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Skip directly to site content Skip directly to page options Drug Overdose Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People Search Search Menu Navigation Menu Submit * Drug Basics * Understanding Drug Overdoses and Deaths * Overdose Prevention * Extramural Funded Research * BACK Extramural Funded Research * Connection to Other Drug Overdose Funding Efforts * Previously and Currently Funded Research * Recently Awarded Funded Research * Recently Announced Funding Opportunities * Drug Overdose Home * Data Briefs * BACK Data Briefs * SUDORS Data Brief 1 * SUDORS Data Brief 2 * Drug Overdose Home * Data Dashboards & Alerts * BACK Data Dashboards & Alerts * Nonfatal Overdose Dashboards * BACK Nonfatal Overdose Dashboards * BACK Data Dashboards & AlertsNonfatal Overdose Dashboards * About DOSE: Nonfatal Overdose Data * DOSE Dashboard: Nonfatal Overdose Syndromic Surveillance Data * DOSE Dashboard: Nonfatal Overdose Discharge Data * Fentalog Study Dashboard: Nonfatal Opioid Overdoses * Drug Overdose Home * SUDORS Dashboard: Fatal Overdose Data * BACK SUDORS Dashboard: Fatal Overdose Data * BACK Data Dashboards & AlertsSUDORS Dashboard: Fatal Overdose Data * About SUDORS * Accessible Version * Drug Overdose Home * Data Alerts from CDC * Drug Overdose Home * Drug Overdose Deaths * BACK Drug Overdose Deaths * Opioid Overdose * BACK Opioid Overdose * BACK Drug Overdose DeathsOpioid Overdose * Prescribing Practices * Overview * Drug Overdose Home * Stimulant Overdose * Other Drugs * BACK Other Drugs * BACK Drug Overdose DeathsOther Drugs * What You Should Know About Xylazine * Xylazine Resources * Overview * Drug Overdose Home * Overview * Drug Overdose Home * US Dispensing Rate Maps * BACK US Dispensing Rate Maps * Buprenorphine Dispensing Rate Maps * Naloxone Dispensing Rate Maps * Opioid Dispensing Rate Maps * Drug Overdose Home * Overdose Data to Action * BACK Overdose Data to Action * About OD2A * Surveillance * OD2A in States * OD2A: LOCAL * Prevention * Evaluation * Impact * Case Studies * BACK Case Studies * BACK Overdose Data to ActionCase Studies * ACEs * Harm Reduction * Linkage to Care * Public Safety * State & Local * Stigma Reduction * Drug Overdose Home * Funded Jurisdictions * Drug Overdose Home * Drug-Free Communities * BACK Drug-Free Communities * About DFC * Coalitions * Program Success * Apply for DFC Funding * BACK Apply for DFC Funding * BACK Drug-Free CommunitiesApply for DFC Funding * New Funding * Continuing Funding * Drug Overdose Home * Archived Funding Announcements * Infographics * Drug Overdose Home * Promising State Strategies * BACK Promising State Strategies * PHPS Partnerships * PHPS Safety Resources * PDMPS: What States Need to Know * Drug Overdose Home * Publications * BACK Publications * Journal Articles * MMWR Articles * Related Publications * Guides and Meeting Reports * PBSS Data Briefs * Drug Overdose Home * Featured Topics * Health Equity * BACK Health Equity * Promoting Health Equity * Drug Overdose Prevention in Tribal Communities * Drug Overdose Home * Awareness and Health Observances * Resource Center * BACK Resource Center * Digital Media Toolkits * Pressroom * Shareable Content * BACK Shareable Content * BACK Resource CenterShareable Content * Overdose Graphics * Prescribing Graphics * Illicit Opioid Graphics * Drug Overdose Home * COVID-19 * BACK COVID-19 * BACK Resource CenterCOVID-19 * People at Increased Risk * Resources for Organizations * Drug Overdose Home * Partner Toolkits * Drug Overdose Home * Drug Overdose Home Drug Overdose Drug Overdose Home 1. CDC 2. Injury Center 3. Drug Overdose 4. Drug Overdose Deaths OVERVIEW Print Overview minus Table of Contents Millions of Americans suffer from pain and are often prescribed opioids to treat their conditions. However, the dangers of prescription misuse, opioid use disorder, and overdose have been a growing problem throughout the United States. Since the 1990s, when the amount of opioids prescribed to patients began to grow, the number of overdoses and deaths from prescription opioids has also increased. Even as the amount of opioids prescribed and sold for pain has increased, the amount of pain that Americans report has not similarly changed. From 1999 to 2020, more than 263,000 people died in the United States from overdoses involving prescription opioids. Overdose deaths involving prescription opioids nearly increased by five times from 1999 to 20201. REFERENCES 1. Wide-ranging online data for epidemiologic research (WONDER). Atlanta, GA: CDC, National Center for Health Statistics; 2021. Available at http://wonder.cdc.gov. Page last reviewed: May 18, 2022 Content source: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control * Facebook * Twitter * LinkedIn * Syndicate homeDrug Overdose * Drug Basics * Understanding Drug Overdoses and Deaths * Overdose Prevention * Extramural Funded Researchplus icon * Connection to Other Drug Overdose Funding Efforts * Previously and Currently Funded Research * Recently Awarded Funded Research * Recently Announced Funding Opportunities * Data Briefsplus icon * SUDORS Data Brief 1 * SUDORS Data Brief 2 * Data Dashboards & Alertsplus icon * Nonfatal Overdose Dashboardsplus icon * About DOSE: Nonfatal Overdose Data * DOSE Dashboard: Nonfatal Overdose Syndromic Surveillance Data * DOSE Dashboard: Nonfatal Overdose Discharge Data * Fentalog Study Dashboard: Nonfatal Opioid Overdoses * SUDORS Dashboard: Fatal Overdose Dataplus icon * About SUDORS * Accessible Version * Data Alerts from CDC * Drug Overdose Deathsplus icon * Opioid Overdoseplus icon * Prescribing Practices * Overview * Stimulant Overdose * Other Drugsplus icon * What You Should Know About Xylazine * Xylazine Resources * Overview * Overview * US Dispensing Rate Mapsplus icon * Buprenorphine Dispensing Rate Maps * Naloxone Dispensing Rate Maps * Opioid Dispensing Rate Maps * Overdose Data to Actionplus icon * About OD2A * Surveillance * OD2A in States * OD2A: LOCAL * Prevention * Evaluation * Impact * Case Studiesplus icon * ACEs * Harm Reduction * Linkage to Care * Public Safety * State & Local * Stigma Reduction * Funded Jurisdictions * Drug-Free Communitiesplus icon * About DFC * Coalitions * Program Success * Apply for DFC Fundingplus icon * New Funding * Continuing Funding * Archived Funding Announcements * Infographics * Promising State Strategiesplus icon * PHPS Partnerships * PHPS Safety Resources * PDMPS: What States Need to Know * Publicationsplus icon * Journal Articles * MMWR Articles * Related Publications * Guides and Meeting Reports * PBSS Data Briefs * Featured Topics * Health Equityplus icon * Promoting Health Equity * Drug Overdose Prevention in Tribal Communities * Awareness and Health Observances * Resource Centerplus icon * Digital Media Toolkits * Pressroom * Shareable Contentplus icon * Overdose Graphics * Prescribing Graphics * Illicit Opioid Graphics * COVID-19plus icon * People at Increased Risk * Resources for Organizations * Partner Toolkits email_03Get Email Updates To receive email updates about this topic, enter your email address: Email Address What's this? 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