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TASKFORCE COVID-19



COVID-19

From beginning April 2020 this website aims to collect and link the most
relevant studies and guidelines in connection with COVID-19. Target audience are
healthcare professionals from all specialities.

Die Zusammenstellung der Website update-coronavirus.ch richtet sich an
medizinische Fachpersonen, die in kurzer Zeit einen Überblick über die
wichtigsten aktuellen wissenschaftlichen Publikationen im Zusammenhang mit
COVID-19 haben wollen. Die Website hat keinen Anspruch auf Vollständigkeit noch
wird mit der Auflistung eine wissenschaftliche Würdigung oder Gewichtung des
Inhaltes vorgenommen. Sie widerspiegelt die persönliche Einschätzung der
Mitglieder der Taskforce.

Aufgrund der aktuellen Lage der Pandemie hat die Taskforce entschieden, die
vorliegende Webseite vorläufig nicht mehr aktiv zu bewirtschaften. am 16.
Februar 2022 (16. Feb. 22)

Due to the current situation of the pandemic, the taskforce decided to no longer
actively update this website for the time being. (16th Feb. 22)




PUBLICATIONS AND GUIDELINES

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16.02.2022

ASSOCIATION BETWEEN MENSTRUAL CYCLE LENGTH AND CORONAVIRUS DISEASE 2019
(COVID-19) VACCINATION

Objective: To assess whether coronavirus disease 2019 (COVID-19) vaccination is
associated with changes in cycle or menses length in those receiving vaccination
as compared with an unvaccinated cohort. Methodes: Prospectively tracked
menstrual cycle data using application “Natural Cycles”. U.S. residents aged
18–45 years with normal cycle lengths (24–38 days); 3,959 individuals
(vaccinated 2,403; unvaccinated 1,556). Conclusion: COVID-19 vaccination is
associated with a small change in cycle length but not menses length.

COMMENT KNOWLEDGE-MANAGEMENT TASKFORCE COVID-19

Es gibt zahlreiche Studien, welche den Effekt der COVID-19-Impfung in
verschiedensten Bereichen untersucht hatten. Eine der ganz wenigen, welche
tatsächlich eine Folge der Impfung nachweisen kontte ist diese Untersuchung,
welche zeigen konnte, dass nach einer COVID-19-Impfung die Dauer der
Menstruationszyklen etwas verlängert sind; nicht aber die Dauer der
Menstruationsblutung. Da dieser Unterschied der Zykluslänge weniger als einen
Tag beträgt, ist dieses Resultat klinisch jedoch von irrelevanter Bedeutung.

Edelman A. et al., Obstet Gynecol. 2022 Jan 5
#general #obstetrics & gynaecology
16.02.2022

ASSOCIATION BETWEEN MENSTRUAL CYCLE LENGTH AND CORONAVIRUS DISEASE 2019
(COVID-19) VACCINATION

Objective: To assess whether coronavirus disease 2019 (COVID-19) vaccination is
associated with changes in cycle or menses length in those receiving vaccination
as compared with an unvaccinated cohort. Methodes: Prospectively tracked
menstrual cycle data using application “Natural Cycles”. U.S. residents aged
18–45 years with normal cycle lengths (24–38 days); 3,959 individuals
(vaccinated 2,403; unvaccinated 1,556). Conclusion: COVID-19 vaccination is
associated with a small change in cycle length but not menses length.

COMMENT KNOWLEDGE-MANAGEMENT

Es gibt zahlreiche Studien, welche den Effekt der COVID-19-Impfung in
verschiedensten Bereichen untersucht hatten. Eine der ganz wenigen, welche
tatsächlich eine Folge der Impfung nachweisen kontte ist diese Untersuchung,
welche zeigen konnte, dass nach einer COVID-19-Impfung die Dauer der
Menstruationszyklen etwas verlängert sind; nicht aber die Dauer der
Menstruationsblutung. Da dieser Unterschied der Zykluslänge weniger als einen
Tag beträgt, ist dieses Resultat klinisch jedoch von irrelevanter Bedeutung.

Edelman A. et al., Obstet Gynecol. 2022 Jan 5
#general #obstetrics & gynaecology
15.02.2022

IMAGING AND CLINICAL FEATURES OF COVID-19 BREAKTHROUGH INFECTIONS: A MULTICENTER
STUDY

Chest CTs of vaccinated patients with COVID-19 breakthrough infection displayed
fewer signs of pneumonia than chest CTs of unvaccinated patients with COVID-19
infections.

COMMENT KNOWLEDGE-MANAGEMENT TASKFORCE COVID-19

Radiologischer Nachweis des Impfschutzes: CT-Bilder CT von geimpften COVID-19
Patienten weisen viel weniger entzündliche Lungenveränderungen auf als
diejenigen von ungeimpften COVID-19 Patienten. 

J. E. Lee et al. Radiology 2022 February 1
#imaging #radiology
13.01.2022

CHILD MORTALITY IN ENGLAND DURING THE FIRST YEAR OF THE COVID-19 PANDEMIC

During the first year of the COVID-19 pandemic overall child mortality in
England went down by 10% in 2020-2021 compared with 2019-2020 (RR 0.90 [95%
confidence interval, 0.85-0.94]).

COMMENT KNOWLEDGE-MANAGEMENT TASKFORCE COVID-19

Dieser unerwartete Rückgang der Mortalität war auf eine geringere Sterblichkeit
wegen Infektionen und wegen chronischen Grundkrankheiten zurückzuführen und war
maximal bei den unter 10-jährigen Kindern. Diese Daten zeigen, dass die
nicht-pharmakologischen Pandemie-Massnahmen einen direkten Effekt auf die
Kindersterblichkeit haben können, während die moderne Medizin in entwickelten
Ländern seit vielen Jahren keine weiteren Reduktionen der Mortalität bewirkt
hat.

10.1136/archdischild-2021-323370
#prevention #pediatrics #epidemiology
05.01.2022

CT LUNG ABNORMALITIES AFTER COVID-19 AT 3 MONTHS AND 1 YEAR AFTER HOSPITAL
DISCHARGE

This study investigated the evolution of pulmonary abnormalities in COVID-19
patients. 3 months after discharge from hospital, CT revealed residual lung
findings in 41/73 patients, but signs of fibrosis were seen in only 9/73. After
1 year abnormalities were found in 26/32 patients. 

COMMENT KNOWLEDGE-MANAGEMENT COVID-19

Obwohl Lungenveränderungen nach einer COVID-19 Pneumonie radiologisch über
mehrere Monate sichtbar bleiben können, führt die Erkrankung offenbar nur selten
zu einer Lungenfibrose.

B. Vijayakumar et al. Radiology 2021 October 5
#imaging #radiology
09.01.2022

EFFECTIVENESS OF BNT162B2 (PFIZER-BIONTECH) MRNA VACCINATION AGAINST MULTISYSTEM
INFLAMMATORY SYNDROME IN CHILDREN AMONG PERSONS AGED 12–18 YEARS — UNITED
STATES, JULY–DECEMBER 2021

This large US study reports a vaccine efficacy (VE) of 91% (95% CI, 78-97) of 2
doses of the BNT162b2 mRNA vaccine (Pfizer-BioNTech) against PIMS-TS (MIS-C) in
persons 12-18 years of age.

COMMENT KNOWLEDGE-MANAGEMENT COVID-19

Diese neuen Daten liefern eine wichtige Evidenzgrundlage für die Impfempfehlung
für Jugendliche. Sie zeigen, dass die mRNA Impfung grundsätzlich vor dieser
seltenen, aber gefährlichen immunologischen Spätreaktion schützen kann.
Einschränkend ist festzuhalten, dass diese Studie zur Zeit der Delta-Dominanz
durchgeführt wurde. Daten zur Omikron-Variante sind noch nicht verfügbar.

Zambrano LD et al. MMWR 2022 Jan 7
#prevention #vaccine #infectious diseases #immunoresponses #pediatrics
21.12.2021

MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN BY COVID-19 VACCINATION STATUS OF
ADOLESCENTS IN FRANCE

This is the first preliminary evidence to indicate that a COVID-19 vaccine
(BNT162b2, Pfizer-BioNTech) may protect not only against acute infection with
SARS-CoV-2, but also against PIMS-TS (MIS-C) in adolescents

COMMENT KNOWLEDGE-MANAGEMENT TASKFORCE COVID-19

Aufgrund der Seltenheit von PIMS-TS (MIS-C) konnte ein Impfschutz gegen diese
Spätkomplikation bei Kindern und Jugendlichen in Zulassungsstudien nicht erfasst
werden. Eine robuste Aussage über den Impfschutz gegen PIMS-TS erfordert
allerdings noch weitere Studienresultate.

Levy M et al. JAMA 2021 Dec 20
#prevention #vaccine #pediatrics #infectious diseases #immunoresponses
17.12.2021

DEATH FOLLOWING PULMONARY COMPLICATIONS OF SURGERY BEFORE AND DURING THE
SARS-COV-2 PANDEMIC

This multi-institutional study reveals the outcomes of patients with Covid-19
undergoing surgery.

COMMENT KNOWLEDGE-MANAGEMENT TASKFORCE COVID-19

Trotz einer möglichen Patientenselektion für Operationen, welche im Rahmen der
Pandemie wahrscheinlich ist, ist die Inzidenz von pulmonalen Komplikationen
unverändert im Vergleich zu einer Population vor der Pandemie. Die Mortalität an
Pneumonie bei operierten Patienten ist jedoch signifikant höher.

BJS, 2021, 108, 1448–1464
#therapy #clinical #surgery
16.12.2021

HOW COMMON IS LONG COVID IN CHILDREN AND ADOLESCENTS?

This interesting review of the literature illustrates the profound
methodological shortcomings of studies addressing the issue of pediatric Long
COVID or PASC currently available.

COMMENT KNOWLEDGE-MANAGEMENT TASKFORCE COVID-19

Neben der grundsätzlich anspruchsvollen Quantifizierung der Long-COVID
Leitsymptome Kopfschmerzen, Müdigkeit oder Konzentrationsschwierigkeiten bei
Kindern, erschweren die Art der Datengenerierung (Elternfragebogen, oft
restrospektiv) sowie die durchwegs fehlende Verblindung der COVID-19
Testresultate für die Beobachter der Studienpatienten eine robuste
Dateninterpretation. Es braucht bessere Studien.   

Zimmermann P et al. Pediatr Infect Dis J 2021 Dec 1
#prevention #vaccine #infectious
diseases #pediatrics #immunoresponses #psychiatry
14.12.2021

MONOCLONAL ANTIBODIES CASIRIVIMAB AND IMDEVIMAB IN PREGNANCY FOR CORONAVIRUS
DISEASE 2019 (COVID-19)

Monoclonal antibodies such as casirivimab and imdevimab, approved under an
emergency use authorization, should be considered in unvaccinated pregnant
individuals with mild-to-moderate COVID-19 to decrease the risk of severe
disease.

COMMENT KNOWLEDGE-MANAGEMENT TASKFORCE COVID-19

Die Gabe von Casirivimab/Imdevimab ist in der Schwangerschaft möglich, gilt als
sicher und scheint bei sero-negativen Patientinnen die Mortalitäts- sowie
Hospitalisierungsrate zu senken. FDA hat im Mai 2021 die Behandlung mittels
monoklonaler Antikörpertherapie (Casirivimab/Imdevimab, REGN-COV2) auch für
schwangere Frauen zugelassen. Die Schweizerischen Gesellschaft für Infektiologie
(SSI) und des Clinical Care Group (CCG) der Swiss National COVID-19 Science Task
Force hat am 28.09.21 für Antikörpertherapien während der Schwangerschaft
zugelassen.

Mayer et al. Obstetrics & Gynecology: December 2021 - Volume 138 - Issue 6 - p
937-939
#therapy #treatment #obstetrics & gynaecology #immunoresponses
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GUIDELINES COVID-19

Score-Calculator schwere Verläufe Covid-19

Covid-19 - Informationen für Zuweiser und Patienten

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BAG-Richtlinien Impfung Covid-19

Swiss Recommendation: SARS-CoV-2 associated PIMS-TS management


HIGHLIGHTS COVID-19 SCIENCE


HOSPITALISATIONEN FÜR AKUTE COVID-19 UND PIMS-TS AN DER KINDERKLINIK




WAS IST BESONDERS AN OMICROM?




THE SARS-COV-2 OMICRON VARIANT: A SNAPSHOT OF WHERE WE ARE




MRNA VACCINES FOR INFECTIOUS DISEASES: PRINCIPLES, DELIVERY AND CLINICAL
TRANSLATION




LÄNDER IM VERGLEICH - INTERAKTIV


Image captured and color-enhanced at the NIAID Integrated Research Facility in
Fort Detrick, Maryland.


LINKS

Breaking bad news in times of Covid-19

Naming the coronavirus disease (COVID-19) and the virus that causes it

Living Evidence on Covid-19

Covid-Fälle - Schweiz

Covid-Fälle - Global

NIH Research Portfolio Covid-19

Monitoring COVID-19 spread in Switzerland (ETH)

Wichtige Info - Swissethics Covid-19

Swiss Ethics - approved research projects

Medicine Basecamp – a medical curriculum for redeployed trainees

Covid-19 AI Publication Search Covid-19 (with sign-up)

Pubcovid19 - quick search of medical articles

Covid-19 HSS / Horizon Scanning

Content provided by:

Taskforce Knowledge-Management Covid-19
University Hospital Bern
CH-3010 Bern, Switzerland

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