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CONTENTS

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 * (Top)
 * 1 List of guidelines
   Toggle List of guidelines subsection
   * 1.1 Section 1: Physical Chemical Properties
   * 1.2 Section 2: Effects on Biotic Systems
   * 1.3 Section 3: Environmental Fate and Behaviour
   * 1.4 Section 4: Health Effects
   * 1.5 Section 5: Other Test Guidelines
 * 2 External links

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OECD GUIDELINES FOR THE TESTING OF CHEMICALS

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From Wikipedia, the free encyclopedia

Set of accepted specifications

OECD Guidelines for the Testing of Chemicals (OECD TG) are a set of
internationally accepted specifications for the testing of chemicals decided on
by the Organisation for Economic Co-operation and Development (OECD). They were
first published in 1981. They are split into five sections:

 * Section 1: Physical Chemical Properties
 * Section 2: Effects on Biotic Systems
 * Section 3: Environmental Fate and Behaviour
 * Section 4: Health Effects
 * Section 5: Other Test Guidelines

Guidelines are numbered with three digit numbers, the section number being the
first number. Sometimes guidelines are suffixed with a letter.

Guidelines are under constant review, with guidelines being periodically
updated, new guidelines being adopted, and guidelines being withdrawn. Previous
guidelines are maintained on the website for reference purposes. Animal welfare
concerns are dealt with by ensuring that animal tests are only permitted where
necessary.

The guidelines are available in both English and French.


LIST OF GUIDELINES

[edit]


SECTION 1: PHYSICAL CHEMICAL PROPERTIES

[edit]

Number Title 101 UV-VIS absorption spectra 102 Melting point/Melting range 103
Boiling point 104 Vapour pressure 105 Water solubility 106 Adsorption –
Desorption Using a Batch Equilibrium Method 107 Partition coefficient
(n-octanol/water): Shake Flask Method 108 Complex formation ability in water 109
Density of liquids and solids 110 Particle size distribution/ fibre length and
diameter distributions 111 Hydrolysis as a function of pH 112 Dissociation
constants in water 113 Screening test for thermal stability and stability in air
114 Viscosity of liquids 115 Surface tension of aqueous solutions 116 Fat
solubility of solid and liquid substances 117 Partition coefficient
(n-octanol/water), HPLC Method 118 Determination of the Number-Average molecular
weight and the molecular weight distribution of polymers using Gel Permeation
Chromatography 119 Determination of the Low Molecular Weight Content of a
Polymer Using Gel Permeation Chromatography 120 Solution/Extraction Behaviour of
Polymers in Water 121 Estimation of the adsorption coefficient (KOC) on Soil and
on sewage sludge using High Performance Liquid Chromatography (HPLC) 122
Determination of pH, Acidity and Alkalinity 123 Partition coefficient
(1-Octanol/Water): Slow-Stirring Method


SECTION 2: EFFECTS ON BIOTIC SYSTEMS

[edit]

Number Title 201 Freshwater Alga and Cyanobacteria, Growth Inhibition Test 202
Daphnia sp. Acute Immobilisation Test 203 Fish, Acute Toxicity Test 204 Fish,
Prolonged Toxicity Test: 14-Day Study 205 Avian Dietary Toxicity Test 206 Avian
Reproduction Test 207 Earthworm, Acute Toxicity Tests 208 Terrestrial Plant
Test: Seedling Emergence and Seedling Growth Test 209 Activated Sludge,
Respiration Inhibition Test (Carbon and Ammonium Oxidation) 210 Fish, Early-life
Stage Toxicity Test 211 Daphnia magna Reproduction Test 212 Fish, Short-term
Toxicity Test on Embryo and Sac-Fry Stages 213 Honeybees, Acute Oral Toxicity
Test 214 Honeybees, Acute Contact Toxicity Test 215 Fish, Juvenile Growth Test
216 Soil Microorganisms: Nitrogen Transformation Test 217 Soil Microorganisms:
Carbon Transformation Test 218 Sediment-Water Chironomid Toxicity Using Spiked
Sediment 219 Sediment-Water Chironomid Toxicity Using Spiked Water 220
Enchytraeid Reproduction Test 221 Lemna sp. Growth Inhibition Test 222 Earthworm
Reproduction Test (Eisenia fetida/Eisenia andrei) 223 Avian Acute Oral Toxicity
Test 224 Determination of the Inhibition of the Activity of Anaerobic Bacteria
225 Sediment-Water Lumbriculus Toxicity Test Using Spiked Sediment 226 Predatory
mite (Hypoaspis (Geolaelaps) aculeifer) reproduction test in soil 227
Terrestrial Plant Test: Vegetative Vigour Test 228 Determination of
Developmental Toxicity of a Test Chemical to Dipteran Dung Flies (Scathophaga
stercoraria L. (Scathophagidae), Musca autumnalis De Geer (Muscidae)) 229 Fish
Short Term Reproduction Assay 230 21-day Fish Assay 231 Amphibian Metamorphosis
Assay 232 Collembolan Reproduction Test in Soil 233 Sediment-Water Chironomid
Life-Cycle Toxicity Test Using Spiked Water or Spiked Sediment 234 Fish Sexual
Development Test 235 Chironomus sp., Acute Immobilisation Test 236 Fish Embryo
Acute Toxicity (FET) Test 237 Honey Bee (Apis Mellifera) Larval Toxicity Test,
Single Exposure 238 Sediment-Free Myriophyllum Spicatum Toxicity Test 239
Water-Sediment Myriophyllum Spicatum Toxicity Test 240 Medaka Extended One
Generation Reproduction Test (MEOGRT) 241 The Larval Amphibian Growth and
Development Assay (LAGDA)


SECTION 3: ENVIRONMENTAL FATE AND BEHAVIOUR

[edit]

Number Title 301 Ready Biodegradability 302A Inherent Biodegradability: Modified
SCAS Test 302B Inherent Biodegradability: Zahn-Wellens/ EVPA Test 302C Inherent
Biodegradability: Modified MITI Test (II) 303 Simulation Test – Aerobic Sewage
Treatment – A: Activated Sludge Units; B: Biofilms 304A Inherent
Biodegradability in Soil 305 Bioaccumulation in Fish: Aqueous and Dietary
Exposure 306 Biodegradability in Seawater 307 Aerobic and Anaerobic
Transformation in Soil 308 Aerobic and Anaerobic Transformation in Aquatic
Sediment Systems 309 Aerobic Mineralisation in Surface Water – Simulation
Biodegradation Test 310 Ready Biodegradability – CO2 in sealed vessels
(Headspace Test) 311 Anaerobic Biodegradability of Organic Compounds in Digested
Sludge: by Measurement of Gas Production 312 Leaching in Soil Columns 313
Estimation of Emissions from Preservative – Treated Wood to the Environment 314
Simulation Tests to Assess the Biodegradability of Chemicals Discharged in
Wastewater 315 Bioaccumulation in Sediment-dwelling Benthic Oligochaetes 316
Phototransformation of Chemicals in Water – Direct Photolysis 317
Bioaccumulation in Terrestrial Oligochaetes


SECTION 4: HEALTH EFFECTS

[edit]

Number Title 401 Acute Oral Toxicity 402 Acute Dermal Toxicity 403 Acute
Inhalation Toxicity 404 Acute Dermal Irritation/Corrosion 405 Acute Eye
Irritation/Corrosion 406 Skin Sensitisation 407 Repeated Dose 28-day Oral
Toxicity Study in Rodents 408 Repeated Dose 90-Day Oral Toxicity Study in
Rodents 409 Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents 410 Repeated
Dose Dermal Toxicity: 21/28-day Study 411 Subchronic Dermal Toxicity: 90-day
Study 412 Subacute Inhalation Toxicity: 28-Day Study 413 Subchronic Inhalation
Toxicity: 90-day Study 414 Prenatal Development Toxicity Study 415
One-Generation Reproduction Toxicity Study 416 Two-Generation Reproduction
Toxicity 417 Toxicokinetics 418 Delayed Neurotoxicity of Organophosphorus
Substances Following Acute Exposure 419 Delayed Neurotoxicity of
Organophosphorus Substances: 28-day Repeated Dose Study 420 Acute Oral Toxicity
– Fixed Dose Procedure 421 Reproduction/Developmental Toxicity Screening Test
422 Combined Repeated Dose Toxicity Study with the Reproduction/Developmental
Toxicity Screening Test 423 Acute Oral toxicity – Acute Toxic Class Method 424
Neurotoxicity Study in Rodents 425 Acute Oral Toxicity: Up-and-Down Procedure
426 Developmental Neurotoxicity Study 427 Skin Absorption: In Vivo Method 428
Skin Absorption: In Vitro Method 429 Skin Sensitisation 430 In Vitro Skin
Corrosion: Transcutaneous Electrical Resistance Test Method (TER) 431 In Vitro
Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method 432 In Vitro 3T3
NRU Phototoxicity Test 435 In Vitro Membrane Barrier Test Method for Skin
Corrosion 436 Acute Inhalation Toxicity – Acute Toxic Class Method 437 Bovine
Corneal Opacity and Permeability Test Method for Identifying i) Chemicals
Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for
Eye Irritation or Serious Eye Damage 438 Isolated Chicken Eye Test Method for
Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not
Requiring Classification for Eye Irritation or Serious Eye Damage 439 In Vitro
Skin Irritation: Reconstructed Human Epidermis Test Method 440 Uterotrophic
Bioassay in Rodents 441 Hershberger Bioassay in Rats 442A Skin Sensitization
442B Skin Sensitization 442C In Chemico Skin Sensitisation 442D In Vitro Skin
Sensitisation 443 Extended One-Generation Reproductive Toxicity Study 451
Carcinogenicity Studies 452 Chronic Toxicity Studies 453 Combined Chronic
Toxicity/Carcinogenicity Studies 455 Draft Performance-Based Test Guideline for
Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor
Agonists and Antagonists 456 H295R Steroidogenesis Assay 457 BG1Luc Estrogen
Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists
and Antagonists 460 Fluorescein Leakage Test Method for Identifying Ocular
Corrosives and Severe Irritants 471 Bacterial Reverse Mutation Test 473 In Vitro
Mammalian Chromosomal Aberration Test 474 Mammalian Erythrocyte Micronucleus
Test 475 Mammalian Bone Marrow Chromosomal Aberration Test 476 In Vitro
Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes 477 Genetic
Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster 478
Rodent Dominant Lethal Test 479 Genetic Toxicology: In vitro Sister Chromatid
Exchange Assay in Mammalian Cells 480 Genetic Toxicology: Saccharomyces
cerevisiae, Gene Mutation Assay 481 Genetic Toxicology: Saacharomyces
cerevisiae, Miotic Recombination Assay 482 Genetic Toxicology: DNA Damage and
Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro 483 Mammalian
Spermatogonial Chromosomal Aberration Test 484 Genetic Toxicology: Mouse Spot
Test 485 Genetic toxicology, Mouse Heritable Translocation Assay 486 Unscheduled
DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo 487 In Vitro
Mammalian Cell Micronucleus Test 488 Transgenic Rodent Somatic and Germ Cell
Gene Mutation Assays 489 In Vivo Mammalian Alkaline Comet Assay 490 In Vitro
Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene 491 Short
Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious
Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or
Serious Eye Damage 492 Reconstructed human Cornea-like Epithelium (RhCE) test
method for identifying chemicals not requiring classification and labelling for
eye irritation or serious eye damage 493 Performance-Based Test Guideline for
Human Recombinant Estrogen Receptor (hrER) In Vitro Assays to Detect Chemicals
with ER Binding Affinity


SECTION 5: OTHER TEST GUIDELINES

[edit]

Number Title 501 Metabolism in Crops 502 Metabolism in Rotational Crops 503
Metabolism in Livestock 504 Residues in Rotational Crops (Limited Field Studies)
505 Residues in Livestock 506 Stability of Pesticide Residues in Stored
Commodities 507 Nature of the Pesticide Residues in Processed Commodities – High
Temperature Hydrolysis 508 Magnitude of the Pesticide Residues in Processed
Commodities 509 Crop Field Trial


EXTERNAL LINKS

[edit]
 * OECD Guidelines for the Testing of Chemicals



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