www.cancer.gov Open in urlscan Pro
2a02:26f0:ab00::5c7a:d708  Public Scan

Form analysis
2 forms found in the DOM

GET /search/results

<form class="nci-header-search" method="get" action="/search/results" role="search">
  <div class="nci-autocomplete">
    <div class="nci-autocomplete__status" aria-live="assertive"></div>
    <label class="usa-sr-only" for="nci-header-search__field"> Search </label>
    <input class="usa-input" id="nci-header-search__field" type="search" name="swKeyword" data-autosuggest-collection="cgov" role="combobox" aria-autocomplete="list" aria-haspopup="listbox" aria-expanded="false"
      aria-owns="nci-header-search__field-terms" aria-activedescendant="">
    <button class="usa-button nci-header-search__search-button" type="submit" aria-label="Search">
      <span class="nci-header-search__label" aria-hidden="true">Search</span>
      <svg class="usa-icon" xmlns="http://www.w3.org/2000/svg" role="img" viewBox="0 0 24 24" aria-hidden="true">
        <path d="M0 0h24v24H0z" fill="none"></path>
        <path
          d="M15.5 14h-.79l-.28-.27C15.41 12.59 16 11.11 16 9.5 16 5.91 13.09 3 9.5 3S3 5.91 3 9.5 5.91 16 9.5 16c1.61 0 3.09-.59 4.23-1.57l.27.28v.79l5 4.99L20.49 19l-4.99-5zm-6 0C7.01 14 5 11.99 5 9.5S7.01 5 9.5 5 14 7.01 14 9.5 11.99 14 9.5 14z">
        </path>
      </svg>
    </button>
    <div id="nci-header-search__field-termswrapper" class="nci-autocomplete__listbox listboxWidth">
      <div id="nci-header-search__field-terms" tabindex="-1" role="listbox"></div>
    </div>
  </div>
</form>

POST https://public.govdelivery.com/accounts/USNIHNCI/subscribers/qualify

<form action="https://public.govdelivery.com/accounts/USNIHNCI/subscribers/qualify" aria-label="Footer subscribe" class="usa-form" accept-charset="UTF-8" method="post" novalidate="" target="_blank" id="signup">
  <input type="hidden" name="category_id" id="category_id" value="">
  <div class="usa-form-group">
    <label class="usa-label" for="email"> Enter your email address </label>
    <span class="usa-error-message hidden" id="email-error-message" aria-hidden="true" role="alert">Enter a valid email address</span><input class="usa-input width-full" id="email" name="email" type="email" value=""
      aria-describedby="email-error-message">
  </div>
  <button class="usa-button usa-button--accent-warm" type="submit"> Sign up </button>
</form>

Text Content

Skip to main content
An official website of the United States government
Menu

Search Search

 * About Cancer
 * Cancer Types
 * Research
 * Grants & Training
 * News & Events
 * About NCI



 1. Home
 2. About NCI
 3. NCI Organization
 4. CSSI
 5. Research Areas & Programs
 6. COnsortium of METabolomics Studies (COMETS)

Print Email
 * CSSI
   * Research Areas & Programs
     * IMAT
     * ITCR
     * COMETS
       * Bylaws
       * Projects
       * Interest Groups
       * Members
     * BD-STEP
     * SynBio
     * Past Programs
   * Reporting & Analysis
   * Funding Opportunities
   * Resources
   * News & Events
   * About CSSI


CONSORTIUM OF METABOLOMICS STUDIES (COMETS)

The COnsortium of METabolomics Studies (COMETS) facilitates
extramural-intramural partnerships and promotes collaboration among prospective
cohort studies from around the world that follow participants for a range of
outcomes and perform metabolomic profiling of individuals. Participating cohorts
are each allowed one representative on the COMETS Steering Committee. Members
participate in interest groups, propose new projects, and are expected to follow
the COMETS by-laws.

COMETS was established after a meeting that took place at the NCI on October
28-29, 2014, "Think Tank on Metabolomics and Prospective Cohorts: How to
Leverage Resources." The objectives of COMETS are to:

 * Provide a framework to foster international collaborations among studies
   sharing common objectives;
 * Provide a forum for the discussion, development and pursuit of new
   collaborative studies and research directions;
 * Support the development of early career researchers; and
 * Advance the knowledge of the metabolome to improve our understanding of
   prediction of disease etiology, diagnosis and prognosis.

Based on these objectives, COMETS facilitates an open exchange of ideas,
knowledge, and results in order to accelerate the study of metabolomics profiles
associated with chronic disease phenotypes (e.g. heart disease, diabetes,
cancer). Learn more about COMETS through The Consortium of Metabolomics Studies
(COMETS): Metabolomics in 47 Prospective Cohort Studies publication.

ON THIS PAGE

 * Membership

 * Proposing New COMETS Projects and Collaborations

 * COMETS Analytics

MEMBERSHIP


CURRENT MEMBERS

List of cohorts participating in COMETS and members of the Executive Committee
and Steering Committee


MEMBERSHIP ELIGIBILITY FOR COHORT STUDIES

Cohorts must meet the following criteria to participate in COMETS:

 * Prospective cohort, 100+ participants with blood metabolomics data
 * Identified metabolite data
 * Follow-up for disease, including cancer and non-cancer outcomes
 * Mass-spectrometry and NMR platforms are eligible

Researchers representing cohorts who want to participate in COMETS should apply
through the Steering Committee membership form below.


MEMBERSHIP CATEGORIES FOR INVESTIGATORS


COMETS BY-LAWS

Policies for membership, interest groups, project proposals, and other
activities in COMETS.

Consortium membership falls under the 3 categories below. All COMETS members are
expected to comply with the consortium's bylaws.

 * Steering Committee: Primary representatives for cohort studies participating
   in COMETS join as Steering Committee members. Steering Committee members
   review project proposals, participate in Interest Groups, and are eligible to
   become Executive Committee members. They participate in voting to elect new
   members of the Executive Committee and advise the Executive Committee on all
   consortium matters. Membership is effective upon notification and
   confirmation of acceptance of the consortium membership application by the
   current Executive Committee.
   Investigators interested in joining COMETS and representing a prospective
   cohort should fill out the Application for Steering Committee Membership and
   e-mail the completed form to Luciana Crotti Espinoza and Kelly Crotty.
 * Executive Committee: There are 12 Executive Committee members who are
   responsible to and elected from the Steering Committee members of COMETS. The
   Executive Committee coordinates COMETS policies and guidelines, approves
   membership and project proposal requests, serves to facilitate scientific
   progress through assisting with the planning and development of collaborative
   consortium activities and with cross-consortium communications, and assists
   in the resolution of procedural disputes among members.
 * Consortium Members: Individuals who are interested in joining COMETS and do
   not represent a cohort on the Steering Committee can join as Consortium
   Members. Consortium Members are investigators who are working in the field of
   metabolomics but will not be representing a cohort. Membership requires a
   nomination by a Steering Committee member and is effective upon acceptance by
   the Executive Committee. Consortium Members are required to maintain active
   participation in at least one Interest Group or COMETS project. Consortium
   Members do not have voting rights. Consortium Members are eligible to propose
   new projects; those in training positions will need Steering Committee
   sponsorship.
   Researchers, including trainees, interested in becoming a Consortium Member
   should fill out the Application for Consortium membership form and discuss
   with the Steering Committee member who is nominating you for COMETS
   membership. After they approve this form, please submit this application
   along with your CV to Luciana Crotti Espinoza and Kelly Crotty (CCing the
   nominating SC member).

PROPOSING NEW COMETS PROJECTS AND COLLABORATIONS


COMETS PROJECTS

List of approved projects and collaborations being pursued by COMETS members.

The 2024 deadlines for submitting proposals are March 15, July 12, and November
15. Although COMETS members can submit proposals at any time throughout the
year, they will not be reviewed until after the next deadline closest to the
time of submission.

Download the Study Proposal Form


OVERVIEW OF THE REVIEW PROCESS FOR COMETS PROPOSALS

Proposals prepared using the Study Proposal Form are submitted by sending them
to Luciana Crotti Espinoza and Kelly Crotty via email by the indicated deadline.

 1. Initial Review - This will be completed within three weeks of the submission
    deadline and will consist of the following steps:
    * The Proposal Review Chair will make the proposals available to all
      steering committee members interested in participating in the review. One
      steering committee member will be assigned to be the primary reviewer for
      each proposal.
    * Comments and preliminary scores (1-5, corresponding to the criteria listed
      below, are due two weeks after the submission deadline.)
      * Approve as is
      * Approve with modifications
      * Deny with suggestions for revision
      * Deny due to overlap with other COMETS ongoing project
      * Deny due to insufficiently narrow in scope
    * During the third week, all proposals will be reviewed during a
      teleconference to which all investigators that submitted proposals will be
      invited to participate
      * The primary reviewer for each proposal will lead the discussion of that
        application. Proposal investigators may be asked to provide additional
        information about their project.
      * All steering committee members on the call will vote for a final score
        for each proposal.
 2. For proposals receiving a 2 (Approve with minor modifications), revisions
    can be approved by email.
 3. For proposals requiring major revisions or modifications in scope,
    investigators should submit a revised proposal and explanatory cover letter.
    The revised proposal will be discussed on the next Executive Committee call.


Timeline for 2024 Proposal Submission and Review Cycles

Step Round 1 Round 2 Round 3 Submission deadline 3/15/2024 7/12/2024 11/15/2024
Comments and preliminary recommendation deadline 4/5/2024 8/2/2024 12/6/2024
Proposal review conference call 4/8/2024 – 4/19/2024 8/5/2024 – 8/16/2024
12/9/2024 – 12/20/2024 If required, revised proposals due 5/15/2024 8/21/2024
1/17/2025 Revised proposals reviewed by Steering Committee 5/22/2024 8/28/2024
1/22/2025

COMETS ANALYTICS

COMETS AnalyticsExit Disclaimer is a cloud-based, self-serviced analytic
platform developed to improve rigor and reproducibility in consortium-based
metabolomics analyses, including single-cohort and meta-analysis investigations.
It is available for anyone to use and can be accessed through the web-based tool
or through GitHub as an R packageExit Disclaimer.

Read more about COMETS Analytics in the following publications and associated
commentary:

 * Temprosa et al., 2022: COMETS Analytics: An online tool for analyzing and
   meta-analyzing metabolomics data in large research consortia
 * Lacey and Benbow, 2022: Standards, Inputs, and Outputs: Strategies for
   improving data-sharing and consortia-based epidemiologic research

In May of 2024, NIH hosted a workshop on the COMETS Analytics platform
called Metabolomic epidemiology on a global scale: accelerating discovery and
enhancing rigor and reproducibility of single cohort and meta-analyses. The
workshop included tutorials on consortium-based analyses of metabolomics data
covering metabolite name harmonization, integrity checks, single cohort analyses
and meta-analyses as well as scientific talks about the last developments in
prospective analyses of cohort studies. View the recording through the NIH
Videocast. 

RELATED RESOURCES

 * COMETS Projects and Collaborations
 * COMETS Membership
 * COMETS By-Laws
 * COMETS Interest Groups

 * Posted: June 17, 2024

If you would like to reproduce some or all of this content, see Reuse of NCI
Information for guidance about copyright and permissions. In the case of
permitted digital reproduction, please credit the National Cancer Institute as
the source and link to the original NCI product using the original product's
title; e.g., “COnsortium of METabolomics Studies (COMETS) was originally
published by the National Cancer Institute.”

Print Email
Back To Top
About
 * About This Website
 * en Español
 * Reuse & Copyright
 * Social Media

Resources
 * Contact Us
 * Publications
 * Dictionary of Cancer Terms
 * Find a Clinical Trial

Policies
 * Accessibility
 * FOIA
 * Privacy & Security
 * Disclaimers
 * Vulnerability Disclosure

Sign up for email updates
Enter your email address Enter a valid email address
Sign up

National Cancer Institute at the National Institutes of Health

Contact Us
Live Chat
1-800-4-CANCER
NCIinfo@nih.gov
Site Feedback
Follow us
Facebook
Follow on X
Instagram
Youtube
Linkedin
U.S. Department of Health and Human Services National Institutes of Health
National Cancer Institute USA.gov