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MONOGENIC CONDITIONS DETECTED BY PANEL SEQUENCING OF GENERAL NEWBORN POPULATION

Researchers demonstrated that targeted gene panel sequencing is an effective
first-tier method for newborn screening, providing an avenue to expand the
conditions considered.


ENDOCANNA HEALTH AIMS TO FLAG CANNABINOID SAFETY RISKS WITH DNA TEST
PREMIUM

Physicians are intrigued by the concept but want to see more data on the
benefits of medical cannabis and on the underlying genetic links that can
facilitate personalization.


MICROENVIRONMENTS GIVE CLUES TO DISTINCT IMMUNOTHERAPY RESPONSES IN BRAIN
METASTASES, GLIOBLASTOMAS

Investigators found microenvironment differences in checkpoint blockade
immunotherapy-treated cases involving brain metastases versus recurrent
glioblastoma.


HUMAN POPULATION NEARLY WENT EXTINCT 900,000 YEARS AGO, GENETIC STUDY SUGGESTS

Using genomic data from present-day humans and a new analytical approach,
investigators found a population bottleneck that resulted in fewer than 1,300
breeding individuals.


LARGE-SCALE PROTEOMIC STUDIES IDENTIFY PROTEINS LINKED TO DIABETES, METABOLIC
SYNDROME

The two studies, published separately in Cell Reports Medicine, used
affinity-based and mass spec platforms to analyze thousands of blood samples.


WATCHMAKER GENOMICS PARTNERS WITH EXACT SCIENCES TO BRING EPIGENETIC ANALYSIS
TECHNOLOGY TO MARKET
PREMIUM

Under the co-exclusive agreement, Watchmaker will gain access to Exact's
bisulfite-free DNA methylation analysis technology, called TAPS.
Business, Policy & Funding


 * ILLUMINA TAPS AGILENT EXEC JACOB THAYSEN AS NEXT CEO


 * LABGENOMICS ACQUIRES QDX PATHOLOGY


 * GUARDANT HEALTH RECEIVES GUARDANT360 CDX REGULATORY APPROVAL IN JAPAN FOR
   HER2 LUNG CANCER TREATMENT


 * GENETIC SIGNATURES FILES 510(K) APPLICATION FOR GI PARASITE DETECTION KIT


 * MAINZ BIOMED PARTNERS WITH GERMAN DIAGNOSTIC LABORATORY TO OFFER COLOALERT
   TEST

Technology


 * ESOPHAGEAL CANCER SUSCEPTIBILITY RISK VARIANTS FOUND IN SOUTH AFRICAN
   POPULATION


 * WITH 2024 LAUNCH OF MULTI-CANCER TEST, EDGC PLANS ENTRY INTO EARLY CANCER
   SCREENING MARKET
   PREMIUM


 * MICROENVIRONMENTS GIVE CLUES TO DISTINCT IMMUNOTHERAPY RESPONSES IN BRAIN
   METASTASES, GLIOBLASTOMAS


 * MONOGENIC CONDITIONS DETECTED BY PANEL SEQUENCING OF GENERAL NEWBORN
   POPULATION


 * WITH TEMPUS TEST INTEGRATION, CUREMD WANTS GENOMICS TO INFORM ONCOLOGY
   CLINICAL DECISION SUPPORT
   PREMIUM

Research & Discovery


 * CIRCULAR GENOMICS, WASHINGTON UNIVERSITY RESEARCHER TO EXPLORE CIRCRNA AS
   ALZHEIMER'S BIOMARKER


 * MONOGENIC CONDITIONS DETECTED BY PANEL SEQUENCING OF GENERAL NEWBORN
   POPULATION


 * GENOMIC MEDICINE 'SALES PITCH' DOESN'T SIT WELL WITH THOSE LEFT OUT OF
   RESEARCH IN UK STUDY
   PREMIUM


 * GWAS META-ANALYSIS IDENTIFIES 26 RISK LOCI LINKED TO EPILEPSY


 * HUMAN POPULATION NEARLY WENT EXTINCT 900,000 YEARS AGO, GENETIC STUDY
   SUGGESTS

Diagnostics


 * CIRCULAR GENOMICS, WASHINGTON UNIVERSITY RESEARCHER TO EXPLORE CIRCRNA AS
   ALZHEIMER'S BIOMARKER


 * LABGENOMICS ACQUIRES QDX PATHOLOGY


 * GUARDANT HEALTH RECEIVES GUARDANT360 CDX REGULATORY APPROVAL IN JAPAN FOR
   HER2 LUNG CANCER TREATMENT


 * GENETIC SIGNATURES FILES 510(K) APPLICATION FOR GI PARASITE DETECTION KIT


 * WITH 2024 LAUNCH OF MULTI-CANCER TEST, EDGC PLANS ENTRY INTO EARLY CANCER
   SCREENING MARKET
   PREMIUM

Applied Markets: Ag-Bio, Veterinary, Forensics, Food Safety, & Environmental
Testing


 * ALVEO TECHNOLOGIES, FRAUNHOFER IZI TO CODEVELOP ANIMAL HEALTH MDX TESTS


 * MICROBIOME FIRM INTUS BIO ACQUIRES BIOINFORMATICS COMPANY PATTERN GENOMICS


 * QI BIODESIGN BETS ON AGRICULTURAL MARKET WITH GENOME EDITING TECHNOLOGIES
   PREMIUM


 * GINKGO BIOWORKS, SYNGENTA SEEDS STRIKE RESEARCH DEAL FOR PLANT TRAIT
   DEVELOPMENT

Disease Areas


 * CIRCULAR GENOMICS, WASHINGTON UNIVERSITY RESEARCHER TO EXPLORE CIRCRNA AS
   ALZHEIMER'S BIOMARKER


 * ESOPHAGEAL CANCER SUSCEPTIBILITY RISK VARIANTS FOUND IN SOUTH AFRICAN
   POPULATION


 * GUARDANT HEALTH RECEIVES GUARDANT360 CDX REGULATORY APPROVAL IN JAPAN FOR
   HER2 LUNG CANCER TREATMENT


 * GENETIC SIGNATURES FILES 510(K) APPLICATION FOR GI PARASITE DETECTION KIT


 * MICROENVIRONMENTS GIVE CLUES TO DISTINCT IMMUNOTHERAPY RESPONSES IN BRAIN
   METASTASES, GLIOBLASTOMAS

Breaking News


 * CIRCULAR GENOMICS, WASHINGTON UNIVERSITY RESEARCHER TO EXPLORE CIRCRNA AS
   ALZHEIMER'S BIOMARKER


 * ESOPHAGEAL CANCER SUSCEPTIBILITY RISK VARIANTS FOUND IN SOUTH AFRICAN
   POPULATION


 * ILLUMINA TAPS AGILENT EXEC JACOB THAYSEN AS NEXT CEO


 * LABGENOMICS ACQUIRES QDX PATHOLOGY


 * GUARDANT HEALTH RECEIVES GUARDANT360 CDX REGULATORY APPROVAL IN JAPAN FOR
   HER2 LUNG CANCER TREATMENT


Recent Headlines from 360Dx


 * RENALYTIX RAMPS UP COMMERCIALIZATION EFFORTS FOR KIDNEY DISEASE TEST AFTER
   FDA APPROVAL
   PREMIUM


 * AS LABS ADD CPT CODES FOR DIGITAL PATHOLOGY SLIDES, SOME PAYORS BALK AT
   REIMBURSEMENTS
   PREMIUM


 * RESEARCHERS FIND CARDIOVASCULAR MARKER LINKED TO OVERALL MORTALITY RISK
   PREMIUM


 * DIAGMETRICS DEVELOPING CAPTURE MOLECULE- AND BIOSENSOR-BASED BREATH ASSAYS
   PREMIUM


 * BECKMAN COULTER, FUJIREBIO COLLABORATION TARGETING ALZHEIMER'S, OTHER
   NEURODEGENERATIVE DISEASES
   PREMIUM

The Scan


POSITIVE FRAMING OF GENETIC STUDIES CAN SPARK MISTRUST AMONG UNDERREPRESENTED
GROUPS

Researchers in Human Genetics and Genomics Advances report that how researchers
describe genomic studies may alienate potential participants.


SMALL STUDY OF GENE EDITING TO TREAT SICKLE CELL DISEASE

In a Novartis-sponsored study in the New England Journal of Medicine,
researchers found that a CRISPR-Cas9-based treatment targeting promoters of
genes encoding fetal hemoglobin could reduce disease symptoms.


GUT MICROBIOME CHANGES APPEAR IN INFANTS BEFORE THEY DEVELOP ECZEMA, STUDY FINDS

Researchers report in mSystems that infants experienced an enrichment in
Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before
developing eczema.


ACUTE MYELOID LEUKEMIA TREATMENT SPECIFICITY ENHANCED WITH STEM CELL EDITING

A study in Nature suggests epitope editing in donor stem cells prior to bone
marrow transplants can stave off toxicity when targeting acute myeloid leukemia
with immunotherapy.

What's Popular?


 1. MONOGENIC CONDITIONS DETECTED BY PANEL SEQUENCING OF GENERAL NEWBORN
    POPULATION


 2. PEOPLE IN THE NEWS AT NANOSTRING, INVITAE, TELESIS BIO, BIOCARTIS, DELVE
    BIO, CO-DIAGNOSTICS


 3. HUMAN POPULATION NEARLY WENT EXTINCT 900,000 YEARS AGO, GENETIC STUDY
    SUGGESTS


 4. FDA CLEARS 23ANDME BRCA1/2 CONSUMER HEALTH RISK REPORT FOR 41 ADDITIONAL
    VARIANTS


 5. NEW PRODUCTS POSTED TO GENOMEWEB: SCALE BIOSCIENCES, BIO-RAD, LABORATORY
    SERVICES MSO




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