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 1. Home
 2. Archives
 3. Vol. 1 No. 1 (2022)
 4. Original Articles


HISTOPATHOLOGICAL AND BIOCHEMICAL EVALUATION OF ALBENDAZOLE IN THE TREATMENT OF
INFECTED MICE WITH HYDATID CYST


ARTICLE SIDEBAR


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Published: Dec 25, 2022
Updated: 2022-12-25
DOI: https://doi.org/10.58803/jlar.v1i1.6
Keywords:
Albendazole, Biochemistry, Chemotherapy, Hydatid cyst, Histopathology
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Abstract View: 309
PDF downloads: 75
XML-DOAJ downloads: 10
Crossref Citations: 0

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MAIN ARTICLE CONTENT

Khadijeh Haji Mohammadi
Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University
of Mashhad, Mashhad, Iran
https://orcid.org/0009-0001-8318-0769
Mohammad Heidarpour
Department of Clinical Sciences, Faculty of Veterinary Medicine, Ferdowsi
University of Mashhad, Mashhad, Iran
https://orcid.org/0000-0002-0580-7984
Zahra Moosavi
Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University
of Mashhad, Mashhad, Iran
https://orcid.org/0000-0002-8388-2699
Hassan Borji
Department of Pathobiology, Faculty of Veterinary Medicine, Ferdowsi University
of Mashhad, Mashhad, Iran
https://orcid.org/0000-0003-4706-4995


ABSTRACT

Introduction: Hydatidosis, caused by the larval stage of Echinococcus
granulosus, is a prevalent parasitic disease affecting both humans and animals.
Albendazole is currently the most effective drug for treating hydatid cysts.
This research aimed to investigate the histopathological and biochemical effects
of Albendazole on the liver, lung, and kidney of mice experimentally infected by
hydatid cysts.


Materials and methods: A total of 20 mice weighing approximately 220 g were
used. The rats were randomly divided into the Albendazole group (100 mg/kg/day)
and the control group (infected Rats without treatment). At the end of the
experiment, tissue samples from the liver, lung, and kidney were collected for
histopathological evaluation. Liver blood tests were used to assess liver
functions or liver injury (alkaline phosphatase, alanine aminotransferase, and
bilirubin).


Results: After 30 days of daily treatment, the total numbers of cysts, size, and
weight of the largest cyst were significantly lower in the Albendazole group,
compared to the control group. The study addressed histopathological changes in
the liver, kidneys, and lungs caused by hydatid cysts, such as tissue necrosis,
hemorrhage, and local inflammation, indicating the potential for serious
complications and significant damage to these organs. The group treated with
Albendazole showed severe histopathological changes in the liver, kidneys, and
lungs, compared to the control group. This suggests that Albendazole may trigger
a more aggressive response in these organs to the cysts, leading to increased
tissue damage. In addition, alkaline phosphatase, alanine aminotransferase, and
bilirubin concentrations revealed a significant increase in the Albendazole
group.


Conclusion: While Albendazole is an effective drug for treating hydatidosis, it
can also cause severe side effects on various organs in the body. Therefore,
alternative treatment strategies need to be developed to minimize these adverse
effects.

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ARTICLE DETAILS

How to Cite
Haji Mohammadi, K., Heidarpour, M., Moosavi, Z., & Borji, H. (2022).
Histopathological and Biochemical Evaluation of Albendazole in the Treatment of
Infected Mice with Hydatid Cyst. Journal of Lab Animal Research, 1(1), 1–7.
https://doi.org/10.58803/jlar.v1i1.6
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Issue
Vol. 1 No. 1 (2022)
Section
Original Articles

This work is licensed under a Creative Commons Attribution 4.0 International
License.





FUNDING DATA

 * Ferdowsi University of Mashhad
   Grant numbers 39833


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In vivoCancerParasiteCancer therapyWound healingHydatid cystIn-vivoBreast
cancerAutophagyApoptosisAnimal modelIvermectinCRISPRGarlicMesenchymal stem
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