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Within this study we aim to investigate the predictive value of early serum
trough levels of brodalumab and determine the therapeutic window of brodalumab
in psoriasis patients. Patients will be included after siging informed consent.
After inclusion, patients will continue on standard dosing schedule of
brodalumab i. Furthermore, T2T can create value in the management of psoriasis
as observed in RA: the definition of minimal disease activity has been
extensively investigated to achieve the best and most relevant outcome in RA. In
psoriasis, the definition of minimal disease activity or remission in psoriasis
has not been studied as extensively as in RA and PsA.

However, it is primordial to employ an unambiguous, yet holistic definition. Our
T2T outcome defines value in a multileveled manner.

Additionally, all dimensions weigh equally in the treatment decision, but may
differ in reality: each dimension may vary in importance or contribution to the
definition of minimal disease activity, which will require further
investigation. Furthermore, the sample sizes were rather limited. However, our
study included input from experienced dermatologists and patients, rendering the
score highly relevant for both parties. The score in itself was also safeguarded
for feasibility requiring minimal infrastructure and experience in real life.
With this study, we fulfil the 5 principles of T2T as proposed by van
Vollenhoven.

However, we believe the paradigm can guide any dermatologist treating psoriasis,
dependent on the means available to attain this. Preliminary T2T outcomes
presented during Delphi round 3. File S2. Delphi questionnaire amongst Belgian
dermatology KOL and experts. We would like to express our gratitude to the
participating dermatologists and psoriasis patients for their contributions by
sharing their expertise and insights.

This project was realized with logistical support by Novartis Belgium during the
meetings for which the authors are thankful; Novartis Belgium did not intervene
in the study's design, progress or outcome. We would like to extend our
gratitude to Prof Kristian Reich for his advice. Finally, we would also like to
thank the Flemish Psoriasis League for their support. The copyright line for
this article was changed on 28 March after original online publication.

Read article at publisher's site DOI : This data has been text mined from the
article, or deposited into data resources. To arrive at the top five similar
articles we use a word-weighted algorithm to compare words from the Title and
Abstract of each citation. J Dermatolog Treat , 26 2 , 08 Apr Cited by: 6
articles PMID: Osteoporos Int , 29 2 , 24 Nov Medical Advisory Secretariat. Free
to read.

Int J Rheum Dis , 22 5 , 22 Feb Cited by: 1 article PMID: Cited by: 0 articles
PMID: Coronavirus: Find the latest articles and preprints. Europe PMC requires
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Search articles by 'M de la Brassinne'. Search articles by 'P-D Ghislain'.
Ghislain PD 3 ,. Search articles by 'T Hillary'. Hillary T 4 ,. Search articles
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Here, we define a T2T outcome for moderate-to-severe psoriasis vulgaris.
METHODS:Briefly, the study included a literature review, discussions with key
opinion leaders, recruitment of additional dermatologists with experience in
managing moderate-to-severe psoriasis, 3 eDelphi survey rounds and a patient
focus group. Surveys were based on the eDelphi methodology for
consensus-building using a series of statements.


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We defined 'ideal' and 'acceptable' targets; the latter referring to conditions
restricting certain drugs. At all times, safety should not exceed the presence
of mild side-effects. J Eur Acad Dermatol Venereol. Published online Jan 2.
PMID: Ghislain , 4 T. Hillary , 5 J. Lambert , 6 S. Segaert , 7 F. Lambert 1 ,
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