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HORMONE PATCHES OR CREAMS FOR MENOPAUSE SYMPTOMS MAY HAVE LOWER BLOOD PRESSURE
RISK THAN PILLS

FILE - This Tuesday, Oct. 2, 2012 photo shows a low-dose estrogen skin patch.
Women often use hormone therapy to relieve hot flashes and other menopause
symptoms — and new research suggests whether they choose pills, patches or
creams might matter for their blood pressure. The findings were published in the
journal Hypertension on Monday, June 5, 2023. (AP Photo/File)

Read More
By Lauran Neergaard
Published [hour]:[minute] [AMPM] [timezone], [monthFull] [day], [year] Published
2:15 AM PDT, June 5, 2023
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WASHINGTON (AP) — Women often use hormone therapy to relieve hot flashes and
other menopause symptoms — and new research suggests patches or creams may be
safer for their blood pressure than pills.

As women’s bodies produce lower levels of reproductive hormones during menopause
their risk for heart disease rises. High blood pressure further increases that
risk — but it’s not clear whether there’s a link with hormone therapy for
menopause symptoms.

Canadian researchers wondered if the way hormones are absorbed — orally,
vaginally or through the skin -- could play a role.

The University of Calgary team examined health records of more than 112,000
women ages 45 and older who filled prescriptions for at least six months’ worth
of estrogen-only hormone treatment between 2008 and 2019. They tracked which
women went on to develop high blood pressure at least a year after starting
treatment.



While the differences weren’t huge, women who took estrogen pills had a 14%
higher risk of developing hypertension compared to those using skin patches or
creams, the researchers reported Monday. Oral estrogen carried a 19% greater
risk than vaginal versions.

READ MORE
Halle Berry shouts from the Capitol, ‘I’m in menopause’ as she seeks to end a
stigma and win funding
Halle Berry shouts from the Capitol, ‘I’m in menopause’ as she seeks to end a
stigma and win funding

The findings were published in the journal Hypertension.

Hormone therapy has a mix of risks and benefits that mean it’s not for everyone.
Today it’s prescribed not to prevent disease but to relieve menopause-related
symptoms — generally using the lowest possible dose for the shortest time. Most
commonly used are combination pills of estrogen and another hormone, progestin.
(Estrogen-only pills typically are prescribed to women without a uterus.)



Different versions of hormone therapy may work better for different menopause
symptoms, something the study didn’t address.

But it adds important clues to understanding the complex relationship between
hormone therapy and blood pressure, said Dr. Garima Sharma, a women’s heart
specialist with Virginia’s Inova Health System and the American Heart
Association.



Sharma would like to see a more rigorous trial that compares different hormone
versions. But she pointed to a possible biological explanation: Maybe oral
estrogen affects enzymes linked to blood pressure as it’s being processed, while
skin and vaginal versions have much more limited activity in the body.

Still, “these findings are very clinically relevant,” Sharma said in an an
email, and suggest it’s especially important to monitor blood pressure in women
who use oral hormone therapy.


___

The Associated Press Health and Science Department receives support from the
Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is
solely responsible for all content.


    
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