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 * RESEARCH
 * ONGOING PROJECTS
 * NEWS
 * ABOUT US
 * PUBLICATIONS
 * SPIN-OFF
 * COLLABORATIONS & FUNDING
 * CONTACT

 * RESEARCH
 * ONGOING PROJECTS
 * NEWS
 * ABOUT US
 * PUBLICATIONS
 * SPIN-OFF
 * COLLABORATIONS & FUNDING
 * CONTACT

 * RESEARCH
 * ONGOING PROJECTS
 * NEWS
 * ABOUT US
 * PUBLICATIONS
 * SPIN-OFF
 * COLLABORATIONS & FUNDING
 * CONTACT

 * RESEARCH
 * ONGOING PROJECTS
 * NEWS
 * ABOUT US
 * PUBLICATIONS
 * SPIN-OFF
 * COLLABORATIONS & FUNDING
 * CONTACT

Welcome to the SinuesLab


TRANSLATIONAL RESEARCH OF TODAY,
STANDARD CARE OF TOMORROW


RESEARCH

Unleashing the Full Potential of Breath Metabolomics to Advance Precision
Medicine



GENERATE HYPOTHESIS

Our interdisciplinary team work coordinately to generate working hypotheses to
address our clinical questions

DESIGN THE EXPERIMENT

Together with our clinical colleagues we design the right experiment to answer
our research questions

MEASURE

We use state-of-the-art high resolution-mass spectrometry to map the exhaled
metabolome of our patients

ANALYZE

We use sophisticated bioinformatic tools to decode complex datasets.

VALIDATE

Our results are further validated and generate further hypotheses to advance
answering our research questions.

ONGOING PROJECTS

DEVELOPMENT OF STANDARD OPERATING PROCEDURES FOR REPRODUCIBLE REAL-TIME BREATH
ANALYSIS

In this project we develop the necessary procedures to ensure the highest data
quality possible, enabling multi-center studies.

THERAPEUTIC DRUG MONITORING GUIDED BY BREATH ANALYSIS

The objective in this project is to optimize the therapeutic regimen of
pediatric patients to maximize efficacy and minimize side effects.

DECIPHERING THE IMPACT OF AIR POLLUTION EXPOSURE FOR THE RESPIRATORY SYSTEM

In this project we combine air pollution models, state-of-the-art lung function
tests and our breath metabolomics approach to better understand the detrimental
effects of air pollution exposure in children.

RAPID DIAGNOSIS OF INFECTIOUS RESPIRATORY DISEASES BY BREATH ANALYSIS

Our objective is to diagnose infectious diseases, with a focus on pneumonia, by
combining our high resolution/high mass accuracy real-time breath analysis
technology combined with Artificial Intelligence to provide a positive/negative
response within 15 minutes.

News

AX Social Stream: There is no feed to show or there is a connectivity problem!


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ABOUT US


RESEARCH GROUP
MEMBERS

PROF. DR. PABLO SINUES PH.D.

Head of Translational Medicine Research Group

pablo.sinues@ukbb.ch
+41 617 042 949
 * Facebook
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 * LinkedIn

DR. KAPIL DEV SINGH PH.D.

Senior Scientist

kapil.singh@ukbb.ch
+41 61 704 29 48

 

MÉLINA RICHARD

Lead Research Coordinator, Research Associate

melina.richard@ukbb.ch

+41 61 704 14 11

PROJECTS

> PLACEBOLOMICS; BREATH METABOLOMICS OF PLACEBO EFFECTS

> BREATH METABOLOMICS OF PAIN AND STRESS

 * LinkedIn

JIAFA ZENG

PhD Candidate

jiafa.zeng@ukbb.ch
+41 61 704 25 76

PROJECTS

> Therapeutic Drug Monitoring Guided by Breath Analysis

ZHIHONG YIN

PhD Candidate

zhihon.yin@ukbb.ch
+41 61 704 25 76

PROJECTS

> Therapeutic Drug Monitoring Guided by Breath Analysis

NOEMI KÜNSTLE

PhD Candidate

noemi.kuenstle@ukbb.ch
+41 61 704 19 67 

PROJECTS

>Differences in markers of oxidative stress response, autophagy, cellular
senescence and remodeling in cord blood in preterm infants compared to term
infants and their correlation with air pollution and lung function

DR. JAKOB USEMANN, M.D. PH.D.

Resident Physician, Postdoctoral Research Fellow

Jakob.Usemann@ukbb.ch
+41 61 704 22 91

ISABEL GONZALEZ

Lead Study Nurse

isabel.gonzalez@ukbb.ch
+41 61 704 29 43
+41 61 704 29 42

 

MANA OKADA THOMMEN

Study Nurse BILD, EBECA

mana.okada@ukbb.ch
+41 61 704 10 41



FORMER GROUP MEMBERS

MO AWCHI

PhD Candidate

mohamad.awchi@ukbb.ch
+41 61 704 28 98

PROJECTS

> Therapeutic Drug Monitoring Guided by Breath Analysis

AMANDA GISLER, PHD

amanda.gisler@ukbb.ch
+41 61 704 27 84

PROJECTS

> Development of Standard Operating Procedures for Reproducible Real-Time Breath
Analysis

> Deciphering the Impact of Air Pollution Exposure for the Respiratory System

KIM FABIENNE ARNOLD, PHD

kim.arnold@ukbb.ch
+41 617 042 949

PROJECTS

> Rapid Diagnosis of Infectious Respiratory Diseases by Breath Analysis

 * LinkedIn



PUBLICATIONS


REAL-TIME VOLATILE METABOLOMICS ANALYSIS OF DENDRITIC CELLS

2023

AUTHORS: Kim Arnold, Philippe Dehio, Jonas Lötscher, Kapil Dev Singh, Diego
García-Gómez, Christoph Hess, Pablo Sinues*, and Maria L. Balmer* JOURNAL INFO:
Anal. Chem. 2023, 95, 25, 9415–9421 YEAR: 2023 LINK:...


LATE BREAKING ABSTRACT – PRENATAL EXPOSURE TO AIR POLLUTION AFFECTS NEWBORNS’
AUTOPHAGY, SENESCENCE AND REMODELLING PROTEINS

2023

AUTHORS: Olga Gorlanova, Heide Oller, Uri Nahum, Noemi Künstle, Loretta Müller,
Andrea Marten, Céline Rüttimann, Danielle Vienneau, Kees De Hoogh, David
Schürmann, Carla Rebeca Da Silva Sena, Martin Röösli, Pablo Sinues, Sven
Schulzke, Ruth Steinberg, Jakob Usemann,...


LATE BREAKING ABSTRACT – DIFFERENCES IN AUTOPHAGY MARKER LEVELS AT BIRTH IN
PRETERM VS. TERM INFANTS

2023

AUTHORS: Noëmi Künstle, Olga Gorlanova, Andrea Marten, Loretta Müller, Pawan
Sharma, Martin Röösli, Pablo Sinues, David Schürmann, Céline Rüttimann, Carla
Rebeca Da Silva Sena, Uri Nahum, Jakob Usemann, Ruth Steinberg, Sophie Yammine,
Sven Schulzke, Philipp Latzin,...


PREDICTION OF SYSTEMIC FREE AND TOTAL VALPROIC ACID BY OFF-LINE ANALYSIS OF
EXHALED BREATH IN EPILEPTIC CHILDREN AND ADOLESCENTS

2023

AUTHORS: Mo Awchi, Kapil Dev Singh, Patricia E Dill, Urs Frey, Alexandre N
Datta, Pablo Sinues JOURNAL INFO: J. Breath Res. 17 046013 YEAR: 2023 LINK:
https://doi.org/10.1088/1752-7163/acf782


UHPLC-MS/MS-BASED IDENTITY CONFIRMATION OF AMINO ACIDS INVOLVED IN RESPONSE TO
AND SIDE EFFECTS FROM ANTISEIZURE MEDICATIONS

2023

AUTHORS: Mo Awchi, Pablo Sinues, Alexandre N. Datta, Diego García-Gómez, and
Kapil Dev Singh* JOURNAL INFO: Journal of Proteome Research. 2023, 22, 3,
990–995 YEAR: 2023 LINK: https://doi.org/10.1021/acs.jproteome.2c00835


AMBIENT PRENATAL AIR POLLUTION EXPOSURE IS ASSOCIATED WITH LOW CORD BLOOD IL-17A
IN INFANTS

2023

AUTHORS: Olga Gorlanova, Heide Oller, Andrea Marten, Loretta Müller, Jessica
Laine-Carmelli, Fabienne Decrue, Yasmin Salem, Danielle Vienneau, Kees de Hoogh,
Amanda Gisler, Jakob Usemann, Insa Korten, Sophie Yammine, Uri Nahum, Noemi
Künstle, Pablo Sinues, Sven...


COMPARISON OF PLASMA IONIZATION- AND SECONDARY ELECTROSPRAY IONIZATION-
HIGH-RESOLUTION MASS SPECTROMETRY FOR REAL-TIME BREATH ANALYSIS

2022

Comparison of Plasma Ionization- and Secondary Electrospray Ionization-
High-resolution Mass Spectrometry for Real-time Breath Analysis AUTHORS: Jiafa
Zeng, Alexandra Christen, Kapil Dev Singh, Urs Frey, Pablo Sinues JOURNAL INFO: 
Chimia 2022 YEAR: 2022 LINK:...


PERSONALIZED MEDICINE, CURATED COLLECTIONS

2022

Human Breath Analysis May Support the Existence of Individual Metabolic
Phenotypes AUTHORS: Pablo Martinez-Lozano Sinues, Malcolm Kohler, Renato Zenobi
JOURNAL INFO:  PLOS ONE, Curated Collections YEAR: 2022 (2013) LINK:...


IN VIVO DETECTION OF METABOLIC 2H-INCORPORATION UPON INGESTION OF 2H2O

2022

AUTHORS: Arnold, Kim; Chen, Xing; Zhang, Hui; Singh, Kapil Dev; Yin, Zhihong;
Yao, Yao; Luan, Tiangang; Sinues, Pablo*; Li, Xue* JOURNAL INFO:  Journal of
Bio-X Research YEAR: 2022 LINK:...


RAPID DETECTION OF STAPHYLOCOCCUS AUREUS AND STREPTOCOCCUS PNEUMONIAE BY
REAL-TIME ANALYSIS OF VOLATILE METABOLITES

2022

AUTHORS: Alejandro Gómez-Mejia, Arnold Kim, Bär Julian, Kapil Dev Singh, Thomas
C. Scheier, Silvio D. Brugger, Annelies S. Zinkernagel, Pablo Sinues JOURNAL
INFO: iScience YEAR: 2022 LINK: https://doi.org/10.1016/j.isci.2022.105080

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SPINOFF

Spin-off company

Deep Breath Intelligence A.G. is a spin-off company of the University of Basel
co-founded by Prof. Pablo Sinues.
DBI’s vision is to uncover the full potential of Molecular Breath Analysis to
advance precision medicine and make it available for general health care.

COLLABS

FUNDING

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Keep in touch


UKBB – Universitäts-Kinderspital beider Basel Spitalstrasse 33, 4056 Basel

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