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Try our high quality amino acids, resins and reagents and see just how much
better your peptides can be!

* Minimum Order Fee: Orders less than $100 will incur a fee to meet $100.

Welcome to AAPPTec! We have over 35 years of experience in supplying products
worldwide for peptide research and industrial-scale production. Our easy-to-use
instruments for peptide synthesis and large selection of products increase
chemists’ productivity, reduce project time and improve lab results. We assure
you that our automated peptide synthesizers and peptide synthesis reagents
provide high-purity crude peptides with minimum solvent consumption and the
lowest production costs. We also offer custom peptide synthesis, lyophilizers,
HPLC columns, resins, and amino acid derivatives including pseudoproline
dipeptides, isoacyl dipeptides, PEGylation reagents, glyco-amino acids and
products for stapled peptides. Visit our Resources page for Solid Phase Peptide
Synthesis best practices, and always know your online purchase includes the best
pricing, secure checkout, and fast delivery.

 * Lab-scale Automated Peptide/
   Organic Synthesizers
 * Pilot / Mini-Pilot Scale
 * Parallel Multiple Libraries

 * Split-and-Combine Libraries
 * pNA and DNA
 * Solid Phase and Solution Phase Organic Synthesis


SYNTHESIS REAGENTS


PEPTIDES


CUSTOM PEPTIDES


RELATED PRODUCTS


PEPTIDE SYNTHESIS COSTS

The cost of peptide synthesis is related to the following:

 * Fmoc amino acids, coupling reagents and solventsare approximately 30-35% of
   the total cost;
 * Purification and labor costs amount to 65-70% of the total cost.

Therefore,the raw material cost is approximately 1/3 the total cost of peptide
synthesis.

Using the most inexpensive reagents, solvents, and amino acids in peptide
synthesis results in the most expensive cost of peptide synthesis. The least
expensive amino acids are also the lowest quality amino acids.

The most expensive peptide to produce is actually the one when the lowest
quality of amino acids and reagents is used.Some scientists use low quality
amino acids because they are cheaper than higher quality amino acids. Therefore,
the cheaper cost of lower quality reagents for peptide synthesis is actually the
most expensive cost of peptide production.

The cost of producing high purity peptides is not expensive if the synthesis is
begun using high purity amino acids.To reduce the cost of peptide synthesis,some
scientists have chosen to use lower purity, cheaper protected amino acids and
reagents.Although this may seem a reasonable approach, it actually is more
expensive for a 20-residue amino acid long peptide. Starting with lower quality
raw material (98% purity) reduces the quality and the quantity of peptide by 40%
if every coupling is 100% successful while the synthesis using higher quality
raw material (99.7%)only loses 6%, provides a substantially higher yield, is
easier to purify and results in a lower loss of peptide during purification.

Therefore, the use of high purity amino acids is essential in the synthesis of
any peptide, especially long peptides. Table 1 compares the theoretical purity
of peptides prepared utilizing 99.7% pure, 99% pure, and 98% pure amino acids.
As the table illustrates, the purity of a 20-residue peptide prepared with 99.7%
pure amino acids would have a maximum expected purity of approximately 97% while
a peptide prepared with 98% pure amino acids would only be approximately 81%
pure.

Thus, even if the 98% pure amino acids are 30-50% less expensive than the 99.7%
pure amino acids, it would cost more to produce the same amount of final
peptide.

This does not even include purification costs which is 65 -70% of the total
cost.One saves substantial money by starting with higher purity crude peptides
to purify.This results in less labor costs and less solvent usage; and less
waste is generated which further reduces the amount of amino acid and reagent
usage. If one has less crude peptide, more peptide needs to be produced in order
to obtain a given quantity of purified peptide.

Therefore, using lower cost and/or lower purity standard amino acids and
reagents is actually more expensive than using higher priced,high purity amino
acids.

It is our mission at AAPPTec to always provide high quality amino acids and
reagents with competitive pricing for production of high quality crude peptides.


MAXIMUM THEORETICAL PURITY OF SYNTHESIZED PEPTIDE

Residue99.7%99%98%199.7%99%98%299.4%98.01%96.04%498.81%96.06%92.24%698.21%94.15%88.58%897.63%92.27%85.08%1097.04%90.44%81.71%1595.59%86.01%73.86%

Table 1 – Use of 99.7% vs. 99% Amino Acids vs. 98% Pure Amino Acids

“Speeds up my work. Simple to use. Very good customer service, I like the Focus
XC.” – Research Triangle International

“Easy to use, great flexibility. Great for scale up and long peptides, no
drawbacks.” – University of Nebraska

“User friendly, walk away synthesizer. Very easy software.” – Vanderbilt
University


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Phone: 502-968-2223
Fax: 502-968-3338
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