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Latest News
THE SOCIO-ECONOMIC CONSEQUENCES OF CANCER - AN UNDERESTIMATED PROBLEM
Many cancer patients suffer not only from health problems, but experience loss
of income and out-of-pocket expenditures for medical services. This is true even
in European countries with high incomes and comprehensive health insurance
systems. This problem has been largely underestimated in the past and little
systematic research has been carried out. The Organization of European Cancer
Institutes (OECI) is now presenting consensus recommendations to guide future
research into the socio-economic consequences of cancer.
Latest News
MACHINE LEARNING CLASSIFIER ACCELERATES THE DEVELOPMENT OF CELLULAR
IMMUNOTHERAPIES
Making a personalised T cell therapy for cancer patients currently takes at
least six months; scientists at the German Cancer Research Center (DKFZ) and the
University Medical Center Mannheim have shown that the laborious first step of
identifying tumor-reactive T cell receptors for patients can be replaced with a
machine learning classifier that halves this time.
Hopp Children’s Cancer Center Heidelberg
$25 MILLION OF FUNDING FOR NEW CANCER TREATMENTS FOR CHILDREN
The development of cancer therapies specifically for children and adolescents is
still in its proverbial infancy. A total of ten cancer centers from five
countries are involved in the international "PROTECT" team, led by the Hopp
Children's Cancer Center in Heidelberg (KiTZ), the Dana-Farber Cancer Institute
in Boston and Stanford University in California. It is one of five projects
being funded by the "Cancer Grand Challenges" initiative with up to $25 million
each. The international team will develop novel cancer therapies that break down
cancer-specific proteins in the tumor cells and which have not yet been used in
young cancer patients. Cancer Grand Challenges finances particularly ambitious,
forward-looking cancer research projects that have great potential to
sustainably improve the situation of those affected.
WE ARE ASKING FOR YOUR SUPPORT
Your Donation for Cancer Research
Donate now
MORE NEWS
Press Releases
Latest News
AI-SUPPORTED IMAGE ANALYSIS: METRICS DETERMINE QUALITY
How well do the algorithms used in the AI-supported analysis of medical images
perform their respective tasks? This depends to a large extent on the metrics
used to evaluate their performance. An international consortium led by
scientists from the German Cancer Research Center (DKFZ) and the National Center
for Tumor Diseases (NCT) in Heidelberg has compiled the knowledge available
worldwide on the specific strengths, weaknesses and limitations of the various
validation metrics. With "Metrics Reloaded", the researchers are now providing a
widely available online tool that supports users in selecting the most suitable
algorithm for their task.
Latest News
NEXT GENERATION MODELS FOR BRAIN TUMOR RESEARCH
"GLO", glioblastoma-like organoids grown in the laboratory from human stem
cells, are a suitable model for investigating the correlation between genetic
mutations and molecular subtypes in glioblastoma. This was published by
scientists from the German Cancer Research Center (DKFZ). When investigating the
GLOs, they discovered that glioblastoma development is characterised by a
reprogrammed lipid metabolism. This could be the starting point for developing
new drugs.
Latest News
THE UNEXPECTED LONG-TERM CONSEQUENCES OF FEMALE FERTILITY
The constant remodeling of the organs of the female reproductive tract during
the reproductive cycle leads to fibrosis and chronic inflammation over the
years. Scientists from the German Cancer Research Center (DKFZ) have now
uncovered these unexpected long-term consequences of female reproductive
function in mice. The results have been published in the scientific journal
CELL.
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Latest News
EPIGENETIC STATUS DETERMINES METASTASIS
Scientists from the German Cancer Research Center (DKFZ) and Medical Faculty
Mannheim of the Heidelberg University investigated in mice how spreading tumor
cells behave at the site of metastasis: Some tumor cells immediately start to
form metastases. Others leave the blood vessel and may then enter a long period
of dormancy. What determines which path the cancer cells take is their
epigenetic status. This was also confirmed in experiments with human tumor
cells. The results of the study could pave the way for novel diagnostic and
therapeutic applications.
Latest News
PRECURSOR OF CHOLESTEROL PROTECTS CANCER CELLS FROM CELL DEATH AND MAKES THEM
AGGRESSIVE
A precursor of cholesterol can protect cancer cells from a form of cell death
known as ferroptosis. Scientists of the University of Würzburg, the German
Cancer Research Center (DKFZ), and the Stem Cell Institute HI-STEM* published
this finding in the journal Nature. The results opens up exciting prospects for
further improving the treatment of cancer and other diseases associated with
oxidative stress and ferroptosis.
Latest News
HOPP CHILDREN'S CANCER CENTER HEIDELBERG LAUNCHES DEVELOPMENT COOPERATION TO
PROVIDE CHILDREN WORLDWIDE WITH MODERN CANCER DIAGNOSTICS
Worldwide, about 40 percent of all children and adolescents with cancer die from
their disease. Accurate cancer diagnostics and access to appropriate therapies
could significantly improve the success of treatment. With the recently launched
"MNP Outreach" program, the Hopp Children's Cancer Center Heidelberg (KiTZ), the
German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD)
aim to provide low-income countries worldwide with free access to modern
precision diagnostics. This project is supported by Illumina and the
organization BILD hilft e.V. "Ein Herz für Kinder".
CANCER IN THE EU
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FURTHER NEWS
Indicator for liver health status identified
A high-fat, high-sugar diet damages the liver in the long term. Scientists at
the German Cancer Research Center (DKFZ) have now identified a characteristic
change in the molecular signaling pathways of liver cells in mice that were
exposed to such a diet for weeks. It fuels the division activity of hepatocytes
and correlates with the risk of patients suffering liver failure after liver
surgery.
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AI-based support system for skin cancer diagnostics explains its decisions
Artificial intelligence (AI) can help dermatologists to detect skin cancer.
However, many dermatologists distrust the algorithms' decisions, which they
cannot comprehend. Scientists at the German Cancer Research Center have now
developed an AI-based support system for skin cancer diagnostics that explains
its decisions. The system uses established diagnostic features that relate to
specific areas of suspicious lesions. The explanations increased doctors'
confidence in the machine's decisions - as well as in their own diagnoses.
Brain tumors in children: Cancer cells become less aggressive as they migrate
within the tumor
Certain brain tumors in small children contain cells that develop very similarly
to normal brain cells and others that have already developed malignantly,
depending on where they are located within the tumor. By analyzing individual
cells, a team of researchers from the Hopp Children's Cancer Center Heidelberg
(KiTZ), the German Cancer Research Center (DKFZ) and Heidelberg University
Hospital (UKHD) were able to characterize the genetic programs of the individual
cells in detail and identify their developmental pathway within the tumor.
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Reprogrammed fat cells support tumor growth
Mutations of the tumor suppressor p53 not only have a growth-promoting effect on
the cancer cells themselves, but also influence the cells in the tumor's
microenvironment. Scientists at the German Cancer Research Center (DKFZ) and the
Weizmann Institute in Israel have now shown that p53-mutated mouse breast cancer
cells reprogram fat cells. The manipulated fat cells create an inflammatory
microenvironment, impairing the immune response against the tumor and thus
promoting cancer growth.
ERC Starting Grant for DKFZ researcher Angelika Feldmann
Funding from the European Research Council (ERC) is regarded as an accolade for
scientists at all career stages. With its "Starting Grants", the ERC aims to
pave the way to an independent career for excellent young scientists. This year,
Angelika Feldmann from the German Cancer Research Center (DKFZ) has been awarded
the prestigious grant: she wants to explore the molecular processes that are
required during the development of an organism so that all cells can read the
right genes at the right time. Defects in this process can result in
developmental disorders or cancer.
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