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CANNABIS COMPOUNDS IN FRACTURE PAIN RELIEF AND HEALING

L. Joseph Parker, MD
Meds
October 31, 2023
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In a recent study published in the Journal of Bone and Mineral Research, it was
found that two compounds found in cannabis, cannabidiol, and cannabigerol, may
not just ease the pain of fractures but also speed up fracture healing. The
study, titled “Cannabidiol (CBD) and Cannabigerol (CBG), Nonpsychotropic
Cannabinoids, as Analgesics that Effectively Manage Bone Fracture Pain and
Promote Healing in Mice,” is important because, as the researchers stated,
“NSAIDs may help patients manage pain, but they also reduce inflammation, which
is a crucial first step in fracture healing,” Dr. Elbarbary, the chief
researcher, said. “An alternative for pain management is needed that does not
prevent inflammation from occurring.”

Over 175 million people suffer a fracture every year around the world, and these
fractures hurt. Opioids used to be the go-to medication for fractures, but the
current political environment in the U.S. makes it almost impossible to use them
safely. I don’t mean safely for the patient; opioids have been used medically
for over a hundred years and medicinally for thousands. I mean safely for the
doctor. Right now, if an elderly patient on the same dose for twenty years dies
in their sleep, a doctor can be prosecuted for prescribing opioids and
“contributing” to their death. Prove it didn’t. That leaves doctors all over the
U.S. talking about how acupuncture and VR can be used to treat pain. That’s
true. They can be. And they will help some. But a propane blowtorch can be used
to treat skin infections, and it would be very effective. That doesn’t make it
good medicine. Doctors need something new, and they need it now.

ADVERTISEMENT



Bone fractures heal by going through an inflammatory phase and then a repair and
remodeling phase. NSAIDs are not recommended for fracture pain because their
inhibition of the inflammatory phase impairs healing. Dr. Elbarbary and his team
decided to measure whether CBD and CBG could be used to alleviate pain safely.
They decided to use mice as it is easy to correct for genetics and to create a
controlled fracture. This was the first study to analyze cannabinoids in the
context of fracture healing and pain management.

A fractured tibia causes mice to exhibit an increased sensitivity to pain and
discomfort of almost any kind. Mechanical, cold, and hot stimuli were all
tested, and in the end, the analgesic effects of both CBD and CBG were
comparable to NSAIDs. Then, by using immunofluorescence microscopy,
microcomputer tomography imaging, and biomechanical testing, the researchers
were able to study the fracture healing process and discovered that, as an
incredible bonus, instead of inhibiting bone healing, both chemicals promoted
bone healing.



Early in the inflammatory phase, both compounds stimulated stem cells in the
bone to produce periosteal bone progenitor cells as the healing hematoma formed
around the fracture. In the later phases of healing, they enhanced the
mineralization of the fibrocartilaginous callus and enhanced the proliferation
and viability of bone marrow cells. These changes created higher bone volume and
mineral density, which improved the mechanical properties of the healed bone.
The compounds seemed to accomplish this by increasing the expression of genes
that are necessary for the progression of fracture healing.



The study went further, analyzing the expression of the cannabinoid receptors.
CB1 and CB2 are the primary cannabinoid receptors, and their respective genes
are CNR1 and CNR2. After analyzing the expression of these genes, the research
found that treatment with either CBD or CBG increased the abundance of the
PDGFRa progenitors by three to four times, thereby promoting bone formation and
healing and normalizing their gait pattern.

The study went on to conclude, “Overall, the protective, proliferative, and
pro-osteogenic effects that we identified for CBD and CBG during the different
healing phases culminated in accelerated repair, promoted bone formation, and
enhanced biomechanical strength of the healed bone. These data extend our
understanding of the impact of CBD on fracture healing and demonstrate for the
first time the therapeutic potential of CBG in the context of bone regeneration
and repair. Taken together, the data we present here propose CBD and CBG as
effective alternatives to NSAIDs in managing pain in fracture patients.”

It never fails to amaze me how many therapeutic treatments are being developed
from a substance that the federal government has declared to be “with no
currently accepted medical use and a high potential for abuse.”



L. Joseph Parker is a distinguished professional with a diverse and accomplished
career spanning the fields of science, military service, and medical practice.
He currently serves as the chief science officer and operations officer,
Advanced Research Concepts LLC, a pioneering company dedicated to propelling
humanity into the realms of space exploration. At Advanced Research Concepts
LLC, Dr. Parker leads a team of experts committed to developing innovative
solutions for the complex challenges of space travel, including space
transportation, energy storage, radiation shielding, artificial gravity, and
space-related medical issues. 

He can be reached on LinkedIn and YouTube.




WHAT DOES THE TERM "DOCTOR" MEAN, WHO CAN USE IT, AND DOES IT MATTER?

October 31, 2023 Kevin 0


…


Kevin








Tagged as: Pain Management


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