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Submitted URL: https://doi.org/10.1002/ana.410110607
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Öffnet in einem neuen Fenster Öffnet eine externe Website Öffnet eine externe Website in einem neuen Fenster <!---->Schließen Sie diesen Dialog<!----> Auf dieser Website werden Daten wie Cookies gespeichert, um wichtige Funktionen der Website sowie Marketing, Personalisierung und Analyse zu ermöglichen. Sie können Ihre Einstellungen jederzeit ändern oder die Standardeinstellungen übernehmen. Sie können dieses Banner schließen, um nur mit essenziellen Cookies fortzufahren. Datenschutz-Bestimmungen Einstellungen verwalten Alle akzeptieren Alles ablehnen <!---->Schließen Sie die Cookie-Einstellungen<!----> * Skip to Article Content * Skip to Article Information Working off-campus? Learn about our remote access options Search withinThis JournalAnywhere * Search term Advanced Search Citation Search * Search term Advanced Search Citation Search Login / Register Annals of Neurology Volume 11, Issue 6 p. 592-598 Article SLOWLY PROGRESSIVE APHASIA WITHOUT GENERALIZED DEMENTIA Dr. M.-Marsel Mesulam MD, Corresponding Author Dr. M.-Marsel Mesulam MD Bullard and Denny-Brown Laboratories and the Behavioral Neurology Section, Harvard Neurology Department, and the Charles A. Dana Research Institute at the Beth Israel Hospital, Boston, MA Director, Behavioral Neurology, Beth Israel Hospital, 330 Brookline Ave, Boston, MA 02215Search for more papers by this author Dr. M.-Marsel Mesulam MD, Corresponding Author Dr. M.-Marsel Mesulam MD Bullard and Denny-Brown Laboratories and the Behavioral Neurology Section, Harvard Neurology Department, and the Charles A. Dana Research Institute at the Beth Israel Hospital, Boston, MA Director, Behavioral Neurology, Beth Israel Hospital, 330 Brookline Ave, Boston, MA 02215Search for more papers by this author First published: June 1982 https://doi.org/10.1002/ana.410110607 Citations: 746 About * * RELATED * INFORMATION * PDF PDF Tools * Request permission * Export citation * Add to favorites * Track citation ShareShare Give access Share full text access Close modal Share full-text access Please review our Terms and Conditions of Use and check box below to share full-text version of article. I have read and accept the Wiley Online Library Terms and Conditions of Use -------------------------------------------------------------------------------- Shareable Link Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Copy URL Share a link Share on * Facebook * Twitter * Linked In * Reddit * Wechat ABSTRACT Six right-handed patients experienced a slowly progressing aphasic disorder without the additional intellectual and behavioral disturbances of dementia. The symptoms almost universally started in the presenium. The initial difficulty was an anomic aphasia in five of the patients and pure word deafness in the sixth. Continuous and gradual deterioration occurred in the five patients who presented with an anomic aphasia. They eventually experienced additional impairment of reading, writing, and comprehension. In four patients, other areas of comportment were not involved within the 5 to 11 years of follow-up. A more generalized state of dementia may have emerged in the other two patients, but only after 7 years of progressive and debilitating aphasia. Neurodiagnostic procedures were consistent with preferential involvement of the left perisylvian region. In one patient, cortical biopsy did not show any pathognomonic change; specifically, no neurofibrillary tangles, amyloid plaques, neuronal inclusions, or gliosis were seen. This condition may constitute a syndrome of relatively focal cerebral degeneration with a predilection for the left perisylvian region. CITING LITERATURE Volume11, Issue6 June 1982 Pages 592-598 * RELATED * INFORMATION RECOMMENDED * A case of slowly progressive aphasia without generalized dementia in a Japanese patient H. Yamamoto, H. Tanabe, A. Kashiwagi, Y. Ikejiri, H. Fukuyama, J. Okuda, J. Shiraishi, T. Nishimura, Acta Neurologica Scandinavica * Progressive aphasia without dementia: Two cases with focal spongiform degeneration Howard S. Kirshner, Oguz Tanridag, Lawrence Thurman, William O. Whetsell, Annals of Neurology * Primary progressive aphasia Andrew Kertesz, Michał Harciarek, Scandinavian Journal of Psychology * Primary progressive aphasia M.-Marsel Mesulam MD, Annals of Neurology * Cognition and anatomy in three variants of primary progressive aphasia Maria Luisa Gorno-Tempini MD, PhD, Nina F. Dronkers PhD, Katherine P. Rankin PhD, Jennifer M. Ogar MS, La Phengrasamy BA, Howard J. Rosen MD, Julene K. Johnson PhD, Michael W. Weiner MD, Bruce L. Miller MD, Annals of Neurology Close Figure Viewer Return to Figure Previous FigureNext Figure Caption Download PDF back ADDITIONAL LINKS ABOUT WILEY ONLINE LIBRARY * Privacy Policy * Terms of Use * About Cookies * Manage Cookies * Accessibility * Wiley Research DE&I Statement and Publishing Policies HELP & SUPPORT * Contact Us * Training and Support * DMCA & Reporting Piracy OPPORTUNITIES * Subscription Agents * Advertisers & Corporate Partners CONNECT WITH WILEY * The Wiley Network * Wiley Press Room Copyright © 1999-2022 John Wiley & Sons, Inc. All rights reserved The full text of this article hosted at iucr.org is unavailable due to technical difficulties. LOG IN TO WILEY ONLINE LIBRARY Email or Customer ID Password Forgot password? -------------------------------------------------------------------------------- FOR ANA MEMBERS, YOU MUST BE SIGNED INTO MYANA.ORG TO VIEW ARTICLES. 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