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Text Content

 * ROW
   * Change location:
   * Europe (Français)
   * United States
   * Rest of the world


A NEW CLINICALLY VALIDATEDUBIO-SIGNAL TO DIAGNOSE SLEEP APNEA.

Sunrise detects respiratory events based on the analysis of the trigeminal
drive. This new technology measures movements caused by the contraction of
respiratory muscles and provides reliable and accurate information to analyze
sleep.

 * Highest level of accuracy*
 * At home
 * Non-invasive
 * Disposable
 * Cost effective

* JAMA Network Open

Contact us

 * FDA De Novo granted
 * CE Mark Cleared
 * Conformity assessment certification


MANDIBULAR MOVEMENTS INFORM ABOUT THE CENTRAL COMMAND.

The brain plays a critical role in maintaining upper airway patency by
contracting muscles which are attached to a mobile bone called the mandible.

The mandibular movements reveal the changes in the trigeminal motor nucleus
activity driven by the brainstem center. These mandibular movements are a direct
proxy of how the sleeping centers in the brain regulate sleep and respiration,
informing about the major events required for characterizing sleep apnea:

 * Robust and accurate measurement of Total Sleep Time
 * Micro-arousals index
 * Obstructive Apnea/hypopnea
 * Head position
 * Sleep staging1
 * Respiratory effort measurement (RERAs)1

1. Available for products commercialized in Europe, the United Kingdom, and
Australia. Information disclosed in the report may vary, please refer to the
Instructions for Use supplied with the product.


HOW CAN WE GET
THAT MUCH INFORMATION
THROUGH MANDIBULAR MOVEMENTS?





CLINICAL VALIDATION OF THE
SUNRISE DIGITAL SOLUTION

 * Published in 2022
   
   
   MANDIBULAR MOVEMENTS ARE A RELIABLE NONINVASIVE ALTERNATIVE TO ESOPHAGEAL
   PRESSURE FOR MEASURING RESPIRATORY EFFORT IN PATIENTS WITH SLEEP APNEA
   SYNDROME
   
   Pepin JL, Le-Dong NN, Cuthbert V, Coumans N, Tamisier R, Malhotra A, Martinot
   JB
   
   
   
   In OSA patients, MM signals facilitated the measurement of specific levels of
   RE associated with obstructive, central or mixed apneas and/or hypopneas. A
   high degree of similarity was observed with the PES gold-standard signal.
   
   
   
   Nature and Science of Sleep

 * Published in 2022
   
   
   DIAGNOSIS OF SLEEP APNEA USING A MANDIBULAR MONITOR AND MACHINE LEARNING
   ANALYSIS: ONE-NIGHT AGREEMENT COMPARED
   
   Julia L. Kelly, Raoua Ben Messaoud, Marie Joyeux-Faure, Robin Terrail, Renaud
   Tamisier, Jean-Benoît Martinot, Nhat-Nam Le-Dong, Mary J. Morrell and
   Jean-Louis Pépin
   
   
   
   The diagnosis of OSA, using MM with machine learning analysis, is comparable
   to manually scored in-home PSG. Therefore, this novel monitor could be a
   convenient diagnostic tool that can easily be used in the patients’ own home.
   
   
   
   Frontiers

 * Published in 2021
   
   
   ARTIFICIAL INTELLIGENCE ANALYSIS OF MANDIBULAR MOVEMENTS ENABLES ACCURATE
   DETECTION OF PHASIC SLEEP BRUXISM IN OSA PATIENTS: A PILOT STUDY
   
   Jean-Benoit Martinot ; Nhat-Nam Le-Dong ; Valérie Cuthbert ; Stéphane Denison
   ; David Gozal ; Gilles Lavigne ; Jean-Louis Pépin
   
   
   
   Sleep bruxism can be reliably identified, quantified, and characterized with
   mandibular jaw movements when subjected to automated analysis supported by
   Artificial Intelligence technology.
   
   
   
   Nature and Science of Sleep

 * Published in 2021
   
   
   MACHINE LEARNING-BASED SLEEP STAGING IN SLEEP APNEA PATIENTS USING A SINGLE
   MANDIBULAR MOVEMENT SIGNAL
   
   Nhat-Nam Le-Dong , Jean-Benoit Martinot ; Nathalie Coumans , Valérie
   Cuthbert , Renaud Tamisier ; Sébastien Bailly ; Jean-Louis Pépin 
   
   
   
   The algorithm classified sleep epochs with substantial qualitative agreement
   with manual PSG scorers. A sleep stage-wise ROC curve analysis confirmed the
   well-balanced performance for each target sleep stage.
   
   
   
   AJRCCM

 * Published in 2020
   
   
   AUTOMATED SLEEP APNEA DIAGNOSIS THROUGH MANDIBULAR MOVEMENT MONITORING
   COUPLED WITH MACHINE LEARNING ANALYSIS.
   
   Pépin, J. L., Letesson, C., Le-Dong, N.N., Dedave, A., Denison, S., Cuthbert,
   V., Martinot, J., Gozal, D.
   
   
   
   The performance of Sunrise not only favorably compares with but also, in many
   instances, surpasses the performance of other fully automated diagnostic
   devices.
   
   
   
   JAMA Netw Open.

 * Published in 2021
   
   
   CLINICAL VALIDATION OF A MANDIBULAR MOVEMENT SIGNAL BASED SYSTEM FOR THE
   DIAGNOSIS OF PEDIATRIC SLEEP APNEA
   
   Jean-Benoit Martinot MD, Valérie Cuthbert MSc, Nhat N. Le-Dong PhD, Nathalie
   Coumans MSc, Deborah De Marneffe MSc, Clément Letesson PhD, Jean L. Pépin MD,
   PhD, David Gozal MD, MBA
   
   
   
   MM automated analysis shows significant promise to diagnose
   moderate-to-severe pediatric OSA.
   
   
   
   Pediatric Pulmonology

 * Published in 2020
   
   
   BRUXISM RELIEVED UNDER CPAP TREATMENT IN A PATIENT WITH OBSTRUCTIVE SLEEP
   APNEA SYNDROME.
   
   Martinot, J. B., Borel, J. C., Le-Dong, N. N., Silkoff, P. E., Denison, S.,
   Gozal, D., Pépin, J. L.
   
   
   
   Mandibular movements recording allows to identify not only OSA and RERA, but
   also bruxism.
   
   
   
   Chest

 * Published in 2020
   
   
   MANDIBULAR MOVEMENT MONITORING WITH ARTIFICIAL INTELLIGENCE ANALYSIS FOR THE
   DIAGNOSIS OF SLEEP BRUXISM.
   
   J.-B. Martinot, N. Le-Dong, V. Cuthbert, S. Denison, D. Gozal, J.-L. Pepin.
   
   
   
   Sleep bruxism can be identified, quantified, and characterized with
   mandibular movements analysis supported by artificial intelligence.
   
   
   
   Sleep

 * Published in 2020
   
   
   THE POLYVALENT ROLE OF MANDIBULAR MOVEMENT SIGNAL IN OBSTRUCTIVE SLEEP APNEA
   SYNDROME DETECTION AND EVALUATION.
   
   N. Le-Dong, J.-B. Martinot, C. Letesson, J.-L. Pepin.
   
   
   
   Mandibular movements are correlated with the key PSG indexes and contribute
   as importantly as AHI, RDI and ODI for the diagnosis and severity
   stratification of OSAS.
   
   
   
   AJRCCM

 * Published in 2020
   
   
   DESIGN AND VALIDATION OF A NEW TECHNOLOGY FOR HOME-BASED SCREENING OF SLEEP
   APNEA SYNDROME.
   
   J.-B. Martinot, N. Le-Dong, C. Letesson, V. Cuthbert, D. Gozal, J.-L. Pepin.
   
   
   
   Mandibular movements recording are the most important contributors for
   optimized OSAS screening approach, when interfaced with self-reported
   symptoms and co-morbidities.
   
   
   
   AJRCCM

 * Published in 2019
   
   
   THE MOVEMENTS OF THE MANDIBLE PROVIDE INFORMATION ON THE THERAPEUTIC EFFICACY
   OF THE MANDIBULAR ADVANCEMENT DEVICE
   
   Martinot Jean-Benoît, Crespeigne E., Bolly Antoine, Butenda Babapu Dominique,
   Le-Dong, Nhat-Nam
   
   
   
   The study of mandibular movements during sleep provides precise information
   on the change in apnoea / hypopnoea indices during mandibular advancement
   device titration in the treatment of obstructive sleep apnoea.
   
   
   
   "Vaisseaux, Coeur, Poumons"

Clinical evidence


HOW DOES IT WORK?

Check out our clinical compendium!

Download


WE ARE PROUD TO WORK WITH SOME OF
THE BRIGHTEST EXPERTS IN OUR FIELD!


 * PROFESSOR ATUL MALHOTRA
   
    * M.D. Research Chief, Pulmonary, Critical Care and Sleep Medicine
    * Peter C. farrell Presidential Chair and Professor in Respiratory Medicine
    * Former President, American Thoracic Society 2015-2016
    * expertscape.com acknowledges Prof. Malhotra among the top 3 international
      experts in the field of Obstructive Sleep Apnea
   
   > “Having been involved with some of the recent clinical research, I am
   > impressed with the mandibular movement signal and its potential to provide
   > comprehensive information to the clinician to diagnose various sleep
   > disorders.”


 * PROFESSOR JEAN-LOUIS PÉPIN
   
    * M.D. Research Chief, Pulmonary and Sleep Medicine
    * Head of the French registry of sleep apnea and a member of the European
      sleep apnea database (ESADA)
    * Former President of the French Sleep Research and Medicine Society 2016
    * expertscape.com acknowledges Prof. Pépin among the top 3 international
      experts in the field of Obstructive Sleep Apnea
   
   > “The performance of Sunrise, not only favourably compares with, but also,
   > in many instances, surpasses the performance of other fully automated
   > diagnostic devices.”


PRESS & UPDATES


> CES 2021 INNOVATION AWARD HONOREE "HEALTH & WELLNESS"


> LISTED AMONG EUROPE’S 100 HOTTEST SCALEUPS OF 2021


> 2021 AWARD FOR DISRUPTIVE INNOVATION OF THE YEAR

> 

> 

> 

More press reviews

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