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Research cores & servicesSummer internship program
News & Events


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OKRA Coordinating CenterSummer Internship ProgramUM KUHR Training
NetworkUM Division of NephrologyWolverines for Life

National Kidney Disease Education ProgramNational Kidney FoundationNIDDK Kidney
Disease CentersPolycystic Kidney Disease Research Resource Consortium

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Michigan George M. O'Brien National Resource Center






ADVANCING RESEARCH THROUGH INNOVATION AND COLLABORATION


Work with usLearn about our centerView publications

The George M. O'Brien Kidney National Resource Center at the University of
Michigan (MKTC) is dedicated to accelerating advancements in kidney disease
research by providing kidney researchers with specialized resources, tools,
technologies, services, and expertise beyond those typically available in an
individual lab or institutional core. We strive to improve the lives of patients
with kidney diseases through our state-of-the-art facilities, cutting-edge
technologies, and collaborative approach.


Our center, funded the National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK), is a member of the George M. O'Brien Kidney Resource Alliance
(OKRA) consortium.


Discover



OUR INNOVATIVE APPROACH



We utilize a three-pronged approach to support all basic and patient-oriented
kidney research investigators.




MOLECULAR
INVESTIGATION



We enable investigators to investigate the molecular causes and endpoints of
acute and chronic kidney diseases.


MODERN SYSTEMS
BIOLOGY APPROACHES



We disseminate and support the most modern and powerful systems biological
approaches for identifying novel biomarkers and targets for diagnosis and
treatment of kidney diseases.


ANALYSIS
AND INTEGRATION



Our expert analysis and integration of cohort and systems data through
sophisticated bioinformatics and database integration help identify specific
pathways and targets for treatments.


RESEARCH CORES AND SERVICES




ADMINISTRATIVE CORE
(AC)


Coordinate activities, distribute resources, and assess operations to support
the Center's goals and objectives. Through an ongoing review process, we ensure
the effectiveness and advancement of kidney research.




APPLIED SYSTEMS BIOLOGY CORE (ASBC)


Provide expert consulting services for data mining genome-wide renal data sets
and unique sets of tools to assist in bridging the gap between deep biological
and clinical understanding with large-scale molecular and clinical data sets.




DATA ANALYTIC SERVICES CORE (DASC)


Enhance the understanding of complex kidney diseases and the multi-scalar data
sets that accompany systems-biology approaches to their functional implications
regarding kidney disease development, diagnosis, progression and therapeutic
potential.




RESOURCE DEVELOPMENT CORE (RDC)


Develop a unified platform and methods to integrate multidimensional data,
cohort selection and clinical trial design.




CONTACT


University of Michigan Medical School
5100 Brehm Tower
1000 Wall Street
Ann Arbor, MI 48105-5714
‍
Phone: (734) 936-5645
Fax: (734) 232-8162

Email: dikmj@umich.edu





WORK WITH US




GET STARTED


To get started, please fill out our Request for sevices or training form.
One of our staff will respond within 5-7 business days.




1-HOUR CONSULTAION


Your request will be reviewed. For projects, a consultation will be scheduled to
review the project/experimental design and quote.



EVALUATION


We will evaluate your project to determine resources and cost.

PLEASE NOTE: Highest priority for services is given to investigators a) who are
conducting kidney-related research that is federally funded or b) those funded
by DCC Pilot and Feasibility grants, or c) to early-career investigators who are
starting careers in kidney research but who may not have yet obtained funding.
The next highest priority is given to researchers who are conducting research in
kidney disease supported by non-federal agencies or are conducting unfunded
research to support the submission of federal grant applications.


OUR LEADERSHIP


Subramaniam Pennathur, MD
MKTC Director
Core Director (AC)

View profileView website
Matthias Kretzler, MD
MKTC Associate Director
Core Director (ASBC)

View profileView website
Brian Athey, PhD
Core Director (DASC)

View profileView website
Salim Hayek, MD
Core Director (RDC)

View profileView website


LATEST PUBLICATIONS

See all publications




EXTRACORPOREAL IMMUNOMODULATION THERAPY IN ACUTE CHRONIC LIVER FAILURE WITH
MULTIORGAN FAILURE: FIRST IN HUMAN USE

Yessayan, Lenar T., et al.
March 2024
,
ASAIO Journal



UNBIASED KIDNEY-CENTRIC MOLECULAR CATEGORIZATION OF CHRONIC KIDNEY DISEASE AS A
STEP TOWARDS PRECISION MEDICINE

Reznichenko, Anna, et al.
January 2024
,
Kidney International



DEFINING THE MOLECULAR CORRELATE OF ARTERIOLAR HYALINOSIS IN KIDNEY DISEASE
PROGRESSION BY INTEGRATION OF SINGLE CELL TRANSCRIPTOMIC ANALYSIS AND PATHOLOGY
SCORING

Menon, Rajasree, et al.
August 2023
,
medRxiv [preprint]



CRABTREE EFFECT IN KIDNEY PROXIMAL TUBULE CELLS VIA LATE-STAGE GLYCOLYTIC
INTERMEDIATES

Darshi, Manjula, et al.
March 2023
,
iScience




UPCOMING EVENTS

See all events


30
April



GEORGE O'BRIEN KIDNEY CENTER RESEARCH SEMINAR


Tuesday, April 30, 2024
9:00 - 10:00 AM
07
May



GEORGE O'BRIEN KIDNEY CENTER RESEARCH SEMINAR


Tuesday, May 7, 2024
9:00 - 10:00 AM
14
May



GEORGE O'BRIEN KIDNEY CENTER RESEARCH SEMINAR


Tuesday, May 14, 2024
9:00 - 10:00 AM


FEATURED NEWS & STORIES

See more




REQUEST FOR PILOT & FEASIBILITY GRANT APPLICATIONS FOR BASIC & CLINICAL RESEARCH
OF KIDNEY DISEASE

June 18, 2022

The intent of this pilot program is to provide seed money for researchers to
obtain subsequent extramural funding. If funded, the proposed start date for the
P&F grants will be January 1, 2023.



WE RECENTLY FUNDED SEVERAL PILOT & FEASIBILITY AND SMALL GRANT AWARDS!

June 3, 2019

Congratulations to all who got funded!



UROP MENTEE AWARDED OUTSTANDING POSTER AWARD

May 1, 2019

Nephrology had two Undergraduate Research Opportunity Program (UROP) students
the past academic school year. Both presented in the annual UROP Research
symposium April 24, 2019.


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FEED



>
When using any core services, users agree to cite the George M. O’Brien Michigan
Kidney Translational Resource Center (MKTC), funded by NIH/NIDDK grant
U54DK137314 in any publications and/or presentations resulting from the use of
these core services.
The George M. O'Brien National Resource Center at the University of Michigan
(MKTC) is supported by grant U54-DK137314 from the National Institute of
Diabetes and Digestive and Kidney Diseases (NIDDK)