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 * Home
 * Research
 * People
   * Former Lab Members
 * Publications
 * News
 * Join our Team


 * Home
 * Research
 * People
   * Former Lab Members
 * Publications
 * News
 * Join our Team



LEARN MORE LEARN MORE WOLBERGER
LAB



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WOLBERGER LAB

Welcome to the laboratory of Cynthia Wolberger, located in the Department of
Biophysics and Biophysical Chemistry. Our research is focused on the structural
and mechanistic basis of transcriptional regulation and ubiquitin signaling. We
use a combination of cryo-EM, x-ray crystallography, and a variety of
biophysical and biochemical approaches to gain insights into the fundamental
mechanisms underlying these processes. Please follow the links on this page to
learn more about our research and lab members.




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RECENT NEWS

Sep 25, 2024
JAMES FIELDS AWARDED AN NRSA FELLOWSHIP

Congratulations to James Fields, who has received a postdoctoral Ruth L.
Kirschstein National Research Service Award (F32) from the National Cancer
Institute. Kudos!


Uncategorized
Feb 29, 2024
CONGRATULATIONS TO OUR NEWEST PH.D., CHAD HICKS!

Congratulations to Dr. Chad Hicks, who gave his thesis seminar on Feb. 23. We
are all very proud of you. Good luck in the next phase of your career!


News
Mar 15, 2023
SANIM RAHMAN AWARDED AN F31 FELLOWSHIP

Congratulations to PMB student, Sanim Rahman, who has received an F31 fellowship
from NCI!


News

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LAB INFO


PROSPECTIVE GRADUATE STUDENTS…

should visit the following web sites:

 * Program in Biochemistry, Cellular and Molecular Biology
 * Program in Molecular Biophysics
 * XDbio
 * Chemistry-Biology Interface Program

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INTERESTED IN A POSTDOCTORAL POSITION?

Please see the Join Our Team page for information.

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LOOKING FOR A PLASMID?

Many of our plasmids are available through Addgene. View the list of available
plasmids.






OUR RESEARCH

THE ROLE OF HISTONE H2B UBIQUITINATION IN TRANSCRIPTION AND CHROMATIN DYNAMICS




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UBIQUITIN SIGNALING IN THE DNA DAMAGE RESPONSE




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UBIQUITINATION AND ACETYLATION IN GENE ACTIVATION




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View All Research





SELECTED RECENT PUBLICATIONS

Hicks CW, Rahman S, Gloor SL, Fields JK, Husby NL, Aup Vaidya A, Maier KE,
Morgan M, Keogh MC, Wolberger C. (2024) Ubiquitinated histone H2B as gatekeeper
of the nucleosome acidic patch. bioRxiv 2024.02.22.581437.

Zhao F, Hicks CW, Wolberger C (2023) Mechanism of histone H2B monoubiquitination
by Bre1 (2023) Nat Struct Mol Biol. 30(11):1623-1627. doi:
10.1038/s41594-023-01137-x.

Rahman S, Hoffmann NA, Worden EJ, Smith ML, Namitz KEW, Knutson BA, Cosgrove MS,
Wolberger C. (2022) Multistate structures of the MLL1-WRAD complex bound to
H2B-ubiquitinated nucleosome. Proc Natl Acad Sci U S A. 20;119(38):e220569111.
doi: 10.1073/pnas.2205691119

Lombardi PM, Haile S, Rusanov T, Rodell R, Anoh R, Baer JG, Burke KA, Gray LN,
Hacker AR, Kebreau KR, Ngandu CK, Orland HA, Osei-Asante E, Schmelyun DP, Shorb
DE, Syed SH, Veilleux JM, Majumdar A, Mosammaparast N, Wolberger C. (2022) The
ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent
ubiquitins in K63-linked polyubiquitin. J Biol Chem. 28:101545. doi:
10.1016/j.jbc.2021.101545.

Morgan MT, Ikenoue T, Suga H, Wolberger C. (2022) Potent macrocycle inhibitors
of the human SAGA deubiquitinating module. Cell Chem Biol 29(4):544-554.e4 doi:
10.1016/j.chembiol.2021.12.004


View All Publications (on NCBI site)





 * Johns Hopkins University
   School of Medicine
   Biophysics and Biophysical Chemistry
   725 N. Wolfe Street, WBSB 614
   Baltimore, MD 21205-2185
   410.955.0728


 * COMMUNITY
   
   Community We are part of the Dept. of Biophysics and Biophysical Chemistry
   Dept. at JHMI, as well as of the the Johns Hopkins Graduate Program in
   Molecular Biophysics (PMB), the Biochemistry, Cellular and Molecular Biology
   Graduate Program (BCMB), and the Chemistry-Biology Interface Graduate Program
   (CBI):
   
   Dept. of Biophysics
   PMB
   BCMB
   CBI
   The Sidney Kimmel Comprehensive Cancer Center


 * OPPORTUNITIES
   
   Information for those interested in our research:
   Please contact the PI directly for inquiries regarding research opportunities
   for undergraduates, graduate students, medical students and postdoctoral
   fellows.


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