www.acs.org Open in urlscan Pro
45.60.80.135  Public Scan

Form analysis
1 forms found in the DOM

GET https://search.acs.org

<form action="https://search.acs.org" method="get" role="search" class="search-form">
  <button class="search-form__close" type="reset" aria-label="Close Search"></button>
  <span class="twitter-typeahead" style="position: relative; display: inline-block;"><input type="text" class="search-form__input tt-hint" title="Enter keywords to search" aria-label="Enter keywords to search" aria-labelledby="search-button"
      autocomplete="off" readonly="" spellcheck="false" tabindex="-1" dir="ltr"
      style="position: absolute; top: 0px; left: 0px; border-color: transparent; box-shadow: none; opacity: 1; background: none 0% 0% / auto repeat scroll padding-box border-box rgb(255, 255, 255);"><input type="text" name="q" id="searchsite"
      class="search-form__input tt-input" title="Enter keywords to search" placeholder="Search" aria-label="Enter keywords to search" aria-labelledby="search-button" autocomplete="off" spellcheck="false" dir="auto"
      style="position: relative; vertical-align: top; background-color: transparent;">
    <pre aria-hidden="true"
      style="position: absolute; visibility: hidden; white-space: pre; font-family: &quot;Open Sans&quot;, Arial, sans-serif; font-size: 13.5px; font-style: normal; font-variant: normal; font-weight: 100; word-spacing: 0px; letter-spacing: 0px; text-indent: 0px; text-rendering: auto; text-transform: none;"></pre>
    <div class="tt-menu" style="position: absolute; top: 100%; left: 0px; z-index: 100; display: none;">
      <div class="tt-dataset tt-dataset-0"></div>
      <div class="tt-dataset tt-dataset-1"></div>
    </div>
  </span>
  <button id="search-button" class="search-form__button" role="button" aria-label="Submit Search"></button>
</form>

Text Content

Skip to Main Content
 * ACS
 * Publications
 * C&EN
 * CAS

< Back
 * Donate
 * Membership
 * Log In
   
   YOUR ACS ACCOUNT
   
    * Manage Account
    * Renew ACS Membership
    * Change Contact Info
    * Manage Email Preferences
    * ACS Network
    * My Technical Divisions
      
   
   QUICK ACCESS
   
    * Donate
    * Volunteer
    * ACS Member Benefits
    * ACS Store

 * Meetings & Events
   
   MEETINGS & EVENTS
   
   Network with colleagues and access the latest research in your field
   
    * ACS Meetings & Expositions
    * Regional Meetings
    * Green Chemistry Conferences
   
    * Events Calendar
    * Future ACS Meetings
    * Submit an Abstract
   
    * Leadership Development
    * ACS Institute
    * ACS Webinars
   
   View all Meetings & Events
   
   Registration & housing are open

 * Careers
   
   CAREERS
   
   Launch and grow your career with career services and resources
   
    * Develop and grow in your career
    * Find and land a job
    * Explore career options
   
    * Find networking opportunities
    * Careers & the Chemical Sciences
    * Career Events
   
    * ACS Institute
    * Get Experience
   
   View all Careers
   
   Explore Career Options
   Let ACS help you navigate your career journey with tools, personal coaching
   and networking.

 * Students & Educators
   
   STUDENTS & EDUCATORS
   
   Promoting excellence in science education and outreach
   
    * Educational Resources
    * For Students
    * For Educators
   
    * Explore Chemistry
    * Standards & Guidelines
    * Science Outreach
   
    * Books & Magazines
    * American Association of Chemistry Teachers
   
   View all Students & Educators
   
   ACS-Hach Programs
   Learn about financial support for future and current high school chemistry
   teachers.

 * Communities
   
   COMMUNITIES
   
   Find a chemistry community of interest and connect on a local and global
   level.
   
    * Technical Divisions
    * Local Sections
    * Industry Resources
    * International Chapters
   
    * International Resources
    * Green Chemistry Roundtables
    * Senior Chemists
    * Student Chapters
   
    * High School Club
    * Women Chemists
   
   View all Communities
   
   Technical Divisions
   Collaborate with scientists in your field of chemistry and stay current in
   your area of specialization.

 * Discover Chemistry
   
   DISCOVER CHEMISTRY
   
   Explore the interesting world of science with articles, videos and more.
   
    * Science Articles
    * ACS Webinars
    * Green Chemistry
   
    * Safety
    * Tiny Matters Podcast
    * News Releases
   
    * Reactions Videos
    * Landmarks in Chemical History
    * Infographics
   
   View all Discover Chemistry
   
   Reactions: Chemistry Science Videos & Infographics
   Uncover the Chemistry in Everyday Life

 * Funding & Awards
   
   FUNDING & AWARDS
   
   Celebrating and advancing your work with awards, grants, fellowships &
   scholarships.
   
    * Awards
    * Grants
    * Scholarships & Fellowships
   
    * National Awards
    * Petroleum Research Fund
    * Industry Awards
   
    * Green Chemistry
    * Local Sections
    * Technical Divisions
   
   View all Funding & Awards
   
   ChemLuminary Awards
   Recognizing ACS local sections, divisions and other volunteers for their work
   in promoting chemistry.

 * More
   * About ACS
   * Membership
   * Green Chemistry
   * Chemical & Laboratory Safety
   * Donate
   * Volunteer

Membership



 * You are here:
 * ACS
 * Discover Chemistry
 * PressPacs


ESPRESSO CAN PREVENT ALZHEIMER’S PROTEIN CLUMPING IN LAB TESTS

PressPacs July 19, 2023
Facebook LinkedIn Twitter Pinterest Email

FOR IMMEDIATE RELEASE

“Espresso coffee mitigates the aggregation and condensation of Alzheimer’s
associated tau protein”
Journal of Agricultural and Food Chemistry

In an in vitro study, espresso and certain compounds found within it could
prevent tau aggregation, which is associated with Alzheimer’s disease.
Alessio Orru/Shutterstock.com


Whether enjoyed on its own or mixed into a latte, Americano or even a martini,
espresso provides an ultra-concentrated jolt of caffeine to coffee lovers. But
it might do more than just wake you up. Research now published in ACS’ Journal
of Agricultural and Food Chemistry shows that, in preliminary in vitro
laboratory tests, espresso compounds can inhibit tau protein aggregation — a
process that is believed to be involved in the onset of Alzheimer’s disease.

Roughly half of all Americans drink coffee every day, and espresso is a popular
way to consume it. To “pull” an espresso shot, hot water is forced through
finely ground coffee beans, creating a concentrated extract. This is often used
as a base for other drinks, including the trendy espresso martini. Recent
research has suggested that coffee could also have beneficial effects against
certain neurodegenerative diseases, including Alzheimer’s disease. Although the
exact mechanisms that cause these conditions are still unclear, it’s thought
that a protein called tau plays a significant role. In healthy people, tau
proteins help stabilize structures in the brain, but when certain diseases
develop, the proteins can clump together into fibrils. Some researchers propose
that preventing this aggregation could alleviate symptoms. So, Mariapina
D’Onofrio and colleagues wanted to see if compounds in espresso could prevent
tau aggregation in vitro.

The researchers pulled espresso shots from store-bought beans, then
characterized their chemical makeup using nuclear magnetic resonance
spectroscopy. They chose caffeine and trigonelline, both alkaloids, the
flavonoid genistein and theobromine, a compound also found in chocolate, to
focus on in further experiments. These molecules, along with the complete
espresso extract, were incubated alongside a shortened form of the tau protein
for up to 40 hours. As the concentration of espresso extract, caffeine or
genistein increased, fibrils were shorter and didn’t form larger sheets, with
the complete extract showing the most dramatic results. Shortened fibrils were
found to be non-toxic to cells, and they did not act as “seeds” for further
aggregation. In other experiments, the researchers observed that caffeine and
the espresso extract could both bind pre-formed tau fibrils. Although much more
research is needed, the team says that their preliminary in vitro findings could
pave the way toward finding or designing other bioactive compounds against
neurodegenerative diseases, including Alzheimer’s.

The authors acknowledge funding from the Italian Ministry of University and
Research.

###

The American Chemical Society (ACS) is a nonprofit organization chartered by the
U.S. Congress. ACS’ mission is to advance the broader chemistry enterprise and
its practitioners for the benefit of Earth and all its people. The Society is a
global leader in promoting excellence in science education and providing access
to chemistry-related information and research through its multiple research
solutions, peer-reviewed journals, scientific conferences, eBooks and weekly
news periodical Chemical & Engineering News. ACS journals are among the most
cited, most trusted and most read within the scientific literature; however, ACS
itself does not conduct chemical research. As a leader in scientific information
solutions, its CAS division partners with global innovators to accelerate
breakthroughs by curating, connecting and analyzing the world’s scientific
knowledge. ACS’ main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive press releases from the American Chemical Society,
contact newsroom@acs.org.

Note: ACS does not conduct research, but publishes and publicizes peer-reviewed
scientific studies.

Related Tags: Medicine Candy Health Food



MEDIA CONTACT

ACS Newsroom
newsroom@acs.org


RELATED CONTENT

 * Magnolia bark compound could someday help treat drug-resistant epilepsy
 * Cannabis compound acts as an antibiotic
 * New compounds thwart multiple viruses, including coronavirus
 * One drug, many diseases




MORE FROM THIS SERIES

 * Why do we love the smell of fall? (video)
 * Antibiotic resistance genes in three Puerto Rican watersheds after Hurricane
   Maria *Instant Replay*
 * Colorful, magnetic Janus balls could help foil counterfeiters (video)
 * A non-destructive method for analyzing Ancient Egyptian embalming materials

Accept & Close The ACS takes your privacy seriously as it relates to cookies. We
use cookies to remember users, better understand ways to serve them, improve our
value proposition, and optimize their experience. Learn more about managing your
cookies at Cookies Policy.

GET TO KNOW US About ACS Press Room Jobs at ACS Governance ACS Store
JOIN US Join ACS Renew Membership Member Benefits
GET INVOLVED Advocate Volunteer Donate ACS Network
Follow Us


1155 Sixteenth Street, NW, Washington, DC 20036, USA
| service@acs.org | 1-800-333-9511 (US and Canada) | 614-447-3776 (outside North
America)

 * Top ^
 * Terms of Use
 * Security
 * Privacy
 * Accessibility
 * Site Map
 * Contact
 * Help

Copyright © 2023 American Chemical Society



×
We Value Your Privacy
Settings
NextRoll, Inc. ("NextRoll") and our advertising partners use cookies and similar
technologies on this site and use personal data (e.g., your IP address). If you
consent, the cookies, device identifiers, or other information can be stored or
accessed on your device for the purposes described below. You can click "Allow
All" or "Decline All" or click Settings above to customize your consent.
NextRoll and our advertising partners process personal data to: ● Store and/or
access information on a device; ● Create a personalized content profile; ●
Select personalised content; ● Personalized ads, ad measurement and audience
insights; ● Product development. For some of the purposes above, our advertising
partners: ● Use precise geolocation data. Some of our partners rely on their
legitimate business interests to process personal data. View our advertising
partners if you wish to provide or deny consent for specific partners, review
the purposes each partner believes they have a legitimate interest for, and
object to such processing.
If you select Decline All, you will still be able to view content on this site
and you will still receive advertising, but the advertising will not be tailored
for you. You may change your setting whenever you see the Manage consent
preferences on this site.
Decline All
Allow All
Manage consent preferences