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 * Neuron Lab
    * Opening Screen
    * 1. Cells and Ions
    * 2. Ionic Currents
    * 3. NeuronLab Simulator
    * 4. Synapse and Dendrites
    * 5. Soma
    * 6. Axon
    * 7. Neuron
    * 8. STDP
    * Development Notes
       * Chapter 1
       * Chapter 2
       * Chapter 3
       * Chapter 4
       * Chapter 5
       * Chapter 6
   
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NEURON LABORATORY PROJECT

'Sapere aude'



What process in the brain allows us to participate in the moment ?

"More likely, we will take experience itself as a fundamental feature of the
world, alongside mass, charge,and space-time. If we take experience as
fundamental, then we can go about the business of constructing a theory of
experience."
D.J. Chalmers 1995

Neuroscience has a pretty good idea of how long term memories are created and
stored in the brain (Donald Hebb's Fire together/Wire together), but this
function requires an actual growth of interconnections in the brain and requires
long periods of time - days to weeks to complete. Learning to play a passage on
the piano is this type of learning.

Short term or working memory is being studied but there doesn't seem to be an
agreement on the mechanical apparatus that does the work. Remembering a list of
numbers read to you five minutes ago is an example of this type of learning.

I want to understand the processes that allow us to be aware of our surroundings
in the tens of milliseconds time frame. No one seems to have an idea on this, or
at least I haven't run across it yet. Needless to say - its complex. .

Along the way, I wanted to present what I have found in a format that is
accessible to others like myself - interested in the subject but not expert in
it. I decided publish my learning process as well in near real time and this web
site is the result. It will be continuously updated as I work on the project.

I made the decision to move toward an understanding of the neuron using
simulations rather than a exhaustive accounting of all neuron actions, bits and
pieces. For this reason, the synapse topics like neural transmitters, RDNA,
re-uptake, etc are all ignored. They are completely covered in endless detail in
other well written books and on-line classes many of which I used in this quest.

I don't consider my effort will result in a solution to the question only a way
for me to gain an understanding using the tools I have at hand.

This project consists of:
 * The Cell and Ions - Description of the cell membrane and its chemical makeup.
   The movement of charged ions across the lipid bilayer and what is an ion
   channel.
 * Ionic Currents - The electrical calculations of time and the effect of
   opening an ion channel
 * NeuronLab Simulator - Description and download link for the simulator along
   with a video for installation and basic operation. The simulator is for
   Windows only.
 * Synapse and Dendrites - The Synapse in this simulator adn the organization of
   the dendrite tree including calculations of the charge in the compartments.
 * Soma - The makeup of this vital part of a neuron and a simulator setup that
   illustrates the generation of the action potential using Izhikevich neuron
   calculations.
 * Axon - Transmission of action potential down the axon compartments.
 * Complete Neuron - The complete operation of a simulated neuron with
   Dendrites, Soma and Axons all firing. Includes several videos of the
   NeuronLab simulator in action.
 * Neuron Papers - A collection of publications on the subject
 * Notes: - Collection of thoughts and notes as the simulator was being built

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MY BRAIN WITH NEURONS FIRING.

... yes that is my actual brain


WOULD YOU WANT TO LIVE IN A WORLD LIKE THIS?


GUESS WHAT - ITS YOUR WORLD



Dendrites 'growing' a memory

 

NEXT - Cells and Ions



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ART BY : STEPHAN MARTINIERE



Questions - Comments eMail Me I will respond..

©2013 SETI Network


X

During this process I used several books and made use of on-line classes:

Books:

 * Principles of Neural Science - Kandle and Schwartz
 * Neuroscience - Bear, Conne and Paradiso
 * Neuroscience - Purvis et. al
 * Dynamical Systems in Neuroscience - Izhikevich
 * How to Build a Brain - Ellasmith
 * The NEURON Book - Carnevale and Hines
 * From Neuron to Brain - Wallace
 * Theoretical Neuroscience - Dayan and Abott

On-Line Classes

 * Computational Neuroscience - U. Washington via Coursera
 * Simulation Neuroscience - EdX
 * Medical Neuroscience - Duke via Coursera
 * Fundamental Neuroscience - Johns Hopkins via Coursera
 * Fundamentals of Neuroscience 1,2 and 3 - Harvard Online
 * Cellular Mechanisms of Brain Function EPFlx via BrainX
 * Circuits and Electronics - MIT via MITx
 * Neuroscience - School of Physics, University of Sydney
   (ian.cooper@sydney.edu.au)