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Clinical Daily News
ANEMIA RISK 20 PERCENT HIGHER FOR SENIORS TAKING LOW-DOSE ASPIRIN: STUDY
June 21, 2023
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(HealthDay News) — For older adults, low-dose aspirin is associated with
increased incident anemia and a decrease in ferritin when compared with placebo,
according to a study published online June 20 in the Annals of Internal
Medicine.
Zoe K. McQuilten, MBBS, PhD, of Monash University in Melbourne, Australia, and
colleagues examined the effect of low-dose aspirin on incident anemia,
hemoglobin and serum ferritin concentrations in a post hoc analysis of the
ASPirin in Reducing Events in the Elderly trial involving community-dwelling
individuals aged 70 years or older. A total of 19,114 individuals were randomly
assigned to 100 mg of aspirin daily or placebo.
The researchers found that the incidence of anemia was 51.2 events per 1,000
person-years and 42.9 events per 1,000 person-years in the aspirin and placebo
groups, respectively (hazard ratio, 1.20). In the placebo group, hemoglobin
concentrations decreased by 3.6 g/L per five years, while a steeper decline of
0.6 g/L per five years was experienced by the aspirin group.
In 7,139 participants with ferritin measures at baseline and year 3, the
prevalence of ferritin levels <45 µg/L at year 3 was greater in the aspirin
group (13% versus 9.8%); the aspirin group also had a greater overall decline in
ferritin by 11.5% when compared with those receiving placebo. Similar results
were seen in a sensitivity analysis quantifying the effect of aspirin in the
absence of major bleeding.
“Daily low-dose aspirin increased the risk for incident anemia by approximately
20 percent, which, after taking into account risk for clinically significant
bleeding, was most likely due to occult blood loss given the observed steeper
decline in ferritin in participants allocated to aspirin,” the authors wrote.
Several authors disclosed financial ties to industry.
Abstract/Full Text (subscription or payment may be required)
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