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Menu
MENUMENU
 * Company
   * About Us
   * Events
   * Careers
   * Contact us
   * Distributors
 * DNA/RNA Writing
   * Gene Synthesis
     * Codon Optimization
     * Gene Synthesis
     * Antibody Gene Synthesis
     * Pathway Synthesis
     * Chip Based DNA Synthesis
     * Genome Synthesis
     * Vector Building
     * Gene Fragments
   * Synthetic DNA Libraries
     * Alanine Scan Library
     * Site Saturation Library
     * Random Library
     * Antibody Library
     * sgRNA Library
     * Case Studies
   * Molecular Biology
     * Plasmid DNA Preparation
     * PCR Cloning
     * Site-Directed Mutagenesis
     * ssDNA Synthesis
   * RNA Synthesis
     * Custom RNA Oligos
     * siRNA/miRNA Synthesis
     * CRISPR-Cas9 sgRNA Synthesis
     * In Vitro Transcription Service
     * RNA Modifications
   * DNA Data Storage
     * Your IP, Our DNA
   * Oligo Synthesis
     * Custom DNA Oligos
     * Diagnostic Probes & Oligos
     * NGS Oligos
     * Modified Oligos
     * Antisense Oligonucleotides
     * CpG ODNs
     * Oligo Libraries
     * Oligo Pools
   * COVID-19 Solutions
     * Probe for COVID-19Hot
     * Protein for COVID-19
     * Antibody and Vaccine
 * DNA Editing
   * CRISPR-Cas9
   * sgRNA Design
   * sgRNA Library Construction
   * sgRNA Panel
   * Microbial Genome Editing
   * Mammalian Cell Genome Editing
   * ssDNA Synthesis
   * CRISPR Amplicon Sequencing
   * CRISPR NGS Data Analysis
 * DNA Reading
   * Hybridoma Antibody Sequencing
   * Immune Repertoire Sequencing
   * DNA Sequencing & Gene Analysis
   * NGS High Throughput Sequencing
   * 16S rDNA Sequencing
   * Metagenome Sequencing
   * RNA Sequencing
   * CRISPR Amplicon Sequencing
 * Antibody Services
   * Geno®Ab
     * Hybridoma Antibody Sequencing
     * Immune Repertoire Sequencing
     * Antibody NGS Data Analysis
     * Single B Cell Antibody
   * Syno® Ab
     * Antibody Design and Production
     * Antibody Affinity Maturation
     * Antibody Humanization
   * Antibody Generation
     * Recombinant Ab Production
     * Monoclonal Antibody Preparation
     * Polyclonal Antibody Preparation
     * Single Domain Antibody (sdAb)
   * Synthetic Antibody Libraries
     * Synthetic CDRs Variant Antibody Library
     * Error-prone scFv Variant Antibody Library
     * Phage Display
 * Protein & Peptide
   * Protein Products
     * Protein for COVID-19
     * Immune Checkpoint Proteins
     * CD Antigens
     * Receptor Proteins
     * Signal Transduction
     * Cytokines
   * Protein Expression
     * Codon Optimization
   * Mammalian Expression
     * Recombinant Ab Production
     * Mammalian Cell Expression Vectors
   * Bacterial Expression
     * Syno®Guaranteed Package
     * Rha Promoter Bacterial Expression Vectors
   * Yeast Expression
   * Insect Expression
   * Peptide Synthesis
     * Custom Peptide Synthesis
     * Peptide Library
     * Peptide Modification
   * Structural Biology
     * NMR Services
 * Synthetic Biology
   * Design
     * Enzyme Engineering
     * Genome-scale Metabolic Models
   * Build
     * DNA Synthesis
     * Pathway assembly
     * Genome editing
     * Strain Construction
   * Test
     * Bioprocess Development
     * Analytic Method Development
   * Learn
     * Metagenome Sequencing
     * RNA Sequencing
     * Proteomics
     * Metabolomics
     * Metabolic Flux Analysis
   * Gene Therapy
     * Gene Delivery
     * AAV Gene Delivery
     * Adeno Virus Gene Delivery
     * Lentivirus Gene Delivery
 * Resources
   * Applications of Gene Synthesis on the Syno® Platform
     * Codon Optimization for Peptide and Protein Expression
     * Study on the Functions of Nucleic Acid
     * Genome Editing Tool
     * Metabolic Pathway Synthesis
     * Design and Synthesis of Gene Circuits
     * Ultra-long Genome Synthesis and Assembly
     * Digital Information Storage
   * Applications of the CRISPR-Cas9
     * Mammalian Cell Gene/Genome Editing
     * Target Screening for New Drug Development
     * Applications and Research of Gene Therapy
     * Plant Genome Editing
     * Microbe Genome Editing
     * CRISPRi/a and Its Application
   * Learning Center
     * Brochures & FlyersHot
     * Customer Academic Publications
     * Synbio Wiki
     * Frequently Asked Questions
   * Promotion
     * Current Promotions
     * Referral Program
   * Synbio Bioinfomatics
     * Bioinformatics Tool
     * DNA Studio™
   * Others
     * Terms and Conditions
     * Privacy Policy


Synbio Technologies > Gene Synthesis


GENE SYNTHESIS

DNA/RNA Writing
Gene Synthesis
+

Codon Optimization Gene Synthesis Antibody Gene Synthesis Pathway Synthesis Chip
Based DNA Synthesis Genome Synthesis Vector Building Gene Fragments

Synthetic DNA Libraries
+

Alanine Scan Library Site Saturation Library Random Library Antibody Library
sgRNA Library Case Studies

RNA Synthesis
+

Custom RNA Oligos siRNA/miRNA Synthesis CRISPR-Cas9 sgRNA Synthesis In Vitro
Transcription Service RNA Modifications

Molecular Biology
+

Plasmid DNA Preparation PCR Cloning Site-Directed Mutagenesis ssDNA Synthesis

DNA Data Storage
+

Your IP, Our DNA

Oligo Synthesis
+

Custom DNA Oligos Diagnostic Probes & Oligos NGS Oligos Modified Oligos
Antisense Oligonucleotides CpG ODNs Oligo Libraries Oligo Pools

COVID-19 Solutions
+

Probe for COVID-19Hot Protein for COVID-19 Antibody and Vaccine


With our professional research team and effective systems in place, Synbio
Technologies provides our customers a simple one-stop shop that satisfy all
their DNA manufacturing needs. We have developed the most comprehensive
platforms of oligo synthesis, gene synthesis (fragment and clonal genes) and
next-generation high-throughput gene synthesis to meet our customers’ needs in
quality, speed, budget, and applications. We routinely synthesize over 3 million
base pairs of gene sequences each month for a wide range of applications
including protein production, antibody discovery, genetically engineered
vaccine, molecular breeding, biofuel and many more.


WHY US?

Industry’s most competitive rate, FREE to subclone into most commercial vectors,
FREE to deposit your vector for future use, effectively 15-40% savings per gene.

Quote online

A combined 100+ years of experience from our scientific leaders in DNA
synthesis. Experience with challenging sequences and genes for various
applications.

Bulk order

Over 250 scientific staff in our state of the art facilities certified with the
highest manufacturing standards (ISO9001 & ISO13485). Routinely deliver 3
Mbp/month.

See case studies

--------------------------------------------------------------------------------

 


GENE SYNTHESIS SERVICE SPECIFICATIONS

Below is the price table for standard gene synthesis services. The turnaround
time only applies to the non-complex sequences. The genes will be cloned into
our default pUC57-Amp or pUC57-Kan vectors with multiple cloning sites. We can
also clone the genes into customers’ supplied vectors upon request.



Gene LengthPriceTurnaround Time
(business days)Optional ServicesDeliverables<250 bp$505-10
 * Free codon optimization
 * Free vector deposit

 * 2~5 µg lyophilized plasmid DNA
 * Sequencing chromatogram
 * Certificate of analysis (COA)

250-1,500 bp$0.20/bp5-101,501-3,000 bp$0.21/bp10-153,001-4,500
bpQuote15-204,501-6,000 bpQuote20-25>6,000 bpQuoteQuote

* We offer bulk discount for gene synthesis services. Please contact
quote@synbio-tech.com for additional information.


STANDARD GENE SYNTHESIS PROCESS

According to the DNA or amino acid sequences customers provided, our scientists
will design the oligos and the procedure of fragment assembly and cloning within
30 minutes. By using our automated system that guarantees efficient and
error-free synthesis, our customers will be provided with the highest quality
output. Sanger sequencing will be conducted to verify 100% sequence accuracy. 



--------------------------------------------------------------------------------

--------------------------------------------------------------------------------


ADD-ON SERVICES

Cloning

Streamlined process. Ability to clone any requested genetic sequence into any
site of any vector.

Mutagenesis

Base deletion, insertion, site-directed mutagenesis and arbitrary editing.

Plasmid Preparation

High quality plasmids from milligram to gram scale.

Protein Expression and Purification

Guaranteed 3 mg protein of 85% purity with our Syno®Guaranteed Protein Package
in E. coli expression system

--------------------------------------------------------------------------------


OTHER DNA SYNTHESIS PLATFORMS

NGTM Codon Optimization

Patented codon optimization technology that improves the protein expression
level in most host cells

Next Generation Gene Synthesis

High throughput and most cost-effective: starting at $0.09/bp for synthesis.



Synthetic DNA Libraries

All types of mutant/variant libraries with diversity of up to 1014 confirmed by
sequencing analysis. Flexible deliverables upon request.

Vector Construction

shRNA, TALEN, CRISPR-Cas9 construction and validation.

Small Genome Synthesis & Assembly

Synthesis and assembly of gene cluster and small genome. Guaranteed 100%
sequence accuracy.

Pathway Synthesis & Assembly

Proprietary metabolic pathway design platform, Syno® Assembly Technology ensures
long sequence synthesis up to 150 Kb.


CASE STUDIES

Typically the genes with high GC content, hairpin structure and repetitive
sequences present great challenges to standard gene synthesis process. Synbio
Technologies’ new NGTM Codon system (patent pending) provides a robust and
sophisticated algorithm to solve those challenges and enable successful
synthesis of even the most complex sequences as demonstrated by the case studies
below.

i. A gene with high GC content and repeats

This gene has a length of 1,606 bp with GC content: of 71.98% and 176 CpG. The
gene was delivered in 5 weeks.

Figure 1. This graph shows the GC distribution and secondary structure of the
mentioned gene.

ii. A gene with low GC content (AT rich) and palindromic repeats

This gene has a length of 580 bp and GC content of 32.76% and palindromic
repeats of 15 loxP sites. The gene was delivered in 4 weeks.

Figure 2. This graph shows the GC distribution and secondary structure of the
mentioned gene.

iii. Large yeast genome DNA assembly

This 49 kb long yeast genome fragment was made through one-step assembly in
yeast.

Figure 3. Illustration of the gene suquence assmbly and DNA gel eletrophoresis
results for the successful synthesis of 49 kb yeast genome



SERVICES

 * Gene Synthesis & DNA Fragment Synthesis
 * Cloning & Plasmid DNA Preparation
 * Synthetic DNA Libraries
 * Genome editing service & CRISPR Cas9 sgRNA
 * Oligo Synthesis & RNA Synthesis
 * Protein Expression and Purification
 * Antibody Discovery Services

RESOURCES

 * Bioinformatics Tool
 * DNA Studio™
 * Customer Academic Publications
 * Frequently Asked Questions

CONTACT US

 * Tel: +1 732-230-3003
 * Fax: +1 609 228 5911
 * For inquiries: quote@synbio-tech.com

 * FOLLOW US


2013 - 2021 © All Rights Reserved by Synbio Technologies




 * Send Inquiries

 * Online Quotes

 * +17322303003


Synbio Technologies

 * Company
   
   * About Us
   * Events
   * Careers
   * Contact us
   * Distributors
 * DNA/RNA Writing
   
   * Gene Synthesis
     
     * Codon Optimization
     * Gene Synthesis
     * Antibody Gene Synthesis
     * Pathway Synthesis
     * Chip Based DNA Synthesis
     * Genome Synthesis
     * Vector Building
     * Gene Fragments
   * Synthetic DNA Libraries
     
     * Alanine Scan Library
     * Site Saturation Library
     * Random Library
     * Antibody Library
     * sgRNA Library
     * Case Studies
   * RNA Synthesis
     
     * Custom RNA Oligos
     * siRNA/miRNA Synthesis
     * CRISPR-Cas9 sgRNA Synthesis
     * In Vitro Transcription Service
     * RNA Modifications
   * Molecular Biology
     
     * Plasmid DNA Preparation
     * PCR Cloning
     * Site-Directed Mutagenesis
     * ssDNA Synthesis
   * DNA Data Storage
     
     * Your IP, Our DNA
   * Oligo Synthesis
     
     * Custom DNA Oligos
     * Diagnostic Probes & Oligos
     * NGS Oligos
     * Modified Oligos
     * Antisense Oligonucleotides
     * CpG ODNs
     * Oligo Libraries
     * Oligo Pools
   * COVID-19 Solutions
     
     * Probe for COVID-19Hot
     * Protein for COVID-19
     * Antibody and Vaccine
 * DNA Editing
   
   * CRISPR-Cas9
   * sgRNA Design
   * sgRNA Library Construction
   * sgRNA Panel
   * Microbial Genome Editing
   * Mammalian Cell Genome Editing
   * ssDNA Synthesis
   * CRISPR Amplicon Sequencing
   * CRISPR NGS Data Analysis
 * DNA Reading
   
   * Hybridoma Antibody Sequencing
   * Immune Repertoire Sequencing
   * DNA Sequencing & Gene Analysis
   * NGS High Throughput Sequencing
   * 16S rDNA Sequencing
   * Metagenome Sequencing
   * RNA Sequencing
   * CRISPR Amplicon Sequencing
 * Antibody Services
   
   * Geno®Ab
     
     * Hybridoma Antibody Sequencing
     * Immune Repertoire Sequencing
     * Antibody NGS Data Analysis
     * Single B Cell Antibody
   * Syno® Ab
     
     * Antibody Design and Production
     * Antibody Affinity Maturation
     * Antibody Humanization
   * Antibody Generation
     
     * Recombinant Ab Production
     * Monoclonal Antibody Preparation
     * Polyclonal Antibody Preparation
     * Single Domain Antibody (sdAb)
   * Synthetic Antibody Libraries
     
     * Synthetic CDRs Variant Antibody Library
     * Error-prone scFv Variant Antibody Library
     * Phage Display
 * Protein & Peptide
   
   * Protein Products
     
     * Protein for COVID-19
     * Immune Checkpoint Proteins
     * CD Antigens
     * Receptor Proteins
     * Signal Transduction
     * Cytokines
   * Protein Expression
     
     * Codon Optimization
   * Mammalian Expression
     
     * Recombinant Ab Production
     * Mammalian Cell Expression Vectors
   * Bacterial Expression
     
     * Syno®Guaranteed Package
     * Rha Promoter Bacterial Expression Vectors
   * Yeast Expression
   * Insect Expression
   * Peptide Synthesis
     
     * Custom Peptide Synthesis
     * Peptide Library
     * Peptide Modification
   * Structural Biology
     
     * NMR Services
 * Synthetic Biology
   
   * Design
     
     * Enzyme Engineering
     * Genome-scale Metabolic Models
   * Build
     
     * DNA Synthesis
     * Pathway assembly
     * Genome editing
     * Strain Construction
   * Test
     
     * Bioprocess Development
     * Analytic Method Development
   * Learn
     
     * Metagenome Sequencing
     * RNA Sequencing
     * Proteomics
     * Metabolomics
     * Metabolic Flux Analysis
   * Gene Therapy
     
     * Gene Delivery
     * AAV Gene Delivery
     * Adeno Virus Gene Delivery
     * Lentivirus Gene Delivery
 * Resources
   
   * Applications of Gene Synthesis on the Syno® Platform
     
     * Codon Optimization for Peptide and Protein Expression
     * Study on the Functions of Nucleic Acid
     * Genome Editing Tool
     * Metabolic Pathway Synthesis
     * Design and Synthesis of Gene Circuits
     * Ultra-long Genome Synthesis and Assembly
     * Digital Information Storage
   * Applications of the CRISPR-Cas9
     
     * Mammalian Cell Gene/Genome Editing
     * Target Screening for New Drug Development
     * Applications and Research of Gene Therapy
     * Plant Genome Editing
     * Microbe Genome Editing
     * CRISPRi/a and Its Application
   * Learning Center
     
     * Brochures & FlyersHot
     * Customer Academic Publications
     * Synbio Wiki
     * Frequently Asked Questions
   * Promotion
     
     * Current Promotions
     * Referral Program
   * Synbio Bioinfomatics
     
     * Bioinformatics Tool
     * DNA Studio™
   * Others
     
     * Terms and Conditions
     * Privacy Policy