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THE MAJOR MOUSE TESTING PROGRAM
Testing a new class of compounds, Senolytics, on their ability to extend healthy
lifespan by clearing out dysfunctional cells in the body.
BY DR. ALEXANDRA STOLZING
Funding Successful. This project reached its goal before June 25, 2016.
Help support Lifespan.io by donating to our Hero Campaign. Join our Hall of
Heroes and gain access to exclusive Hero content.
* Overview
* Updates
* Comments
* Backers
* $52,070
PLEDGED OF STRETCH GOAL 1
STRETCH GOAL : $60,000
* 538
Backers
*
* 115% FUNDED
campaign complete
Campaign Completed
Flexible Funding: All funds this campaign raises will be collected.
ABOUT THE RESEARCHER
Dr. Alexandra Stolzing
Created 1 Campaign • View Profile
Alexandra has dedicated her scientific career to the understanding and
development of rejuvenation biology. She holds a PhD from Humboldt University
Berlin for her work on degradation of damaged proteins by aged microglia, and
received her Habilitierung (Professorial Qualification) at the University of
Leipzig, Germany for her thesis “Modification of aging in mesenchymal stem
cells”.
She worked at the Kroto Research Institute (UK) and as Group leader and deputy
Head of Department at the Fraunhofer Institute for Cell Therapy and Immunology
(Germany). She was tenured in 2018 as a full Professor for Biogerontological
Engineering at Loughborough University, UK. In addition she has worked as VP for
Research and CSO in start-up companies in the rejuvenation biology sector.
She has over 70 academic publications and has led several international research
consortia.
Her research in aging spans areas including regenerative medicine, cell & gene
therapy development and neurodegenerative diseases.
Ask Question
* Pledge $5
PLEDGE $5
111 Backers
OUR ETERNAL GRATITUDE! — By donating you are pushing the investigation of
longevity therapies forward and helping to obtain healthy longevity for all
people. We will proudly put you on the list of campaign supporters on our
website as a thank you for your support. All higher donations will include
this reward.
Estimated delivery:
Shortly after campaign completion
* Pledge $20
PLEDGE $20
110 Backers
E-BOOK AGING PREVENTION FOR ALL — Get the new beautiful electronic English
version of Aging Prevention for All compatible with your computer, tablet or
mobile phone. This book, developed by the International Longevity Alliance
together with famous gerontologist and longevity researcher Vladimir
Anisimov, will provide you with an overview on aging processes and the
practical evidence-based advice on currently available healthy life extension
techniques.
Estimated delivery:
3 months after campaign completion
* Pledge $25
PLEDGE $25
141 Backers
$20 Pledge Reward + E-BOOK DEATH IS WRONG — Receive the electronic version of
the book Death is Wrong by Gennady Stolyarov; a story about aging and how
society might change the way they think about it. It is available in English,
Russian, French, Spanish, and Portuguese. We will also thank you on social
media and give you the e-book Aging Prevention for All!
Estimated delivery:
3 months after campaign completion
* Pledge $50
PLEDGE $50
60 Backers
MMTP T-SHIRT — Put the sexy back into science with an awesome MMTP T-shirt to
amaze your friends! We will follow up with you to select a size and choose
one of our three beautiful designs. + $10 for international shipping.
Estimated delivery:
3 months after campaign completion
* Pledge $60
PLEDGE $60
5 Backers
$20 Pledge Reward + SCIENCE MOUSE T-SHIRT — Wear our new special edition
T-shirt that shows you are a true science geek and also receive a copy of our
lovely new E-book "Aging Prevention for All”. You can also opt to have the
alternative T-shirt with MMTP logo if you prefer. + $10 for international
shipping.
Estimated delivery:
3 months after campaign completion
* Pledge $70
PLEDGE $70
16 Backers
MMTP T-SHIRT + E-BOOKS COMBO! — Receive a stunning MMTP T-shirt along with
two interesting electronic books: Aging Prevention for All and Death is
Wrong! + $10 for international shipping.
Estimated delivery:
3 months after campaign completion
* Pledge $75
PLEDGE $75
2 Backers
Science Mouse T-shirt + GENE THERAPY CONFERENCE TICKET — Get the awesome
special edition Science Mouse MMTP T-shirt as well as a ticket to the
exciting D.N.A.- Gene Therapies Congress - 9th July Utrecht, Netherlands. You
may also choose to have the alternative T-shirt with MMTP logo if you prefer.
Travel not included. + $10 for international shipping.
Estimated delivery:
3 months after campaign completion
* Pledge $100
PLEDGE $100
39 Backers
SIGNED COPY OF AGING PREVENTION FOR ALL + E-BOOK OF YOUR CHOICE — A physical
copy of Aging Prevention For All, signed by the authors and sent to you with
best wishes! You will also receive an e-book of either Ending Aging, The
Singularity is Near, or The Telomerase Revolution. We hope you will enjoy
your reading! + $10 for international shipping.
Estimated delivery:
3 months after campaign completion
* Pledge $150
PLEDGE $150
11 Backers
$20 Pledge Reward + ILA SPORTS BAG — Did you know that physical activity can
significantly influence your lifespan? Well, it can! Receive this stylish ILA
sports bag to support your motivation to be in a good shape and live longer!
You will also receive our e-book Aging Prevention for All to help you learn
about the science of healthy longevity. + $10 for international shipping.
Estimated delivery:
3 months after campaign completion
* Pledge $200
PLEDGE $200
4 Backers
$20 Pledge Reward + ILA SPORTS BAG + 2 MMTP T-SHIRTS — Receive a stylish ILA
sports bag and 2 MMTP T-shirts all together to support your motivation to be
in a good shape and live longer! You will also receive our e-book Aging
Prevention for All to help you learn about the science of healthy longevity.
+ $10 for international shipping.
Estimated delivery:
3 months after campaign completion
* Pledge $250
PLEDGE $250
25 Backers
Limit of 40 — 15 remaining
Sports Bag, T-Shirt + NAME A MOUSE! — Name a mouse in the experiment and
follow his/her life course. If it is in the longest lived you will get a
special secret prize! We have only 40 mice to name so this opportunity is
limited. You will also receive the ILA Sports Bag, MMTP T-Shirt, and the
Aging Prevention for All E-Book. + $10 for international shipping.
Estimated delivery:
3 months after campaign completion
* Pledge $500
PLEDGE $500
6 Backers
Limit of 30 — 24 remaining
Q & A WITH THE TEAM AND E-BOOK COLLECTION! — Participate in two personal
30-minute video conferences with the project team to ask questions and hear
the most exciting news about the ongoing experiment! You will also receive
our e-book Aging Prevention for All and the electronic versions of all other
books: Ending Aging, Singularity is Near, and Telomerase Revolution and Death
is Wrong in order to amplify your knowledge even more!
Estimated delivery:
3 months after campaign completion
* Pledge $1,000
PLEDGE $1,000
3 Backers
Limit of 10 — 7 remaining
ONLINE PANEL DISCUSSION + MMTP T-SHIRT AND ILA SPORTS BAG — Join a 1.5 hour
online discussion with the MMTP project team and several invited experts to
discuss the latest breakthroughs in life extension research as well as the
best ways to promote the idea of aging prevention among general public. You
will also receive a a stylish MMTP T-shirt and an ILA bag to commemorate the
event. + $10 for international shipping.
Estimated delivery:
3 months after campaign completion
* Pledge $2,000
PLEDGE $2,000
1 Backer
Limit of 5 — 4 remaining
SILVER SPONSORSHIP RECOGNITION + LONGEVITY CONFERENCE IN EUROPE TICKET — A
free ticket to attend the Eurosymposium on Healthy Ageing (EHA), organized in
Brussels by our partner HEALES, in October 2016. We will also mention you as
a Silver sponsor of our campaign and mention you in all media activities
during the campaign and until the experiment begins. Travel not included.
Estimated delivery:
3 months after campaign completion
* Pledge $5,000
PLEDGE $5,000
4 Backers
Limit of 5 — 1 remaining
GOLD SPONSORSHIP RECOGNITION + TRIP TO LONGEVITY CONFERENCE IN EUROPE — We
will arrange your travel and accommodations to the Eurosymposium on Healthy
Ageing (EHA), hosted in Brussels by our partner HEALES, in October 2016. This
includes your entry ticket and the option to speak at the conference. We will
also mention your support as a Gold sponsor in all media activities during
the campaign AND the Senolytics experiment (2 years long). You will also
receive official acknowledgement of your support in any resulting scientific
peer reviewed publication or public report.
Estimated delivery:
3 months after campaign completion
Launched: May 10, 2016
Funding Ends: June 25, 2016
Leipzig University, Germany
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SENOLYTICS — SEEK AND DESTROY
According to modern science aging is the accumulation of damage that the body
cannot completely eliminate, due to the imperfections of its protection and
repair systems. The good news is that the processes that constitute aging are
amenable to medical intervention. We can slow down or even reverse some aspects
of aging through the application of different therapies, which prevent or block
some of these processes.
One of these processes of aging is cell senescence.
Senescent cells normally self destruct via a process called apoptosis, but
unfortunately not all of them do. These “death resistant” senescent cells
accumulate in the body with age and secrete toxic signals. This causes
inflammation and damage to organs and tissues, increasing risks for cancer and
other diseases of old age. This is why these cells are often called “good
citizens but bad neighbors”. They remain partially functional, but their
presence does more harm than good.
A new class of drugs known as Senolytics have recently demonstrated the ability
to remove senescent cells to improve health. However, the potential of
senolytics to increase health and lifespan beyond current maximums remains
unknown. This is what we at Major Mouse Testing Program want to investigate –
with your help!
Why is this study of particular interest?
It was discovered that senescent cells have increased expression of pro-survival
genes, consistent with their resistance to natural cell death – apoptosis. Drugs
targeting these pro-survival factors selectively killed senescent cells and
improved health. Two such drugs were Dasatinib and Quercetin which were both
able to remove senescent cells, albeit each in different tissue types. Even more
excitingly it was discovered that a combination of the two drugs formed a
synergy that was significantly more effective at removing some senescent cell
types.
Venetoclax has also recently been discovered to be senolytic in nature and is a
therapy we wish to explore as part of our combination testing. In cancer therapy
Venetoclax has shown to work well with Dasatinib so we are interested in seeing
if this can be applied to clearing senescent cells too.
Recent studies have shown removing senescent cells mitigates age related decline
and improves healthy lifespan. Additional studies have shown that clearance of
senescent cells is beneficial for cardiovascular health and lowers high
cholesterol levels in the blood. This strongly suggests that Senolytics may be a
viable therapeutic approach to combat aging.
In our study we have opted to treat already naturally aged mice. These mice will
be 16-18 months old (equivalent to a human of approximately 60 years old). This
has two advantages: we speed up research, and also demonstrate the feasibility
of translating Senolytics to already middle aged or older humans.
Dasatinib and Venetoclax are already approved for use in humans to treat
specific diseases, and Quercetin is a readily available supplement, so the
application of these drugs or improved versions based upon them to prevent and
postpone age-related damage to health could be developed relatively quickly.
Senolytics and Stem Cells
So far senolytics have only been shown to reduce the number of senescent somatic
cells, but what effect do they have on stem cells? This has not been closely
studied, and is a question we intend to fully answer in addition to the
implications this presents for lifespan.
It is entirely possible that Senolytics taken alone may not extend
maximum lifespan, but rather healthspan. Even if this is the case, it is no
reason to be discouraged. What we learn in this first phase, paves the way for
our next step – combining Senolytics with Stem Cell Therapy to encourage tissue
regeneration.
About our lead researcher
Dr Alexandra Stolzing is our chief researcher and a world class expert in her
field, with over fifteen years in the medical research field, and a decade of
work in regenerative medicine, Alexandra brings substantial experience to our
project. She has worked with stem cell transplants and and is keen to explore
new possibilities in the rapidly advancing field of regenerative medicine.
As part of our commitment to the sharing of scientific research the team plans
to publish the results of our research as open access. We believe that knowledge
should be shared and this is the level of our contribution to sharing and
growing as a community together.
$5 — Our Eternal Gratitude! Thank you very much for supporting the cause of
healthy longevity! By donating you are pushing the investigation of longevity
therapies forward and helping to obtain healthy longevity for all people. We
will proudly put you on the list of campaign supporters on our website as a
thank you for your support.
$20 — E-Book “Aging Prevention for All”
Get the new beautiful electronic English version of Aging Prevention for All
compatible with your computer, tablet or mobile phone. This book, developed by
the team of the International Longevity Alliance together with famous
gerontologist and longevity researcher Vladimir Anisimov, will provide you with
an overview on aging processes and the practical evidence-based advice on the
available healthy life extension techniques.
$25 — $20 Pledge Reward + E-Book “Death is Wrong”
We will send you the electronic version of the book Death is Wrong by Gennady
Stolyarov; a story about aging and how society might change the way they think
about it. It is available in English, Russian, French, Spanish, and Portuguese.
We will also thank you on social media and give you the e-book Aging Prevention
for All!
$50 — A Stylish MMTP T-Shirt!
Put the sexy back into science – get an awesome MMTP T-shirt to amaze your
friends! We will follow up with you to select a size and choose one of our three
beautiful designs. + $10 for international shipping.
$60 — $20 Pledge Reward + Science Mouse T-Shirt
Wear our new special edition T-shirt that shows you are a true science geek and
also receive a copy of our lovely new E-book “Aging Prevention for All”. You can
also opt to have the alternative T-shirt with MMTP logo if you prefer. We will
follow up with you to select a size. + $10 for international shipping.
$70 — MMTP T-Shirt and 2 E-Books Combo!
Your chance to receive a stunning MMTP T-shirt combined with two interesting
electronic books: Aging Prevention for All and Death is Wrong! + $10 for
international shipping.
$75 — Science Mouse T-Shirt + Gene Therapy Conference Ticket!
Get the awesome special edition MMTP T-shirt that shows you are a true science
geek as well as a ticket to the exciting D.N.A.- Gene Therapies Congress – 9th
July Utrecht, Netherlands. Speakers will include Aubrey de Grey, Elizabeth
Parrish, Oliver Medvedik, Tatjana Kochetkova, and Keith Comito. You may also
choose to have the alternative T-shirt with MMTP logo if you prefer. We will
follow up with you to select a size. Travel not included. + $10 for
international shipping.
$100 — Signed Copy of “Aging Prevention for All” + 1 E-Book of Your Choice
A physical copy of Aging Prevention For All, signed by the authors and sent to
you with best wishes! You will also be able to choose an e-book of either Ending
Aging, The Singularity is Near, or The Telomerase Revolution. We hope you will
enjoy your reading! + $10 for international shipping.
$150 — ILA Sports Bag + E-Book “Aging Prevention for All”
Did you know that physical activity can significantly influence your lifespan?
Well, it can! Receive this stylish ILA sports bag to support your motivation to
be in a good shape and live longer! You will also receive our e-book Aging
Prevention for All to help you learn about the science of healthy longevity. +
$10 for international shipping.
$200 — ILA Sports Bag + 2 MMTP T-Shirts Combo + E-Book “Aging Prevention for
All”
A stylish ILA sports bag and 2 MMTP T-shirts all together to support your
motivation to be in a good shape and live longer! You will also receive our
e-book Aging Prevention for All to help you learn about the science of healthy
longevity. + $10 for international shipping.
$250 — ILA Sports Bag, MMTP T-Shirt, and Name a Mouse!
Name a mouse in the experiment and follow his/her life course. If it is in the
longest lived you will get a special secret prize. We have only 40 mice to name
so this opportunity is limited. The electronic version of Aging Prevention for
All is also yours! You also receive the MMTP T-shirt and an ILA sports bag! +
$10 for international shipping.
$500 — Meet the Team Online + E-Book Collection!
You will get to meet the project team online in two personal 30-minute video
conferences and we will share the most exciting news about the ongoing
experiment! You can also ask us any questions: the most promising directions of
scientific research, fresh news from other researchers, our favorite methods of
life extension, tips on health behavior changes, and of course the initiatives
for longevity advocacy. It would be a pleasure to talk with like-minded people!
Our beautiful electronic version of Aging Prevention for All is also yours! And
we will also provide you with the electronic versions of all other books: Ending
Aging, Singularity is Near, and Telomerase Revolution and Death is Wrong in
order to amplify your knowledge even more!
$1000 — Online panel discussion: “How to promote longevity?”
Join a 1.5 hour online discussion with the MMTP project team and several invited
experts to discuss the latest breakthroughs in life extension research as well
as the best ways to promote the idea of aging prevention among general public.
You will also receive a a stylish MMTP T-shirt and an ILA sports bag to
commemorate the event. + $10 for international shipping.
$2000 — A Ticket to European Longevity Conference + Silver Sponsorship
Recognition
Receive a ticket to attend Eurosymposium on Healthy Ageing (EHA), organized in
Brussels by our partner HEALES, in October 2016. Travel costs are not included
in this perk. We will also mention you as a Silver sponsor of our Senolytics
campaign and promote you (or your company*) in all media activities during the
campaign and until the experiment begins. *Please check the disclaimer on the
MMTP website.
$5000 — Trip to Longevity Conference in Europe + Gold Sponsorship Recognition +
Formal Acknowledgement!
We will arrange your travel and accommodation to the Eurosymposium on Healthy
Ageing (EHA), hosted in Brussels by our partner HEALES, in October 2016. This
includes your entry ticket to the conference and the option to speak about the
social mission of your company*. We will also mention your support as a Gold
sponsor in all media activities during the campaign AND the Senolytics
experiment (2 years long), and you will receive official acknowledgement of your
support in any resulting scientific peer reviewed publication or public report.
*Please check the disclaimer on the MMTP website.
T-SHIRTS AND BAGS ARE FINALLY ON THEIR WAY!
Posted on 03/05/2017 by Alexandra Stolzing
Hello dear friends! We are delighted to let you know that we have successfully
received the funds from the last big donor, the t-shirts and the bags have now
been produced, and we have started sending them out. Be sure to check your email
for shipping notification as some parcels are already on the way. Thank you for
your patience and trust! Hopefully in the next two weeks you will receive your
reward!
We are also polishing the book Aging Prevention for Everyone. Once all the
co-authors have approved the final text, we will start the process of layout and
production. We can’t wait to share our knowledge with you! While you are
waiting, we invite you to read the informative articles and blog posts we write
as a part of Lifespan Extension Advocacy Foundation education program. They
cover a wide range of topics and may help you learn more about aging, as well as
help in your advocacy activities.
Thanks again!
HAPPY HOLIDAYS AND SOME UPDATES!
Posted on 12/26/2016 by Alexandra Stolzing
Hello dear friends! Firstly we would like to wish you all a Happy Holiday and
secondly we would like to update you on the developments with our project.
Recently we have been busy conducting in-vitro culture testing of the chosen
candidates and after two rounds of testing we are almost finished. The reason we
have opted to test in culture prior to moving into full testing is that a number
of renowned labs have controversial data on how Dasatinib and Quercetin affect
senescent cells separately and in combination. Therefore we are testing the
efficacy of these compounds and combinations before committing to testing them
in mice. Should the data confirm that these compounds are not effective, have no
fear because we have a candidate list of other senolytic compounds we can test
instead.
Regarding campaign rewards, there has been a slight delay we are working
through. In addition to the funds raised during the campaign which have been
allocated to research, we also rely on the support of partner organizations. One
major such donation is arriving a bit later than expected, in February. As this
amount was slated for the production of the gifts, the delivery of the t-shirts
and the book Aging Prevention for All must take place after the receipt of these
funds, approximately March 2017. We wish to apologize for the delay and to thank
you for your patience.
The good news is that we have had some additional time to work on our book, and
have thus made it even more informative and interesting through the addition of
new sections, covering emerging biotechnologies to bring aging under medical
control and more. The text is mostly complete, and we will send this out along
with the other rewards when ready. Thank you.
FUNDS ARRIVE AT THE LAB!
Posted on 09/01/2016 by Alexandra Stolzing
Hey folks, great news the fundraising money has finally cleared the final
security checks and has arrived safely at the University of Leipzig! Dr Stolzing
asked us to express her deepest gratitude to everyone who supported the MMTP
campaign with donations and who were cheering on the team and giving a hand to
promote the project during the campaign. Together we made this happen – an
important experiment to see if a combination of senolytics can improve health
and extend life in mammals.
The research team is now busy with our testing application and we are preparing
to order our mice from Charles Rivers! Research approval by the authorities
unfortunately can be a long process with a lot of paperwork, but we want to
share with you today the good news and assure you that the experiment is going
to begin once all the necessary papers are obtained.
In meanwhile we are preparing to send out the gifts – the electronic version of
Death is Wrong by Gennady Stolyarov has been already sent! Last month we have
sent out an email asking people to specify the colors and sizes for their
T-shirts, but some people have not yet answered. If you have not already done so
please get in touch soon, as we would like to place an order with the the
printers.
UNIVERSITY ACCEPTS FUNDS - RESEARCH COMMENCES SOON!
Posted on 08/14/2016 by Alexandra Stolzing
Hi everyone just a quick post to let you know things are moving along with the
experiment. We have finally completed all the paperwork and the funds are
transfering to the University in the next week which is great news!
What follows next is our application for animal testing in Germany, this is a
complex legal requirement to ensure that our research is conducted in an ethical
manner. We fully support such measures of course and will update you on progress
once we know more.
CANCER BASELINE DONATES TO THE MMTP
Posted on 07/14/2016 by Alexandra Stolzing
Dear friends we are delighted to announce that the Cancer Baseline project lead
by MMTP founder Edouard Debonneuil has also generously donated $2700 (2450€) to
the project post campaign! The baseline project was a project of the EPIDEMIUM
Challenge4Cancer, a 6 month hackathon launched by Roche France and La Paillasse
on the 5th of November 2015 that concluded successfully recently with the team
winning a prize for their efforts!
The project investigated the various factors of cancer as closely as possible
from many open data sets: the baseline model a wide range of factors from data
sets that they can then connect with each other. This served to further detect
other factors from other datasets that were then individually compared to the
baseline. Finally, this brought them to the objective, to see how the results
could be translated into concrete action against cancer.
The world of cancer research and senescent cells are not a million miles apart
and it is possible that the more we learn about senescent cells and senolytics
some of this information may be of use to the cancer research community. As most
of you already know beating cancer is paramount for human longevity and we wish
to thank the Cancer Baseline team for their kind donation and also congratulate
them on their successful project completion recently.
The research project will launch shortly thanks to your help and we will let you
know when our furry friends arrive :)
FINAL DAY — TOP 10 REASONS TO SUPPORT MMTP!
Posted on 06/24/2016 by Alexandra Stolzing
Hello dear friends! Our campaign to support the investigation of Senolytics and
their potential to promote health and extend life in mice has gathered over
$50,000 and it is the last day to support us! If you like our project and were
considering making a contribution, now is the time!
During our campaign we have shared with you information about the aging
processes, the danger of senescent cells, and the promise of Senolytics to clear
the body of these toxic cells. We’ve endeavored to help you become more familiar
with animal studies and their place in the process of drug development, as well
as the bottlenecks which slow the progress of fundamental gerontology. We have
also provided you with additional information, must-read articles, books and
sites, and of course we shared our podcasts – all to help you learn more about
aging and longevity and to make informed decisions about the future and your
relationship to it.
And finally today we share with you a look at our new video showcasing some
compelling reasons why supporting our research is a great idea! Thank you
sincerely for all of your support.
INITIAL GOAL MET!!
Posted on 06/20/2016 by Alexandra Stolzing
Hello Dear friends! This is an historic moment! Crowd-funding for the ILA’s
Major Mouse Testing Program has reached its initial goal of $45,000 and is
climbing toward our stretch goal of $60,000, and perhaps even more!
With a generous $5k contribution of Jeremy Wertheimer, a new Gold Sponsor, we
have achieved our initial goal, allowing MMTP’s researcher Dr. Alexandra
Stolzing to begin our senolytic lifespan experiment. And that’s not all! Our
campaign has already surpassed the amount raised and backer numbers of earlier
campaigns, and we still have five days to go before it ends on June 25, 2016!
This clearly shows that support and interest in longevity is rising as science
increasingly demonstrates that aging is not the one way process people assumed
it was. Our success in this campaign shows that the community is becoming more
skilled in coordinating research into gerontology. More and more, people are
feeling responsible for their future, and the possibility of a solution for
aging becomes more and more real.
We still need your support to reach or surpass our stretch goal. Particularly,
greater support will allow us to add a third group of mice to the experiment, a
positive control which will increase the accuracy of our data. Will you help us
by making an affordable contribution? Or, if you have already donated, can you
add to your support by making another donation in the final days of our
campaign? The fight against aging depends on YOU!
Thank you for your support of the ILA and the Major Mouse Testing Program!
FUND MATCH SUCCESSFUL / INTERVIEW WITH PROFESSOR DAVID GEMS (INSTITUTE OF
HEALTHY AGING)!
Posted on 06/16/2016 by Alexandra Stolzing
Dear friends, the campaign has raised over $40,500 and the FUND MATCH has
successfully ended! In the next days we will receive the prize and it is the
biggest amount we could get during FUND MATCH – $2,500. We are very grateful to
all of you for your timely support, and of course we want to thank Didier
Coeurnelle, Co-chair of Heales (Healthy Life Extension Society), and
vice-president of the French association AFT-Technoprog, for this wonderful
gesture! This means we will have a total of over $43,000 after we receive the
matched funds, meaning we are now very close to our initial goal of $45,000 !
Let us make a final push so we can get this critical research started!
In case you didn’t know, Didier is the author of a book about the promise of
longevity: “Et si on arrêtait de vieillir ! : Réalité, enjeux et perspectives
d’une vie en bonne santé beaucoup plus longue” (French), and we invite our
french speaking supporters check it out.
Senescent cell clearance has been shown to improve various symptoms of aging by
reducing chronic inflammation in the body as well as reducing risks for a range
of pathologies. Our work investigates combinations of senolytic drugs seeking
synergy as well as increases in lifespan and could help support the push to
bring these therapies to people. Here is Professor David Gems from the institute
of Healthy Aging speaking about the importance of testing senolytics and
combinations of these drugs.
Also, a few days ago Steve Hill and Elena Milova took part in the podcast of the
Intentional Insights – a community of science advocates helping people to refine
and reach their goals by providing research-based content to help improve
thinking, feeling, and behavior patterns. We shared some details about the
forthcoming research of Senolytics, and also our vision of the advocacy goals of
longevity community. Enjoy the discussion!
FUND MATCH!
Posted on 06/14/2016 by Alexandra Stolzing
Hello dear friends! So far we have raised over 37,000 dollars! There are 10
days left before the Senolytics campaign ends, and it is time to make a final
dash to the finish line!
Some great news from Heales leader Didier Coeurnelle, he has offered a FUND
MATCH! Whatever we will raise from Tuesday, June 14, 11 AM UTC (6 AM EST) to
Thursday, June 16, 11 AM UTC (6 AM EST) up to $2500 will be doubled!
If you will contribute during this period, every dollar you donate will become
two – and the project will receive a nice push to get us to our goal!
Didier is Co-chair of Heales (Healthy Life Extension Society), the largest
non-profit organization in Continental Europe promoting and advocating
scientific research into longevity and biogerontology, and vice-president of the
French association AFT-Technoprog, that aims to spread the themes and questions
related to technologies that could extend and enhance the lives of individuals
and of humankind. He recently appeared on TEDxTALK speaking about the idea of
longevity and the possibilities the future holds:
DR. ILIA STAMBLER FROM THE ILA EXPLAINS THE IMPORTANCE OF ANIMAL STUDIES
Posted on 06/07/2016 by Alexandra Stolzing
Hi there! So far we have raised over 34,000 dollars! This is an amazing level of
support from the community and we are close to reaching our initial goal of 45k
and starting some awesome science! The great news is Lifespan.io has also
enabled Paypal donations to its campaign site so now there are more ways to
support science and donate!
This result could not be achieved without the many active pro-longevity groups
all over the world would uniting their efforts. Longevite et Sante from France,
Longevity Technologies, Council for Public Health and the Problems of Demography
from Russia, India Future Society, HEALES from Belgium, Israeli Longevity
Alliance, Astrum Fundation from Mexico, IERFH from Brazil, and many many more
are helping us to organize this important research. Thank you, dear friends!
We have also been featured in Connexion this week which is a popular
Anglo-French newspaper, proving that longevity research is rapidly becoming
mainstream. You can find a nice article about our work here should you wish to
read more and please check out the rest of the newspaper as well.
Finally, here is Dr. Ilia Stambler from the Israeli Longevity Alliance speaking
about the importance of animal studies in the development of new longevity
therapies:
Thank you for your continued support!
INTERVIEW WITH AWESOME FUTURE TV!
Posted on 06/02/2016 by Alexandra Stolzing
A few days ago some of the MMTP team took part in another podcast at Awesome
Future TV, and we invite you to watch our discussion. We talk not only about our
experiment but also cover wider topics, such as why mice are interesting to deal
with, what to expect from regenerative medicine in the coming years, and why it
is important to include aging as a disease in ICD-11.
Enjoy and don’t forget that we still need your financial support to test the
ability of Senolytics to extend healthy lifespan!
DR. AUBREY DE GREY FROM SENS RESEARCH FOUNDATION
Posted on 06/01/2016 by Alexandra Stolzing
Hello dear friends! The campaign has raised over $32000 (which makes about 70%
of the intermediary goal and 53% of the stretch goal) and keeps moving towards
success – all thanks to your support! Every contribution, even $25, is a great
step forward, and we are very grateful you are helping us carry out this
important experiment!
Today we would like to help you learn more about mice. Yes, mice are nice, but
apart from that they are one of the best models for aging research.
Here is one of our scientific advisors Dr Aubrey de Grey from SENS speaking
about the importance and relevance of mouse studies in the research of aging and
interventions against it. By the way, Dr. de Grey donated $500 to our project
and now can join the regular meetings with the team to follow the experiment and
receive the updates; if you donate at that level, so can you!
AGING IS A DISEASE WITH DARIA KHALTOURINA FROM THE ILA
Posted on 05/25/2016 by Alexandra Stolzing
Hello dear friends! The campaign has raised over $27500 (which makes about 60%
of the intermediary goal and 45% of the stretch goal) and keep moving towards
success – all thanks to your support!
We have received wonderful support from three Gold Sponsors, who donated 5
thousand dollars each! A supporter of longevity research Arthur Helfstein
Fragoso, IERFH coordinator from Brazil, Russian businessman Andrey Ulitin and
venture angel Leon Apel from Canada are interested in the development of life
extension technologies based on senolytics, and they have decided to support us
in a big way!
We are also very pleased to see that the project is getting truly international
support. The donations are coming from many countries all over the world!
Today we invite you to watch a short interview with Daria Khaltourina, an ILA
Board Member, and a famous health care advocate from Russia.
Daria is currently part of an international initiative to include aging as a
disease into the International Classification of Diseases (ICD-11) in 2017. This
is an important change because it will allow researchers to test and register
geroprotective drugs as such, and for doctors to prescribe them to prevent aging
in healthy middle age people. You can learn more about Daria and her work with
the World Health Organization here and how she is helping to change regulations
so aging can be studied and treated medically.
To learn more about the opinion of the scientific community for the inclusion of
aging as a disease in ICD-11, read the articles in the specialized section in
Frontiers of Genetics by Sven Bulterijs, Alex Zhavoronkov, Alexey Moskalev and
their colleagues.
Our fundraising goals are ambitious, so if you have not already supported please
consider donating to our project, and also please ask your friends and
colleagues to do the same. Even a few dollars is a step closer to this important
test of Senolytics potential to extend healthy lifespan!
ANNOUNCING NEW GOAL STRUCTURE
Posted on 05/23/2016 by Alexandra Stolzing
Hi everyone! We have so far raised almost 22k dollars which is an amazing effort
from the community, and as many people are asking for a more detailed budget, we
are going to provide more information and accordingly revise the goal structure
of the campaign a bit.
A total of 45k is enough funding to run two mouse groups, a control and test
group and enough to allow us to begin useful and meaningful research. With two
test groups we will have enough to begin testing combinations of our three
senolytic compounds (Quercetin, Dasatinib and Venetoclax) and compare results
against the untreated control group. If we observe an increase in lifespan in
the test group vs the control group we will know the therapy works.
We are therefore moving the immediate goal to raising 45k in order to begin this
critical work as soon as possible. Note: As our campaign is Flexible Funding,
this change in no way affects how payments work for donations already
contributed to the campaign.
The 60k goal will now reflect the addition of a positive control group as a
stretch goal. A positive control group such as this receives a treatment with a
known response, so that this positive response can be compared to the unknown
response of the treatment. This helps to improve the quality of the data
gathered during an experiment but it is not always included in exploratory
studies such as this. We plan to use caloric restriction as our positive control
group which involves a modest reduction of calorie intake and is well documented
as increasing lifespan predictably in mice and other animals.
TAKE A LOOK AT OUR RESEARCH SUMMARY AND WATCH A MINI-INTERVIEW WITH DR. JOAO
PEDRO DE MEGALHAES ABOUT THE IMPORTANCE OF ANIMAL DATA!
Posted on 05/19/2016 by Alexandra Stolzing
Hey everyone! The campaign has raised over $9500 so far which is great and
thanks to your support! You are helping to fast track this research and make a
difference. We are happy about 2 contributions of $1000 each, as it means that
the Panel Discussion with opinion leaders in gerontology will definitely take
place! There are 3 more seats available, and we hope more people would like to
join this intriguing event!
The MMTP is committed to sharing knowledge with the community as we believe this
is the only way to make rapid progress. As many people were curious about the
study design, the MMTP team prepared a short version of the study proposal so
everyone could learn more about what animal study looks like.You can read about
it here and get more familiar with what is happening in the lab when
geroprotectors are being tested in animals!
To provide you with more details, we invite you to watch a mini-interview with
Dr. Joao Pedro de Magalhaes, a leading researcher of geroprotectors at Liverpool
University, UK, where he is speaking about the importance of experiments and
animal data. You may also enjoy visiting his site www.senescence.info for more
deep learning.
MMTP SECRETS REVEALED AT AMA ON REDDIT!
Posted on 05/17/2016 by Alexandra Stolzing
Hi there! We have now raised an amazing $8000 and we would like to thank all our
supporters who contributed financially and helped us to spread the word!
Yesterday we have held our first AMA on Reddit in r/Futurology, where the MMTP
team answered various questions, provocative and not, technical and personal,
and now you can learn more about our project and people behind by clicking on
the Reddit logo below:
We would also like to share this short movie by ILA Founding Member Edouard
Debonneuil, who has researched aging at UCLA, the Pasteur Institute and Inserm,
speaking about the potential of Senolytic therapies. Enjoy!
And finally we are pleased to share with you our new interview about MMTP and
Senolytics at FightAging! The more people know about aging and the processes
behind it, the better healthcare decisions they can make, and the higher their
quality of life could be. Everyone deserves a healthier and longer life, so
sharing this important information with family, friends and co-workers is the
best way to show your compassion and care!
BRIAN KENNEDY FROM THE BUCK INSTITUTE IS SUPPORTING MMTP!
Posted on 05/12/2016 by Alexandra Stolzing
Dear friends, it’s been a two days since we launched our Senolytics campaign on
Lifespan.io, and during this time we have already raised over $3000, which
brings us a big step closer to our goal of funding some real breakthrough
research! We thank all the early donors for their support; we are currently
building a Page of Glory on our site to praise your effort to help investigate a
cure for the disease of aging. We are glad that Gennady Stolyarov, the author of
“Death is wrong”, and Matthew O’Connor from SENS Research Foundation have
already expressed their support.
We also want to pass our deep gratitude to a significant number of people who
helped us to repost the news all over Facebook and other social media these
days!
We are excited to tell you that Brian Kennedy from the Buck Institute gave us a
short interview to amplify the educational part of the project! Here you can
learn what one of the leaders in aging and longevity research says about how
important animal data is and the promise of Senolytics!
Translated in Spanish https://www.youtube.com/watch?v=FmF1YX5ghJM Translated in
Russian https://www.youtube.com/watch?v=RJurh2zkBm8
To help you learn more about aging and longevity, we would also like to share a
link to one of our recent articles about Senolytics, that was published in H+
Magazine under the title “SEEK and DESTROY”(exactly what needs to be done to
senescent cells, don’t you agree?).
Also, please don’t forget to share with your friends, family and co-workers, and
ask them to support our initiative with donations!
Thank you!
MMTP FINALLY GETS GOVERNMENT APPROVAL
Posted on 04/13/2020 by Alexandra Stolzing
It has been quite a while since the community had fundraised for the MMTP
senolytics project; unfortunately, the start of the experiment was delayed due
to a number of issues encountered along the way. However, today, we are
delighted to announce that the experiment has been approved and has finally
launched!
The COVID-19 situation
To really top this off and add some extra problems, the study was just about
ready to launch when COVID-19 made an appearance. Labs were closing down and
supplies and deliveries were erratic, but I managed to get everything together
and got ready to begin, thanks to all the people and scientists that are still
working to make science happen.
Experiment details
A total of 40 C57BL mice will be treated with a combination of senolytics
(ABT-263, ABT-199, dasatinib, isoquercetin) and compared to 40 control mice. The
mice were all 18 months old when the experiment started. Blood samples have been
taken to determine aging marker analyses before the start of the senolytic
treatment, and subsequent blood draws will happen during the study to track
changes and determine the health of the animals in addition to a range of other
murine health parameters. Stay tuned for more news!
THE EXPERIMENT IS OVER!
Posted on 10/11/2021 by Steve Hill
Hi Everyone!
It has been a while since the last update but we are pleased to announce that
the senolytic study is now finally completed. While the results are not as we
may have hoped, there is still plenty of valuable data that we and other
researchers can learn from. Currently the final publication is being prepared
and will be released as an open access preprint on Biorxiv.org.
We firmly believe that all study results should be published, not just the
successful ones. There is an unfortunate culture in science where many journals
and even researchers do not like to publish studies with negative results. This
has lead to valuable data not seeing the light of day. This is harmful for
science given that something can be learned in even from failures. We are
committed to transparency in science and so you will be able to read the study
in full and for free soon.
We hope that the open access publication will be available to you all in the
next few months, it mostly depends on quickly the study can be written up and
published. We will make a final update on here once the data is publicly
published.
4 COMMENTS
1. Reply
Peter Xing May 13, 2016
Great initiative. Good luck with the program!
2. Reply
Kelly Martin May 14, 2016
Lets get to $7000 before the days end (5-14-16) !!!!! Go major MMTP!!!!!
3. Reply
dmitry kirsanov June 17, 2020
4 years later, has there been anything to come out of this?
* Reply
Steve Hill June 17, 2020
Yes, there was an update recently on the campaign page and also here:
https://www.lifespan.io/news/mmtp-finally-gets-government-approval/
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* Raymond Gough
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* Anonymous
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* Daria Khaltourina
$150.00
* Anonymous
$250.00
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* RICH LEE
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* Anonymous
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* Peter Spriggs
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* ELLIOTT SCHOLES
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* Jason Morton-McKay
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* Anonymous
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* Anonymous
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* Anonymous
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* Anonymous
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* Mathieu Roy
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* Anonymous
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* Alen Akhabaev
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* Karina Tsymbal
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* Thomas Munyon
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* Thomas Alsop
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* Karel Hulec
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* Nader Chehab
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* Brandyn Webb
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* Dominic Zedan
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* Anton Fermelin
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* Adam Perrotta
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* Joshua Phelps
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* Sean Roy
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* Arthur Helfstein Fragoso
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* Anonymous
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* Edouard DEBONNEUIL
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* ILIA STAMBLER
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* Paul Spiegel
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* Michael Greve
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* Mikel Hädrich
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* Ken Alexander
$200.00
* George Seibel
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* Anonymous
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* Justin Fontenot
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* Cryonica Lamm
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* Pamela Keefe
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* david kekich
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* Michael RAE
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* Lars Claussen
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* aaron traywick
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* Nico NVH
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* Mike Hädrich
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* Anonymous
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* Anonymous
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* marian szczepkowski
$50.00
* Corbin S.
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* Gennady Stolyarov II
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* Paul Spiegel
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* Sadi Khan
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* William DeVore
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* Matthew O'Connor
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* Reason .
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* Ron Salesky
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* Daniel Lemire
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* Amund Hov
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* André Heinonen
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* Mike Hädrich
$100.00
* Karen Comito
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* Brian & Sabine Atkins
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* Lucas Schneble
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* Keith Hoyes
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* Poul Martin Jensen
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* James Clement
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* Curry Taylor
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* Trent Eady
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* Dmitry Veselov
$20.00
* Ryan Berkani
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* Greg D'Agostino
$100.00
* David King
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* Yury Khait
$5.00
* Alexander HighCat
$10.00
* Alexander Kamosko
$5.00
* Elena Milova
$25.00
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