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Cancer patients often do better with less intensive treatment, research shows

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Cancer


CANCER PATIENTS OFTEN DO BETTER WITH LESS INTENSIVE TREATMENT, RESEARCH SHOWS

Patients with three kinds of cancer live longer and feel better with less
chemotherapy and less surgery or radiation, according to studies presented at a
cancer conference.

Thirty years ago, cancer research was about doing more, not less. Now, in a
quest to optimize cancer care, researchers are asking: “Do we need all that
treatment that we have used in the past?”GHI / Universal Images Group via Getty
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June 3, 2024, 4:02 PM GMT+2 / Source: The Associated Press
By The Associated Press

Scaling back treatment for three kinds of cancer can make life easier for
patients without compromising outcomes, doctors reported at the world’s largest
cancer conference.

It’s part of a long-term trend toward studying whether doing less — less
surgery, less chemotherapy or less radiation — can help patients live longer and
feel better. The latest studies involved ovarian and esophageal cancer and
Hodgkin lymphoma.




Thirty years ago, cancer research was about doing more, not less. In one
sobering example, women with advanced breast cancer were pushed to the brink of
death with massive doses of chemotherapy and bone marrow transplants.
The approach didn’t work any better than chemotherapy and patients suffered.



Now, in a quest to optimize cancer care, researchers are asking: “Do we need all
that treatment that we have used in the past?”

It’s a question, “that should be asked over and over again,” said Dr. Tatjana
Kolevska, medical director for the Kaiser Permanente National Cancer Excellence
Program, who was not involved in the new research.

Often, doing less works because of improved drugs.


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“The good news is that cancer treatment is not only becoming more effective,
it’s becoming easier to tolerate and associated with less short-term and
long-term complications,” said Dr. William G. Nelson of Johns Hopkins School of
Medicine, who was also not involved in the new research.


LATEST NEWS ON CANCER TREATMENT

 * Cancer-fighting antibodies inject chemo directly into tumor cells, upping
   effectiveness.
 * Long-term study shows 'remarkable' treatment helps patients with deadly
   nonsmoking-related lung cancer.
 * FDA approves groundbreaking treatment for advanced melanoma.

Studies demonstrating the trend were discussed over the weekend at an American
Society of Clinical Oncology conference in Chicago. Here are the highlights:


OVARIAN CANCER

French researchers found that it’s safe to avoid removing lymph nodes that
appear healthy during surgery for advanced ovarian cancer. The study compared
the results for 379 patients — half had their lymph nodes removed and half did
not. After nine years, there was no difference in how long the patients lived
and those with less-extreme surgery had fewer complications, such as the need
for blood transfusions. The research was funded by the National Institute of
Cancer in France.


ESOPHAGEAL CANCER

This German study looked at 438 people with a type of cancer of the esophagus
that can be treated with surgery. Half received a common treatment plan that
included chemotherapy and surgery on the esophagus, the tube that carries food
from the throat to the stomach. Half got another approach that includes
radiation too. Both techniques are considered standard. Which one patients get
can depend on where they get treatment.

After three years, 57% of those who got chemo and surgery were alive, compared
to 51% of those who got chemo, surgery and radiation. The German Research
Foundation funded the study.


HODGKIN LYMPHOMA

A comparison of two chemotherapy regimens for advanced Hodgkin lymphoma found
the less intensive treatment was more effective for the blood cancer and caused
fewer side effects.



After four years, the less harsh chemo kept the disease in check in 94% of
people, compared to 91% of those who had the more intense treatment. The trial
included 1,482 people in nine countries — Germany, Austria, Switzerland, the
Netherlands, Denmark, Sweden, Norway, Australia and New Zealand — and was funded
by Takeda Oncology, the maker of one of the drugs used in the gentler chemo that
was studied.


The Associated Press

The Associated Press



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