validated, and implemented to better understand these complex therapies
and safeguard patients. <br>Regulators have played a crucial role by providing opportunities for collaboration, offering clear feedback, and providing guidance to ensure the safe and effective development of these
innovative therapies. This track aims to highlight success stories, share lessons learned, address challenges, and provide a framework for accelerating innovation while enabling Pharmaceutical Manufacturing 4.0. </p>
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<p><img src="https://higherlogicdownload.s3.amazonaws.com/AAPS/6ab7f0bc-b417-4a16-bedb-21afc588c1d6/UploadedImages/2023_PharmSci/Formulation_and_Quality_no-words-Icon-02.png" alt=""
data-mce-hlimagekey="d08ad7bb-3715-6c54-8740-725dff0eb3b8" data-mce-hlselector="#TinyMceContent_b21135dd-471c-ce72-1ce4-b992b43d8b72-tinyMceHtml" width="79" height="73"><strong><span style="font-size: 16pt;">Formulation and
Delivery</span></strong></p>
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<p><strong>Theme 1: Formulation Approaches to Overcome Development Challenges Across Modalities</strong></p>
<p><strong>Keywords:</strong> Modelling, Modality-Specific Formulation Development, Stability and Prediction, Processes and technologies, Quality by Design (QbD).</p>
<p>Accelerated timelines in the drug discovery and development space, combined with increasingly complex drug substances such as biomolecules, RNA-based vaccines, and low-solubility small molecules, are presenting significant
challenges to formulation development. This theme will focus on strategies to address and overcome these challenges, including the use of Artificial Intelligence (AI), Machine Learning (ML), and modeling for formulation design
and understanding, in-vivo predictive tools, formulation screening tools, risk-based development approaches, overcoming solubility and permeability issues, and improving and predicting formulation performance and stability.
Further emphasis will be given to formulation approaches for biologics (e.g., mAbs, ADCs, bispecific antibodies), vaccines (e.g., mRNA, antigen), peptides, chemical entities, gene and cell therapies, highly concentrated
formulations for subcutaneous applications, and novel formulations and processes such as additive manufacturing. </p>
<p><strong>Theme 2: Turbocharging Drug Product Development: The Critical Role of Excipients </strong></p>
<p><strong>Keywords:</strong> Novel Excipients, Advanced Applications of Traditional Excipients, Material Properties, Physicochemical and Biological Properties, Supply Chain Management, Sustainability, Quality and Regulatory
Compliance, Impurities.</p>
<p>Excipients play a pivotal role in the formulation and development of drug products for both chemical substances and biomolecules. Although typically considered pharmacologically inert, excipients influence a wide range of
performance characteristics, including manufacturing robustness, stability, and bioavailability. This theme addresses the increasing demand for knowledge about excipients and the regulatory considerations to enable and
accelerate the formulation development of new molecular entities, which are growing in complexity. The theme also explores the risk assessment of incorporating novel excipients into drug products such as compatibility and
biocompatibility studies. Additionally, the theme encompasses the use of permeation enhancers, complex formulation stabilizers, and lipid and polymeric excipients in various drug delivery techniques. Furthermore, it covers the
effects of excipients on the solubility, viscosity, and stability of biologics, such as proteins, mAbs, and ADCs. The discussion will also include the role of excipients in facilitating the development and administration of
high-concentration and high-volume biologics.</p>
<p><strong>Theme 3: Advanced Drug Delivery Technologies for Targeted Therapeutics</strong></p>
<p><strong>Keywords:</strong> Targeted Drug Delivery, Controlled Release, Site and Disease-Specific Drug Delivery, Long-Acting Therapeutics, Nanomedicine, Drug-Device Combination, Patient Centricity, Target Product Profile.</p>
<p>Therapeutics that are more specialized and directly target specific disease areas necessitate approaches that extend beyond the scope of traditional drug delivery. Additionally, diverse patient populations and health care
settings across different regions pose specific challenges to drug formulation and delivery. This theme covers disease-specific targeting; innovative delivery routes, multifunctional micro- and nano-delivery systems;
controlled and modified release; long-acting injectables or implants; and immune-targeted delivery. In addition, use of novel delivery routes and patient-centric dosage forms can be developed. This includes fixed-dose
combinations, age-appropriate dosage forms (e.g. pediatric), drug-device combination products (e.g. autoinjectors or patch pumps) enabling patient self-administration; delivery technologies allowing subcutaneous delivery of
large volumes; and alternative routes of administration (e.g. intranasal, pulmonary, or transdermal). </p>
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<p><img src="https://higherlogicdownload.s3.amazonaws.com/AAPS/6ab7f0bc-b417-4a16-bedb-21afc588c1d6/UploadedImages/2023_PharmSci/2458-002_CareerDevlopment__Icon_300x300_1.png" alt=""
data-mce-hlimagekey="d08ad7bb-3715-6c54-8740-725dff0eb3b8" data-mce-hlselector="#TinyMceContent_b21135dd-471c-ce72-1ce4-b992b43d8b72-tinyMceHtml" width="79" height="73"><strong><span style="font-size: 16pt;">Career
Development</span></strong></p>
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<p><strong>Theme 1: Elevate your Scientific Career with Strong Business Acumen</strong></p>
<p>In the dynamic world of pharma, possessing a profound understanding of business intricacies is a game-changer for career advancement. Blend your scientific expertise with business savvy to make astute decisions and carve out
a thriving career path in the industry. A well-developed technical set of goals coupled with business knowledge will prepare scientists to become leaders in tomorrow’s environment. <br>The following examples are provided
to help submitters develop proposal ideas. The Career Development Committee will consider any proposal that fits the track theme and description above.<br>Example topics: </p>
<ul>
<li>Mastering the Art of Contract Negotiation</li>
<li>Safeguarding Intellectual Property in the Evolving Scientific Landscape</li>
<li>Unveiling the Secrets in Job Offers: Pharmaceutical Science Career Acceleration</li>
<li>Securing Resources for Innovations: A Business-Centric Approach for Academic Professionals</li>
<li>Decoding Stock Options: A Strategic Approach for Pharma Professionals</li>
<li>Investor Relationship Management: Navigating Objectives Effectively</li>
<li>Crafting Successful Inter-Company Collaborations in Pharma (In-licensing, Mergers, Acquisitions, Co-developed Assets)</li>
<li>Entrepreneurship Unleashed: Initiating Your Venture</li>
<li>Securing Venture Capital for Start-ups: Strategies for Success</li>
</ul>
<p><strong>Theme 2: Nurturing a Sense of Equity and Inclusion to Build a Diverse Workforce</strong></p>
<p>Globalization has brought pharmaceutical scientists and professionals from diverse cultural, socioeconomic, and educational backgrounds together to achieve common goals and objectives. Successful teams that have benefited
from diversity in culture, education, training, and experiences that foster innovative ideas, have promoted and nurtured these values and parameters at the organizational level.<br>The following examples are provided to help
submitters develop proposal ideas. The Career Development Committee will consider any proposal that fits the track theme and description above.<br>Example topics: </p>
<ul>
<li>Cultivating Meaningful Diversity to Enrich a Workforce</li>
<li>Navigating Unconscious Bias: Strategies for Understanding and Inclusive Decision-making</li>
<li>Promoting Mental Health and Wellness in a Competitive and Diverse Work Environment</li>
<li>Effective Communication for Diverse Teams: From Listening to Using Inclusive Languages, to Building a Diverse and Successful Team</li>
<li>Strategies for Work-life Balance for a Diverse and Successful Team</li>
<li>Role of Mentorship in Building and Nurturing a Diverse and Successful Workforce</li>
<li>Creating a safe environment to foster new ideas and innovations.</li>
<li>Develop Intelligence for Effective Cross-Cultural Collaboration</li>
</ul>
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<h3><i class="fa fa-id-card-o text-gold" aria-hidden="true"></i> Contact Information</h3>
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<h4 class="text-gold">Registration & Housing</h4>
<p><strong>eShow Registration Team</strong></p>
<p><i class="fa fa-envelope-square" aria-hidden="true"></i><a href="mailto:aaps.helpdesk@goeshow.com" target="_blank" rel="noopener">aaps.helpdesk@goeshow.com</a></p>
<p><i class="fa fa-phone-square" aria-hidden="true"></i> 1.847.620.4256</p>
<h4 class="text-gold"><br>Sales</h4>
<p><strong>Erik Burns</strong></p>
<p><i class="fa fa-envelope-square" aria-hidden="true"></i> <a href="mailto:BurnsE@aaps.org">BurnsE@aaps.org</a></p>
<p><i class="fa fa-phone-square" aria-hidden="true"></i> <span>+1.703.248.4738</span></p>
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<h4 class="text-gold">Scientific & Career Development Programming</h4>
<p><strong>Amber Sims-Mowatt</strong></p>
<p><i class="fa fa-envelope-square" aria-hidden="true"></i><a href="mailto:simsmowatta@aaps.org" target="_blank" rel="noopener">SimsmowattA@aaps.org</a></p>
<p><i class="fa fa-phone-square" aria-hidden="true"></i> <span>+1.703.248.4702</span></p>
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<h4 class="text-gold">Abstracts & Posters</h4>
<p><strong>Teresa Homrich</strong></p>
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1. PHARMSCI 360
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PHARMSCI 360
AAPS 2024 PHARMSCI 360
October 20-23, 2024
Salt Palace Convention Center
Salt Lake City, UT
2024 Program Submission Information
Discovery and Basic Research
Theme 1: Leveraging AI in the Processes of Drug Discovery, Lead Validation,
Preclinical Development, and Regulatory Submissions
Keywords: Artificial Intelligence (AI), Bioinformatics, Drug Discovery, Drug
Repurposing, Machine Learning (ML), Metabolomics, Predictive Network Analysis,
Proteomics, Regulatory Guidelines, Target Identification.
Artificial Intelligence (AI) is playing a critical role in the metamorphosis of
drug discovery and development -- expediting processes, refining
decision-making, and optimizing resource allocation. The integration of AI is
transforming diverse phases of drug discovery, lead validation, and drug
development by introducing innovative solutions for augmenting efficiency,
precision, and swiftness during the preclinical stage. Furthermore, AI and
Machine Learning (ML) have enabled the repurposing of currently marketed drugs
toward novel disease indications. AI-based approaches also include integration
of “-omics” data sets into the drug discovery process, thereby enabling
predictions of novel therapeutic targets and indices of drug effectiveness. The
overarching objective of this theme is to impart firsthand insights into
approaches related to target identification and validation, AI-based compound
screening, on biological activities, and predictive model development. Specific
emphasis will be given to predicting adverse effects. The theme will focus on
how predictive modeling can be harnessed to recognize new therapeutic
indications for difficult-to-treat and rare diseases. Attention will be directed
toward strategies to expedite preclinical discovery steps in alignment with the
evolving requirements from regulatory submissions.
Theme 2: Challenges and Opportunities Associated with Targeted Therapeutics
Keywords: Antibody-Drug Conjugates, Cancer, Drug Delivery, Infectious Diseases,
Intracellular Signaling, Molecular Pharmacology, Neurological Diseases,
Precision Medicine, Targeted Therapeutics, Transporters, Receptor-Mediated
Transcytosis.
Targeted therapy has demonstrated improved efficacy and safety in a diverse
array of medical conditions, particularly cancers, neurological diseases, and
other ailments characterized by molecular or genetic irregularities. The
application of targeted therapeutics has now been extended to include
functionalized antibodies and protein substitution, as well as small molecule
and protein-based approaches for treating and mitigating human genetic and
acquired diseases. Additionally, gene editing and RNA-based therapeutics, such
as SiRNAs, microRNAs, CRISPR, and antisense oligonucleotides (ASOs) directly
target the mechanisms responsible for producing disease-associated proteins. It
is noteworthy that targeted modulation of immune responses has been successfully
integrated into cancer vaccines and the management of various pathogenic
infections. The overarching aim of this theme is to furnish the audience with
state-of-the-art advancements in drug targeting and precision medicine for the
development of novel approaches to treat human diseases.
Theme 3: Innovative Methodologies for Advancing Therapeutics from Bench to
Bedside
Keywords: DNA Microarray, Drug Metabolism, Drug Transport, Imaging Modalities,
Large Molecule Drugs, Organ-on-a-Chip, Pharmacokinetics, Single-Cell
Technologies, Small Molecule Drugs.
The progression of therapeutics from the laboratory bench to the patient's
bedside represents a multifaceted and dynamic undertaking, necessitating the
deployment of innovative methodologies to rigorously ensure efficacy, safety,
and the seamless translation of scientific breakthroughs into tangible clinical
applications. Within this context, emphasis is placed on advanced tools and
technologies that significantly contribute to the development of both small- and
large-molecule drugs. Cutting-edge imaging modalities, such as positron emission
tomography (PET) and magnetic resonance imaging (MRI), along with theranostic
approaches as diagnostic tools to identify specific biomarkers or disease
characteristics, as well as the targeted delivery of therapeutic agents, are now
routinely utilized in early-stage development of innovative therapeutic drugs.
Additionally, DNA microarrays play a crucial role in understanding the genetic
basis of diseases and drug responses. Organ-on-a-chip platforms replicate the
microenvironment and physiological conditions of human organs, offering insights
into pharmacokinetic properties of novel therapeutics. Furthermore, single-cell
techniques provide valuable information on the therapeutic efficacy and
metabolite profiling of new drugs, especially when cell heterogeneity is a
concern.
Preclinical, Clinical and Translational Sciences
Theme 1: Translating the Translational Sciences - Different Understanding,
Common Aim
Keywords: Translation, Preclinical Pharmacology, Clinical Development,
Biomarkers, Patient Outcome.
Translational science is a multi-disciplinary field that focuses on applying
knowledge from basic scientific research to practical advancements in
healthcare. Translational sciences play a crucial role in expediting the
transformation of scientific insights into tangible benefits for patients, such
as new drugs, therapies, and diagnostic tools. With that, this theme explores
different types of translations that form the backbone of successful drug
discovery, development, and implementation. These include molecular and genetic
translation, bridging the gap between preclinical studies to clinical research
(Phase 1, Phase 2, Phase 3), and moving from clinical trials to implementation
in real world and global settings, ultimately leading to improvement in patient
outcomes.
This theme brings together scientists involved across the spectrum of
translational research to compare and discuss novel approaches, practical
applications including case studies, and areas where such tools have been used
successfully in practice.
Theme 2: Making Data Work for Us – Applying and Combining Empirical (AI/ML) and
Mechanistic Modeling in the Preclinical, Clinical, and Post-Approval Realms
Keywords: Modeling and Simulation, PBPK/QSP, Mechanistic Models, Empirical
Models, AI/ML, Digital Biomarkers.
This theme explores the gaps in making AI/ML successful in delivering
breakthrough medicines and/or approaches/discoveries in the drug development
field and debates the need to apply combined approaches to empirical and
mechanistic modeling.
This theme covers includes: virtual data / synthetic data / synthetic control
(at preclinical and clinical levels); replacement of placebo/vehicle control in
preclinical trials with computational models, replacement of control group in
clinical trials with computational models; data quality and datasets size and
heterogeneity and its influence on the model quality, large datasets, Real World
data and its use; empirical and mechanistic (PBPK/QSP) models combined to solve
problems – i.e. virtual BE studies; use of virtual data to dynamically adapt
trial designs in real-time based on accumulated information.
Theme 3: Advancing Vaccine Development: Utilizing the Power of Model-Based
Approaches
Keywords: Model informed drug development, vaccines, immunogenicity prediction,
dose optimization, QSP, real world data
Model-informed drug development is a key tool that is broadly used to support
drug discovery and development as well as regulatory review. This theme centers
on the application of model-informed approaches in vaccine development and will
highlight the strategic integration of clinical pharmacology tools, including
dose/exposure-response analyses, mechanistic PK/PD modeling, model-based
meta-analysis, and other quantitative approaches to address challenges and
inform decision-making across all stages of vaccine development. Applications
will include (but are not limited to) optimization of dosing regimen and
formulation components, informing dosing for special populations, prediction of
immunogenicity, and leveraging real world data for refinement (e.g. variants,
long term safety).
Our aim is to bring together scientists from industry, academia and regulatory
agencies in a collaborative dialog that encourages the adoption of quantitative
tools leading to the accelerated development of more effective and safer
vaccines.
Bioanalytics
Theme 1: Bioanalytical Lab Innovations
Keywords: Automation, Artificial Intelligence (AI), Machine Learning (ML), High
Throughput, Assay Design, Predictive Outcomes, Devices, Platforms, Supply Chain,
GLP, GCP, Clinical, Drug Development, Troubleshooting, Validation,
Bioanalytical, Therapeutic, Robotics, Cut-Point Analysis.
This theme explores new technologies -- including Artificial Intelligence (AI)
and Machine Learning (ML) – and their applications to bioanalysis. It also
explores platforms, robotics, and automation solutions for advancing
therapeutics in the bioanalytical lab. Topics include integration of robotics,
microfluidics, and automation in high throughput platforms; assay design;
automated sample processing; adaptation of 96 well assay format to 384 well
format --case studies of development, validation, and analysis for non-standard
therapeutics; solutions for GLP and GCP lab documentation using AI technologies;
and innovative lab solutions for troubleshooting complex therapeutics.
Theme 2: Current Challenges in Bioanalytical Labs
Keywords: PK, PD, ADA, APA, NAb, Assays, Immunogenicity, PCR, Molecular, RT-PCR,
dd-PCR, ELISPOT, Potency Assays, Domain Specificity, CAR-T, Cross-Validation,
Biodistribution, Cell and Gene Therapy, ADCs, AOCs, Oligonucleotides, RNA
Therapeutics, Biologics, Multidomain Therapeutics, Critical Reagents, Genomics,
Stability, Matrices, Surrogate, LCMS, LBA, Troubleshooting, Microsampling,
Con-Conforming Modalities, Cut-Point Analysis.
This theme explores current challenges for the bioanalytical lab’s assay
development, validation, analysis, and assay lifecycle management. Topics
include the selection of platforms for genomics-based molecular assays;
challenges for cell and gene therapy -- unique issues to the development of the
ADCs, AOCs, and multi-domain therapeutics; hybrid approaches for the small
molecule/complex therapeutic analysis; stability challenges and critical reagent
management for complex therapeutics; matrix selection; nontraditional samples in
matrices such as whole blood, tissues, PMBC, cerebrospinal fluid etc.;
patient-centric sampling and bioanalytical challenges and approaches for
personalized medicine; and troubleshooting-focused case studies.
Theme 3: Regulatory Implications for Bioanalysis
Keywords: PCR, Molecular, RT-PCR, dd-PCR, ELISPOT, Domain Specificity, CAR-T,
Cross-Validation, LCMS, LBA, Study Design and Implementation, Cell and Gene
Therapy, Immunogenicity, Gaps, Regulatory, Biomarkers, Clinical, Assays, Rare
Diseases, Animal Models, Alternate Animal Models, Microsampling, Sample
Logistics (China HGRA).
This theme explores the implications of the gaps in the current regulatory
guidelines and incorporation of industry recommendations. Topics include
biomarkers, hybrid LC/MS, cell and gene therapies and nucleic acid analysis;
incorporation of automation and Artificial Intelligence (AI); selection and
testing of unique or rare matrices; cut point for rare diseases; outsourcing;
study design and implementation through application of current guidance and
industry white papers; harmonization across regulatory authorities or where gaps
in guidance exist; impacts and implementation of new regulatory guidance; and
quality considerations when guidance is undefined.
Manufacturing and Analytical Characterization
Theme 1: Innovation in Pharmaceuticals/Biopharmaceuticals Manufacturing and
Characterization
Keywords: Continuous manufacturing, single use technologies, modality agnostic
flex facilities, green chemistry, sustainability, collaborative ecosystems,
smart manufacturing, bioprocessing innovation, pharmaceutical manufacturing 4.0,
EU regulatory reform, cross-industry collaborations, disruptive innovation,
industry-academia collaboration, federal funding for innovation, digital
replicas, predictive modeling, ICH Q12 and Q 14, capillary zone electrophoresis,
isoelectric focusing, ion exchange, size exclusion (SEC), reversed phase (RP) or
hydrophilic interaction liquid chromatography (HILIC), coupled with ultraviolet
(UV), fluorescence, or mass spectrometric (MS), LC MS/MS, SEC-MS, Drug release
and dissolution.
The pharmaceutical and biopharmaceutical industries are experiencing a wave of
innovations that are revolutionizing their traditional manufacturing and
characterization. These innovations include continuous manufacturing, single-use
technologies, flexible facilities, modality-agnostic manufacturing systems, and
modular manufacturing systems including use of robotics. Additionally, there is
a growing emphasis on green chemistry and sustainability in pharmaceutical and
excipient industry.
Characterization techniques have evolved commensurate to the complex nature of
novel formulations and manufacturing processes. These advanced techniques offer
more accurate and rapid results, contributing to improved speed and reliability
throughout the entire product lifecycle. By embracing these disruptive
innovations, the industry demonstrates its commitment to efficiency,
adaptability, and sustainability.
Moving forward, the pharmaceutical industry, in collaboration with academia and
regulatory, is actively embracing innovative technologies, sustainable
practices, and adaptable manufacturing and testing methodologies. This theme
provides a forum for Innovations in small molecule, biologics, cellular
therapies, oligonucleotides, and antibody drug conjugates manufacturing and
characterization agnostic of their development and implementation stage.
Theme 2: Digital Tools to Accelerate Drug Development, Manufacturing and
Analysis
Keywords: Automation and Robotics, Simulation And Modeling Platforms To Increase
Efficiency, Virtual Testing And Process Design, Digital Twins, Mini Piloting,
Platform Ecosystem For DS and DP, Line of Sight to Commercialization, Predictive
Modeling for Manufacturing, Supply Chain Visibility (Enhanced Traceability And
Visibility), Internet Of Things (IOT) Devices, Real-Time Data Collection,
Analysis and Decision Making, Training Simulations Using Virtual Reality (VR)
and Augmented Reality (AR), Drug Repurposing -- Artificial Intelligence (AI) and
Machine Learning (ML) to Identify New Uses, Regulatory Guidance For Digital
Tools, Validation Of Digital Tools, Model Maintenance, Safeguards for Digital
Tools.
The pharmaceutical industry has wholeheartedly embraced a range of digital tools
and platform technologies to expedite drug development, manufacturing, and
analysis. These tools harness advanced technologies to enhance efficiency,
reduce costs, and improve overall processes. They also leverage historical
learning from industry and academia. Key examples of these tools include
computational drug design, training simulations, digital twins, cloud computing,
high-throughput experiments, crystal structure prediction, regulatory
information management systems and standardization of submission data format.
By integrating these tools into the product lifecycle, the pharmaceutical
industry can accelerate drug development, manufacturing, and analysis. These
tools leverage data automation and advanced analytics to make processes more
efficient, cost-effective, and innovative, therefore taking drug to patients
faster. They enable the industry to leverage vast amounts of data, leading to
faster decision-making and improved outcomes.
The adoption of these tools represents a significant step forward in the
pharmaceutical industry's quest for enhanced productivity and competitiveness.
The track will also elaborate on the latest in regulatory guidance and
safeguards for digital tools.
Theme 3: Challenges and Lessons Learned in Commercializing (Manufacturing and
Product Quality Analysis) Novel Modalities
Keywords: Commercialization of Antibody-Drug Conjugates (ADC), Nano-Medicine,
Protein Degradation Therapies (PROTACS), Cell Therapy, CRISPER, Bispecifics,
Oral Peptide, RNA-Based Therapies, mRNA, SiRNA, Antisense Oligonucleotides, Gene
Therapy, Phage Therapy, 3D Printing In Drug Delivery, mRNA Vaccines, Abuse
Deterrent Formulations, Life Cycle Management of Analytical Methods, Regulatory
Strategy, Intellectual Property Protection, Manufacturing Scalability, Cost of
Goods and Manufacturing (COGM) Considerations, Long Term Sustainability and End
to End (E2E) Product Lifecycle Management.
Over the past decade, pharmaceutical companies have achieved remarkable success
in commercializing novel therapies that have revolutionized patient safety and
healthcare outcomes. These innovations include antibody-drug conjugates (ADC),
nanomedicine, protein degradation therapies (PROTACS), cell therapy, CRISPER,
bispecifics, oral peptide, RNA-based therapies, mRNA, SiRNA, antisense
oligonucleotides, gene therapy, phage therapy, 3D printing in drug delivery,
mRNA vaccines and abuse deterrent formulations.
These advancements have had a significant impact on improving global health,
thanks to the collaborative efforts of industry, academia, and regulators in a
rapidly changing environment. Manufacturing facilities have been adapted to meet
the unique requirements of these novel modalities, while new analytical
characterization methods have been developed, validated, and implemented to
better understand these complex therapies and safeguard patients.
Regulators have played a crucial role by providing opportunities for
collaboration, offering clear feedback, and providing guidance to ensure the
safe and effective development of these innovative therapies. This track aims to
highlight success stories, share lessons learned, address challenges, and
provide a framework for accelerating innovation while enabling Pharmaceutical
Manufacturing 4.0.
Formulation and Delivery
Theme 1: Formulation Approaches to Overcome Development Challenges Across
Modalities
Keywords: Modelling, Modality-Specific Formulation Development, Stability and
Prediction, Processes and technologies, Quality by Design (QbD).
Accelerated timelines in the drug discovery and development space, combined with
increasingly complex drug substances such as biomolecules, RNA-based vaccines,
and low-solubility small molecules, are presenting significant challenges to
formulation development. This theme will focus on strategies to address and
overcome these challenges, including the use of Artificial Intelligence (AI),
Machine Learning (ML), and modeling for formulation design and understanding,
in-vivo predictive tools, formulation screening tools, risk-based development
approaches, overcoming solubility and permeability issues, and improving and
predicting formulation performance and stability. Further emphasis will be given
to formulation approaches for biologics (e.g., mAbs, ADCs, bispecific
antibodies), vaccines (e.g., mRNA, antigen), peptides, chemical entities, gene
and cell therapies, highly concentrated formulations for subcutaneous
applications, and novel formulations and processes such as additive
manufacturing.
Theme 2: Turbocharging Drug Product Development: The Critical Role of
Excipients
Keywords: Novel Excipients, Advanced Applications of Traditional Excipients,
Material Properties, Physicochemical and Biological Properties, Supply Chain
Management, Sustainability, Quality and Regulatory Compliance, Impurities.
Excipients play a pivotal role in the formulation and development of drug
products for both chemical substances and biomolecules. Although typically
considered pharmacologically inert, excipients influence a wide range of
performance characteristics, including manufacturing robustness, stability, and
bioavailability. This theme addresses the increasing demand for knowledge about
excipients and the regulatory considerations to enable and accelerate the
formulation development of new molecular entities, which are growing in
complexity. The theme also explores the risk assessment of incorporating novel
excipients into drug products such as compatibility and biocompatibility
studies. Additionally, the theme encompasses the use of permeation enhancers,
complex formulation stabilizers, and lipid and polymeric excipients in various
drug delivery techniques. Furthermore, it covers the effects of excipients on
the solubility, viscosity, and stability of biologics, such as proteins, mAbs,
and ADCs. The discussion will also include the role of excipients in
facilitating the development and administration of high-concentration and
high-volume biologics.
Theme 3: Advanced Drug Delivery Technologies for Targeted Therapeutics
Keywords: Targeted Drug Delivery, Controlled Release, Site and Disease-Specific
Drug Delivery, Long-Acting Therapeutics, Nanomedicine, Drug-Device Combination,
Patient Centricity, Target Product Profile.
Therapeutics that are more specialized and directly target specific disease
areas necessitate approaches that extend beyond the scope of traditional drug
delivery. Additionally, diverse patient populations and health care settings
across different regions pose specific challenges to drug formulation and
delivery. This theme covers disease-specific targeting; innovative delivery
routes, multifunctional micro- and nano-delivery systems; controlled and
modified release; long-acting injectables or implants; and immune-targeted
delivery. In addition, use of novel delivery routes and patient-centric dosage
forms can be developed. This includes fixed-dose combinations, age-appropriate
dosage forms (e.g. pediatric), drug-device combination products (e.g.
autoinjectors or patch pumps) enabling patient self-administration; delivery
technologies allowing subcutaneous delivery of large volumes; and alternative
routes of administration (e.g. intranasal, pulmonary, or transdermal).
Career Development
Theme 1: Elevate your Scientific Career with Strong Business Acumen
In the dynamic world of pharma, possessing a profound understanding of business
intricacies is a game-changer for career advancement. Blend your scientific
expertise with business savvy to make astute decisions and carve out a thriving
career path in the industry. A well-developed technical set of goals coupled
with business knowledge will prepare scientists to become leaders in tomorrow’s
environment.
The following examples are provided to help submitters develop proposal ideas.
The Career Development Committee will consider any proposal that fits the track
theme and description above.
Example topics:
* Mastering the Art of Contract Negotiation
* Safeguarding Intellectual Property in the Evolving Scientific Landscape
* Unveiling the Secrets in Job Offers: Pharmaceutical Science Career
Acceleration
* Securing Resources for Innovations: A Business-Centric Approach for Academic
Professionals
* Decoding Stock Options: A Strategic Approach for Pharma Professionals
* Investor Relationship Management: Navigating Objectives Effectively
* Crafting Successful Inter-Company Collaborations in Pharma (In-licensing,
Mergers, Acquisitions, Co-developed Assets)
* Entrepreneurship Unleashed: Initiating Your Venture
* Securing Venture Capital for Start-ups: Strategies for Success
Theme 2: Nurturing a Sense of Equity and Inclusion to Build a Diverse Workforce
Globalization has brought pharmaceutical scientists and professionals from
diverse cultural, socioeconomic, and educational backgrounds together to achieve
common goals and objectives. Successful teams that have benefited from diversity
in culture, education, training, and experiences that foster innovative ideas,
have promoted and nurtured these values and parameters at the organizational
level.
The following examples are provided to help submitters develop proposal ideas.
The Career Development Committee will consider any proposal that fits the track
theme and description above.
Example topics:
* Cultivating Meaningful Diversity to Enrich a Workforce
* Navigating Unconscious Bias: Strategies for Understanding and Inclusive
Decision-making
* Promoting Mental Health and Wellness in a Competitive and Diverse Work
Environment
* Effective Communication for Diverse Teams: From Listening to Using Inclusive
Languages, to Building a Diverse and Successful Team
* Strategies for Work-life Balance for a Diverse and Successful Team
* Role of Mentorship in Building and Nurturing a Diverse and Successful
Workforce
* Creating a safe environment to foster new ideas and innovations.
* Develop Intelligence for Effective Cross-Cultural Collaboration
CONTACT INFORMATION
REGISTRATION & HOUSING
eShow Registration Team
aaps.helpdesk@goeshow.com
1.847.620.4256
SALES
Erik Burns
BurnsE@aaps.org
+1.703.248.4738
SCIENTIFIC & CAREER DEVELOPMENT PROGRAMMING
Amber Sims-Mowatt
SimsmowattA@aaps.org
+1.703.248.4702
ABSTRACTS & POSTERS
Teresa Homrich
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Andre Hermans, Ph.D., Merck (Track Chair)
Shijie Cao, Ph.D., University of Washington (Sub-Track Leader)
Haichen Nie, Ph.D., Teva Pharmaceuticals (Sub-Track Leader)
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