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Peri-Implant Sulcular Fluid (PISF) Nitric Oxide (NO) as an Early Marker of
Inflammation
Georgian Biomedical News

BACKGROUND.Nitric oxide (NO) plays an essential role in the regulation of
peri-implant soft tissue inflammation, immunomodulation, antimicrobial defense,
and anabolic and bone resorption processes.The alterations of NO play important
role in the pathogenesis of periodontitis.OBJECTIVES In the present study, we
aimed to evaluate the role of the peri-implant sulcular fluid (PISF) nitric
oxide (NO) as a marker of early inflammation.METHODS Overall, 20 practically
healthy persons (aged from 18 to 65 years) with a dental implant placed in the
chewing group of teeth, good oral cavity hygiene (Board index <20%), and the
need for rehabilitation were included in the study.The content of nitric oxide
(NO) in PISF was measured before and 1, 2, and 3 months after implantation and
compared with similar values of GSF of healthy teeth. RESULTSThe
Herniarin-treated mice showed approximately the same results as irradiated mice
on post-irradiation days 2 and 7. Furthermore, on days 14 and 30 absorption
spectrum of erythrocyte membrane proteins significantly increased (P<0.05) in
the Herniarin-treated experimental group.In the CSF of healthy teeth of studied
patients, NO content did not significantly change during the post-implantation
period, while the NO concentration in PISF was statistically higher than the
initial level in the first and second post-implantation months (25.09±0.77μM and
19.47±0.84μM, respectively), and returned to the nearly initial level 3 months
after implantation (17.19±0.5 μM). CONCLUSIONSThe results of the present study
indicate the importance of NO metabolism to the inflammatory process around
dental implants.PISF appears to have diagnostic potential for early prediction
of inflammation after implantation.Further studies are needed to evaluate and
compare PISF and GCF, especially concerning the inflammatory process and bone
remodeling.KEYWORDS Gingival crevicular fluid (GCF); nitric oxide (NO);
peri-implant inflammation; peri-implant sulcular fluid (PISF).
Analysis of the Diagnostic Markers in Patients with Post-COVID-19 Disorders
Georgian Biomedical News

Background: The post-COVID complications have turned out to be an urgent
problem.Most patients suffered from dry, lingering cough of assault character,
shortness of breath, sweating, weakness, fatigue, and other symptoms and
signs.There is a need to study the functional status of the respiratory system
and provide permanent monitoring of laboratory markers among patients with
post-COVID-19 disorders.Objectives: The study aimed to evaluate the functional
status of the respiratory system and laboratory markers among Georgian patients
with post-COVID-19 disorders.Methods: 157 patients (18 to 75 years of age, 88
women and 69 men) with post-COVID-19 disorders were involved in the study and
evaluated according to the following plan: (i) collection of anamnesis; (ii)
assessment of the functional state of external respiration performed by a
modern, computerized spirometer -Spirolab 3; (iii) analysis of laboratory
markers, such as D-dimer, coagulogram, C-reactive protein (CRP), procalcitonin,
interleukin-6 (IL-6), total IgE and vitamin D. Based on the obtained results,
the patients were distributed among two groups: 101 (64%) patients with
post-COVID-19 respiratory disorders in study group I, and 56 (36%) patients
without post-COVID-19 disorders -in control group II.Results: No reliable
changes (p<0.05) in the spirometry parameters (FEV1; FVC; FEV1/ FVC) were
observed in the study group.PEF < 70% peak expiratory flow was reduced in only
43 (42%) patients, compared to the norm.Mild restriction and irreversible
obstruction were observed in 25 (24%) cases.In the control group, the spirometry
indicators varied within the referral ranges.Among the correlogram markers,
fibrinogen concentration was increased in most cases, namely in 51 (50%)
patients.In addition, in 35 (34%) of 157 patients studied, a slight increase in
the DD marker was revealed (218.5 ±2.45 (norm < 200)); It should be emphasized
that the increase in CRP was observed in 16 (15%) patients involved in this
study; Only 2 (1.9%) patients with complicated respiratory changes showed a
slight increase in procalcitonin levels.Detection of interleukin-6 showed an
increase in the level of this marker in 38 (37 %) patients, while in the
patients of the control group, changes in the markers mentioned above were
revealed in single case: fibrinogen level in 4 (7%); DD -9 (16%); CRP -2 (1.9%);
procalcitonin -2(1.9%);Interleukin-6 -in 5 (8.9%), respectively.The allergy
marker total IgE was revealed in 34 (33%) of the studied patients, while among
the control group patients, it was fixed in 12 (21%).Vitamin D insufficiency was
detected in 31 (31%) patients, deficiency in 35 (35%), and normal level in only
34 (34%) patients, respectively.In contrast, in the control group, insufficiency
was detected only in 11 (19.7%),deficiency in 15 (26.8%), and norm in 30 (53.5%)
patients.Conclusions: The study has shown the necessity of monitoring laboratory
biomarkers such as vitamin D, IL-6, and total IgE, as well as conducting
computerized spirometry in patients with post-COVID-19 respiratory disorders.
Epstein-Barr Virus Infection in Children Following Acute SARS-CoV-2 Infection
Georgian Biomedical News

BACKGROUND.Epstein-Barr virus (EBV), a human herpesvirus with potent B cell
growth transforming ability, induces multiple cellular immune responses in the
infected host.According to the most recent evidence, the Epstein-Barr virus is
characterized by lifetime latency in B cells and intermittent recrudescence of
lytic infection triggered by stresses.Furthermore, several investigations have
hypothesized that autoimmune mechanisms and the persistence of SARS-CoV-2 virus
fragments induce the development of long-term COVID-19.Therefore, other latent
host viruses, such as Epstein-Barr virus, play an important role.OBJECTIVES The
present study aimed to provide insight into clinical-laboratory aspects in
pediatric patients with EBV after COVID-19.METHODS This prospective study was
conducted from November 2021 to November 2022 at the Tbilisi state medical
university G. Zhvania Pediatric Academic Clinic.1-3 years old, 81 outpatients
with EBV infection (male 42 [51,8%] and female 66 [48,1%]) were distributed into
basic (42 patients after acute SARS-CoV-2 infection) and control groups (32
patients without a history of COVDI-19).All study subjects had EBV infection
markers, and conventional clinical/laboratory indices evaluated. RESULTSThe
incidence of EBV infection is high (60.4%) in the post-COVID-19 period.Tonsil
enlargement, cough, and splenomegaly were more prevalent in the basic group than
in the control group: 85,7% vs. 40,6%, 81,6%, 85,7% vs. 20,5%, and 79,5% vs.
25,6%, respectively.CONCLUSIONS The increased incidence of EBV infection in
children after the COVID-19 pandemic is a challenge requiring optimized clinical
care strategies.
Chemical Composition and Biological Activity of Aerial Parts of Thymus collinus
Bieb. Growing in Georgia
Georgian Biomedical News

Background: Thymus L is one of the most important genera of the Lamiaceae
family.In traditional medicine, leaves and flowers of Thymus species are used as
a tonic, antiseptic, analgesic, anti-inflammatory, and antitussive.Complex
medicines are prepared from Thymus species, such as Neopertussin and
Pertussin.Objectives: The research aimed to study essential oil's chemical
composition and biological from aerial part of Thymus collinus Bieb.endemic
species growing in Georgia.Methods: Thymus collinus aerial parts essential oil
were hydro-distilled with a Clevenger-type apparatus.The quantitative content of
the dominant compound thymol was determined.In order to develop a rational use
of raw material and a resource-saving technology, the study on biologically
active, nonvolatile substances in the residual plant material was continued.The
aqueous extract was lyophilized, and the dried residual plant material was
successfully extracted with chloroform and methanol.The obtained extracts were
dried using a rotary evaporator.Essential oil DPPH radical scavenging capacity
was evaluated.Also, the antibacterial activity of essential oil was evaluated
using five different strains.Essential oil cytotoxic screening was conducted
against lung carcinoma A-549, colon carcinoma DLD-1, and human normal
fibroblasts WS-1 cell lines.Total phenolic content in aqueous, methanolic, and
chloroformic extracts was determined using the Folin-Ciocalteu (FC)
reagent.Essential oil, aqueous, methanolic, and chloroformic extracts
antioxidant activity was evaluated using ORAC test and tests on human skin
fibroblast (WS1).Also, anti-inflammatory activity was evaluated (inhibition of
nitric oxide production).Results: In the essential oil from aerial parts of
Thymus collinus, endemic to the Caucasus, the major constituents are thymol
(42.62 %) and carvacrol (16.51 %).Among the terpene compounds, oxygenated
monoterpenes are dominants -63.23 %.A high content of phenols (53.2 ± 0.9 %) was
detected in aqueous extract.Essential oil's scavenging rate of DPPH free
radicals was 94.2 % at a concentration of 2.87 mg/ml.The essential oil showed
high antioxidant activity in the ORAC and in vitro tests using a cellular model
(WS-1).At the same time, essential oil showed high antibacterial activity
against 5 (Escherichia coli, Salmonella enterica, Enterococcus faecium,
Staphylococcus epidermidis, and Pseudomonas aeruginosa) strains.Thymus collinus
essential oil at 80 μg/ml has inhibited NO production by 63 %; no toxicity was
revealed even at 160 μg/ml concentration.Thymus collins aqueous extract showed
high antioxidant activity in the ORAC test (3.38 ± 0.05 μmol TE/mg); in the case
of methanolic extract, slight anti-inflammatory activity was revealed.Essential
oil demonstrated moderate general cytotoxicity (85 ± 16 µg/ml) against lung
carcinoma (A-549).Conclusions: Thymol is the main component in Thymus collinus
essential oil; oxygenated monoterpenes are abundant in essential oil.EO
exhibited high antioxidant, anti-inflammatory, and antibacterial
activities.Based on the results, Thymus collinus Bieb., an endemic species to
Caucasus, may be used as a substitute raw material for officinal species.
Monitoring Restoration of the Eastern Usangu Wetland by Assessment of Land Use
and Cover Changes
Prosper Laurent Mfilinge
27 Jun 2016
Conflicting interests in the use and management of wetlands have always resulted
in their degradation.The degradation of wetlands affects their natural
functioning, environmental health and livelihood of the people who depend on
them.The eastern Usangu wetland has suffered a lot from multiple-use pressure
arising from both national and local interests.As a result, the government
banned the use of the wetland in 2006 to support its restoration process.The aim
of the current study was to assess the restoration process of the eastern Usangu
wetland using time-series Landsat images over a 20-year period, from 1995 to
2015.Cross-tabulation of composite NDVI images was used to examine the
changes.The results indicate that the land cover declined by 20% between 1995
and 2005, and increased by more than 25% between 2005 and 2015.The size of the
permanent swamp increased consistently, by more than 15% between 1995 and
2015.Wetland use has declined to about 15% over the 20 years.Wetland restoration
seems to be a slow process that depends on multiple factors.It thus is important
that wetlands are managed well for sustained benefits, rather than waiting to
rescue them in a crisis.The well-being of the people depending on the wetlands
should be considered when implementing measures to protect the
wetlands.Awareness creation among the users, diversification of sources of
income and enforcement of the laws and policies governing the use of wetlands by
the government may improve status of wetlands.
The High-Grade Oxidative Profile (OXpr), Aortic Stiffness Parameters, and
Hemogram-Derived Indices (HDI) as Predictors of Long-Term Major Adverse
Cardiovascular Events (MACEs) Following Percutaneous Coronary Intervention (PCI)
in Patients with Non-ST-Elevation Acute Coronary Syndrome (NSTE-ACS) and Chronic
Coronary Syndrome (CCS)
Georgian Biomedical News

BACKGROUND.Despite the achievements in the management of coronary heart disease
(CHD), there is a need to appropriately tailor the long-term management
strategies and risk stratification, particularly after percutaneous coronary
intervention (PCI) because of a non-ST-elevation acute coronary syndrome
(NSTE-ACS) or chronic coronary syndrome (CCS).OBJECTIVES The Present study aimed
to (i) evaluate the long-term cardiovascular prognostic value of oxidative
stress markers, arterial stiffness parameters, and hemogram-derived inflammatory
indices and (ii) compare the long-term predictive performance of the
abovementioned markers with the periprocedural SYNTAX score II (SS-II) in
Georgian patients following PCI.METHODS After PCI because of NSTE-ACS or CCS,
the annual incidence of 6-component MACEs, and values of the oxidative profile,
arterial stiffness measurements, and hemogram-derived indices (HDI) were
measured during the 36-month follow-up period in the development (100 patients
with NSTE-ACS) and validation cohorts (91 patients with CCS),
respectively.RESULTS By the multiple regression analysis NLR (0.505±0.069,
p<0.0001),OXpr (0.181±0.076, p=0.018),SBPao (0.174±0.076, p=0.023), and PLR
(0.164±0.056, p=0.004) are positively correlated with 36-month MACEs.CONCLUSIONS
The oxidative stress profile, central systolic blood pressure, and
hemogram-derived indices such as neutrophil-lymphocyte and monocytelymphocyte
ratios may be novel independent predictors of long-term major adverse
cardiovascular events.KEYWORDS Central systolic blood pressure (SBPao); chronic
coronary syndrome (CCS); major adverse cardiovascular events (MACEs);
neutrophil-tolymphocyte ratio (NLR); non-ST-elevation acute coronary syndrome
(NSTE-ACS); oxidative profile (OXpr); platelet-to-lymphocyte ratio (PLR).
Frequent Cases of Spondylarthritis and Hereditary Propensity (HLA-B27) in the
Same Family Name Relatives from the Keda Region of Ajara, Georgia
Georgian Biomedical News

Background: Typical clinical characteristics of spondyloarthropathies (SpA)
include inflammatory back pain (caused by sacroiliitis and peripheral
oligoarthritis), enteropathy, anterior uveitis, and an association with
HLA-B27.The disease begins in the second or third decade of life and affects
more men than women.The prevalence of SpA among first-degree relatives of the
affected patients was found to be 12%.Ankylosing spondylitis (AS) is the most
common subgroup of SpA, with a crucial role for HLA-B27 in the
pathogenesis.HLA-B27 presents in 88-90% of AS patients, compared to 4-8% among
the general population.Objectives: In this study, we explored the relationship
and hereditary propensity of the same family name relatives from the Keda region
of Ajara, Georgia, where we frequently encountered cases of ankylosing
spondylitis.Methods: The study was conducted at the Clinic "SoloMed" and
"Merlab" Laboratory Services from 05.01-10.03,2023, using real-time polymerase
chain reaction (PCR).Results: Among the 105 evaluated participants included in
this study (average age of 40.5 [15-60] years), 53.33% (n=56) were females, and
46.67% (n=49) were males.The highly HLA-B27-positive individuals were six males
aged ≥56 years and two women between the ages of 26 and 35.In the relatives with
the same family names, 14.29% (n=15) were HLA-B27 positive.Conclusions: The same
family name relatives from the Keda region of Ajara, Georgia, showed a
considerably higher risk of the distribution of ankylosing spondylitis (14.29).
The Experimental Models of Acute Pancreatitis
Georgian Biomedical News

Acute pancreatitis is a severe condition that has a high mortality rate.Animal
models of acute pancreatitis have been created to address this issue.Animal
models can consistently induce mild, moderate, or severe acute
pancreatitis.Caerulein, an analog of cholecystokinin, is administered at
supramaximal doses to elicit acute pancreatitis and is one of the most widely
used models.In this model, rats develop acute mild edematous pancreatitis, while
mice that receive caerulein administration experience acute necrotizing
pancreatitis.The most widely used model of acute severe necrotizing pancreatitis
in rats is acute pancreatitis induced by the administration of an overdose of
caerulein.It is possible to rule out the impact of neurological and hormonal
variables on the onset of acute pancreatitis using ex vivo models.
Morphological Changes Around the Portal Complex and Hepatic Vein During
Experimental Cholangitis
Georgian Biomedical News

Background: Cholangitis, or acute inflammation of the bile ducts, is associated
with infection in the bile ducts during severe obstruction.Cholangitis is
considered a clinical condition that requires urgent treatment.Despite a wide
range of surgical methods, the search for the most effective method to treat
cholangitis efficiently continues today.Against this background, studies on the
portal triad structures are undoubtedly relevant.Objectives: This study aims to
study the morphological changes of the biliary vascular structures of the portal
triad and the hepatic veins during experimental cholangitis.Methods: Twenty-five
rat models were used for experimental cholangitis.Morphological changes of the
portal triad structures and hepatic veins were studied by histological
(hematoxylin and eosin staining), immunohistochemical (Pan Cytokeratin AE1/AE3
staining), and histochemical (Masson's Trichrome staining) methods.Results:
There are infiltration areas around the portal triad; the bile ducts are
dilated, infiltrative changes are observed on the atrophied walls, and sharp
sinusoidal dilatation, edema, and hemorrhage are revealed.Microthrombi and
inflammatory processes with lymphocytes and neutrophils are detected in the
central vein.Bacterial colonies are present in the bile ducts.Conclusions:
During cholangitis, pathological processes in the liver develop very quickly.The
bile is infected; due to many bacteria and a high concentration of endotoxins,
inflammatory reactions develop in the sinusoids.Severe venous outflow impairment
takes place.
The High-Grade Oxidative Profile (OXpr), Aortic Stiffness Parameters, and
Hemogram-Derived Indices (HDI) as Predictors of Long-Term Major Adverse
Cardiovascular Events (MACEs) Following Percutaneous Coronary Intervention (PCI)
in Patients with Non-ST-Elevation Acute Coronary Syndrome (NSTE-ACS) and Chronic
Coronary Syndrome (CCS)
Georgian Biomedical News

BACKGROUND.Despite the achievements in the management of coronary heart disease
(CHD), there is a need to appropriately tailor the long-term management
strategies and risk stratification, particularly after percutaneous coronary
intervention (PCI) because of a non-ST-elevation acute coronary syndrome
(NSTE-ACS) or chronic coronary syndrome (CCS).OBJECTIVES The Present study aimed
to (i) evaluate the long-term cardiovascular prognostic value of oxidative
stress markers, arterial stiffness parameters, and hemogram-derived inflammatory
indices and (ii) compare the long-term predictive performance of the
abovementioned markers with the periprocedural SYNTAX score II (SS-II) in
Georgian patients following PCI.METHODS After PCI because of NSTE-ACS or CCS,
the annual incidence of 6-component MACEs, and values of the oxidative profile,
arterial stiffness measurements, and hemogram-derived indices (HDI) were
measured during the 36-month follow-up period in the development (100 patients
with NSTE-ACS) and validation cohorts (91 patients with CCS),
respectively.RESULTS By the multiple regression analysis NLR (0.505±0.069,
p<0.0001),OXpr (0.181±0.076, p=0.018),SBPao (0.174±0.076, p=0.023), and PLR
(0.164±0.056, p=0.004) are positively correlated with 36-month MACEs.CONCLUSIONS
The oxidative stress profile, central systolic blood pressure, and
hemogram-derived indices such as neutrophil-lymphocyte and monocytelymphocyte
ratios may be novel independent predictors of long-term major adverse
cardiovascular events.KEYWORDS Central systolic blood pressure (SBPao); chronic
coronary syndrome (CCS); major adverse cardiovascular events (MACEs);
neutrophil-tolymphocyte ratio (NLR); non-ST-elevation acute coronary syndrome
(NSTE-ACS); oxidative profile (OXpr); platelet-to-lymphocyte ratio (PLR).
Understanding the Complexities of Melanoma Immunobiology and a Review of
Immunotherapeutic Checkpoint Inhibitors
Georgian Biomedical News

Melanoma immunotherapy has emerged as a promising treatment approach for
advanced melanoma, a lethal form of skin cancer.Despite the remarkable clinical
outcomes observed with immune checkpoint inhibitors, melanoma still poses
significant therapeutic challenges.In this review, we discuss the immune
landscape of melanoma, including the interactions between tumor cells and immune
cells in the tumor microenvironment, according to the latest research studies.We
also cover the immunobiology of melanoma and the mechanisms by which melanoma
can evade immunosurveillance.Additionally, the review highlights emerging
immunotherapeutic strategies that can overcome these mechanisms, including
combination therapies and the use of novel agents that target immune
checkpoints, their efficacy, and potential adverse effects.The goal of this
timely review is to provide an up-to-date understanding of the complex interplay
between melanoma and the immune system, and to identify new opportunities for
developing effective melanoma immunotherapies.
Comparative Analysis of Pilonidal Abscess Drainage
Georgian Biomedical News

Background: A chronic sinus or a fast recurrence occurs after simple drainage of
an acute pilonidal abscess.It is reasonable to expect that the risk of
recurrence will reduce if the acute abscess is removed with minimal excision of
the primary orifices.Objectives: Our study aimed to evaluate the effectiveness
of pilonidal abscess drainage performed by minimal excision of the primary
ducts.Methods: From January 2019 through April 2022, 120 patients with pilonidal
abscesses underwent outpatient proctology surgeries at the Todua Clinic (19
females, 101 males; age range, 18-57 years).60 underwent drainage through an
incision made by minimal excision of the primary ducts (Group 1), and the other
60 underwent simple drainage by dissection of the skin closest to the abscess
(Group 2).Complete wound healing, the time of healing, recurrence, and
complication rates were the primary comparison and success criteria defined.The
length of the procedure, the time spent in the hospital, the time missed from
work, the severity of the intraoperative pain, and the postoperative cosmetic
outcomes were secondary variables.After surgery, an average follow-up time was
28 months (12-42 months).Results: In the simple drainage group, complete healing
was achieved in 35 patients (58.3%), and in the excision group -in 58 patients
(96.6%) -Chi2=25.07,p<0.001.Wound healing was rapid in the simple drainage group
-3.1±1.4 weeks, and 5.3±1.8weeks -in the excision group (p<0.001).There were no
significant differences in terms of complication rates.In the simple drainage
group, an abscess developed in 1 case (1.66%) within 10 days after surgery; in
the excision group, a wound infection developed in 2 cases (3.3%).In the simple
drainage group, recurrence occurred in 15 cases (25.0%), and in the excision
group -in 1 case (1.7%) -OR=19.7 (95%CI -2.5-154.5, p=0.005).No significant
difference was found in cosmetic results, length of hospital delay, and period
off work.Conclusions: Compared to simple drainage, pilonidal abscess drainage
with excision of the primary ducts has a significantly better rate of complete
cure and a lower recurrence rate.It is a safe outpatient operation that can be
recommended as the first-line therapy for an acute pilonidal abscess.
Technology and Composition of Saperavi-Based Cosmetic Emulgel
Georgian Biomedical News

Background: In recent years, wine has gained increasing recognition as a
functional food product that is essential for the treatment and prevention of
various kinds of diseases.Saperavi grape variety, which has a high concentration
of phenolic compounds, is particularly noteworthy from the perspective of its
application in cosmetology practices.Objectives: In this research, we have
determined the recipe and developed the technology of the cosmetic emulgel that
contains wine and oil of the Georgian grape variety "Saperavi."Methods: Modern
pharmaco-technological, biopharmaceutical, physicochemical, and structural and
mechanical methods were used in the research.The pH of the aqueous fluid
extraction of the researched emulgels was determined by the potentiometric
titration method.The osmotic activity of emulgels was determined by the
gravimetric method.The colloidal stability of emulgels was determined on a
laboratory centrifuge.The rheological characteristics of the composition were
studied on a Viscometer RVDV-1 T. Results: Based on biopharmaceutical studies,
the recipe of Saperavi emulgel was developed with the following composition:
saperavi wine 20.0 g, carbopol 940 -1.5 g, propylene glycol -5.0 g, glycerin
-5.0 g, Saperavi grapeseed oil -5.0 g, Tween 80 -1.0 g, sodium hydroxide -0.8 g,
sorbic acid -0.45 g, potassium sorbate -0.15 g, purified water up to 100.0
g.Using Saperavi emulgel on the clean facial skin of volunteers for 21 days led
to a sharp reduction in oiliness, cleansing of pores, reduction in the number of
keratinocytes, and noticeable whitening of pigment spots.Conclusions: Overall,
the Saperavi wine cosmetic emulgel formula and technology have been developed
through this study.Additionally, the developed emulgel demonstrated some
therapeutic benefits on volunteers' skin.
Litter dynamics and particulate organic matter outwelling from a subtropical
mangrove in Okinawa Island, South Japan
Prosper Laurent Mfilinge

Litter dynamics and outwelling of particulate organic matter (POM) was
investigated in a subtropical mangrove (Okinawa Island, South Japan) in order to
quantify the impact of mangrove POM on adjacent intertidal sediments.A distinct
seasonal pattern was found with maximum litter fall during the autumn season,
and minimum during winter.Total litter production between sites did not differ
significantly.Tall mangroves (average 7 m) did not show any higher contribution
to the litter production than short mangroves (average 4 m).The mean annual
litter production was 12.95 G 2.95 t ha ÿ1 (dry weight) with leaf fall
contributing more than 70% of the total litter production.Analysis of fatty
acids (FAs) in the surface sediments of an adjacent mud flat and sand flat
during the winter, spring and autumn seasons indicated that outwelling of POM
from the mangrove ecosystem occurs.However, it is spatially restricted to within
300 m from the mangrove forest.The magnitude of the outwelling increased during
spring and autumn consistent with the increase in the total litter
production.Despite the presence of mangrove-derived organic matter in the
estuarine surface sediments, autochthonous sources of organic matter, green
macroalgae (Ulva pertusa and Enteromorpha intestinalis), diatoms and bacteria
are the main contributors of sedimentary organic matter and u3 and u6 PUFAs than
mangrove-derived (POM) during winter and spring.While the contribution of
mangrove-derived POM to sedimentary organic matter is limited to the autumn
season.
Right Ventricular Global Longitudinal Strain and Its Role in the Prediction of
Chemotherapy-Induced Cardiovascular Toxicity
Georgian Biomedical News

Chemotherapy-induced cardiovascular toxicity (CTR-CVT) poses a substantial risk
to cancer patients, predominantly affecting the left ventricle (LV).However,
recent insights underscore the right ventricle's (RV) vulnerability to these
deleterious effects.This paradigm shift has prompted a burgeoning interest in
systematically evaluating the RV in cancer patients undergoing chemotherapy and
radiotherapy.Notably, the RV may manifest signs of dysfunction preceding those
in the LV, necessitating meticulous monitoring and early intervention.Over the
past few years, studies have increasingly emphasized the importance of
scrutinizing the RV in the context of cancer treatments.The early detection of
RV dysfunction emerges as a critical factor in preventing progressive damage and
enhancing overall cardiac function.The focus on diligent monitoring and timely
intervention in the right ventricle highlights a paradigmatic shift in
cardio-oncology practices.This abstract underscore the current landscape in
which right ventricle dysfunction (RVD) has become a pivotal area of focus
within cardio-oncology.By recognizing the susceptibility of the RV to
chemotherapy-induced toxicity, clinicians can implement proactive measures to
mitigate potential cardiac complications.As the understanding of these dynamics
evolves, this heightened awareness promises to shape future strategies for the
comprehensive care of cancer patients, emphasizing preserving both left and
right ventricular function throughout treatment.
Segmentação automática na avaliação da motilidade gástrica e da distribuição
intragástrica automatic segmentation in evaluating gastric motility and
intragastric distribution
Rafaela Fanelli, Madileine F. Américo, Paulo Roberto da Fonseca Filho  - Show
less +2 more
01 Jan 2014
A avaliacao da motilidade e da distribuicao intragastrica de refeicao (DIR)
utilizando a cintilografia pode auxiliar na compreensao de patologias envolvendo
o trato gastrintestinal envolva os metodos de quantificacao tradicionais por
contagem.
The Key Issues Related to Features and Perspectives of Antioxidants in Asthma
and Allergy Pharmacotherapy
Georgian Biomedical News

The review aims to highlight the anti-allergenic and anti-inflammatory potential
of some antioxidants in the pharmacological treatment of asthma and
allergies.Under various physiological and pathological conditions, oxidative
stress is both a result of and a contributor to redox metabolism.To effectively
manage existing issues, it may be essential to understand the molecular
mechanisms of basal oxidative stress and the role of antioxidants.It has been
demonstrated that antioxidants can change the biomarkers of allergic
inflammation and other consequences of allergy.Antioxidants can neutralize free
radicals and control the level of cholesterol and other lipids in the
blood.Antioxidants have anticancer activity due to prevention and inhibition of
cancer cell growth.Antioxidants stimulate and activate the regeneration of
normal, healthy cells.The complexity of each response and the multiple
physiological effects complicate clinical studies of antioxidant therapy.Based
on the existing evidence, we believe that antioxidants like zeolin-containing
Geomin Forte have promising perspectives as adjunctive pharmacotherapy for
asthma and allergic diseases.
Novel Bronchoscopic Management of Bleeding from The Respiratory Tract
Georgian Biomedical News

Background: Surgery is generally considered the treatment of choice for
pulmonary hemorrhage.Unfortunately, existing data on alternative treatment
methods are very scarce.However, the use of bronchoscopic procedures in managing
such issues is gaining acceptance.Objectives: In the present study, we aimed to
improve the efficacy of managing pulmonary bleeding with a new interventional
bronchoscopic procedure such as endobronchial valve placement (EVP).Methods: For
the first time in Georgia, we used a novel bronchoscopic procedure known as EVP
with Medlung endobronchial valves.Results: In the patients who underwent EVP,
the survival rate of 180 days after the intervention was 85.7%, compared to
54.3% in the conservative treatment group.Furthermore, it should be emphasized
that sudden deaths because of profuse pulmonary bleeding did not occur in the
research group.At the same time, 5 (19.23%) cases of pulmonary bleeding death
occurred in the control group.Conclusions: EVP demonstrated remarkable
effectiveness in pulmonary bleeding, with a lower death rate, while surgery is
linked with a significantly higher risk.
Heterogeneity correction in the construction of optimized planning in
radiotherapy using linear programming
Paulo Roberto da Fonseca Filho

A radiotherapy planning is considered optimal when all the parameters involved,
physical or biological, have been investigated and appropriate for each
patient.In this type of planning, the major concern is with the tumor
irradiation with the minimum possible damage to healthy tissues of the
irradiated region, especially the organs at risk.The optimal planning for
radiotherapy can be aided by Linear Programming and there is a wide literature
addressing this subject.However, most published mathematical formulations do not
contemplate a scenario in terms of practical applications, because they do not
incorporate the heterogeneous composition of the irradiated tissue.This paper
presents a methodology for heterogeneity correction in the composition of
different types of irradiated tissues based on proportions among their different
linear attenuation coefficient.
The Diagnostic Value of MRI in Children with Acute Hematogenous Osteomyelitis
Georgian Biomedical News

Musculoskeletal infections are a significant cause of morbidity and mortality in
children worldwide.This disease category includes osteomyelitis and septic
arthritis, although this review will focus on the specific case of
osteomyelitis.Osteomyelitis is a bone infection that occurs more often in the
long bones and can develop in children of any age.Radiological signs obtained by
magnetic resonance imaging such as bone marrow edema, intraosseous
microabscesses, subperiosteal collection (subperiosteal abscess), sharp
infiltration of soft tissues, interfascial fluid effusion, periosteum
disintegration, inhomogeneity of the femur and deformed contours were the signs,
based on which acute hematogenous osteomyelitis was diagnosed.Magnetic Resonance
Imaging (MRI) can detect radiological signs of a similar type in the early
stages of acute hematogenous osteomyelitis, which is essential role in the
timely detection of the disease and the development of a treatment plan.It
should be noted that ionizing radiation is not used during MRI, and the
patient's body is unaffected by radiation.
High risk of cardiovascular disease in patients with chronic plaque psoriasis
Georgian Biomedical News

BACKGROUND: Psoriasis has recently been associated with systemic
inflammation.Chronic skin inflammation leads to systemic inflammation, which
triggers oxidative stress, dyslipidemia, endothelial dysfunction, and insulin
resistance, increasing the risk of cardiovascular complications in these
patients.Although the link between dyslipidemia and psoriasis has been
demonstrated through various worldwide studies, dyslipidemia in psoriatic
patients is frequently neglected and mistreated in daily practice.Furthermore,
epidemiological studies have revealed that the life expectancy of patients with
severe psoriasis is 3 to 5 years lower than that of non-psoriatic controls due
to comorbidities, particularly cardiovascular disease (CVD).Consequently, many
recent studies have stressed the importance of further screening laboratory
markers for the early identification of cardiovascular risk factors and their
follow-up.OBJECTIVES: The present study aimed to assess lipid profiles in
patients with chronic plaque psoriasis to find cardiovascular disease risk
factors and identify a possible association between the c risk score and plaque
psoriasis severity.METHODS: We investigated the lipid profiles of 70 patients
with moderate to severe chronic plaque psoriasis (CPP) and 30 healthy
individuals.The psoriasis area and severity index (PASI) was used to determine
the severity of psoriasis.In addition, all patients completed Dermatology Life
Quality Index (DLQI) questionnaire.RESULTS: Elevated concentration of total
serum cholesterol (TC), triglycerides (TGs), and low-density lipoprotein
cholesterol (LDL-C) and low concentration of high-density lipoprotein
cholesterol (HDL-C) was detected in psoriasis patients compared to
controls.Above mentioned alterations were more prominent in female patients with
severe psoriasis.CONCLUSIONS: Dyslipidemia is a common finding in patients with
psoriasis and correlates with the severity of psoriasis.Lipid profiles should be
a part of routine screening tests in patients with chronic plaque psoriasis for
the early identification of dyslipidemia and the timely initiation of
lipid-lowering treatment.
Microstructural Features of Primula woronowii Losinsk., Primula macrocalyx
Bunge. and Primula saguramica Gavr. from Georgian Flora
Georgian Biomedical News

Background: The characterization and study of plants begin with the study of
morphological and micro-diagnostic signs.It is essential to determine the common
and distinguishing features of the species of the genus Primula to facilitate
their identification.Objectives: The paper presents the macro-and
micromorphological characteristics of three species of the genus Primula L.: P.
woronowii Losinsk., P. macrocalyx Bunge, and P. saguramica Gavr.In addition,
based on the microstructural and anatomical characteristics, the paper
distinguishes between two closely related species: P. macrocalyx Bunge and P.
saguramica Gavr.Methods: Microstructural research on experimental samples was
carried out using standard laboratory methods adopted in microtechnology.The
microtechnical investigation used light microscopes (Carl Zeiss, Jeneval, and
Omax).Materials were documented using a digital camera (Canon Digital IXUS 75),
and microphotographs were graphically processed in the Adobe Photoshop CS5
program.Results: Based on the data, the following common and distinguishing
microstructural features of P. woronowii, P. macrocalyx, and P. saguramica were
established: The basal cells of the epidermis of the leaf of the studied species
are non-circular, with a curved and curved-walled structure;The ventilation
system is simple, a normocytic structure; the leaf is bifacial Dorsoventra luri,
amphistomatous (P.woronowii, P. saguramica), and hypostomatic (P.macrocalyx);
Conductive tissue both in the leaf and the aboveground axis organs has an open,
collateral, vascular fiber structure; P. macrocalyx and P. saguramica, which are
closely related by macro-and micromorphological characteristics, can be
separated by the anatomical structure of the mesopetiole zone of the leaf stalk
and the structural elements of the wood in the central cylinder of the
root.Conclusions: Common and distinguishing features of all three species were
identified: The basal cells of the upper and lower epidermis of the leaves of P.
woronowii, P. macrocalyx, and P. saguramica are non-stitched, curvilinear, and
curved-walled; also, a chaotically arranged stomata apparatus differentiated
into a simple, anomocytic type is typical for all three species, and the
presence of a cystolith in the cells of the upper epidermis of P. woronowii leaf
is observed.In all three species of petiole xylem, there are large, oval-shaped
openings surrounded by mechanical-type cells.Small-caliber spaces in P.
woronowii and P. saguramica are arranged longitudinally, while in P. macrocalyx,
they are arranged asymmetrically with differentiated spherical lumens.The
cross-section of the axial organs of the flower is oval or spherical in outline;
the flower stem, but not the stalk, is characterized by the obliteration of
medullary cells; P. saguramica collenchyma is of a mixed type, while P.
woronowii and P. macrocalyx have lamellar collenchyma.Endodermal cells of P.
saguramica have clearly expressed Casparian strips, but in the P. woronowii and
P. macrocalyx endoderm, they are less apparent; the central cylinder of P.
woronowii and P. macrocalyx is pentarcular, while P. saguramica tends to have a
multi-beam xylem structure.In all species, the cells of the central tissue of
the crown petals are exceptionally thin-walled, isocytic, and surrounded by
dense epidermal tissue; their transitional tissue is incomplete; only the lumens
of the conducting vessels of the xylem are visible.
Antiplatelet Therapy for Secondary Prevention After Myocardial Infarction in
Antiplatelet-Naive High Cardiovascular Risk Patients with Non-Obstructive
Coronary Artery Disease
Georgian Biomedical News

BACKGROUND.The growing evidence indicates the importance of non-obstructive
coronary artery disease (NOCAD), with a high-risk of MACEs.The relevance of
antiplatelet therapy is high and depends on a type of MINOCA.However, the
effectiveness of different antiplatelet treatment regimens and secondary
prevention strategies for patients with non-obstructive coronary artery disease
is still unclear.OBJECTIVES In our previous cohort study, we found that
secondary prevention with dual antiplatelet therapy with aspirin and P2Y12
receptor antagonist clopidogrel in patients with NOCAD was not significantly
effective than aspirin alone in reducing 1-year MACEs.Because the development
and validation cohorts of patients with NOCAD were heterogeneous in terms of
cardiovascular risk, in the current study we aimed to compare the preventive
effect of DAPT with aspirin alone in high cardiovascular-risk patients.METHODS
Following the aim of our study, we selected 15 of 55 MINOCA patients with a high
10-year risk for ASCVD (≥20%) from the DAPT group and 19 of 60 patients with the
same risk from the no-DAPT group. RESULTSThe results of our previous and present
studies corroborate previously published data.DAPT had no secondary preventive
effect on one-year MACE in MINOCA patients with different cardiovascular
risks.CONCLUSIONS The use of DAPT in patients with MINOCA is a topic for
discussion and requires further investigations with a long-term follow-up
period.KEYWORDS Atherosclerotic cardiovascular disease (ASCVD) risk; dual
antiplatelet therapy (DAPT); myocardial infarction with non-0bstructive coronary
artery (MINOCA) disease; non-obstructive coronary disease (NOCAD).
Diagnostic Capabilities of Ultra-low-dose Computed Tomography with a Dose
Equivalent to Chest X-ray Radiography
Georgian Biomedical News

Background: Digital chest X-ray radiography (CXR) is the imaging modality of
first choice for detecting chest pathology.The average effective dose for CXR
(posteroanterior and lateral projection) is 0.10 mSv (range: 0.01 to 0.26
mSv).CT examinations using ultra-low-dose CT (ULDCT) with doses equivalent to
CXR examinations allow for detecting chest pathologies and pulmonary nodules
with comparable sensitivity to previous standard or low-dose CT techniques.The
ULDCT may improve the detection of pulmonary nodules and diagnose a broader
range of pathologies.Objectives: This study aims to show the possibility of
recognizing and defining a variety of chest pathology using ultralow-dose CT of
the chest below 1mSv.Methods: For all patients, after initial CXR, chest
ultra-low (ULDCT) and standard-dose CT were performed.The ultra-low dose was
achieved by fixing the tube voltage, lowering the tube current, or reducing the
scan length.The field size was adapted individually for each patient.In order to
reduce radiation exposure, sonograms were not obtained throughout this
study.Instead, a conventional laser beam was used to manually set up the start
of the scan range (from the lung apex to the whole diaphragm) at the gantry.The
CT scan was taken while holding a breath during inspiration with the following
parameters: helical scan, 80 kV, 30 mA, 80 0.5 mm collimation, and 0.3 seconds
rotation time.No iodinated contrast material was used.Results: We compare the
imaging properties of low voltage (80 kV -dosages equal to CXR) CT to a standard
voltage (120 kV) CT and CXR in different chest pathologies and lung nodules with
diameters from 4 to 30 mm.The sensitivity of ULDCT was 100% compared to CXR.CXR
was considered diagnostic in 98% and ULDCT in 100%.The mean perceived confidence
for diagnosis was 88±12% with CXR and 98±2% with ULDCT.Ultra-low-dose CT offered
higher sensitivity for lesions like consolidation (97%), pleural effusion (95%),
fibrosis (92%), and solid pulmonary nodules (91%).Conclusions: ULDCT is a safe
and effective method for evaluating lung nodules of different sizes or
densities.
Wetlands Restoration and Conservation
Prosper Laurent Mfilinge

Wetlands are probably the earth's most important freshwater resource and are
also the most threatened.They perform manifold functions in the maintenance of
the ecological balance of the region.Some of the important functions include
water storage, protection from storms and floods, recharge of ground water,
water purification, fisheries, agriculture, wildlife resource, transport,
recreation, etc. India is richly endowed with wetlands evident from the
high-altitude lakes of the Himalayas; floodplain wetlands of major river systems
and their extensive network of tributaries draining from the Indian landmass in
all directions.They are fragile ecosystems that are susceptible to damage even
with only a little change in the composition of biotic and abiotic factors.They
are threatened due to inadequate water holding capacity, excessive withdrawal,
pollution due to raw sewage and sullage, industrial effluents, eutrophication,
leached fertilizers and insecticides.Bangalore (Karnataka state) is endowed with
rich wetland resources that are also facing degradation by the aforementioned
threats.The degradation in the water quality affects the floral and faunal
population along with the people dependent on these ecosystems.Socio -economic
surveys indicate that lakes with water quality conforming to the prescribed
standards have a high economic dependence (Rachenahalli -as high as
Rs.10,000/day), whereas for eutrophic lakes, it may be as low as Rs.20/day
(Amrutahalli).This necessitates the need for restoration and formulation of
conservation strategies for sustainable management of wetlands.This paper
suggests suitable strategies for the restoration of lakes with an overview on
the status of wetlands and prevailing legal measures to protect them.
INTRODUCTION :Wetlands, as the term implies, are 'Wet' lands that exist because
the inflow of water exceeds the outflow for brief to extended periods of time
during the growing season.Inland wetlands receive
Investigating the need for an antimicrobial stewardship program
Rasha Abdelsalam Elshenawy
01 Mar 2014
FADIC “First Arabian Drug Information Center” is an online drug information
center, available in both Arabic and English language. All FADIC team members
are board certified pharmacotherapy specialists (BCPS). It aims at improving the
quality of medication use practice and increasing health care awareness. FADIC
offers a variety of online trainings, such as online conferences, in addition to
continuous improvement programs that help pharmacists stay updated with the
latest advances in clinical practice. FADIC served a variety of successful
programs like the “Drug information program and workshop”, the “patient
Counselling and education program” and many others. Pharmacy education is
continuously developing, incorporating more innovative strategies, such as
active-learning techniques which help in the implementation of effective
pharmacy continuous improvement programs. The online surveys such as Pre & Post
Program Survey, Post Session Survey and Middle program survey are adopted to
attain the achievement of The Learning Program objectives, evaluate the
effectiveness of each session and the streaming of the sessions accordingly. One
of the new upcoming programs provided by FADIC is the “FADIC antimicrobial
stewardship program and workshop”. Antimicrobial stewardship is a coordinated
program that promotes the proper use of antibiotics and other antimicrobials, in
order to improve patient outcomes, reduce microbial resistance and decrease the
spread of infections caused by multidrug resistant organisms. Antibiotics
represent one of the greatest achievements in the medical field, changing once
potentially fatal infections to easily treatable ones. Unfortunately, the
irrational use of antibiotics is leading the world to an impending disaster, due
to the development of resistance. The rapidly growing antibiotics resistance,
prompts the need for adopting new, strict guidelines for antibiotics use. The
objectives of this poster abstract are to assess the need for antimicrobial
stewardship program as well as determine the qualifications of all interested
healthcare professionals who need this program, in addition to determining the
best active learning techniques suitable for achieving the desired outcome from
online learning antimicrobial stewardship program.
Interrelationship of Hepatic Veins with Separate Components of Portal Triad
Georgian Biomedical News

Background: The structure of the intermediate tissue between the components of
the portal triad and the hepatic veins, within the zone of the portocaval
connective tissue connections, depends on which of the elements of the triad is
close to the hepatic vein because the connective tissue surrounding each of the
elements of the triad has its characteristic specificity.Within the framework of
the portocaval connective tissue connection, the interrelationship of the
hepatic veins with the elements of the portal triad varies.Objectives: The goal
of this study is to determine the direct connection of individual components of
the portal triad with the hepatic veins.Methods: Histotopographic and
histological preparations from the archival materials of the Department of
Clinical Anatomy and Operative Surgery were used for the investigation.The
tissue samples material was prepared from 45 livers of adults of both sexes.In
addition, the documented archival samples of the preparations, which had been
prepared with the macro-microscopic classical preparation method from the liver
of adults whose cause of death was unrelated to liver pathology, were also
used.Results: In some zones of the intersection of the portal tract and the
hepatic vein, their connective tissue sheath appears to create a nodular form,
in the thickness of which the hepatic veins establish a direct relationship with
the components of the portal triad.The components of the portal and caval
systems are united by a common connective tissue compartment.Conclusions: In the
portocaval complex of the liver, the hepatic vein is connected to the components
of the hepatic portal triad (portal vein, branches of proper hepatic artery,
bile ducts) as the fourth element of this triad.All of them are surrounded by a
perivascular fibrous capsule, which may contribute to spreading the inflammatory
processes from the bile ducts to the hepatic veins.
Infrared Visualization of the Prostate Cancer
Georgian Biomedical News

BACKGROUND.Among oncological diseases, prostate cancer is the second leading
cause of death in men.Despite the latest diagnostic achievements, there is no
precise method for differentiation of clinically significant malignant
alterations of the prostate from insignificant changes to avoid undertreatment
or overtreatment of such patients.OBJECTIVES The present study aimed to (i)
identify the dependence of prostate tissue resolution on infrared wavelength,
(ii) differentiate malignant tissue from benign prostatic hyperplasia, and (iii)
develop diagnostic software for processing the obtained infrared images.METHODS
The postsurgical biomaterials of the prostate gland were distributed among two
groups.Group 1 consisted of 78 samples of prostate cancer tissue obtained after
radical prostatectomy, and group 2 consisted of 48 samples of benign prostatic
hyperplasia obtained by transvesical prostatic adenomectomy.The infrared images
of retained biomaterials were processed by special diagnostic computer software.
RESULTSThe highest resolution of prostate tissue was obtained in the range of
840-860 nm wavelength of the infrared specter.The intensity of the infrared
images ranged from 0.039550 to 0.293524 for prostatic cancer, and from 0.3245699
to 0.992317 for normal prostatic tissue.CONCLUSIONS Infrared imaging is an
effective method of differentiation of prostatic cancer from benign prostatic
hyperplasia.KEYWORDS Benign prostatic hyperplasia; infrared imaging; prostatic
cancer.
Clinical Features of the Development and Treatment of Carious and Non-carious
Lesions in the Cervical Area of Human Teeth
Georgian Biomedical News

Background: The defects in the cervical area of human teeth are challenging for
clinicians because of the hardly accessible location, multietiology, and three
completely different tissues.Despite multiple investigations, the ideal material
that would resolve the abovementioned issue and be perfect for filling class 5
defects is still being searched for.Objectives: Our study aimed to identify
carious and non-carious diseases of human teeth cervical area and evaluate
restoration's clinical efficiency using adhesive systems of different
generations.Methods: We examined and treated 5,892 teeth in 299 patients.In the
first stage of the study, a special questionnaire was developed to provide
comprehensive data for each patient.In the second stage, we restored 90 cervical
defects of teeth in 43 patients.During treatment, we divided the teeth among
Group A (with the need for replacement and retreatment of existing restorations)
and Group B (with de novo cervical defects) and six subgroups (three in each
group: A-1,2,3; and B-1,2,3).We used three types of adhesive systems: fourth-and
fifth-generation adhesives in subgroups A1, A2, B1, and B2 and
seventh-generation adhesives in subgroups A3 and B3.We evaluated the restoration
status according to Modified USPHS criteria: A (Alpha): ideal restoration; B
(Bravo): clinically acceptable restoration; C (Charlie): clinically unacceptable
restoration; and (Delta): defective restoration.Results: According to the study
results, carious and non-carious cervical lesions are more common with advanced
age.All subgroups tended towards Criteria A, but neither group reported Criteria
C or D. There were no significant differences between groups.The effectiveness
of all three types of adhesives also was similar in both groups.Conclusions: A
comparison of the three types of adhesives demonstrated their equal efficacy in
both the group of patients requiring replacement of existing restorations and
the group of de novo patients with teeth cervical area defects.
Comparative safety study of the phenolic constituents of smokebush (Cotinus
coggygria) leaves
Georgian Biomedical News

Background: The extract (CPLSB) from the smokebush (Cotinus coggygria) leaves is
recommended as the endodontic irrigation solution, and its purified fraction
contains mainly hydrolyzable tannins (PFTLSB).Objectives: The purpose of the
present study was to define the safety margins as well as the potential
irritative and allergenic effects of a polyphenol-containing extract (CPLSB)
from the smokebush (Cotinus coggygria) leaves.Methods: The experiments were
conducted following the OECD Guidelines for Chemical Testing, followed by probit
analysis to precisely establish the median lethal doses (LD50) of CPLSB and
PFTLSB.Results: The LD50 of CPLSB following intraperitoneal and oral dosing in
mice was found to be 19 mg/kg and 389 mg/kg, respectively.LD50 of PFTLSB in a
similar experiment was 46 mg/kg and 720 mg/kg.Both compositions revealed no
signs of toxicity, and the absence of local irritative or allergic reactions was
observed as well.Conclusions: PFTLSB is safer for the intended use because it
appears to be almost twice as non-toxic as CPLSB, the maximum oral irrigant dose
of which varies between 7 and 14 mg/kg.
Comparison of Inflammatory and Oxidative Stress Markers Among Patients with
Non-Obstructive vs. Obstructive Coronary Artery Disease
Georgian Biomedical News

BACKGROUND.Myocardial infarction with non-obstructive coronary artery disease
(MINOCA) accounts for 5-20% of all cases of myocardial infarction.The growing
evidence indicates the importance of oxidative stress and chronic inflammation
in the heterogenous pathophysiology of MINOCA.OBJECTIVES In the present study,
we aimed to evaluate oxidative and inflammatory statuses in patients with MINOCA
and compare them with the same indices of patients with obstructive coronary
disease non-ST-elevation acute coronary syndrome (NSTE-ACS).METHODS Overall, 165
of 1018 patients admitted to the Coronary Care Unit of Tsinamdzgvrishvili Center
of Cardiology LTD (Tbilisi, Georgia) because of the first episode of acute
coronary syndrome (ACS) was divided into two groups: 115 patients with MINOCA
were distributed into the group 1, and 50 patients with obstructive coronary
disease NSTE-ACS into the group 2. Oxidative stress and inflammatory markers
were evaluated in study patients. RESULTSWe found an increase in free radical
concentrations in both groups of study patients, but there was no difference in
the mean amount of overall organic radicals (FORT)(p=0.412).We also found a
significantly lower mean concentration of plasmatic antioxidant compounds (FORD)
in patients with MINOCA (p=0.036)compared with NSTE-ACS patients, indicating a
more pronounced depletion of antioxidant potential in MINOCA patients.The
results of admission inflammatory markers, such as hs-CRP and hemogram-derived
NLR, suggest significantly higher inflammatory status in MINOCA patients than in
those with NSTE-ACS. CONCLUSIONSThe results of the present study emphasize the
significance of oxidative stress and inflammation in the pathogenesis of
MINOCA.KEYWORDS Free Oxygen Radical Defense (FORD); Free Oxygen Radical Test
(FORT); Myocardial infarction with non-obstructive coronary artery disease
(MINOCA); Oxidative profile; Oxidative stress; Oxidative-reductive balance
(REDOX index).
Autoimmunity and Clinical Markers in Chronic Spontaneous Urticaria: A
Retrospective Cohort Study
Georgian Biomedical News

BACKGROUND.Chronic spontaneous urticaria (CSU) is a skin condition that results
in itchy hives or welts on the skin.The underlying cause of CSU is not fully
understood, but it is believed to be mainly associated with
autoimmunity.OBJECTIVES In this retrospective study, we analyzed correlations
between several clinical and biological markers and their associations with
disease control, response to H1-antihistamines, autoimmunity (ANA,
IgG-anti-TPO), and distribution of comorbidities. METHODSThe study was conducted
from September 2020 to December 2022 at the Center of Allergy and Immunology in
Tbilisi, Georgia.131 adults and adolescents (≥ 12 years old) with a diagnosis of
CSU were included.RESULTS Among the 131 patients included in the study, 83%
(n=109) were female, and 17% (n=22) were male.The average age was 33.71 years
(range 12-76).Antinuclear antibodies (ANA antibodies) were found to be positive
in 17% of patients, while 33% had IgG-anti_TPO antibodies.Comparison between the
controlled (n=83) and the uncontrolled disease group (n=48) shows that there is
no substantial difference in age, but there are significant differences in sex
(more females in the controlled group), total IgE (lower in the uncontrolled
group), and the presence of ANA and anti-thyroid peroxidase (anti-TPO)
antibodies (both higher in the uncontrolled group).The p-values for sex, total
IgE, ANA, and anti-TPO are 0.003, 0.007, 0.03, and 0.028,
respectively.CONCLUSIONS The results suggest that autoimmunity may play a role
in the development of CSU and that treatments targeting the underlying
autoimmune response may be effective in managing the condition.KEYWORDS
Autoimmunity, ANA antibodies; chronic spontaneous urticaria; IgG-anti-TPO
antibodies; total IgE.
The Humoral Immunity Features of COVID-19 in the West Georgia Population
Georgian Biomedical News

Background: Background: SARS-CoV-2 is still active and spreading among us, even
though the COVID-19 disease pandemic is believed to have been terminated due to
the extraordinary efforts of healthcare professionals and scientists.Thousands
of people are being infected today.Objectives: The current study aimed to
analyze existing data on the transmission of the SARS-CoV-2 virus among the West
Georgia population and investigate the humoral immune response generated by the
viral infection and vaccination as well.Methods: The research was conducted
between March 2022 and March 2023.The study group included 400 adults (69% women
and 31% men) residing in Kutaisi.Study patients were distributed among four
groups: (i) Group 1: patients with confirmed SARS-CoV-2 infection without
previous vaccination; (ii) Group 2: previously vaccinated patients without
SARS-CoV-2 infection; (iii) Group 3: previously vaccinated patients with
confirmed SARS-CoV-2 infection; and (iv) Group 4: uninfected and unvaccinated
patients.All groups were divided into subgroups with positive and negative
humoral responses.Each subgroup was further divided into subgroups based on
gender.The data were analyzed by STATA 17. Statistical significance was defined
as p < 0.05.Results: 55% of the study population was vaccinated, mainly with
Pfizer's vaccine.The incidence of SARS-CoV-2 infection was equal for women and
men, and they developed active immunity almost equally.The average rate of
humoral immunity was 60%, with the highest rate (≈85% (r<0.05,p<0.001) in the
triple-vaccinated individuals.Finally, the concentration of anti-SARS-CoV-2 IgG
antibodies was particularly high (32% in the previously vaccinated patients with
confirmed SARS-CoV-2 infection).The average duration of effective concentration
of G-class immunoglobulins was maintained for 6-12 months.Conclusions: In most
cases, the SARS-CoV-2 infection in combination with the Pfizer vaccination
induces a maximal humoral immune response, although not always and not for long.
Healthy Nutrition Can Impact Women's Fertility -Myth or Reality?
Georgian Biomedical News

Nowadays, women live in a stressful environment with numerous responsibilities
and challenges, and fertility-related difficulties are one of them.Many factors
influence female fertility, such as genetics, age, environment, sexually
transmitted infections (STIs), lifestyle, etc.Researchers seek to find out which
factors positively impact female fertility.The broad discussion around the
interdependent correlation between healthy nutrition and fertility has recently
unfolded.Studies give credible information on how vital nutrient density and
food quality are for women's health.Consuming unsaturated fats, vegetables,
fruits, fish, whole grains, legumes, and nuts positively affects female
fertility.In contrast, trans fats, refined carbohydrates, animal protein, and
others can negatively influence the reproductive system.
Heterogeneity in INF-γ Levels Among Children with Different Types of Epilepsy
Georgian Biomedical News

Background: Epilepsy is the most frequent chronic neurologic disorder of
childhood, with a reported higher incidence in underdeveloped countries.The
pathogenesis of epilepsy involves complex mechanisms that are still not fully
understood.In recent years, researchers have shown increasing interest in
understanding the role of inflammation in epilepsy.One such component of the
neuroinflammatory cascade is Interferon-Gamma (IFN-γ), a pro-inflammatory
cytokine known for its role in immune responses.However, recent studies have
revealed that IFN-γ possesses multifaceted properties, including potential
neuroprotective and anticonvulsant effects.Multiple studies have reported
elevated levels of IFN-γ in the serum, cerebrospinal fluid, and brain tissue of
patients with epilepsy.The precise mechanisms through which IFNγ contributes to
epilepsy remain incompletely understood.Objectives: The present study aimed to
compare IFN-γ levels in drug-resistant epilepsy patients with those with
well-controlled epilepsy and healthy controls.Methods: This prospective
cross-sectional study enrolled 56 children: 20 with drug-resistant epilepsy, 20
with well-controlled epilepsy, and 16 healthy controls matched in demographic
characteristics.Venous blood samples were collected from all participants for
cytokine (chemokines, PGE2, and interferon-gamma (IFN-γ) analysis.Results: IFN-γ
levels were not elevated in the study groups.The results indicate a considerable
heterogeneity in IFN-γ levels among different types of epilepsy.The
interquartile range (IQR) of targeted IFN-γ was lower in the drug-resistant
epilepsy patients compared to well-controlled epilepsy and healthy control
groups.Conclusions: The role of IFN-γ in epilepsies is complex and
context-dependent.The precise role of IFN-γ in epilepsy warrants exploration;
further research is needed to explore the current understanding of the
relationship between IFN-γ and childhood epilepsy.The findings from this study
may contribute to a better understanding of the role of cytokines in the
pathogenesis of epilepsy and could potentially support the development of novel
therapeutic approaches targeting cytokine dysregulation in epilepsy.
Genetic Heterogeneity of Iduronate-2-Sulfatase in Children Diagnosed with
Mucopolysaccharidosis Type II in Azerbaijan
Georgian Biomedical News

Background: Mucopolysaccharidosis (MPS) is a rare hereditary disease of
lysosomal storage with an X-linked recessive inheritance type, and Hunter's
disease is a fairly rare manifestation of mucopolysaccharidosis type
II.Objectives: In the present study, a modern molecular-genetic diagnostic
method such as New Generation Sequencing (NGS) was used for the first time to
identify iduronate-2-sulfatase (IDS) mutations in the Azerbaijan
population.Methods: In four patients with similar clinical manifestations of
Hunter's disease, we carried out enzyme and molecular genetic analysis for all
MPS types: MPS I, MPS II, MPS III, MPS IV, and MPS VI.Results: All four probands
observed iduronate-2-sulfatase activity deficiency that corresponded with MPS
type II.Molecular genetic analysis of the IDS gene identified three different
mutations: -1215del, 1106 (С-G), and 322 (G-T).In consequence of those
mutations: -1215del, 1106 (С-G), and 322 (G-T) appear correspondent amino acid
substitution in synthesized protein -enzyme composition: Leu406Phefs*34,
Asp358Leu, Tyr108Asp, relatively.Conclusions: Taking into account the
reproductive age of the parents of affected children, further preventive
prenatal studies are recommended in the families of the index patients.
Improvement of Targeted Therapy by E. coli Phage-lysate Vaccination: Tumor
Microenvironment Modulation and Magnetic Nanoparticle Delivery Enhancement in
Tumor Tissue
Georgian Biomedical News

BACKGROUND.The tumor microenvironment (TME) has an essential role in cancer
development.TME reduces the drug and nanoparticle delivery in tumor tissue and
minimizes the treatment outcomes.The new therapeutic strategies of TME
reprogramming have shown great promise.One such strategy is TME modulation by
the E. coli phage-lysate (EcPHL) vaccination with TME modification and
enhancement of magnetic nanoparticles (mNP) uptake by tumor tissue.OBJECTIVES In
the current study, we aimed to evaluate the effects of EcPHL vaccination on TME
and mNP distribution in the tumor tissue.METHODS Experiments were carried out on
20-25 g BALB/c male mice.EcPHL intraperitoneal vaccinations (0,25 ml, 3x, with
3-day intervals) were initiated after 6 days of the Ehrlich ascites carcinoma
(EAC) cells subcutaneous inoculation and intratumoral administration of mNP (5
mg/cm3) -on the 4 th day after the last administration of EcPHL.Tumor volume was
measured using a Vernier caliper.Tumor tissue samples, and the spread of mNPs in
tumor tissue were estimated using microscope Leica DM6B, Motic Easy Scan Pro
scanner (Ultrahigh NA APO 20X [NA 0,75], resolution 40X:0,25 mm/pixel).
RESULTSThe mean tumor volume (MTV) was significantly reduced in EcPHL-vaccinated
mice.The morphological investigation has shown an increased number of
immunocompetent cells, basically macrophages, around the atypical cells in the
tumor stroma, infiltrating the inflammatory regions and necrotic areas in the
center of the tumor tissue.The inflammatory infiltrations with macrophages were
prevalent in the necrotic areas.After mNP injection, the pigment was spread at a
distance from the injection site as concentrated masses in extracellular regions
of tumor tissue.Areas of inflammatory infiltration and concentration of
iron-containing cells were significantly higher in the EcPHL-vaccinated mice
compared to unvaccinated, and iron-containing macrophages were detected at a
much greater distance from the injection site.CONCLUSIONS EcPHL stimulates
anticancer responses, inhibits tumor growth, and enhance the distribution of mNP
in tumor tissue.KEYWORDS Cancer; E. coli phage-lysate (EcPHL); magnetic/iron
nanoparticles (mNP); Tumor microenvironment (TME).
Magnetic multiparticulate colonic delivery systems evaluated by AC
Biosusceptometry
Paulo Roberto da Fonseca Filho

The biomagnetic technique called Alternate Current Biosusceptometry (ACB) is a
proposal to evaluate a multiparticulate drug delivery system in the human
gastrointestinal tract.Results show that ACB was able to quantify the
gastrointestinal transit and spreading of the magnetic material and is an
attractive tool for pharmaceutical research.
Right Ventricular Global Longitudinal Strain and Its Role in the Prediction of
Chemotherapy-Induced Cardiovascular Toxicity
Georgian Biomedical News

Chemotherapy-induced cardiovascular toxicity (CTR-CVT) poses a substantial risk
to cancer patients, predominantly affecting the left ventricle (LV).However,
recent insights underscore the right ventricle's (RV) vulnerability to these
deleterious effects.This paradigm shift has prompted a burgeoning interest in
systematically evaluating the RV in cancer patients undergoing chemotherapy and
radiotherapy.Notably, the RV may manifest signs of dysfunction preceding those
in the LV, necessitating meticulous monitoring and early intervention.Over the
past few years, studies have increasingly emphasized the importance of
scrutinizing the RV in the context of cancer treatments.The early detection of
RV dysfunction emerges as a critical factor in preventing progressive damage and
enhancing overall cardiac function.The focus on diligent monitoring and timely
intervention in the right ventricle highlights a paradigmatic shift in
cardio-oncology practices.This abstract underscore the current landscape in
which right ventricle dysfunction (RVD) has become a pivotal area of focus
within cardio-oncology.By recognizing the susceptibility of the RV to
chemotherapy-induced toxicity, clinicians can implement proactive measures to
mitigate potential cardiac complications.As the understanding of these dynamics
evolves, this heightened awareness promises to shape future strategies for the
comprehensive care of cancer patients, emphasizing preserving both left and
right ventricular function throughout treatment.
Infrared Visualization of Prostate Cancer Tissues with Various Gleason Scores
Georgian Biomedical News

BACKGROUND: Prostate cancer is the second most significant cause of male
mortality, beneath lung cancer.Prostate-specific antigen (PSA) and digital
rectal examination (DRE) play the most critical roles in identifying prostate
cancer, and their use has risen with the incidence of prostate cancer
worldwide.Cancer-specific mortality has been reduced as a result of these
tests.On the other hand, the PSA and DRE led to overdiagnosis, overtreatment,
and inappropriate prostate cancer testing.This situation led to modifications in
prostate cancer recommendations, most notably by the US Preventive Services Task
Force (USPSTF) in 2012.OBJECTIVES: This study evaluated the infrared
transmittance of transrectal prostate biopsy tissue to see a possible difference
between the total and biopsy tissue.We also saw variations based on the total of
Gleason's scores.To fulfill the stated aim, in the following tasks, (i) we
investigated the relationship between prostate tissue resolution and radiation
wavelength in the spectrum's infrared area, and (ii) elaborated software that
allowed the received images to be processed in an infrared environment and
detect prostate cancer tissue with a 95% confidence interval.METHODS: 174
formalin-fixed and paraffin-embedded (FFPE) cases (prostate biopsies) were
included in the study.There were five groups based on Gleason score (GS 6, and
GS 9 [4+5] and 10 [5+5] were combined).After the infrared exposition of each
FFPE biopsy sample, our algorithm generated the image.Furthermore, the findings
were matched to histomorphology reports.We employed the software's integrated
statistical analysis and students' t-distribution.RESULTS: The experiment
revealed that when the Gleason score sum was 6 (3+3) and 7 (3+4) or 7 (4+3),
image intensities in the infrared environment were almost indistinguishable from
each other with 95% confidence, which cannot be said for prostate tissue with a
higher Gleason score sum (8 (4+4; 3+5); (5+3) and 9-10).However, these changes
were not evident in the first three groups since the experiment was conducted on
biopsy material with a tissue thickness of 1 mm.CONCLUSIONS: Infrared radiation
can identify prostate cancer in prostate biopsy tissues.However, further
investigations are needed to validate the modality's effectiveness for prostate
cancer diagnosis.
Protective Effect of Herniarin on the Ionizing Radiation-Induced Alterations of
Erythrocyte Membrane Proteins
Georgian Biomedical News

BACKGROUND.Exposure to ionizing radiation leads to the intensification of
oxidizing processes that directly or indirectly alter target molecules forming
reactive oxygen species targeting cell membrane lipids and proteins.There is a
need for new antioxidants to reduce the effects of ionizing radiation.OBJECTIVES
Our study aimed to determine changes in the absorption spectrum of erythrocyte
membrane proteins in gamma-irradiated mice and evaluate the potential protective
effect of the antioxidant Herniarin.METHODS Overall, 18 2-month-old mice were
distributed evenly among the control (group I) and two experimental (group II
and group III) groups.The whole-body irradiation of experimental mice with 137
Cs was performed at a dose rate of 1,1 Gy/min for a total dose of 5 Gy with a
"Gammacapsule-2", and animals of group 3 were treated with Herniarin (20 mg/kg)
for five days before and one hour after irradiation.The erythrocyte membrane was
separated using Hast Method, and absorbance spectra were measured with a
spectrophotometer at 280 nm wavelength (Spectro UV-UIS BEAM 8 AUTO CELL
[UVS-2800]) on 2 nd , 7 th , 14 th and 30 th post-irradiation days. RESULTSThe
Herniarin-treated mice showed approximately the same results as irradiated mice
on the 2 nd and 7 th post-irradiation days.Furthermore, on days 14 and 30
absorption spectrum of erythrocyte membrane proteins significantly increased
(P<0.05) in the Herniarin-treated experimental group.CONCLUSIONS The ionizing
irradiation induces a decrease in the intensity of the erythrocyte membrane
absorption spectrum at 280 nm due to intensive tyrosine-phosphorylation of B3p
under oxidative stress conditions.Impairments manifested on post-irradiation day
7, were preserved during the whole post-irradiation period.Herniarin, as a
potent antioxidant, significantly amplified the absorption spectrum compared to
the control group on days 14 and 30 of the post-irradiation period.KEYWORDS
Erythrocyte; Herniarin; ionizing radiation.
Lake and River Restoration: Method, Evaluation and Management
Prosper Laurent Mfilinge
30 Mar 2020
Eutrophication has become one of the major environmental issues of global
concern due to the adverse effects on water quality, public health and ecosystem
sustainability.Fundamental research on the restoration of eutrophic freshwaters,
i.e., lakes and rivers, is crucial to support further evidence-based practical
implementations.This Special Issue successfully brings together recent research
findings from scientists in this field and assembles contributions on lake and
river restoration.The 12 published papers can be classified into, and contribute
to, three major aspects of this topic.Firstly, a background investigation into
the migration of nutrients, and the characteristics of submerged biota, will
guide and assist the understanding of the mechanisms of future
restoration.Secondly, various restoration strategies, including control of both
external and internal nutrients loading, are studied and evaluated.Thirdly, an
evaluation of the field sites after restoration treatment is reported in order
to support the selection of appropriate restoration approaches.This paper
focuses on the current environmental issues related to lake and river
restoration and has conducted a comprehensive bibliometric analysis in order to
emphasise the fast-growing attention being paid to the research topic.The
research questions and main conclusions from all papers are summarised to focus
the attention toward how the presented studies aid gains in scientific
knowledge, engineering experience and support for policymakers.
Interrelationship of Hepatic Veins with Separate Components of Portal Triad
Georgian Biomedical News

Background: The structure of the intermediate tissue between the components of
the portal triad and the hepatic veins, within the zone of the portocaval
connective tissue connections, depends on which of the elements of the triad is
close to the hepatic vein because the connective tissue surrounding each of the
elements of the triad has its characteristic specificity.Within the framework of
the portocaval connective tissue connection, the interrelationship of the
hepatic veins with the elements of the portal triad varies.Objectives: The goal
of this study is to determine the direct connection of individual components of
the portal triad with the hepatic veins.Methods: Histotopographic and
histological preparations from the archival materials of the Department of
Clinical Anatomy and Operative Surgery were used for the investigation.The
tissue samples material was prepared from 45 livers of adults of both sexes.In
addition, the documented archival samples of the preparations, which had been
prepared with the macro-microscopic classical preparation method from the liver
of adults whose cause of death was unrelated to liver pathology, were also
used.Results: In some zones of the intersection of the portal tract and the
hepatic vein, their connective tissue sheath appears to create a nodular form,
in the thickness of which the hepatic veins establish a direct relationship with
the components of the portal triad.The components of the portal and caval
systems are united by a common connective tissue compartment.Conclusions: In the
portocaval complex of the liver, the hepatic vein is connected to the components
of the hepatic portal triad (portal vein, branches of proper hepatic artery,
bile ducts) as the fourth element of this triad.All of them are surrounded by a
perivascular fibrous capsule, which may contribute to spreading the inflammatory
processes from the bile ducts to the hepatic veins.
The Possible Relationship Between ABO and Rhesus System Phenotypes and
SARS-CoV-2 Infection
Georgian Biomedical News

Background: The relationship between blood Rhesus factor and SARS-CoV-2 viral
infection has recently been revealed by several studies; however, the underlying
mechanism is still unclear.An intriguing finding was the very low viral
infection rate among blood Rhesus-negative people (notably O(I) and Rh-) and the
high vulnerability in Rh-positive infected patients.Objectives: The current
study aimed to find a possible relationship between Rh blood groups and
susceptibility to the SARS-CoV-2 viral infection.Based on the results of the
comparison of ABO and Rh blood group phenotypes in uninfected (healthy) and
post-infection individuals, we were able to identify SARS-CoV-2 susceptible or
resistant phenotypes.Methods: A total of 447 blood samples were examined,
including 333 from SARS-CoV-2 post-infection patients and 114 from healthy
controls within four months (from January 28, 2021, to April 30, 2021).Results:
The distribution of phenotypic categories for Rhesus positive (Rh+) and Rhesus
negative (Rh-) individuals in the control and postinfection groups has been
demonstrated to be identical.There was no correlation between the Rhesus factor
and susceptibility to SARS-CoV-2 virus infection.However, there was a
significant correlation between the combination of two variables (the Rh and ABO
groups) and SARS-CoV-2 susceptibility.Particularly, the frequency of the O(I)
and Rh-phenotypes was approximately 1.4 times lower in the post-infection period
than in controls.In contrast, patients in the post-infection period exhibit the
largest prevalence of the A(II)Rh+ phenotypic combination.Conclusions: The
SARS-CoV-2 infection susceptibility is low in people with the O(I)Rh-phenotype
and high in individuals with the A(II)Rh+ phenotype.
Detection of Tram Wheel Faults Using MEMS-Based Sensors
Yohanis
24 Aug 2022
Micro-electromechanical-systems (MEMS) based sensors are used for monitoring the
state of machines in condition-based maintenance tasks.This approach is applied
at tram depots for the purpose of identifying faulty wheels on trams in order to
eliminate defective trams at the entry or dispatch gates.The application of
MEMS-based sensors for the detection of wheel faults is the focus of this
study.A method for processing of the collected sensor data is developed.It is
based on assessing the energy of vibrations at different frequency bands.Maximal
Overlap Discrete Wavelet Packet Transform (MODWPT) is used for obtaining a
description of the sensor data.The task of finding the energy threshold for
detecting faulty wheels, frequency band and parameters of MODWPT which most
distinctly distinguish the wheels is the goal of the method.The weighted
difference (DW) between the extreme values of energy in a frequency band for
normal and faulty wheels is proposed as the measure of the ability to
distinguish the wheels.The search for the solution is formulated as a discrete
optimisation problem of maximising this measure.Both the simulation and
experimental results indicate that faulty wheels have greater vibration energy
than normal wheels.The properties of this approach are discussed and evaluated.



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introduction to assess whether large boards reduce firm performance.
RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes
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Elevated LDL Triglycerides and Atherosclerotic Risk.
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01 Jan 2023 - Journal of the American College of Cardiology
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In this paper , a second-order sliding mode control based on super-twisting
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Effect of masonry infill walls on the nonlinear response of reinforced concrete
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01 Jan 2023 - Engineering Failure Analysis
In this article , the effects of infill walls in reinforced concrete buildings
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The Burden of Non-Alcoholic Fatty Liver Disease in Adolescents with Polycystic
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adolescents with polycystic ovary syndrome (PCOS) and its associations with
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syndrome were assessed.
Evaluating Image Super-Resolution Performance on Mobile Devices: An Online
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01 Jan 2023
Zhang et al. as mentioned in this paper developed an online benchmark to
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Awareness and use of maternal and child health-care services among people of
Dagbadna Karu Local Government of Nasarawa State
Olaolorunpo Olorunfemi
01 Jan 2023 - Archives of Medicine and Health Sciences
In this article , the level of MCH awareness and utilization among residents of
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a descriptive cross-sectional study that ran from September 2022 to December
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Learning Management Systems in Flexible Learning Environments - A Study of
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01 Jan 2023
In this paper , the authors conducted a study with ten teachers working in
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Less is Better: Constructing Legal Question Answering System by Weighing Longest
Common Subsequence of Disjunctive Union Text
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Summary of research methods for porosity and permeability of coalbed methane
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01 Jan 2023 - Academic Journal of Environment &amp; Earth Science
In this article , the authors summarized the concepts, influencing factors and
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petrographic composition, metamorphic degree, coal body structure and buried
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Research on the Cultivation of Applied Talents in ASEAN Minor Languages under
the Background of Digital Economy
01 Jan 2023 - Adult and higher education
In this paper , the authors take Thai minor language as an example, and study
the ideas and strategies of ASEAN minor language applied talents training under
the background of digital economy.
An English listening and speaking ability training system based on binary
decision tree
Yu Wang
01 Jan 2023 - International Journal of Continuing Engineering Education and
Lifelong Learning
In this article , a design method of English listening and speaking ability
auxiliary training system based on binary decision tree is proposed to solve the
problems of low speech resolution accuracy and poor auxiliary training effect of
traditional auxiliary training.
Wohnraum auf Zeit (ITA Dossier Nr.69, Feb 2023)
01 Jan 2023
In this article , the authors discuss the problem of temporarien and konkrete
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In this article , a multifunctional near infrared (NIR) nanotherapeutic platform
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From Genomics to Metagenomics in the Era of Recent Sequencing Technologies.
Suparna Mitra
01 Jan 2023
Metagenomics as discussed by the authors is the study of the genomic content of
a sample of organisms obtained from a common habitat, which allows study of
functional metabolic capacity of a community as well as its structure based upon
distribution and richness of species.
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01 Jan 2023
In recent years, with further research on
engineering-procurement-construction（EPC）project contracting mode, it was found
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Acid-fast bacteria as causative agents of skin and soft tissue infections: case
presentations and literature review.
Anastasia Spiliopoulou, Georgia Kyriakou, S. Georgiou, Alexandra Lekkou, Lydia
Leonidou, Maria Militsopoulou, Eleni Papadogeorgaki, Myrto Christofidou,
Fevronia Kolonitsiou, Fotini Paliogianni  - Show less +9 more
01 Jan 2023 - Revista Do Instituto De Medicina Tropical De Sao Paulo
In this paper , two cases of skin and soft tissue infections caused by two
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were identified using Matrix Assisted Laser Desorption Ionization Time of Flight
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The Construction and Application of Blue Label's Continuous M&A Value Model in
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01 Jan 2023
The acquisition of BlueFocus as discussed by the authors is an important part of
smart city construction and digital city management needs to rely on the support
of digital platform companies, such as IBM and Google.
Efficacy and Safety of Prophylactic-Dose Anticoagulation Therapy with
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01 Jan 2023 - Indian journal of forensic medicine and toxicology
In this article , the authors used 6 studies that met the inclusion of
differences in efficacy and safety in administering prophylactic doses with
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Numerical modelling of the cooling water system of a 106MW Hydro-Power Plant
using EPANET
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more
01 Jan 2023 - IOP Conference Series: Earth and Environmental Science
In this article , the behavior of the new proposed cooling water pumps for a 106
MW Hydro-Power Plant using EPANET is studied. But the authors focus on verifying
if the required pressure is ensured at the cooling water consumers of the plant
considering their specific flow demand and if the velocity in the system pipes
is within the acceptable limits during the power production process.
Übungsbuch zur Betriebswirtschaftlichen Steuerlehre
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01 Jan 2023
Schneeloch as mentioned in this paper , Emeritus and Leiter der Abteilung für
Betriebswirtschaftliche Steuerlehre des „Centrum für Steuern und Finanzen (CSF)“
an der FernUniversität in Hagen.
Atenção à saúde de pessoas em situação de rua no cotidiano da atenção primária:
scoping review
Lucas Alves Gontijo, Bruna Morgan da Silva, Selma Maria da Fonseca Viegas  -
Show less +2 more
01 Jan 2023 - Saúde em Debate
In this paper , a revisão constatou que a atenção à saúde de pessoas in situação
de rua is a desafio to saudade pública and requer mais investimentos
profissionais e de políticas transversais.
Recent progress on strategies for enhancement of crystal growth process
Jiawei Zhao, Na Wang, Jingkang Wang, Xiongtao Ji, Jun Li, Xin Huang, Ting Wang,
Lina Zhou, Hongxun Hao  - Show less +8 more
01 Jan 2023 - CrystEngComm
In some instances, enhancing the crystal growth process could improve the
crystal size and crystal habit of the final crystals as mentioned in this paper
, which is an important step of the crystallization process, and crystal growth
will directly determine the size and the crystal habit.
Restoring Dental Rubbles Using an Overlay Removable Partial Denture Fabricated
with Digital Technology - A Case Report
Manoharan Ps
01 Jan 2023 - RGUHS journal of dental sciences
In this paper , a case report of worn dentition rehabilitated with ORPD was
presented, where the patient on short term follow-up reported with optimal
aesthetics and masticatory efficiency.
Ferroelastic phase transition and the role of volume strain in the structural
trapping of a metastable quenched low-spin high-symmetry phase in
[Ru0.35Fe0.65(ptz)6](BF4)2
Elzbieta Trzop, Mousumi Dutta, Chinmoy Das, Pradip Ranjan Chakraborty, Eric
Collet  - Show less +4 more
01 Jan 2023 - CrystEngComm
Spin crossover materials exhibit thermal conversion of their electronic state
from low (LS) to high (HS) spin state, which also involves both intra- and
inter-molecular structural reorganisations within the crystal as mentioned in
this paper .
Polarization‐Tunable Perovskite Light‐Emitting Metatransistor (Adv. Mater.
1/2023)
Maciej Klein, Yutao Wang, Jingyi Tian, Son Tung Ha, Ramón Paniagua-Domínguez,
Arseniy I. Kuznetsov, Giorgio Adamo, Cesare Soci  - Show less +7 more
01 Jan 2023 - Advanced Materials
In this paper , the perovskite light-emitting metatransistor, which enables
active tunability of electroluminescence intensity, polarization, and spectrum,
is demonstrated.
Key Drivers Associated with Effective Sepsis Care on a Surgical Unit
Richele Koehler, Meghan Burke, Elise Rolison, Jennifer Newman, Justin Lockwood 
- Show less +4 more
01 Jan 2023 - Pediatric quality & safety
In this article , the authors identified key drivers associated with effective
care escalation and sepsis care in the inpatient surgical setting as part of the
initial planning phase of a large improvement initiative.
A big blue-shift phenanthroline fluorescent probe with for detecting
hypochlorous acid in live cells
Shuqing Tu, Mei Qi Tan, Yuelin Guo, Xinyao Wu, Lipeng Li, Wei Li, Wuyuan Pan,
Fang Ke  - Show less +7 more
01 Jan 2023 - Tetrahedron Letters
In this article , a new probe based on the imidazo-1,10-phenanthroline skeleton
was created for the detection of reactive oxygen species (ROS) called
hypochlorous acid or hypchlorite (HClO/ClO−).
The freshwater fishes from the Costa Verde Fluminense region of southeastern
Brazil
Manuela Dopazo, Igor Cavalcanti de Araújo Souto-Santos, Marcelo Ribeiro de
Britto, Cristiano Rangel Moreira, Paulo Andreas Buckup  - Show less +4 more
01 Jan 2023 - Biota Neotropica
In this article , the authors presented a list of the species, and dichotomous
identification keys and illustrations of all species belonging to 16 families
and 9 orders of fishes in the Costa Verde Fluminense region of Brazil.
Towards the sustainable extraction and purification of non-animal proteins from
biomass using alternative solvents
Ana I. Valente, Ana M. Ferreira, Mafalda R. Almeida, Ana P. M. Tavares, Mara G.
Freire, João A. P. Coutinho  - Show less +5 more
01 Jan 2023 - RSC Sustainability
In this paper , a review aims to assess the advances in protein extraction and
separation from non-animal biomass using alternative solvents, namely ILs and
DESs, and discuss the economic and environmental challenges of using such
alternative solutions.
Plc技术在电气仪表自动化控制中的应用
王国英
01 Jan 2023 - 机械与电子控制工程 =
Advanced Materials Science and Technology as discussed by the authors is a
peer-reviewed open access journal published semi-annual online by Omniscient
Pte. Ltd. The journal covers properties, applications and synthesis of new
materials related to energy, environment, physics, chemistry, engineering,
biology and medicine, including ceramics, polymers, biological, medical and
composite materials.
Designing polymer electrolytes for advanced solid lithium-ion batteries: Recent
advances and future perspectives
Tiantian Lu, Chang Liu, Lifeng Hou, Huayun Du, Yin Wei, Shi-chao Wang, Qian
Wang  - Show less +6 more
01 Jan 2023 - Materials Chemistry Frontiers
In this paper , Li metal batteries have attracted widespread attention because
of their high energy density and long cycling life, however, its further
development is limited by dendritic Li growth and safety issues.
Study on Magnetic Properties of Toroidal Cores Composed by Electrolytic Iron
Powder with Different Shapes
Phuong Viet Nguyen, T. Miyazaki, Yasushi Endo  - Show less +2 more
01 Jan 2023 - IEEE Transactions on Magnetics
In this article , the effect of particle shape on magnetic properties of
toroidal cores composed of electrolytic iron powder was investigated and it was
shown that the particle shape of powder in a core significantly influences on
its magnetic propeties.
A Wideband 220-GHz Traveling Wave Tube Based on Slotted Piecewise Sine Waveguide
Luqi Zhang, Guowu Ma, Yiran Jiang, Rui Song, Wenqiang Lei, Wanghe Wei, Peng Hu,
Hongbin Chen, Yanyu Wei  - Show less +8 more
01 Jan 2023 - IEEE Electron Device Letters
In this paper , a slotted piecewise sine waveguide (SPWSWG) is proposed as the
slow wave structure (SWS) to develop the terahertz traveling wave tube (TWT).
Small area estimation with multiple covariates under structural measurement
error models
Ita Wulandari, Anang Kurnia, Khairil Anwar Notodiputro, Anwar Fitrianto  - Show
less +3 more
01 Jan 2023 - Procedia Computer Science
In this paper , a model with multiple covariates subject to structural
measurement error and multiple error-free covariates is studied. But the authors
focus on the problem of measurement error in covariates and do not consider the
covariates measured with errors.
Association of Oral Squamous Cell Carcinoma and Human Papilloma Virus Status in
Chronic Periodontitis Patients: A Cross-sectional Study
Shikha Sharma, Shobha Prakash  - Show less +1 more
01 Jan 2023 - Journal of Clinical and Diagnostic Research
In this paper , a cross-sectional study was conducted on 15 chronic generalised
periodontitis patients with oral squamous cell carcinoma (OSCC) affecting
alveoli and gingiva, and DNA was extracted from the biopsy of the tissue sample
for the detection of HPV by Polymerase chain reaction (PCR).
Pionierin in der zweiten Reihe des Hörsaals
Andreas Loos
01 Jan 2023 - Physik in Unserer Zeit
In this article , the erste Physikprofessorin Amerikas, musste aber zeitlebens
um ihre Stellung kämpfen, war die erstephysicianin America.
Population recovery and occurrence of the endemic Rhine sculpin (Cottus
rhenanus)
P. Lemmers, Mark Groen, Ben Crombaghs, Robert Gubbels, Frank van Langevelde,
Gerard van der Velde, Rob S. E. W. Leuven  - Show less +6 more
01 Jan 2023 - Knowledge and Management of Aquatic Ecosystems
The Rhine sculpin (Cottus rhenanus) is a benthic rheophilic fish species that is
endemic to tributaries of the rivers Rhine and Meuse in North-western Europe as
discussed by the authors .
Stable Time for Microstructural Parameters of Fly-Ash Concrete and Its Influence
on Chloride-Diffusion Stability
Yanhong Gao, Meng Wang, Bao Lin Guo, Yurong Zhang, Yun Tao Zhang  - Show less +4
more
01 Jan 2023 - Journal of Materials in Civil Engineering
In this paper , the authors analyzed the relationship between stable time for
chloride diffusivity and stable time of microstructural parameters such as
porosity using nuclear magnetic resonance (NMR) test results.
Providing early intervention services for families with children with
developmental disabilities in war conditions
M.V. Kravchenko
01 Jan 2023
In this paper , the authors proposed an early intervention service for families
with children with developmental disabilities in the field of health care, but
they are mostly practically unavailable due to the military operations on the
territory of Ukraine and the lack of budget in this area.
Perceptions and awareness of dental students toward oral tissues: A
cross-sectional study
Harsh Dadhich, Manisha S Ahire, Saurabh R Nagar, Vijaya Lakshmi Nimma  - Show
less +3 more
01 Jan 2023 - Journal of primary care dentistry and oral health
In this article , a cross-sectional study was designed to assess the perceptions
and awareness of dental students of the Government Dental College and Hospital,
Mumbai, toward oral tissues, and found that most participants believed that it
is the role of the dentist to perform the complete oral examination.
Protocol for Classification Single-Cell PBMC Types from Pathological Samples
Using Supervised Machine Learning.
Minjie Lyu, Huan Jin, Lou Chitkushev, Guang Lan Zhang, Derin B. Keskin, Vladimir
Brusic  - Show less +5 more
01 Jan 2023
In this paper , a protocol that uses supervised machine learning (ML) methods
with SCT data for the classification of peripheral blood mononuclear cells
(PBMC) cell types in samples representing pathological states is described.
Green infrastructure, a thermal regulator for the arid city. Case study of the
city of Bou-saada
Malika Ouzir
01 Jan 2023 - Glasnik Srpskog geografskog društva
In this paper , the authors used a qualitative barometer to assess green
infrastructure in the city of Bou-saada using several themes around the concept
of multifunctionality and thermal comfort, also using some subthemes to break
down the themes.
Template-directed growth of sustainable carboxymethyl cellulose-based aerogels
decorated with ZIF-67 for activation peroxymonosulfate degradation of organic
dyes.
Mengke Zhao, Guigan Fang, Sufeng Zhang, Long Liang, Shuangquan Yao, Ting Wu  -
Show less +5 more
01 Jan 2023 - International Journal of Biological Macromolecules
In this paper , a 3D advanced oxidation catalyst ZIF-67@C-CMC/rGO based on
carboxymethyl cellulose (CMC) and reduced graphene oxide (rGO) was successfully
synthesized by facile in-situ growth of Zeolitic imidazolate framework-67.



TOP PAPERS OF 2022

View all papers 
A review on synthesis and applications of nano metal Oxide/porous carbon
composite
V. Andal
01 Jan 2022 - Materials Today: Proceedings
In this paper , the porosity of the carbon with respect to the physicochemical
properties of metal oxide/porous carbon composite is discussed and reported, and
the future trends and development on the nano metal oxide and porous carbon
composites and their applications in various fields are discussed.
Computational Modeling of Flow and Thrombus Formation in Type B Aortic
Dissection: The Influence of False Lumen Perfused Side Branches
Pengyu Ren
01 Jan 2022 - Studies in mechanobiology, tissue engineering and biomaterials
In this article , the authors demonstrate the importance of including false
lumen-fed side branches in quantitative analysis of hemodynamics in TBAD, and
provide a mechanistic understanding of the role of these branches in FL
thrombosis.
View-Consistency Learning for Incomplete Multiview Clustering
01 Jan 2022 - IEEE Transactions on Image Processing
In this article , a tensor low-rank constraint is introduced to learn a stable
low-dimensional representation, which encodes the complementary information and
takes into account the cluster structure between different views.
Wheat Rusts: Current Status, Prospects of Genetic Control and Integrated
Approaches to Enhance Resistance Durability
Sridhar Bhavani1•Institutions (1)
International Maize and Wheat Improvement Center1
01 Jan 2022
In this article , the use of genetic resistance and deployment of multiple race
specific and pleiotropic adult plant resistance genes in wheat lines can enhance
resistance durability and accelerate our understanding of the genetic basis of
rust resistance bread wheat, at the same time wheat breeders can now use this
information to identify genes conferring rust resistance.
Robust Optimization Approach to Process Flexibility Designs with Contribution
Margin Differentials
01 Jan 2022
In this article , the authors adopt a robust optimization framework and study
process flexibility designs from the worst-case perspective by introducing the
dual margin group index (DMGI), which can provide useful guidelines for the
evaluation and design of flexibility configurations when the products have
heterogeneous margins.
Robust Attentive Deep Neural Network for Detecting GAN-Generated Faces
01 Jan 2022 - IEEE Access
Wang et al. as mentioned in this paper proposed a robust, attentive, end-to-end
framework that spots GAN-generated faces by analyzing eye inconsistencies, which
can effectively learn from imbalanced data using a joint loss function combining
the traditional cross-entropy loss with a relaxation of the ROC-AUC loss via
Wilcoxon-Mann-Whitney (WMW) statistics.
Influence of twisted tape with collective protruded rib parameters of
thermal–hydraulic performance of <mml:math
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altimg="si8.svg"><mml:mrow><mml:msub><mml:mrow><mml:mi
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mathvariant="…
01 Jan 2022 - Materials Today: Proceedings
In this article , the effect of twisted tape (TT) combined with protruded rib
and A l 2 O 3 - H 2 O nanofluid on thermal-hydraulic performance in a heat
exchanger tube (HET) was examined.
Different settings, different patterns of impacts: Effects of a Pre-K math
intervention in a mixed-delivery system
01 Jan 2022 - Early Childhood Research Quarterly
In this article , a large-scale randomized trial of a pre-K math intervention
called Making Pre-K Count (MPC) was conducted in both public schools and
community-based organizations and the results showed that MPC had large positive
impacts on the amount of math instruction children received.
Ammonia-induced (11<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"
altimg="si1.svg"><mml:mrow><mml:mover
accent="true"><mml:mn>1</mml:mn><mml:mo>‾</mml:mo></mml:mover></mml:mrow></mml:math>)
facet exposure of δ-MnO2 with enhanced electrochemical reactivity for
high-performance supercapacitor
01 Jan 2022 - Materials Chemistry and Physics
In this paper , a simple method by using ammonia as a structure-directing agent
to increase the exposure ratio of (111) active plane, and thus enhance the
electrochemical performance of δ-MnO2 was presented.
Magnetic nanoparticles embedded microcryogels for bilirubin removal
Kemal Çetin1•Institutions (1)
Necmettin Erbakan University1
01 Jan 2022 - Process biochemistry
In this article , magnetic micro-engineered cryogels embedded with Fe3O4
nanoparticles were developed as magnetic adsorbents for bilirubin removal and
the results indicated that the adsorption capacity of magnetic microcryogels
increased with higher temperature values while decreased with higher salt
concentrations.
Tidal current classification insights for search, rescue and recovery operations
in the Yellow and East China Seas and Korea Strait
Andy Crow1•Institutions (1)
Materials Processing (United States)1
01 Jan 2022 - Continental Shelf Research
In this article , the authors investigated spatial relationships between
barotropic tidal currents and tides in the tidally predominant Yellow and East
China Seas and Korea Strait (YESKS) continental shelf region to understand which
tidal current and tide (TCE) characteristics underpin essential insights for
maritime search, rescue and recovery operations.
Evaluating the therapeutic efficacy of nano-drugs targeting epidermal growth
factor receptor
01 Jan 2022 - Chemical Communications
In this paper , the therapeutic efficacy of nano-drugs targeting EGFR was
evaluated from the perspective of cell entry efficiency and induced cell
mechanical properties using force tracing and nano-indentation techniques at the
single particle/cell level in real time.
Sustainable Renaturation in Desertification Control: Expediting the Natural
Succession of Large-Scale Vegetation in Drylands
01 Jan 2022
In this paper , the authors proposed a simple and fast way to expedite the
development of a vegetation cover in semi-arid and arid regions by combining
active planting and the succession of native and climate adaptable savanna
vegetation.
Identification of New &lt;i&gt;Halomonas&lt;/i&gt; Strains from Food-related
Environments
01 Jan 2022 - Microbes and Environments
In this paper , the authors identify food-related Halomonas strains for
bioremediation and the industrial production of biochemicals, 20 strains were
isolated from edible seashells, shrimp, and umeboshi (pickled Japanese plum)
factory effluents.
Removing harvest residues from hardwood stands affects tree growth, wood density
and stem wood nutrient concentration in European beech (Fagus sylvatica) and oak
(Quercus spp.)
Исломов Исломхўжа Азимхўжаевич, Carolyn L. Wiener  - Show less +1 more
01 Jan 2022 - Forest Ecosystems
In this paper , the authors quantify the impact of removing harvest residuals
and litter on tree growth, wood density, and stem wood nutrient concentrations
in young beech and oak forest stands.
Who (or What) Is an AI Artist?
01 Jan 2022 - Leonardo
The authors examines several claimants to the term and grounds these in art
history and theory, arguing that the art market alienates AI artists from their
work and proposes that AI art's interactions with art institutions have not
promoted new creative possibilities but have instead reinforced conservative
forms and aesthetics.
Convergence of a particle approximation for the quasi-stationary distribution of
a diffusion process: Uniform estimates in a compact soft case
01 Jan 2022
In this paper , the convergence of a Moran/Fleming-Viot type particle scheme
toward the quasi-stationary distribution of a diffusion on the d-dimensional
torus, killed at a smooth rate, was established.
A new minimizing-movements scheme for curves of maximal slope
01 Jan 2022 - ESAIM: Control, Optimisation and Calculus of Variations
In this article , an alternative minimizing-movements approach, yielding more
regular discretizations, serving as a-posteriori convergence estimator, and
allowing for a simple convergence proof.
Identifying the beta-site amyloid precursor protein cleaving enzyme 1
interactome through the proximity-dependent biotin identification assay
01 Jan 2022 - Neuroscience Letters
In this article , the biotin identification proximity assay was used to
establish the BACE1 interactome in healthy neuronal cells and identified
interactions involved in BACE 1 trafficking, post-translational modification and
substrates.
Implementation Guidance for VVSG 2.0:
Richard Buggs
01 Jan 2022
In this article , N.nan et al. presented a method to solve the problem of
homonymity.http://www.nannan.edu.edu/blog/blogs/
Tempi duri per la storia. Il contributo della Public History of Education alla
consapevolezza delle nostre complesse identità
Mariana Ferreira Seyfried1•Institutions (1)
University of Florence1
01 Jan 2022
In the educational training pathway, the history of education is usually present
as discussed by the authors , however, from the moment of recruitment onwards,
the interest in a historical approach disappears completely, and teachers tend
to focus on the current challenges of their work.
Oxidative Damage Induced Telomere Mediated Genomic Instability in Cells from
Ataxia Telangiectasia Patients
01 Jan 2022 - Genome Integrity
In this paper , the role of AT proteins in DNA repair and telomere maintenance
under oxidative stress has been investigated and it was found that AT-/- cells
show considerable DNA attrition and genomic instability.
Escola, Família e Educação: pesquisas emergentes na formação do ser humano -
Volume 2
Ilia M. Guliy
01 Jan 2022
Escola, Família, and Educação: Escola, family, and education as discussed by the
authors , a book about the evolution of the human form and the role of the
escola, a família and an espaço educativo in the process of humanização.
Mechanical properties of polymer jute rods reinforced with carbon / glass fiber
FLORENT PEREK1•Institutions (1)
University of Mosul1
01 Jan 2022 - Nucleation and Atmospheric Aerosols
In this article , the tensile strength of polymer jute fiber rods with 50%
carbon fibers and glass fibers was investigated. But the results showed that the
failure occurred suddenly at the ultimate stress.
Características y currículos de las primeras residencias médicas en la
Universidad del Valle (1955-1980)
Zhi Zhou
01 Jan 2022
A mediados de los años cincuenta del siglo pasado, se formalizó en Colombia el
estudio de los posgrados médicos por medio de la estrategia de las residencias
in la Universidad del Valle, que había been the primera en adoptar the modelo
Flexner and, también, one of las primeras en montar los programas de residcias
as mentioned in this paper .
The Structure of Society Based on Private Joint Ownership
Christer Hublin1•Institutions (1)
University of Tehran1
01 Jan 2022
In this article , the authors propose a method to solve the problem of the
problem: the one-dimensional graph. [2] . . . ] . . , [3]
Introduction. An Archaeology of Modernism
Zhi Su1•Institutions (1)
University of Málaga1
01 Jan 2022
In this article , the authors analyze the history of the critical reception of
avantguard art through the interpretations received by one of its greatest
emblems, Les Demoiselles d'Avignon by Picasso, 1907.
An Approximation Algorithm for Graph Clustering with Clusters of Bounded Sizes
Rupert Beale
01 Jan 2022
In this paper , a polynomial-time approximation algorithm for this problem was
proposed, which is the best known algorithm for any fixed > 0.5-approximation.
Poder e resistência nas páginas do lampião da esquina
FLAVIA RIBEIRO AMARO
01 Jan 2022
In this paper , a survey of análise dos discursos de linguagens, sociedade, and
a cultura em geral can be found in Portugal.
Von Einstellungen zu polizeilichen Praxen
Dipima Borgohain
01 Jan 2022
In this article , the Verhältnis zwischen Einstellungen und polizeilichen Praxen
is beleuchtet, dabei wird berücksichtigt, dass es häufig zu Diskrepanzen
zwärmpen zwys der Einstelle und den Handlungen eines Individuums kommt and es
werden die Entstehungsbedingungen menschlichen Verhaltens skizziert.
Application of Organic-Inorganic Nanohybrids in Wastewater Treatment
Christian Ducuara Herreño
01 Jan 2022
In this paper , a magnetic chitosan-grafted graphene oxide composite can be
utilized for treating pharmaceutical waste because of its outstanding adsorption
capacity (282.9 mg/g).
Überblick über die bedeutendsten Krypto-Assets
Patricia Radelet-de Grave
01 Jan 2022
In 2017, Bitcoin (BTC) and Ether (ETH) became the älteste and bekanntest
blockchain-basierte Währung eine Vorreiterrolle ein this paper .
MHR-Net: Multiple-Hypothesis Reconstruction of Non-Rigid Shapes from 2D Views
Rozineide Gomes de Souza Maia
01 Jan 2022
In this article , the non-rigid shape is first expressed as the sum of a coarse
shape basis and a flexible shape deformation, then multiple hypotheses are
generated with uncertainty modeling of the deformation part.
Developments in Data Science and Artificial Intelligence in Learning Technology
and CCI Research
Lorenzo Cuccoli1•Institutions (1)
Norwegian University of Science and Technology1
01 Jan 2022
In this article , the authors provide a brief presentation of the developments
in data science and AI, and the role of those developments in learning
technology and CCI research, focusing on experimental studies.
Biomechanics of Keratoconus
Vishal Jhanji1•Institutions (1)
University of Pittsburgh1
01 Jan 2022
Keratoconus (KCN) as mentioned in this paper is a bilateral ectasia marked by
progressive thinning and protrusion at the apex, which is secondary to molecular
changes resulting in structural instability and biomechanical changes.
The Comprehensiveness of Thinking
None Adedamola
01 Jan 2022
For instance, this article pointed out that the study of thinking has followed a
winding road, and that after endless mountains and rivers that leave doubt
whether there is a path out, suddenly one encounters the shade of a willow,
bright flowers, and a lovely village.
Title: Gentle Protest – Contemplations on an Interactive Tableau
K Carter
01 Jan 2022 - [ ] With Design: Reinventing Design Modes
Gentle Protest as mentioned in this paper is an Environmentally Sensitive
Interactive Textile Design created with the Rationales of Critical Design
Practice, which intersects the ideas of interactivity, metaphoric connotation
expression, aesthetics of use, engagement uncertainty, potential ambiguity and
textile craftsmanship to create a dynamic interactive tableau.
Dielectric Properties of Barium Titanate Using Different Preparation Techniques
Victor S. Pineda
01 Jan 2022
In this paper , a brief review over the various preparation techniques of BaTiO3
with different dopants and its effect of grain size and dielectric properties at
different temperatures are deliberated.
3D Multi-Object Tracking based on Dual-tracker and D-S Evidence Theory
01 Jan 2022 - IEEE transactions on intelligent vehicles
Li et al. as mentioned in this paper proposed a dual-tracker-based 3D MOT
system, which fuses 2D and 3D information to track objects and can still ensure
good tracking accuracy when the 3D sensor fails in a single frame or multiple
consecutive frames.
Optimal Time Selection for ISAR Imaging of Ship Target via Novel Approach of
Centerline Extraction With RANSAC Algorithm
01 Jan 2022 - IEEE Journal of Selected Topics in Applied Earth Observations and
Remote Sensing
In this article , a novel optimal time selection method based on the random
sample consensus (RANSAC) technique is proposed, which can extract the ship
centerline with high accuracy in the case of ship superstructure and low signal
to noise ratio.
A method for assessing the level of reliability of employees in the personnel
security system of an enterprise (using the example of CII enterprises)
Lisbet Skregelid
01 Jan 2022 - Doklady Tomskogo gosudarstvennogo universiteta sistem upravleniâ i
radioèlektroniki
In this paper , a method for assessing the level of trustworthiness based on the
compilation of a competence profile is discussed, which provides a qualitative
assessment of employee competencies and has been applied to employees employed
at critical information infrastructure enterprises.
Spectrophotometric determination of cefixime trihydrate via oxidative coupling
reaction with amino phenazone
Dennis Liu
01 Jan 2022 - Nucleation and Atmospheric Aerosols
In this paper , a simple, precise, rаpid, аccurate, sensitive and economical
method was developed for the determination of Cefixime trihydrate (CFX).
Measuring Particle Concentrations and Composition in Indoor Air
Thomas Michael McDonnell
01 Jan 2022 - Handbook of Indoor Air Quality
In this article , the authors focus on methods to measure the mass
concentrations of airborne particulate matter, its chemical composition, and the
particle number concentrations and the size distributions in indoor air.
Some properties of subclass of P-valent function with new generalized operator
Alparslan Özaltuğ1•Institutions (1)
University of Anbar1
01 Jan 2022 - Nucleation and Atmospheric Aerosols
In this article , the authors introduced and investigated the subclass T[μ, τ;
p] for p-valent functions defined by the new linear operator ϒξ,ηm,s.
Argon Ions Beam Irradiation of Copper Nanowires for Transparent Electrodes
Shehla Honey1•Institutions (1)
University of Okara1
01 Jan 2022
In this article , the influence of 4 meV Argon ions (Ar+) on properties of
copper nanowires (Cu NWs) meshes is studied using X-ray diffraction (XRD) and
optical analysis was made through UV-vis spectroscopy.
Emerging Directions and New Challenges
Jenny Povey1•Institutions (1)
University of Queensland1
01 Jan 2022
In this paper , the authors provide a brief summary of the key themes of the
book, identify emerging directions and challenges in life course theory and data
designs and highlight some policy challenges for researchers going forward.
West Nile virus and climate change
Mukhopadhyay, Sanjoy1•Institutions (1)
University at Albany, SUNY1
01 Jan 2022
In this article , a review of WNV epidemiology, transmission, disease and
genetics in the context of laboratory studies, field investigations, and
infectious disease models under climate change is presented.
Den blendende musikken
Eliza Duncan
01 Jan 2022
In this paper , the authors explore the religious potential of music via ideas
taken from Olivier Messiaen, and present his categorization of music and the
concepts of sound-colour and dazzlement as the "directional meaning" of music.
A new hybrid conjugate gradient method for unconstraint optimization
AMNH Mammalogy
01 Jan 2022 - Nucleation and Atmospheric Aerosols
In this article , a linear combination with parameters βk of the PR method and
the ME method was made, and the global convergence and descent property of this
method were established, the numerical results show that the proposed hybrid
method is effective.
Introduction: The Science–Emancipation Dialectic or Mobius Strip
Enrico Zanini
01 Jan 2022
In this paper , the authors describe the historical development of
macro-cultural psychology and explain how the anti-vaccine movement against
COVID-19 vaccination is a psychological reaction that reflects neoliberal
philosophy and politics.



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