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3 forms found in the DOM

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/search

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 * Comunidad de alto nivel 05082024  
   Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut leo neque,
   viverra a purus sit amet, venenatis volutpat nisl. Pellentesque habitant
   morbi tristique senectus et netus et malesuada fames ac turpis egestas.
   Nullam dictum malesuada felis sed facilisis. Etiam volutpat massa augue, et
   facilisis lorem scelerisque ultricies. Pellentesque tincidunt erat eu euismod
   vestibulum. Ut vel nibh lorem. Nam sollicitudin faucibus ligula, sit amet
   aliquam lorem vestibulum a. Sed vestibulum, nisl ut mollis suscipit, eros
   lorem vestibulum magna, eu accumsan velit libero vitae ante. Quisque nec erat
   id nibh condimentum viverra. Praesent vestibulum pretium gravida. In vel
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RECENT SUBMISSIONS

Item
Study on the forming mechanism and evolutionary pattern of stagnant region in
mechanical scratching.
(2024-08-02) Ding, Yanchun; Yu, Wenxin; Shi, Guangfeng; Lv, Hailong; Wu, Jiayu;
Mao, Li; Li, Guohong
Show more
In this paper, a combination of theoretical modeling, finite element simulation,
and experimental methods is employed to investigate the forming mechanism and
evolutionary pattern of the stagnant region during mechanical scratching with a
diamond wedge tool. The study is structured as follows: Firstly, a theoretical
calculation model for the geometric parameters of the stagnant region on the
formed groove surface is established based on the contact friction partition
mechanism and slip-line field theory. The model indicates that the geometric
parameters l, l, and ∆l of the stagnant region are determined by the length of
the stagnant region l in the plastic flow plane and the transformation
parameters. Secondly, the formation process of the stagnant region in mechanical
scratching is investigated using an orthogonal cutting simulation model with a
negative rake angle tool. The results reveal that the stagnant region is a
plastic deformation region formed due to the geometrical characteristics of the
negative front surface of the scratching tool and its excessive extrusion, which
leads to the formation of adhesive friction within the material. Thirdly, the
characteristics of the stagnant region are determined through scratching
experiments. Compared to the material in the plastic flow region, the material
within the stagnant region exhibits finer and denser microstructures, reduced
surface hardening peaks and hardened layer depths, and significantly improved
surface roughness. Finally, the evolutionary pattern of the stagnant region
under the influence of scratching processing parameters is examined based on the
theoretical calculation model of the geometric parameters and the scratching
experiment. The findings indicate that as the wedge angle of the scratching tool
decreases, the relief angle increases, the absolute value of the rotation angle
around the Y-axis decreases, the scratching speed decreases, and the material's
plastic adherence improves, the P value decreases, the l value increases, and
consequently, the geometric parameters l, l, and ∆l of the stagnant region on
the formed groove surface also increase. The deviation analysis of the geometric
parameters of the stagnant region reveals a consistent trend between the
theoretical and experimental values of l and ∆l, with maximum deviations of
15 μm and 4.13%, respectively. This study provides theoretical and experimental
evidence for the establishment of the theoretical model of the stagnant region
in mechanical scratching, the analysis of its forming mechanism, and the control
of the stagnant region geometric parameters on the formed groove surface.
Show more
Item
Structural basis for the allosteric regulation and dynamic assembly of DNMT3B.
(2023-12-11) Lu, Jiuwei; Fang, Jian; Zhu, Hongtao; Liang, Kimberly Lu;
Khudaverdyan, Nelli; Song, Jikui
Show more
Oligomerization of DNMT3B, a mammalian de novo DNA methyltransferase, critically
regulates its chromatin targeting and DNA methylation activities. However, how
the N-terminal PWWP and ADD domains interplay with the C-terminal
methyltransferase (MTase) domain in regulating the dynamic assembly of DNMT3B
remains unclear. Here, we report the cryo-EM structure of DNMT3B under various
oligomerization states. The ADD domain of DNMT3B interacts with the MTase domain
to form an autoinhibitory conformation, resembling the previously observed
DNMT3A autoinhibition. Our combined structural and biochemical study further
identifies a role for the PWWP domain and its associated ICF mutation in the
allosteric regulation of DNMT3B tetramer, and a differential functional impact
on DNMT3B by potential ADD-H3K4me0 and PWWP-H3K36me3 bindings. In addition, our
comparative structural analysis reveals a coupling between DNMT3B
oligomerization and folding of its substrate-binding sites. Together, this study
provides mechanistic insights into the allosteric regulation and dynamic
assembly of DNMT3B.
Show more
Item
El papel del cardiólogo clínico en un programa de prevención cardiovascular
(Laboratorio de Hemodinámica, Clínica Las Américas, Medellín, Colombia, 2016)
Autor de prueba 01
Show more
Para iniciar tan apasionante tema editorial se tendrá en cuenta una definición
sobre la prevención en la enfermedad cardiovascular (enfermedad cardiovascular),
que sea acertada y conceptualmente universal. En concordancia con ello, se
asumirá aquella adoptada por el sexto grupo de trabajo continuo (6 th . Joint
Task Force) de la Sociedad Europea de Cardiología1 , entidad que la define como
un conjunto de acciones coordinadas, dirigidas a una población o un individuo,
con el objetivo de eliminar o minimizar su impacto y las discapacidades
relacionadas con esta
Show more
Item
Biteca pruebas 05082024
(Editor1, 2024) Autor de prueba 01; Autor de prueba 02; Autor de prueba 03
Show more
Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut leo neque, viverra a
purus sit amet, venenatis volutpat nisl. Pellentesque habitant morbi tristique
senectus et netus et malesuada fames ac turpis egestas. Nullam dictum malesuada
felis sed facilisis. Etiam volutpat massa augue, et facilisis lorem scelerisque
ultricies. Pellentesque tincidunt erat eu euismod vestibulum. Ut vel nibh lorem.
Nam sollicitudin faucibus ligula, sit amet aliquam lorem vestibulum a. Sed
vestibulum, nisl ut mollis suscipit, eros lorem vestibulum magna, eu accumsan
velit libero vitae ante. Quisque nec erat id nibh condimentum viverra. Praesent
vestibulum pretium gravida. In vel risus nec ante tempus iaculis eu ut enim.
Nulla eleifend eros nec facilisis aliquam. Fusce bibendum sit amet nulla et
sagittis. Vivamus scelerisque eleifend diam eget sollicitudin. Cras ut nisl non
orci lacinia viverra vitae ac velit. Aenean at quam sed eros convallis fringilla
at vitae risus. Nullam vel nunc iaculis, efficitur dolor id, rhoncus neque.
Aenean sed finibus orci, ac ornare lectus. Donec augue turpis, vestibulum vitae
leo at, posuere luctus quam. Maecenas quis fringilla magna. Etiam ut ornare
risus. Donec eros eros, eleifend id est vel, rutrum congue dui. Duis fringilla
consectetur augue, et cursus neque ornare at. Proin consequat enim in odio
feugiat laoreet. Donec et finibus sapien. Donec in ultricies dolor. Nulla
condimentum, nibh a tempor cursus, dolor augue accumsan sapien, at commodo purus
nisi id lorem. Morbi eget tristique orci, quis tempus nunc. Mauris tempus a urna
eu semper. Pellentesque a felis vel ante tristique ornare eu vitae ipsum.
Pellentesque viverra bibendum aliquam.
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