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Submission: On November 14 via api from US — Scanned from US
Submission: On November 14 via api from US — Scanned from US
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<h1><a href="/diseases-conditions/drug-allergy/symptoms-causes/syc-20371835" data-di-id="di-id-f09e30a3-54488792">Drug allergy</a></h1>
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<h2>Diagnosis</h2>
<p>An accurate diagnosis is essential. Research has suggested that drug allergies may be overdiagnosed and that patients may report drug allergies that have never been confirmed. Misdiagnosed drug allergies may result in the use of less
appropriate or more-expensive medicines.</p>
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<p>A healthcare professional typically does a physical exam and asks you questions. Details about when symptoms started, the time you took the medicine, and improvement or worsening of symptoms are important clues for helping your health
professional make a diagnosis.</p>
<p>Your health professional may order more tests or refer you to an allergy specialist, called an allergist, for tests. These may include the following.</p>
<h3>Skin test</h3>
<p>With a skin test, the allergist or a nurse administers a small amount of a suspect medicine to the skin with a tiny needle that scratches the skin, a shot or a patch. A positive reaction to a test often causes a red, itchy, raised
bump.</p>
<p>A positive result suggests that you may have a drug allergy.</p>
<p>A negative result isn't as clear-cut. For some medicines, a negative test result usually means that you're not allergic to the medicine. For other medicines, a negative result may not completely rule out the possibility of a drug
allergy.</p>
<h3>Blood tests</h3>
<p>A healthcare professional may order blood tests to rule out other conditions that could be causing symptoms.</p>
<p>While there are blood tests for detecting allergic reactions to a few medicines, these tests aren't used often because of the relatively limited research on their accuracy. They may be used if there's concern about a serious reaction
to a skin test.</p>
<h3>Results of diagnostic work-up</h3>
<p>After looking at your symptoms and test results, a healthcare professional can usually reach one of the following conclusions:</p>
<ul>
<li>You have a drug allergy.</li>
<li>You don't have a drug allergy.</li>
<li>You may have a drug allergy — with varying degrees of certainty.</li>
</ul>
<p>These conclusions can help when making future treatment decisions.</p>
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<h2>Treatment</h2>
<p>Treatments for a drug allergy can be divided into two general strategies:</p>
<ul>
<li>Treatment for present allergy symptoms.</li>
<li>Treatment that may enable you to take an allergy-causing medicine if it's medically necessary.</li>
</ul>
<h3>Treating current symptoms</h3>
<p>The following treatments may be used to treat an allergic reaction to a medicine:</p>
<ul>
<li><strong>Stopping the medicine.</strong> If a healthcare professional determines that you have a drug allergy — or likely allergy — stopping the medicine is the first step in treatment. For many people, this may be the only
intervention necessary.</li>
<li><strong>Antihistamines.</strong> Your health professional may prescribe an antihistamine or recommend a nonprescription antihistamine such as diphenhydramine (Benadryl). An antihistamine can block immune system chemicals triggered
during an allergic reaction.</li>
<li><strong>Corticosteroids.</strong> Corticosteroids given as a shot or taken by mouth may be used to treat symptoms associated with more-serious reactions.</li>
<li><strong>Treatment of anaphylaxis.</strong> Anaphylaxis requires an immediate epinephrine shot. Hospital care also is needed to maintain blood pressure and support breathing.</li>
</ul>
<h3>Taking allergy-causing medicines</h3>
<p>If you have a confirmed drug allergy, a healthcare professional likely would not prescribe the medicine that causes a reaction unless it is necessary. Sometimes — if the diagnosis of drug allergy is uncertain or there's no other
treatment — your health professional may use one of two strategies to give you the suspect medicine.</p>
<p>With either strategy, your health professional provides careful supervision. Supportive care also is available in the event of an adverse reaction. These treatments are generally not used if medicines have caused serious,
life-threatening reactions in the past.</p>
<h3>Graded challenge</h3>
<p>If the diagnosis of a drug allergy is uncertain and a healthcare professional judges that an allergy is unlikely, a graded drug challenge may be an option. With this procedure, you receive 2 to 5 doses of the medicine, starting with a
small dose and increasing to the desired dose, also called the therapeutic dose.</p>
<p>If you reach the therapeutic dose with no reaction, then your health professional may recommend that you take the medicine as prescribed.</p>
<h3>Drug desensitization</h3>
<p>If it's necessary for you to take a medicine that has caused an allergic reaction, your care professional may recommend a treatment called drug desensitization. With this treatment, you receive a very small dose and then increasingly
larger doses every 15 to 30 minutes over several hours or days. If you can reach the desired dose with no reaction, then you can continue the treatment.</p>
<h2>Clinical trials</h2>
<p>
<a id="phmaincontent_0_phleftchannel_0_SectionRepeater_phclinicaltrials_0_9_ctLink_9" href="https://www.mayo.edu/research/clinical-trials/search-results?studySiteStatusesGrouped=Open/Status Unknown&pocId=CON-20371820" data-di-id="#phmaincontent_0_phleftchannel_0_SectionRepeater_phclinicaltrials_0_9_ctLink_9">Explore Mayo Clinic studies</a>
testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.
</p>
<h2>Preparing for your appointment</h2>
<p>See a healthcare professional if you have symptoms that may be related to a medicine you recently started taking or take regularly. Be prepared to answer the following questions. These details are important in helping determine the
cause of your symptoms.</p>
<ul>
<li>What symptoms did you experience? Don't leave out details even if they seem not related.</li>
<li>When did the symptoms start? Be as specific as possible.</li>
<li>How long did the symptoms last?</li>
<li>What new medicine have you taken?</li>
<li>When did you take it?</li>
<li>Have you stopped taking the new medicine?</li>
<li>What other nonprescription or prescription medicines do you take?</li>
<li>What herbal medicines, vitamins or other dietary supplements do you take?</li>
<li>At what time of day do you take your other medicines or supplements?</li>
<li>Have you increased the dosage of any regular medicine or supplement?</li>
<li>Have you stopped taking your regular medicines or supplements?</li>
<li>Did you take anything to treat your symptoms, and if so, what was the effect?</li>
<li>Have you had a reaction to a medicine in the past? If so, what medicine was it?</li>
<li>Do you have hay fever, food allergies or other allergies?</li>
<li>Is there a history of drug allergies in your family?</li>
</ul>
<p>You may want to take pictures of any condition, such as a rash or swelling, to show your healthcare team. These may help if symptoms have eased by the time of your appointment.</p>
<div class="thin-content-by"><a href="/about-this-site/meet-our-medical-editors" data-di-id="di-id-e2c54cf2-ed42ebc0">By Mayo Clinic Staff</a></div>
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<div class="pubdate"> Nov. 09, 2024 </div>
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<ol>
<li>Goldman L, et al., eds. Drug allergy. In: Goldman-Cecil Medicine. 27th ed. Elsevier; 2024. https://www.clinicalkey.com. Accessed Aug. 21, 2024.</li>
<li>Pichler WJ. Drug hypersensitivity: Classification and clinical features. https://www.uptodate.com/contents/search. Accessed Aug. 21, 2024.</li>
<li>Walls RM, et al., eds. Allergy, hypersensitivity and anaphylaxis. In: Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, Pa.: Elsevier; 2023. https://www.clinicalkey.com. Accessed Aug. 21, 2024.
</li>
<li>Burks AW, et al. Drug allergy. In: Middleton's Allergy: Principles and Practice. 9th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Aug. 21, 2024.</li>
<li>Sousa-Pinto B. Frequency of self-reported drug allergy — A systematic review and meta-analysis with meta-regression. Annals of Allergy and Immunology. doi:10.1016/j.anai.2017.07.009. Accessed Aug. 21, 2024.</li>
<li>Drug allergies. American College of Allergy, Asthma and Immunology. https://acaai.org/allergies/types/drug-allergies. Accessed Aug. 21, 2024.</li>
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<a href="https://www.mayo.edu/research/faculty" class="cmp-anchor--plain cmp-button cmp-button__link " id="button-9ad9df65ee" data-cmp-data-layer="{"target":"Research Faculty","category":"global-footer","action":"click"}" data-di-id="#button-9ad9df65ee"><span aria-hidden="false" class="cmp-button__inner cmp-button__inner--width-full cmp-button__inner--type-text-xsmall cmp-button__inner--color-primary-inverse "><span class="cmp-button__inner-wrapper"><span class="cmp-button__inner-main"><span role="text" class="cmp-button__text"> <!-- -->Research Faculty</span></span><span class="cmp-icon icon__chevron-right cmp-icon--size-16"><svg data-name="32x32-Guides" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" data-di-res-id="9f1a37f7-19ca9d18" data-di-rand="1731596296620"><path d="M5.707 13.707L4.293 12.293 8.586 8 4.293 3.707 5.707 2.293 11.414 8 5.707 13.707z"></path></svg></span></span></span></a>
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<a href="/departments-centers/international" class="cmp-anchor--plain" data-cmp-data-layer="{"target":"International Patients","category":"global-footer","action":"click"}" data-di-id="di-id-3a632dff-5bae9016"><span role="text" class="cmp-title__inner">International<!-- --> <span class="cmp-title__no-break">Patients<!-- --> <span class="cmp-icon icon__chevron-right cmp-icon--size-16"><svg data-name="32x32-Guides" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" data-di-res-id="27a65092-762115e2" data-di-rand="1731596296621"><path d="M5.707 13.707L4.293 12.293 8.586 8 4.293 3.707 5.707 2.293 11.414 8 5.707 13.707z"></path></svg></span></span></span></a>
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<a href="/departments-centers/international/appointments" class="cmp-anchor--plain cmp-button cmp-button__link " id="button-83fc99de7b" data-cmp-data-layer="{"target":"Appointments","category":"global-footer","action":"click"}" data-di-id="#button-83fc99de7b"><span aria-hidden="false" class="cmp-button__inner cmp-button__inner--width-full cmp-button__inner--type-text-xsmall cmp-button__inner--color-primary-inverse "><span class="cmp-button__inner-wrapper"><span class="cmp-button__inner-main"><span role="text" class="cmp-button__text"> <!-- -->Appointments</span></span><span class="cmp-icon icon__chevron-right cmp-icon--size-16"><svg data-name="32x32-Guides" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" data-di-res-id="27a65092-46a6db47" data-di-rand="1731596296621"><path d="M5.707 13.707L4.293 12.293 8.586 8 4.293 3.707 5.707 2.293 11.414 8 5.707 13.707z"></path></svg></span></span></span></a>
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<a href="/departments-centers/international/financial-services" class="cmp-anchor--plain cmp-button cmp-button__link " id="button-cca326f163" data-cmp-data-layer="{"target":"Financial Services","category":"global-footer","action":"click"}" data-di-id="#button-cca326f163"><span aria-hidden="false" class="cmp-button__inner cmp-button__inner--width-full cmp-button__inner--type-text-xsmall cmp-button__inner--color-primary-inverse "><span class="cmp-button__inner-wrapper"><span class="cmp-button__inner-main"><span role="text" class="cmp-button__text"> <!-- -->Financial Services</span></span><span class="cmp-icon icon__chevron-right cmp-icon--size-16"><svg data-name="32x32-Guides" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" data-di-res-id="3513ff7c-7651cdcc" data-di-rand="1731596296622"><path d="M5.707 13.707L4.293 12.293 8.586 8 4.293 3.707 5.707 2.293 11.414 8 5.707 13.707z"></path></svg></span></span></span></a>
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<a href="/departments-centers/international/locations" class="cmp-anchor--plain cmp-button cmp-button__link " id="button-5e92046078" data-cmp-data-layer="{"target":"International Locations & Offices","category":"global-footer","action":"click"}" data-di-id="#button-5e92046078"><span aria-hidden="false" class="cmp-button__inner cmp-button__inner--width-full cmp-button__inner--type-text-xsmall cmp-button__inner--color-primary-inverse "><span class="cmp-button__inner-wrapper"><span class="cmp-button__inner-main"><span role="text" class="cmp-button__text"> <!-- -->International Locations & Offices</span></span><span class="cmp-icon icon__chevron-right cmp-icon--size-16"><svg data-name="32x32-Guides" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 16 16" data-di-res-id="a93df620-db6ebd4e" data-di-rand="1731596296623"><path d="M5.707 13.707L4.293 12.293 8.586 8 4.293 3.707 5.707 2.293 11.414 8 5.707 13.707z"></path></svg></span></span></span></a>
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DRUG ALLERGY
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Print
DIAGNOSIS
An accurate diagnosis is essential. Research has suggested that drug allergies
may be overdiagnosed and that patients may report drug allergies that have never
been confirmed. Misdiagnosed drug allergies may result in the use of less
appropriate or more-expensive medicines.
A healthcare professional typically does a physical exam and asks you questions.
Details about when symptoms started, the time you took the medicine, and
improvement or worsening of symptoms are important clues for helping your health
professional make a diagnosis.
Your health professional may order more tests or refer you to an allergy
specialist, called an allergist, for tests. These may include the following.
SKIN TEST
With a skin test, the allergist or a nurse administers a small amount of a
suspect medicine to the skin with a tiny needle that scratches the skin, a shot
or a patch. A positive reaction to a test often causes a red, itchy, raised
bump.
A positive result suggests that you may have a drug allergy.
A negative result isn't as clear-cut. For some medicines, a negative test result
usually means that you're not allergic to the medicine. For other medicines, a
negative result may not completely rule out the possibility of a drug allergy.
BLOOD TESTS
A healthcare professional may order blood tests to rule out other conditions
that could be causing symptoms.
While there are blood tests for detecting allergic reactions to a few medicines,
these tests aren't used often because of the relatively limited research on
their accuracy. They may be used if there's concern about a serious reaction to
a skin test.
RESULTS OF DIAGNOSTIC WORK-UP
After looking at your symptoms and test results, a healthcare professional can
usually reach one of the following conclusions:
* You have a drug allergy.
* You don't have a drug allergy.
* You may have a drug allergy — with varying degrees of certainty.
These conclusions can help when making future treatment decisions.
TREATMENT
Treatments for a drug allergy can be divided into two general strategies:
* Treatment for present allergy symptoms.
* Treatment that may enable you to take an allergy-causing medicine if it's
medically necessary.
TREATING CURRENT SYMPTOMS
The following treatments may be used to treat an allergic reaction to a
medicine:
* Stopping the medicine. If a healthcare professional determines that you have
a drug allergy — or likely allergy — stopping the medicine is the first step
in treatment. For many people, this may be the only intervention necessary.
* Antihistamines. Your health professional may prescribe an antihistamine or
recommend a nonprescription antihistamine such as diphenhydramine (Benadryl).
An antihistamine can block immune system chemicals triggered during an
allergic reaction.
* Corticosteroids. Corticosteroids given as a shot or taken by mouth may be
used to treat symptoms associated with more-serious reactions.
* Treatment of anaphylaxis. Anaphylaxis requires an immediate epinephrine shot.
Hospital care also is needed to maintain blood pressure and support
breathing.
TAKING ALLERGY-CAUSING MEDICINES
If you have a confirmed drug allergy, a healthcare professional likely would not
prescribe the medicine that causes a reaction unless it is necessary. Sometimes
— if the diagnosis of drug allergy is uncertain or there's no other treatment —
your health professional may use one of two strategies to give you the suspect
medicine.
With either strategy, your health professional provides careful supervision.
Supportive care also is available in the event of an adverse reaction. These
treatments are generally not used if medicines have caused serious,
life-threatening reactions in the past.
GRADED CHALLENGE
If the diagnosis of a drug allergy is uncertain and a healthcare professional
judges that an allergy is unlikely, a graded drug challenge may be an option.
With this procedure, you receive 2 to 5 doses of the medicine, starting with a
small dose and increasing to the desired dose, also called the therapeutic dose.
If you reach the therapeutic dose with no reaction, then your health
professional may recommend that you take the medicine as prescribed.
DRUG DESENSITIZATION
If it's necessary for you to take a medicine that has caused an allergic
reaction, your care professional may recommend a treatment called drug
desensitization. With this treatment, you receive a very small dose and then
increasingly larger doses every 15 to 30 minutes over several hours or days. If
you can reach the desired dose with no reaction, then you can continue the
treatment.
CLINICAL TRIALS
Explore Mayo Clinic studies testing new treatments, interventions and tests as a
means to prevent, detect, treat or manage this condition.
PREPARING FOR YOUR APPOINTMENT
See a healthcare professional if you have symptoms that may be related to a
medicine you recently started taking or take regularly. Be prepared to answer
the following questions. These details are important in helping determine the
cause of your symptoms.
* What symptoms did you experience? Don't leave out details even if they seem
not related.
* When did the symptoms start? Be as specific as possible.
* How long did the symptoms last?
* What new medicine have you taken?
* When did you take it?
* Have you stopped taking the new medicine?
* What other nonprescription or prescription medicines do you take?
* What herbal medicines, vitamins or other dietary supplements do you take?
* At what time of day do you take your other medicines or supplements?
* Have you increased the dosage of any regular medicine or supplement?
* Have you stopped taking your regular medicines or supplements?
* Did you take anything to treat your symptoms, and if so, what was the effect?
* Have you had a reaction to a medicine in the past? If so, what medicine was
it?
* Do you have hay fever, food allergies or other allergies?
* Is there a history of drug allergies in your family?
You may want to take pictures of any condition, such as a rash or swelling, to
show your healthcare team. These may help if symptoms have eased by the time of
your appointment.
By Mayo Clinic Staff
Request an appointment
Symptoms & causesDoctors & departments
Nov. 09, 2024
Print
Show references
1. Goldman L, et al., eds. Drug allergy. In: Goldman-Cecil Medicine. 27th ed.
Elsevier; 2024. https://www.clinicalkey.com. Accessed Aug. 21, 2024.
2. Pichler WJ. Drug hypersensitivity: Classification and clinical features.
https://www.uptodate.com/contents/search. Accessed Aug. 21, 2024.
3. Walls RM, et al., eds. Allergy, hypersensitivity and anaphylaxis. In:
Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed.
Philadelphia, Pa.: Elsevier; 2023. https://www.clinicalkey.com. Accessed
Aug. 21, 2024.
4. Burks AW, et al. Drug allergy. In: Middleton's Allergy: Principles and
Practice. 9th ed. Elsevier; 2020. https://www.clinicalkey.com. Accessed Aug.
21, 2024.
5. Sousa-Pinto B. Frequency of self-reported drug allergy — A systematic review
and meta-analysis with meta-regression. Annals of Allergy and Immunology.
doi:10.1016/j.anai.2017.07.009. Accessed Aug. 21, 2024.
6. Drug allergies. American College of Allergy, Asthma and Immunology.
https://acaai.org/allergies/types/drug-allergies. Accessed Aug. 21, 2024.
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