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HomeScienceVol. 319, No. 5867Synaptic Protein Degradation Underlies
Destabilization of Retrieved Fear Memory
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SYNAPTIC PROTEIN DEGRADATION UNDERLIES DESTABILIZATION OF RETRIEVED FEAR MEMORY

Sue-Hyun Lee, Jun-Hyeok Choi, [...] , Nuribalhae Lee, Hye-Ryeon Lee, [...] ,
Jae-Ick Kim, Nam-Kyung Yu, Sun-Lim Choi, Seung-Hee Lee, Hyoung Kim, and
Bong-Kiun Kaang kaang@snu.ac.kr+7 authors +5 authors fewerAuthors Info &
Affiliations
Science
29 Feb 2008
Vol 319, Issue 5867
pp. 1253-1256
DOI: 10.1126/science.1150541

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ABSTRACT

Reactivated memory undergoes a rebuilding process that depends on de novo
protein synthesis. This suggests that retrieval is dynamic and serves to
incorporate new information into preexisting memories. However, little is known
about whether or not protein degradation is involved in the reorganization of
retrieved memory. We found that postsynaptic proteins were degraded in the
hippocampus by polyubiquitination after retrieval of contextual fear memory.
Moreover, the infusion of proteasome inhibitor into the CA1 region immediately
after retrieval prevented anisomycin-induced memory impairment, as well as the
extinction of fear memory. This suggests that ubiquitin- and
proteasome-dependent protein degradation underlies destabilization processes
after fear memory retrieval. It also provides strong evidence for the existence
of reorganization processes whereby preexisting memory is disrupted by protein
degradation, and updated memory is reconsolidated by protein synthesis.
Related Others
Memory Breakdown
By Peter R. SternScience Signaling4 Mar 2008


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Volume 319 | Issue 5867
29 February 2008

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NOTES

Supporting Online Material
www.sciencemag.org/cgi/content/full/1150541/DC1
Materials and Methods
Figs. S1 to S5
References


AUTHORS

AFFILIATIONSEXPAND ALL

SUE-HYUN LEE

National Creative Research Initiative Center for Memory, Department of
Biological Sciences, College of Natural Sciences, Seoul National University, San
56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
View all articles by this author

JUN-HYEOK CHOI

National Creative Research Initiative Center for Memory, Department of
Biological Sciences, College of Natural Sciences, Seoul National University, San
56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
View all articles by this author

NURIBALHAE LEE

National Creative Research Initiative Center for Memory, Department of
Biological Sciences, College of Natural Sciences, Seoul National University, San
56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
View all articles by this author

HYE-RYEON LEE

National Creative Research Initiative Center for Memory, Department of
Biological Sciences, College of Natural Sciences, Seoul National University, San
56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
View all articles by this author

JAE-ICK KIM

National Creative Research Initiative Center for Memory, Department of
Biological Sciences, College of Natural Sciences, Seoul National University, San
56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
View all articles by this author

NAM-KYUNG YU

National Creative Research Initiative Center for Memory, Department of
Biological Sciences, College of Natural Sciences, Seoul National University, San
56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
View all articles by this author

SUN-LIM CHOI

National Creative Research Initiative Center for Memory, Department of
Biological Sciences, College of Natural Sciences, Seoul National University, San
56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
View all articles by this author

SEUNG-HEE LEE

National Creative Research Initiative Center for Memory, Department of
Biological Sciences, College of Natural Sciences, Seoul National University, San
56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
View all articles by this author

HYOUNG KIM

National Creative Research Initiative Center for Memory, Department of
Biological Sciences, College of Natural Sciences, Seoul National University, San
56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
View all articles by this author

BONG-KIUN KAANG* KAANG@SNU.AC.KR

National Creative Research Initiative Center for Memory, Department of
Biological Sciences, College of Natural Sciences, Seoul National University, San
56-1 Silim-dong, Gwanak-gu, Seoul 151-747, Korea.
View all articles by this author

NOTES

*
To whom correspondence should be addressed. E-mail: kaang@snu.ac.kr


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Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear
Memory.Science319,1253-1256(2008).DOI:10.1126/science.1150541

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